> top > docs > PubMed:29049388 > annotations

PubMed:29049388 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 13-18 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T3 296-300 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T5 332-337 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T7 350-355 OrganismTaxon denotes human NCBItxid:9606
T8 1690-1695 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T10 1761-1766 OrganismTaxon denotes human NCBItxid:9606
T11 1849-1854 OrganismTaxon denotes human NCBItxid:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-72 Sentence denotes An inducible mouse model of podocin-mutation-related nephrotic syndrome.
T2 73-156 Sentence denotes Mutations in the NPHS2 gene, encoding podocin, cause hereditary nephrotic syndrome.
T3 157-286 Sentence denotes The most common podocin mutation, R138Q, is associated with early disease onset and rapid progression to end-stage renal disease.
T4 287-443 Sentence denotes Knock-in mice carrying a R140Q mutation, the mouse analogue of human R138Q, show developmental arrest of podocytes and lethal renal failure at neonatal age.
T5 444-632 Sentence denotes Here we created a conditional podocin knock-in model named NPHS2 R140Q/-, using a tamoxifen-inducible Cre recombinase, which permits to study the effects of the mutation in postnatal life.
T6 633-751 Sentence denotes Within the first week of R140Q hemizygosity induction the animals developed proteinuria, which peaked after 4-5 weeks.
T7 752-856 Sentence denotes Subsequently the animals developed progressive renal failure, with a median survival time of 12 (95% CI:
T8 857-870 Sentence denotes 11-13) weeks.
T9 871-994 Sentence denotes Foot process fusion was observed within one week, progressing to severe and global effacement in the course of the disease.
T10 995-1119 Sentence denotes The number of podocytes per glomerulus gradually diminished to 18% compared to healthy controls 12-16 weeks after induction.
T11 1120-1223 Sentence denotes The fraction of segmentally sclerosed glomeruli was 25%, 85% and 97% at 2, 4 and 8 weeks, respectively.
T12 1224-1382 Sentence denotes Severe tubulointerstitial fibrosis was present at later disease stage and was correlated quantitatively with the level of proteinuria at early disease stages.
T13 1383-1516 Sentence denotes While R140Q podocin mRNA expression was elevated, protein abundance was reduced by more than 50% within one week following induction.
T14 1517-1646 Sentence denotes Whereas miRNA21 expression persistently increased during the first 4 weeks, miRNA-193a expression peaked 2 weeks after induction.
T15 1647-1864 Sentence denotes In conclusion, the inducible R140Q-podocin mouse model is an auspicious model of the most common genetic cause of human nephrotic syndrome, with a spontaneous disease course strongly reminiscent of the human disorder.
T16 1865-2089 Sentence denotes This model constitutes a valuable tool to test the efficacy of novel pharmacological interventions aimed to improve podocyte function and viability and attenuate proteinuria, glomerulosclerosis and progressive renal failure.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
13466 13-18 OrganismTaxon denotes mouse NCBITaxon:10090
13467 28-35 GeneOrGeneProduct denotes podocin NCBIGene:170484
13468 53-71 DiseaseOrPhenotypicFeature denotes nephrotic syndrome MESH:D009404
13469 90-95 GeneOrGeneProduct denotes NPHS2 NCBIGene:7827
13470 111-118 GeneOrGeneProduct denotes podocin NCBIGene:7827
13471 137-155 DiseaseOrPhenotypicFeature denotes nephrotic syndrome MESH:D009404
13472 173-180 GeneOrGeneProduct denotes podocin NCBIGene:7827
13473 191-196 SequenceVariant denotes R138Q DBSNP:rs74315342
13474 272-285 DiseaseOrPhenotypicFeature denotes renal disease MESH:D007674
13475 296-300 OrganismTaxon denotes mice NCBITaxon:10090
13476 312-317 SequenceVariant denotes R140Q p|SUB|R|140|Q
13477 332-337 OrganismTaxon denotes mouse NCBITaxon:10090
13478 350-355 OrganismTaxon denotes human NCBITaxon:9606
13479 356-361 SequenceVariant denotes R138Q DBSNP:rs74315342
13480 413-426 DiseaseOrPhenotypicFeature denotes renal failure MESH:D051437
13481 474-481 GeneOrGeneProduct denotes podocin NCBIGene:170484
13482 503-508 GeneOrGeneProduct denotes NPHS2 NCBIGene:170484
13483 509-514 SequenceVariant denotes R140Q p|SUB|R|140|Q
13484 526-535 ChemicalEntity denotes tamoxifen MESH:D013629
13485 658-663 SequenceVariant denotes R140Q p|SUB|R|140|Q
13486 709-720 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
13487 799-812 DiseaseOrPhenotypicFeature denotes renal failure MESH:D051437
13488 1231-1258 DiseaseOrPhenotypicFeature denotes tubulointerstitial fibrosis MESH:D007674
13489 1346-1357 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
13490 1389-1394 SequenceVariant denotes R140Q p|SUB|R|140|Q
13491 1395-1402 GeneOrGeneProduct denotes podocin NCBIGene:170484
13492 1525-1532 GeneOrGeneProduct denotes miRNA21 NCBIGene:406991
13493 1593-1603 GeneOrGeneProduct denotes miRNA-193a NCBIGene:406968
13494 1676-1681 SequenceVariant denotes R140Q p|SUB|R|140|Q
13495 1682-1689 GeneOrGeneProduct denotes podocin NCBIGene:170484
13496 1690-1695 OrganismTaxon denotes mouse NCBITaxon:10090
13497 1761-1766 OrganismTaxon denotes human NCBITaxon:9606
13498 1767-1785 DiseaseOrPhenotypicFeature denotes nephrotic syndrome MESH:D009404
13499 1849-1854 OrganismTaxon denotes human NCBITaxon:9606
13500 2027-2038 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
13501 2040-2058 DiseaseOrPhenotypicFeature denotes glomerulosclerosis MESH:D005921
13502 2075-2088 DiseaseOrPhenotypicFeature denotes renal failure MESH:D051437

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 53-71 DiseaseOrPhenotypicFeature denotes nephrotic syndrome 0005377
T2 137-155 DiseaseOrPhenotypicFeature denotes nephrotic syndrome 0005377
T3 709-720 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T4 1346-1357 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T5 1767-1785 DiseaseOrPhenotypicFeature denotes nephrotic syndrome 0005377
T6 2027-2038 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T7 2040-2058 DiseaseOrPhenotypicFeature denotes glomerulosclerosis 0000490

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 191-196 SequenceVariant denotes R138Q
T2 312-317 SequenceVariant denotes R140Q
T3 356-361 SequenceVariant denotes R138Q
T4 509-514 SequenceVariant denotes R140Q
T5 658-663 SequenceVariant denotes R140Q
T6 1389-1394 SequenceVariant denotes R140Q
T7 1676-1681 SequenceVariant denotes R140Q

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 3-12 GeneOrGeneProduct denotes inducible
T2 28-35 GeneOrGeneProduct denotes podocin
T3 36-44 GeneOrGeneProduct denotes mutation
T4 63-71 GeneOrGeneProduct denotes syndrome
T5 73-82 GeneOrGeneProduct denotes Mutations
T6 90-95 GeneOrGeneProduct denotes NPHS2
T7 111-118 GeneOrGeneProduct denotes podocin
T8 147-155 GeneOrGeneProduct denotes syndrome
T9 173-180 GeneOrGeneProduct denotes podocin
T10 181-189 GeneOrGeneProduct denotes mutation
T11 217-222 GeneOrGeneProduct denotes early
T12 262-265 GeneOrGeneProduct denotes end
T13 296-300 GeneOrGeneProduct denotes mice
T14 318-326 GeneOrGeneProduct denotes mutation
T15 382-388 GeneOrGeneProduct denotes arrest
T16 406-412 GeneOrGeneProduct denotes lethal
T17 452-459 GeneOrGeneProduct denotes created
T18 474-481 GeneOrGeneProduct denotes podocin
T19 503-508 GeneOrGeneProduct denotes NPHS2
T20 536-545 GeneOrGeneProduct denotes inducible
T21 550-561 GeneOrGeneProduct denotes recombinase
T22 605-613 GeneOrGeneProduct denotes mutation
T23 837-841 GeneOrGeneProduct denotes time
T24 876-883 GeneOrGeneProduct denotes process
T25 884-890 GeneOrGeneProduct denotes fusion
T26 1019-1022 GeneOrGeneProduct denotes per
T27 1189-1193 GeneOrGeneProduct denotes at 2
T28 1195-1200 GeneOrGeneProduct denotes 4 and
T29 1271-1279 GeneOrGeneProduct denotes at later
T30 1361-1366 GeneOrGeneProduct denotes early
T31 1395-1402 GeneOrGeneProduct denotes podocin
T32 1403-1407 GeneOrGeneProduct denotes mRNA
T33 1433-1440 GeneOrGeneProduct denotes protein
T34 1455-1462 GeneOrGeneProduct denotes reduced
T35 1525-1532 GeneOrGeneProduct denotes miRNA21
T36 1544-1556 GeneOrGeneProduct denotes persistently
T37 1615-1623 GeneOrGeneProduct denotes peaked 2
T38 1666-1675 GeneOrGeneProduct denotes inducible
T39 1682-1689 GeneOrGeneProduct denotes podocin
T40 1777-1785 GeneOrGeneProduct denotes syndrome
T41 1907-1911 GeneOrGeneProduct denotes test
T42 1928-1933 GeneOrGeneProduct denotes novel
T43 2003-2012 GeneOrGeneProduct denotes viability
T44 2017-2026 GeneOrGeneProduct denotes attenuate

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 3-12 GeneOrGeneProduct denotes inducible
T2 28-35 GeneOrGeneProduct denotes podocin
T3 63-71 GeneOrGeneProduct denotes syndrome
T4 90-95 GeneOrGeneProduct denotes NPHS2
T5 111-118 GeneOrGeneProduct denotes podocin
T6 147-155 GeneOrGeneProduct denotes syndrome
T7 173-180 GeneOrGeneProduct denotes podocin
T8 217-222 GeneOrGeneProduct denotes early
T9 382-388 GeneOrGeneProduct denotes arrest
T10 406-412 GeneOrGeneProduct denotes lethal
T11 474-481 GeneOrGeneProduct denotes podocin
T12 503-508 GeneOrGeneProduct denotes NPHS2
T13 536-545 GeneOrGeneProduct denotes inducible
T14 550-561 GeneOrGeneProduct denotes recombinase
T15 884-890 GeneOrGeneProduct denotes fusion
T16 1361-1366 GeneOrGeneProduct denotes early
T17 1395-1402 GeneOrGeneProduct denotes podocin
T18 1403-1407 GeneOrGeneProduct denotes mRNA
T19 1433-1440 GeneOrGeneProduct denotes protein
T20 1455-1462 GeneOrGeneProduct denotes reduced
T21 1525-1532 GeneOrGeneProduct denotes miRNA21
T22 1666-1675 GeneOrGeneProduct denotes inducible
T23 1682-1689 GeneOrGeneProduct denotes podocin
T24 1777-1785 GeneOrGeneProduct denotes syndrome
T25 1928-1933 GeneOrGeneProduct denotes novel
T26 2003-2012 GeneOrGeneProduct denotes viability

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 53-71 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T2 137-155 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T3 223-230 DiseaseOrPhenotypicFeature denotes disease D004194
T4 262-285 DiseaseOrPhenotypicFeature denotes end-stage renal disease D007676
T5 413-426 DiseaseOrPhenotypicFeature denotes renal failure D051437
T6 709-720 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T7 799-812 DiseaseOrPhenotypicFeature denotes renal failure D051437
T8 986-993 DiseaseOrPhenotypicFeature denotes disease D004194
T9 1148-1157 DiseaseOrPhenotypicFeature denotes sclerosed D012598
T10 1250-1258 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T11 1280-1287 DiseaseOrPhenotypicFeature denotes disease D004194
T12 1346-1357 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T13 1367-1374 DiseaseOrPhenotypicFeature denotes disease D004194
T14 1767-1785 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T15 1806-1813 DiseaseOrPhenotypicFeature denotes disease D004194
T16 2027-2038 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T17 2075-2088 DiseaseOrPhenotypicFeature denotes renal failure D051437

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 28-35 GeneOrGeneProduct denotes podocin
T2 90-95 GeneOrGeneProduct denotes NPHS2
T3 111-118 GeneOrGeneProduct denotes podocin
T4 173-180 GeneOrGeneProduct denotes podocin
T5 474-481 GeneOrGeneProduct denotes podocin
T6 503-508 GeneOrGeneProduct denotes NPHS2
T7 1395-1402 GeneOrGeneProduct denotes podocin
T8 1525-1532 GeneOrGeneProduct denotes miRNA21
T9 1682-1689 GeneOrGeneProduct denotes podocin

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 53-71 DiseaseOrPhenotypicFeature denotes nephrotic syndrome 0005377
T2 90-95 DiseaseOrPhenotypicFeature denotes NPHS2 0044765|0010974
T4 126-155 DiseaseOrPhenotypicFeature denotes hereditary nephrotic syndrome 0002350
T5 262-285 DiseaseOrPhenotypicFeature denotes end-stage renal disease 0004375
T6 413-426 DiseaseOrPhenotypicFeature denotes renal failure 0001106
T7 503-508 DiseaseOrPhenotypicFeature denotes NPHS2 0044765|0010974
T9 709-720 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T10 799-812 DiseaseOrPhenotypicFeature denotes renal failure 0001106
T11 1346-1357 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T12 1767-1785 DiseaseOrPhenotypicFeature denotes nephrotic syndrome 0005377
T13 2027-2038 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T14 2040-2058 DiseaseOrPhenotypicFeature denotes glomerulosclerosis 0000490
T15 2075-2088 DiseaseOrPhenotypicFeature denotes renal failure 0001106

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 53-71 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T2 137-155 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T3 223-230 DiseaseOrPhenotypicFeature denotes disease D004194
T4 262-285 DiseaseOrPhenotypicFeature denotes end-stage renal disease D007676
T5 413-426 DiseaseOrPhenotypicFeature denotes renal failure D051437
T6 709-720 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T7 799-812 DiseaseOrPhenotypicFeature denotes renal failure D051437
T8 986-993 DiseaseOrPhenotypicFeature denotes disease D004194
T9 1250-1258 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T10 1280-1287 DiseaseOrPhenotypicFeature denotes disease D004194
T11 1346-1357 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T12 1367-1374 DiseaseOrPhenotypicFeature denotes disease D004194
T13 1767-1785 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T14 1806-1813 DiseaseOrPhenotypicFeature denotes disease D004194
T15 2027-2038 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T16 2040-2058 DiseaseOrPhenotypicFeature denotes glomerulosclerosis DISEASE
T17 2075-2088 DiseaseOrPhenotypicFeature denotes renal failure D051437

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 53-71 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T2 137-155 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T3 262-285 DiseaseOrPhenotypicFeature denotes end-stage renal disease D007676
T4 413-426 DiseaseOrPhenotypicFeature denotes renal failure D051437
T5 709-720 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T6 799-812 DiseaseOrPhenotypicFeature denotes renal failure D051437
T7 1250-1258 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T8 1346-1357 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T9 1767-1785 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T10 2027-2038 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T11 2040-2058 DiseaseOrPhenotypicFeature denotes glomerulosclerosis DISEASE
T12 2075-2088 DiseaseOrPhenotypicFeature denotes renal failure D051437

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 13-18 OrganismTaxon denotes mouse
T2 296-300 OrganismTaxon denotes mice
T3 332-337 OrganismTaxon denotes mouse
T4 350-355 OrganismTaxon denotes human
T5 1690-1695 OrganismTaxon denotes mouse
T6 1761-1766 OrganismTaxon denotes human
T7 1849-1854 OrganismTaxon denotes human

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 526-535 ChemicalEntity denotes tamoxifen D013629|http://purl.obolibrary.org/obo/CHEBI_41774
T3 546-561 ChemicalEntity denotes Cre recombinase C045073

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T3 546-561 ChemicalEntity denotes Cre recombinase C045073
T1 526-535 ChemicalEntity denotes tamoxifen http://purl.obolibrary.org/obo/CHEBI_41774|D013629
T9 1682-1689 GeneOrGeneProduct denotes podocin
T8 1525-1532 GeneOrGeneProduct denotes miRNA21
T7 1395-1402 GeneOrGeneProduct denotes podocin
T6 503-508 GeneOrGeneProduct denotes NPHS2
T5 474-481 GeneOrGeneProduct denotes podocin
T4 173-180 GeneOrGeneProduct denotes podocin
T10911 111-118 GeneOrGeneProduct denotes podocin
T2 90-95 GeneOrGeneProduct denotes NPHS2
T12364 28-35 GeneOrGeneProduct denotes podocin
T12 2075-2088 DiseaseOrPhenotypicFeature denotes renal failure D051437
T11 2040-2058 DiseaseOrPhenotypicFeature denotes glomerulosclerosis DISEASE
T10 2027-2038 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T45427 1767-1785 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T53049 1346-1357 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T63547 1250-1258 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T28747 799-812 DiseaseOrPhenotypicFeature denotes renal failure D051437
T95215 709-720 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T70014 413-426 DiseaseOrPhenotypicFeature denotes renal failure D051437
T19913 262-285 DiseaseOrPhenotypicFeature denotes end-stage renal disease D007676
T41330 137-155 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T24073 53-71 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T23115 1849-1854 OrganismTaxon denotes human
T40596 1761-1766 OrganismTaxon denotes human
T64328 1690-1695 OrganismTaxon denotes mouse
T89878 350-355 OrganismTaxon denotes human
T53346 332-337 OrganismTaxon denotes mouse
T57397 296-300 OrganismTaxon denotes mice
T15197 13-18 OrganismTaxon denotes mouse
T74446 1676-1681 SequenceVariant denotes R140Q
T82552 1389-1394 SequenceVariant denotes R140Q
T80913 658-663 SequenceVariant denotes R140Q
T82040 509-514 SequenceVariant denotes R140Q
T66714 356-361 SequenceVariant denotes R138Q
T35876 312-317 SequenceVariant denotes R140Q
T66323 191-196 SequenceVariant denotes R138Q