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silkworm_phenotype

Id Subject Object Predicate Lexical cue
T8 1448-1456 Chemical:MESH:D014443 denotes tyrosine
T7 1408-1415 Species:7091 denotes B. mori
T6 639-647 Disease:MESH:D064420 denotes toxicity
T5 561-572 Species:7091 denotes Bombyx mori
T4 551-559 Species:7091 denotes silkworm
T39 328-343 Gene:100736431 denotes ABC transporter
T37 1521-1527 BMO_00500 denotes Cry1Ab
T35 1391-1397 BMO_00500 denotes Cry1Ab
T34 1199-1205 BMO_00500 denotes Cry1Ab
T32 748-754 BMO_00500 denotes Cry1Ab
T31 328-364 Gene denotes ABC transporter subfamily members C2
T30 1424-1433 Gene denotes BmABCC2_R
T3 129-151 Species:1428 denotes Bacillus thuringiensis
T29 1232-1239 Gene denotes BmABCC3
T28 1136-1143 Gene denotes BmABCC3
T27 973-980 Gene denotes BmABCC3
T26 855-862 Gene denotes BmABCC3
T25 674-681 Gene denotes BmABCC3
T24 603-610 Gene denotes BmABCC3
T23 596-601 Gene denotes ABCC3
T22 1378-1383 Gene denotes ABCC2
T21 574-579 Gene denotes ABCC2
T20 366-371 Gene denotes ABCC2
T2 94-116 Species:1428 denotes Bacillus thuringiensis
T19 381-386 Gene denotes ABCC3
T18 1542-1551 Gene denotes BmABCC2_S
T17 1218-1227 Gene denotes BmABCC2_S
T16 1071-1080 Gene denotes BmABCC2_S
T15 663-672 Gene denotes BmABCC2_S
T14 581-590 Gene denotes BmABCC2_S
T1 33-41 Species:7091 denotes silkworm

sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Extracellular loop structures in silkworm ABCC transporters determine their specificities for Bacillus thuringiensis Cry toxins.
T2 129-218 Sentence denotes Bacillus thuringiensis Cry toxins are insecticidal proteins used widely for pest control.
T3 219-388 Sentence denotes They are lethal to a restricted range of insects via specific interactions with insect receptors such as the ABC transporter subfamily members C2 (ABCC2) and C3 (ABCC3).
T4 389-500 Sentence denotes However, it is still unclear how these different receptors contribute to insect susceptibility to Cry1A toxins.
T5 501-648 Sentence denotes Here, we investigated the differences between the silkworm (Bombyx mori) ABCC2 (BmABCC2_S) and ABCC3 (BmABCC3) receptors in mediating Cry toxicity.
T6 649-886 Sentence denotes Compared with BmABCC2_S, BmABCC3 exhibited 80- and 267-fold lower binding affinities to Cry1Aa and Cry1Ab, respectively, and these decreased affinities correlated well with the lower receptor activities of BmABCC3 for these Cry1A toxins.
T7 887-1081 Sentence denotes To identify the amino acid residues responsible for these differences, we constructed BmABCC3 variants containing a partial amino acid replacement with extracellular loops (ECLs) from BmABCC2_S.
T8 1082-1206 Sentence denotes Replacing three amino acids from ECL 1 or 3 increased BmABCC3 activity toward Cry1Aa and enabled its activity toward Cry1Ab.
T9 1207-1377 Sentence denotes Meanwhile, BmABCC2_S and BmABCC3 exhibited no receptor activities for Cry1Ca, Cry1Da, and Cry3Bb, correlating with markedly lower binding affinities for these Cry toxins.
T10 1378-1599 Sentence denotes ABCC2 from a Cry1Ab-resistant B. mori strain (BmABCC2_R), which has a tyrosine insertion in ECL 2, displayed 93-fold lower binding affinity to Cry1Ab compared with BmABCC2_S but maintained high binding affinity to Cry1Aa.
T11 1600-1836 Sentence denotes These results indicate that the Cry toxin-binding affinities of ABCC transporters are largely linked to the level of Cry susceptibility of ABCC-expressing cells and that the ABCC ECL structures determine the specificities to Cry toxins.

silkworm

Id Subject Object Predicate Lexical cue
T1 33-41 Species:7091 denotes silkworm
T2 94-116 Species:1428 denotes Bacillus thuringiensis
T3 129-151 Species:1428 denotes Bacillus thuringiensis
T4 551-559 Species:7091 denotes silkworm
T5 561-572 Species:7091 denotes Bombyx mori
T6 639-647 Disease:MESH:D064420 denotes toxicity
T7 1408-1415 Species:7091 denotes B. mori
T8 1448-1456 Chemical:MESH:D014443 denotes tyrosine
T9 1521-1525 Gene:100500923 denotes Cry1

silkwormbase

Id Subject Object Predicate Lexical cue
T1 33-41 Species:7091 denotes silkworm
T14 581-590 Gene denotes BmABCC2_S
T15 663-672 Gene denotes BmABCC2_S
T16 1071-1080 Gene denotes BmABCC2_S
T17 1218-1227 Gene denotes BmABCC2_S
T18 1542-1551 Gene denotes BmABCC2_S
T19 381-386 Gene denotes ABCC3
T2 94-116 Species:1428 denotes Bacillus thuringiensis
T20 366-371 Gene denotes ABCC2
T21 574-579 Gene denotes ABCC2
T22 1378-1383 Gene denotes ABCC2
T23 596-601 Gene denotes ABCC3
T24 603-610 Gene denotes BmABCC3
T25 674-681 Gene denotes BmABCC3
T26 855-862 Gene denotes BmABCC3
T27 973-980 Gene denotes BmABCC3
T28 1136-1143 Gene denotes BmABCC3
T29 1232-1239 Gene denotes BmABCC3
T3 129-151 Species:1428 denotes Bacillus thuringiensis
T30 1424-1433 Gene denotes BmABCC2_R
T31 328-364 Gene denotes ABC transporter subfamily members C2
T32 748-754 BMO_00500 denotes Cry1Ab
T34 1199-1205 BMO_00500 denotes Cry1Ab
T35 1391-1397 BMO_00500 denotes Cry1Ab
T37 1521-1527 BMO_00500 denotes Cry1Ab
T39 328-343 Gene:100736431 denotes ABC transporter
T4 551-559 Species:7091 denotes silkworm
T5 561-572 Species:7091 denotes Bombyx mori
T6 639-647 Disease:MESH:D064420 denotes toxicity
T7 1408-1415 Species:7091 denotes B. mori
T8 1448-1456 Chemical:MESH:D014443 denotes tyrosine

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 205-209 Disease denotes pest http://purl.obolibrary.org/obo/MONDO_0019095

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 33-41 OrganismTaxon denotes silkworm 7091
T2 94-116 OrganismTaxon denotes Bacillus thuringiensis 1428
T3 129-151 OrganismTaxon denotes Bacillus thuringiensis 1428
T4 551-559 OrganismTaxon denotes silkworm 7091
T5 561-572 OrganismTaxon denotes Bombyx mori 7091

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-13 Body_part denotes Extracellular http://purl.obolibrary.org/obo/GO_0005576
T2 1039-1052 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576