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Platelet Rich Fibrin (PRF) in Regeneration of Intrabony Defects- A Randomized Controlled Trial.
BACKGROUND AND OBJECTIVE: Platelet-rich fibrin (PRF) is a autologous non transfusional hemo-component with a high concentration of platelets. It incorporates leukocytes, platelets and growth factors within the dense fibrin matrix and can be used as healing biomaterial. This study assessed the adjunctive use of PRF in regenerative management of intrabony defects in comparison with open flap debridement.
METHODOLOGY: 26 bilateral defects (13 per group) in 13 patients were randomized as either PRF (Test group) or Open flap debridement alone (control group) sites. Probing depth (PD), clinical attachment level (CAL) and bone probing depth were recorded. Reduction in defect depth and percentage of bone fill was assessed radiographically. Primary outcomes assessed were the changes in pocket depth, attachment level and percentage of bone fill assessed at 6months, 9 months and 12 months. Secondary outcome was assessment of wound healing using a wound healing index.
RESULTS: The PRF group showed significant improvement in clinical parameters over control group at 6, 9, and 12 months. PRF group showed a bone fill of 45.18±7.57 percent which was statistically significant compared to 21.6±9.3 percent seen in control group at end of study period. Wound healing index (WHI) also showed significant advantages for the PRF group.
CONCLUSIONS: PRF also showed significant soft tissue healing and reduction in probing depth. The adjunctive use of PRF to conventional open flap debridement may be potentially used in the treatment of intrabony defects.
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