PubMed:29049388 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/29049388","sourcedb":"PubMed","sourceid":"29049388","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/29049388","text":"An inducible mouse model of podocin-mutation-related nephrotic syndrome.\nMutations in the NPHS2 gene, encoding podocin, cause hereditary nephrotic syndrome. The most common podocin mutation, R138Q, is associated with early disease onset and rapid progression to end-stage renal disease. Knock-in mice carrying a R140Q mutation, the mouse analogue of human R138Q, show developmental arrest of podocytes and lethal renal failure at neonatal age. Here we created a conditional podocin knock-in model named NPHS2 R140Q/-, using a tamoxifen-inducible Cre recombinase, which permits to study the effects of the mutation in postnatal life. Within the first week of R140Q hemizygosity induction the animals developed proteinuria, which peaked after 4-5 weeks. Subsequently the animals developed progressive renal failure, with a median survival time of 12 (95% CI: 11-13) weeks. Foot process fusion was observed within one week, progressing to severe and global effacement in the course of the disease. The number of podocytes per glomerulus gradually diminished to 18% compared to healthy controls 12-16 weeks after induction. The fraction of segmentally sclerosed glomeruli was 25%, 85% and 97% at 2, 4 and 8 weeks, respectively. Severe tubulointerstitial fibrosis was present at later disease stage and was correlated quantitatively with the level of proteinuria at early disease stages. While R140Q podocin mRNA expression was elevated, protein abundance was reduced by more than 50% within one week following induction. Whereas miRNA21 expression persistently increased during the first 4 weeks, miRNA-193a expression peaked 2 weeks after induction. In conclusion, the inducible R140Q-podocin mouse model is an auspicious model of the most common genetic cause of human nephrotic syndrome, with a spontaneous disease course strongly reminiscent of the human disorder. This model constitutes a valuable tool to test the efficacy of novel pharmacological interventions aimed to improve podocyte function and viability and attenuate proteinuria, glomerulosclerosis and progressive renal failure.","tracks":[{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":13,"end":18},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":296,"end":300},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":332,"end":337},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":350,"end":355},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":1690,"end":1695},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":1761,"end":1766},"obj":"OrganismTaxon"},{"id":"T11","span":{"begin":1849,"end":1854},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:10090"},{"id":"A2","pred":"db_id","subj":"T1","obj":"NCBItxid:10088"},{"id":"A3","pred":"db_id","subj":"T3","obj":"NCBItxid:10095"},{"id":"A4","pred":"db_id","subj":"T3","obj":"NCBItxid:10088"},{"id":"A5","pred":"db_id","subj":"T5","obj":"NCBItxid:10090"},{"id":"A6","pred":"db_id","subj":"T5","obj":"NCBItxid:10088"},{"id":"A7","pred":"db_id","subj":"T7","obj":"NCBItxid:9606"},{"id":"A8","pred":"db_id","subj":"T8","obj":"NCBItxid:10090"},{"id":"A9","pred":"db_id","subj":"T8","obj":"NCBItxid:10088"},{"id":"A10","pred":"db_id","subj":"T10","obj":"NCBItxid:9606"},{"id":"A11","pred":"db_id","subj":"T11","obj":"NCBItxid:9606"},{"subj":"T1","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T3","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T5","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T7","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T8","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T10","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T11","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":72},"obj":"Sentence"},{"id":"T2","span":{"begin":73,"end":156},"obj":"Sentence"},{"id":"T3","span":{"begin":157,"end":286},"obj":"Sentence"},{"id":"T4","span":{"begin":287,"end":443},"obj":"Sentence"},{"id":"T5","span":{"begin":444,"end":632},"obj":"Sentence"},{"id":"T6","span":{"begin":633,"end":751},"obj":"Sentence"},{"id":"T7","span":{"begin":752,"end":856},"obj":"Sentence"},{"id":"T8","span":{"begin":857,"end":870},"obj":"Sentence"},{"id":"T9","span":{"begin":871,"end":994},"obj":"Sentence"},{"id":"T10","span":{"begin":995,"end":1119},"obj":"Sentence"},{"id":"T11","span":{"begin":1120,"end":1223},"obj":"Sentence"},{"id":"T12","span":{"begin":1224,"end":1382},"obj":"Sentence"},{"id":"T13","span":{"begin":1383,"end":1516},"obj":"Sentence"},{"id":"T14","span":{"begin":1517,"end":1646},"obj":"Sentence"},{"id":"T15","span":{"begin":1647,"end":1864},"obj":"Sentence"},{"id":"T16","span":{"begin":1865,"end":2089},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"},{"subj":"T9","pred":"source","obj":"LitCoin-sentences"},{"subj":"T10","pred":"source","obj":"LitCoin-sentences"},{"subj":"T11","pred":"source","obj":"LitCoin-sentences"},{"subj":"T12","pred":"source","obj":"LitCoin-sentences"},{"subj":"T13","pred":"source","obj":"LitCoin-sentences"},{"subj":"T14","pred":"source","obj":"LitCoin-sentences"},{"subj":"T15","pred":"source","obj":"LitCoin-sentences"},{"subj":"T16","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities","denotations":[{"id":"13466","span":{"begin":13,"end":18},"obj":"OrganismTaxon"},{"id":"13467","span":{"begin":28,"end":35},"obj":"GeneOrGeneProduct"},{"id":"13468","span":{"begin":53,"end":71},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13469","span":{"begin":90,"end":95},"obj":"GeneOrGeneProduct"},{"id":"13470","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"13471","span":{"begin":137,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13472","span":{"begin":173,"end":180},"obj":"GeneOrGeneProduct"},{"id":"13473","span":{"begin":191,"end":196},"obj":"SequenceVariant"},{"id":"13474","span":{"begin":272,"end":285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13475","span":{"begin":296,"end":300},"obj":"OrganismTaxon"},{"id":"13476","span":{"begin":312,"end":317},"obj":"SequenceVariant"},{"id":"13477","span":{"begin":332,"end":337},"obj":"OrganismTaxon"},{"id":"13478","span":{"begin":350,"end":355},"obj":"OrganismTaxon"},{"id":"13479","span":{"begin":356,"end":361},"obj":"SequenceVariant"},{"id":"13480","span":{"begin":413,"end":426},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13481","span":{"begin":474,"end":481},"obj":"GeneOrGeneProduct"},{"id":"13482","span":{"begin":503,"end":508},"obj":"GeneOrGeneProduct"},{"id":"13483","span":{"begin":509,"end":514},"obj":"SequenceVariant"},{"id":"13484","span":{"begin":526,"end":535},"obj":"ChemicalEntity"},{"id":"13485","span":{"begin":658,"end":663},"obj":"SequenceVariant"},{"id":"13486","span":{"begin":709,"end":720},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13487","span":{"begin":799,"end":812},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13488","span":{"begin":1231,"end":1258},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13489","span":{"begin":1346,"end":1357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13490","span":{"begin":1389,"end":1394},"obj":"SequenceVariant"},{"id":"13491","span":{"begin":1395,"end":1402},"obj":"GeneOrGeneProduct"},{"id":"13492","span":{"begin":1525,"end":1532},"obj":"GeneOrGeneProduct"},{"id":"13493","span":{"begin":1593,"end":1603},"obj":"GeneOrGeneProduct"},{"id":"13494","span":{"begin":1676,"end":1681},"obj":"SequenceVariant"},{"id":"13495","span":{"begin":1682,"end":1689},"obj":"GeneOrGeneProduct"},{"id":"13496","span":{"begin":1690,"end":1695},"obj":"OrganismTaxon"},{"id":"13497","span":{"begin":1761,"end":1766},"obj":"OrganismTaxon"},{"id":"13498","span":{"begin":1767,"end":1785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13499","span":{"begin":1849,"end":1854},"obj":"OrganismTaxon"},{"id":"13500","span":{"begin":2027,"end":2038},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13501","span":{"begin":2040,"end":2058},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13502","span":{"begin":2075,"end":2088},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A23","pred":"db_id","subj":"13488","obj":"MESH:D007674"},{"id":"A12","pred":"db_id","subj":"13477","obj":"NCBITaxon:10090"},{"id":"A31","pred":"db_id","subj":"13496","obj":"NCBITaxon:10090"},{"id":"A4","pred":"db_id","subj":"13469","obj":"NCBIGene:7827"},{"id":"A21","pred":"db_id","subj":"13486","obj":"MESH:D011507"},{"id":"A20","pred":"db_id","subj":"13485","obj":"p|SUB|R|140|Q"},{"id":"A35","pred":"db_id","subj":"13500","obj":"MESH:D011507"},{"id":"A16","pred":"db_id","subj":"13481","obj":"NCBIGene:170484"},{"id":"A19","pred":"db_id","subj":"13484","obj":"MESH:D013629"},{"id":"A29","pred":"db_id","subj":"13494","obj":"p|SUB|R|140|Q"},{"id":"A8","pred":"db_id","subj":"13473","obj":"DBSNP:rs74315342"},{"id":"A5","pred":"db_id","subj":"13470","obj":"NCBIGene:7827"},{"id":"A26","pred":"db_id","subj":"13491","obj":"NCBIGene:170484"},{"id":"A30","pred":"db_id","subj":"13495","obj":"NCBIGene:170484"},{"id":"A1","pred":"db_id","subj":"13466","obj":"NCBITaxon:10090"},{"id":"A15","pred":"db_id","subj":"13480","obj":"MESH:D051437"},{"id":"A22","pred":"db_id","subj":"13487","obj":"MESH:D051437"},{"id":"A7","pred":"db_id","subj":"13472","obj":"NCBIGene:7827"},{"id":"A3","pred":"db_id","subj":"13468","obj":"MESH:D009404"},{"id":"A6","pred":"db_id","subj":"13471","obj":"MESH:D009404"},{"id":"A32","pred":"db_id","subj":"13497","obj":"NCBITaxon:9606"},{"id":"A2","pred":"db_id","subj":"13467","obj":"NCBIGene:170484"},{"id":"A10","pred":"db_id","subj":"13475","obj":"NCBITaxon:10090"},{"id":"A24","pred":"db_id","subj":"13489","obj":"MESH:D011507"},{"id":"A33","pred":"db_id","subj":"13498","obj":"MESH:D009404"},{"id":"A14","pred":"db_id","subj":"13479","obj":"DBSNP:rs74315342"},{"id":"A25","pred":"db_id","subj":"13490","obj":"p|SUB|R|140|Q"},{"id":"A9","pred":"db_id","subj":"13474","obj":"MESH:D007674"},{"id":"A34","pred":"db_id","subj":"13499","obj":"NCBITaxon:9606"},{"id":"A27","pred":"db_id","subj":"13492","obj":"NCBIGene:406991"},{"id":"A11","pred":"db_id","subj":"13476","obj":"p|SUB|R|140|Q"},{"id":"A17","pred":"db_id","subj":"13482","obj":"NCBIGene:170484"},{"id":"A37","pred":"db_id","subj":"13502","obj":"MESH:D051437"},{"id":"A18","pred":"db_id","subj":"13483","obj":"p|SUB|R|140|Q"},{"id":"A28","pred":"db_id","subj":"13493","obj":"NCBIGene:406968"},{"id":"A36","pred":"db_id","subj":"13501","obj":"MESH:D005921"},{"id":"A13","pred":"db_id","subj":"13478","obj":"NCBITaxon:9606"},{"subj":"13466","pred":"source","obj":"LitCoin-entities"},{"subj":"13467","pred":"source","obj":"LitCoin-entities"},{"subj":"13468","pred":"source","obj":"LitCoin-entities"},{"subj":"13469","pred":"source","obj":"LitCoin-entities"},{"subj":"13470","pred":"source","obj":"LitCoin-entities"},{"subj":"13471","pred":"source","obj":"LitCoin-entities"},{"subj":"13472","pred":"source","obj":"LitCoin-entities"},{"subj":"13473","pred":"source","obj":"LitCoin-entities"},{"subj":"13474","pred":"source","obj":"LitCoin-entities"},{"subj":"13475","pred":"source","obj":"LitCoin-entities"},{"subj":"13476","pred":"source","obj":"LitCoin-entities"},{"subj":"13477","pred":"source","obj":"LitCoin-entities"},{"subj":"13478","pred":"source","obj":"LitCoin-entities"},{"subj":"13479","pred":"source","obj":"LitCoin-entities"},{"subj":"13480","pred":"source","obj":"LitCoin-entities"},{"subj":"13481","pred":"source","obj":"LitCoin-entities"},{"subj":"13482","pred":"source","obj":"LitCoin-entities"},{"subj":"13483","pred":"source","obj":"LitCoin-entities"},{"subj":"13484","pred":"source","obj":"LitCoin-entities"},{"subj":"13485","pred":"source","obj":"LitCoin-entities"},{"subj":"13486","pred":"source","obj":"LitCoin-entities"},{"subj":"13487","pred":"source","obj":"LitCoin-entities"},{"subj":"13488","pred":"source","obj":"LitCoin-entities"},{"subj":"13489","pred":"source","obj":"LitCoin-entities"},{"subj":"13490","pred":"source","obj":"LitCoin-entities"},{"subj":"13491","pred":"source","obj":"LitCoin-entities"},{"subj":"13492","pred":"source","obj":"LitCoin-entities"},{"subj":"13493","pred":"source","obj":"LitCoin-entities"},{"subj":"13494","pred":"source","obj":"LitCoin-entities"},{"subj":"13495","pred":"source","obj":"LitCoin-entities"},{"subj":"13496","pred":"source","obj":"LitCoin-entities"},{"subj":"13497","pred":"source","obj":"LitCoin-entities"},{"subj":"13498","pred":"source","obj":"LitCoin-entities"},{"subj":"13499","pred":"source","obj":"LitCoin-entities"},{"subj":"13500","pred":"source","obj":"LitCoin-entities"},{"subj":"13501","pred":"source","obj":"LitCoin-entities"},{"subj":"13502","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":53,"end":71},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":137,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":709,"end":720},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1346,"end":1357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1767,"end":1785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":2027,"end":2038},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":2040,"end":2058},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005377"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005377"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0003634"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0003634"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005377"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0003634"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0000490"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T6","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo"}]},{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":191,"end":196},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":312,"end":317},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":356,"end":361},"obj":"SequenceVariant"},{"id":"T4","span":{"begin":509,"end":514},"obj":"SequenceVariant"},{"id":"T5","span":{"begin":658,"end":663},"obj":"SequenceVariant"},{"id":"T6","span":{"begin":1389,"end":1394},"obj":"SequenceVariant"},{"id":"T7","span":{"begin":1676,"end":1681},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T2","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T3","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T4","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T5","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T6","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T7","pred":"source","obj":"LitCoin-SeqVar"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":3,"end":12},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":28,"end":35},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":36,"end":44},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":63,"end":71},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":73,"end":82},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":90,"end":95},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":147,"end":155},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":173,"end":180},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":181,"end":189},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":217,"end":222},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":262,"end":265},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":296,"end":300},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":318,"end":326},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":382,"end":388},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":406,"end":412},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":452,"end":459},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":474,"end":481},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":503,"end":508},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":536,"end":545},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":550,"end":561},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":605,"end":613},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":837,"end":841},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":876,"end":883},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":884,"end":890},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1019,"end":1022},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1189,"end":1193},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1195,"end":1200},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1271,"end":1279},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1361,"end":1366},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1395,"end":1402},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1403,"end":1407},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":1433,"end":1440},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":1455,"end":1462},"obj":"GeneOrGeneProduct"},{"id":"T35","span":{"begin":1525,"end":1532},"obj":"GeneOrGeneProduct"},{"id":"T36","span":{"begin":1544,"end":1556},"obj":"GeneOrGeneProduct"},{"id":"T37","span":{"begin":1615,"end":1623},"obj":"GeneOrGeneProduct"},{"id":"T38","span":{"begin":1666,"end":1675},"obj":"GeneOrGeneProduct"},{"id":"T39","span":{"begin":1682,"end":1689},"obj":"GeneOrGeneProduct"},{"id":"T40","span":{"begin":1777,"end":1785},"obj":"GeneOrGeneProduct"},{"id":"T41","span":{"begin":1907,"end":1911},"obj":"GeneOrGeneProduct"},{"id":"T42","span":{"begin":1928,"end":1933},"obj":"GeneOrGeneProduct"},{"id":"T43","span":{"begin":2003,"end":2012},"obj":"GeneOrGeneProduct"},{"id":"T44","span":{"begin":2017,"end":2026},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T31","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T32","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T33","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T34","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T35","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T36","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T37","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T38","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T39","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T40","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T41","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T42","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T43","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T44","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":3,"end":12},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":28,"end":35},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":63,"end":71},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":90,"end":95},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":147,"end":155},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":173,"end":180},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":217,"end":222},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":382,"end":388},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":406,"end":412},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":474,"end":481},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":503,"end":508},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":536,"end":545},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":550,"end":561},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":884,"end":890},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1361,"end":1366},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1395,"end":1402},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1403,"end":1407},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1433,"end":1440},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1455,"end":1462},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1525,"end":1532},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1666,"end":1675},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1682,"end":1689},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1777,"end":1785},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1928,"end":1933},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":2003,"end":2012},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":53,"end":71},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":137,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":223,"end":230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":262,"end":285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":413,"end":426},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":709,"end":720},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":799,"end":812},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":986,"end":993},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1148,"end":1157},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1250,"end":1258},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1280,"end":1287},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1346,"end":1357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1367,"end":1374},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1767,"end":1785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1806,"end":1813},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":2027,"end":2038},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":2075,"end":2088},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D004194"},{"id":"A17","pred":"originalLabel","subj":"T17","obj":"D051437"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D009404"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D007676"},{"id":"A8","pred":"originalLabel","subj":"T8","obj":"D004194"},{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D009404"},{"id":"A13","pred":"originalLabel","subj":"T13","obj":"D004194"},{"id":"A9","pred":"originalLabel","subj":"T9","obj":"D012598"},{"id":"A12","pred":"originalLabel","subj":"T12","obj":"D011507"},{"id":"A16","pred":"originalLabel","subj":"T16","obj":"D011507"},{"id":"A10","pred":"originalLabel","subj":"T10","obj":"D005355"},{"id":"A11","pred":"originalLabel","subj":"T11","obj":"D004194"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D051437"},{"id":"A15","pred":"originalLabel","subj":"T15","obj":"D004194"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D011507"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D051437"},{"id":"A14","pred":"originalLabel","subj":"T14","obj":"D009404"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T9","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T10","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T11","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T12","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T13","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T14","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T15","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T16","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T17","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":28,"end":35},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":90,"end":95},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":173,"end":180},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":474,"end":481},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":503,"end":508},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1395,"end":1402},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1525,"end":1532},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1682,"end":1689},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":53,"end":71},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":90,"end":95},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":126,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":262,"end":285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":413,"end":426},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":503,"end":508},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":709,"end":720},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":799,"end":812},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1346,"end":1357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1767,"end":1785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":2027,"end":2038},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":2040,"end":2058},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":2075,"end":2088},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0044765"},{"id":"A8","pred":"mondo_id","subj":"T7","obj":"0010974"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0003634"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0001106"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"0005377"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0003634"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005377"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"0000490"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0002350"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0001106"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0044765"},{"id":"A3","pred":"mondo_id","subj":"T2","obj":"0010974"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0003634"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0004375"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"0001106"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T6","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T9","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T10","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T11","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T12","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T13","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T14","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T15","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":53,"end":71},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":137,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":223,"end":230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":262,"end":285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":413,"end":426},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":709,"end":720},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":799,"end":812},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":986,"end":993},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1250,"end":1258},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1280,"end":1287},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1346,"end":1357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1367,"end":1374},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1767,"end":1785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1806,"end":1813},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":2027,"end":2038},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":2040,"end":2058},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":2075,"end":2088},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A16","pred":"ID:","subj":"T16","obj":"DISEASE"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D009404"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D004194"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D011507"},{"id":"A17","pred":"ID:","subj":"T17","obj":"D051437"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D011507"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D009404"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D009404"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D051437"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D051437"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D011507"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D004194"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D005355"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D004194"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D007676"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D004194"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D004194"},{"subj":"T1","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T2","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T3","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T5","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T7","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T8","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T9","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T10","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T11","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T12","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T13","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T14","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T15","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T16","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T17","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":53,"end":71},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":137,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":262,"end":285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":413,"end":426},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":709,"end":720},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":799,"end":812},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1250,"end":1258},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1346,"end":1357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1767,"end":1785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":2027,"end":2038},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":2040,"end":2058},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":2075,"end":2088},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"#label","subj":"T5","obj":"D011507"},{"id":"A10","pred":"#label","subj":"T10","obj":"D011507"},{"id":"A2","pred":"#label","subj":"T2","obj":"D009404"},{"id":"A6","pred":"#label","subj":"T6","obj":"D051437"},{"id":"A7","pred":"#label","subj":"T7","obj":"D005355"},{"id":"A11","pred":"#label","subj":"T11","obj":"DISEASE"},{"id":"A3","pred":"#label","subj":"T3","obj":"D007676"},{"id":"A12","pred":"#label","subj":"T12","obj":"D051437"},{"id":"A8","pred":"#label","subj":"T8","obj":"D011507"},{"id":"A4","pred":"#label","subj":"T4","obj":"D051437"},{"id":"A9","pred":"#label","subj":"T9","obj":"D009404"},{"id":"A1","pred":"#label","subj":"T1","obj":"D009404"},{"subj":"T1","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T2","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T3","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T7","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T8","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T9","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T10","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T11","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T12","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":13,"end":18},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":296,"end":300},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":332,"end":337},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":350,"end":355},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1690,"end":1695},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":1761,"end":1766},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":1849,"end":1854},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T2","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T3","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T4","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T5","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T6","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T7","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":526,"end":535},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":546,"end":561},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D013629"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_41774"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C045073"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T3","span":{"begin":546,"end":561},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":526,"end":535},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":1682,"end":1689},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1525,"end":1532},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1395,"end":1402},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":503,"end":508},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":474,"end":481},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":173,"end":180},"obj":"GeneOrGeneProduct"},{"id":"T10911","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":90,"end":95},"obj":"GeneOrGeneProduct"},{"id":"T12364","span":{"begin":28,"end":35},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":2075,"end":2088},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":2040,"end":2058},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":2027,"end":2038},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T45427","span":{"begin":1767,"end":1785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T53049","span":{"begin":1346,"end":1357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T63547","span":{"begin":1250,"end":1258},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T28747","span":{"begin":799,"end":812},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T95215","span":{"begin":709,"end":720},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T70014","span":{"begin":413,"end":426},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19913","span":{"begin":262,"end":285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T41330","span":{"begin":137,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T24073","span":{"begin":53,"end":71},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23115","span":{"begin":1849,"end":1854},"obj":"OrganismTaxon"},{"id":"T40596","span":{"begin":1761,"end":1766},"obj":"OrganismTaxon"},{"id":"T64328","span":{"begin":1690,"end":1695},"obj":"OrganismTaxon"},{"id":"T89878","span":{"begin":350,"end":355},"obj":"OrganismTaxon"},{"id":"T53346","span":{"begin":332,"end":337},"obj":"OrganismTaxon"},{"id":"T57397","span":{"begin":296,"end":300},"obj":"OrganismTaxon"},{"id":"T15197","span":{"begin":13,"end":18},"obj":"OrganismTaxon"},{"id":"T74446","span":{"begin":1676,"end":1681},"obj":"SequenceVariant"},{"id":"T82552","span":{"begin":1389,"end":1394},"obj":"SequenceVariant"},{"id":"T80913","span":{"begin":658,"end":663},"obj":"SequenceVariant"},{"id":"T82040","span":{"begin":509,"end":514},"obj":"SequenceVariant"},{"id":"T66714","span":{"begin":356,"end":361},"obj":"SequenceVariant"},{"id":"T35876","span":{"begin":312,"end":317},"obj":"SequenceVariant"},{"id":"T66323","span":{"begin":191,"end":196},"obj":"SequenceVariant"}],"attributes":[{"id":"A7043","pred":"#label","subj":"T19913","obj":"D007676"},{"id":"A16216","pred":"#label","subj":"T41330","obj":"D009404"},{"id":"A11","pred":"#label","subj":"T11","obj":"DISEASE"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C045073"},{"id":"A5","pred":"#label","subj":"T95215","obj":"D011507"},{"id":"A10","pred":"#label","subj":"T10","obj":"D011507"},{"id":"A12","pred":"#label","subj":"T12","obj":"D051437"},{"id":"A6","pred":"#label","subj":"T28747","obj":"D051437"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_41774"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D013629"},{"id":"A8","pred":"#label","subj":"T53049","obj":"D011507"},{"id":"A4","pred":"#label","subj":"T70014","obj":"D051437"},{"id":"A7","pred":"#label","subj":"T63547","obj":"D005355"},{"id":"A9","pred":"#label","subj":"T45427","obj":"D009404"},{"id":"A95318","pred":"#label","subj":"T24073","obj":"D009404"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10911","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12364","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T45427","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T53049","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T63547","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T28747","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T95215","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T70014","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T19913","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T41330","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T24073","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T23115","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T40596","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T64328","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T89878","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T53346","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T57397","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T15197","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T74446","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T82552","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T80913","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T82040","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T66714","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T35876","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T66323","pred":"source","obj":"LitCoin-training-merged"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-entities-OrganismTaxon-PD","color":"#ecae93","default":true},{"id":"LitCoin-sentences","color":"#9493ec"},{"id":"LitCoin-entities","color":"#abec93"},{"id":"LitCoin_Mondo","color":"#ec93c5"},{"id":"LitCoin-SeqVar","color":"#93dfec"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ecdf93"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#c493ec"},{"id":"LitCoin-Disease-MeSH","color":"#93ecaa"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#ec9395"},{"id":"LitCoin_Mondo_095","color":"#93afec"},{"id":"LitCoin-MeSH-Disease-2","color":"#c9ec93"},{"id":"LitCoin-MONDO_bioort2019","color":"#ec93e3"},{"id":"LitCoin-NCBITaxon-2","color":"#93ecdb"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#ecc193"},{"id":"LitCoin-training-merged","color":"#a793ec"}]}]}}