PubMed:28747658 / 428-942 JSON TXT

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LitCoin-sentences

{"project":"LitCoin-sentences","denotations":[{"id":"T4","span":{"begin":0,"end":514},"obj":"Sentence"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-entities

LitCoin_Mondo

{"project":"LitCoin_Mondo","denotations":[{"id":"T2","span":{"begin":427,"end":433},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0004992"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-SeqVar

{"project":"LitCoin-SeqVar","denotations":[{"id":"T2","span":{"begin":124,"end":128},"obj":"SequenceVariant"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-GeneOrGeneProduct-v0

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T8","span":{"begin":56,"end":64},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":138,"end":144},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":173,"end":177},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":206,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":242,"end":252},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":260,"end":264},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":265,"end":269},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":313,"end":334},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":347,"end":353},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":355,"end":361},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":363,"end":369},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":376,"end":381},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":388,"end":392},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":394,"end":399},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":402,"end":412},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":447,"end":451},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":453,"end":457},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":459,"end":463},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":479,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":496,"end":500},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":502,"end":512},"obj":"GeneOrGeneProduct"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-GeneOrGeneProduct-v2

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T5","span":{"begin":173,"end":177},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":206,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":260,"end":264},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":265,"end":269},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":313,"end":334},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":347,"end":353},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":355,"end":361},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":363,"end":369},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":376,"end":381},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":388,"end":392},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":394,"end":399},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":402,"end":412},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":447,"end":451},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":453,"end":457},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":459,"end":463},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":479,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":496,"end":500},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":502,"end":512},"obj":"GeneOrGeneProduct"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-Disease-MeSH

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T2","span":{"begin":427,"end":433},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D009369"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-GeneOrGeneProduct-v3

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T2","span":{"begin":206,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":260,"end":264},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":265,"end":269},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":270,"end":273},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":313,"end":334},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":347,"end":353},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":355,"end":361},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":363,"end":369},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":376,"end":381},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":388,"end":392},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":394,"end":399},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":447,"end":451},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":453,"end":457},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":459,"end":463},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":479,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":496,"end":500},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":502,"end":512},"obj":"GeneOrGeneProduct"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-MeSH-Disease-2

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T5","span":{"begin":427,"end":433},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"ID:","subj":"T5","obj":"D009369"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-MONDO_bioort2019

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T4","span":{"begin":427,"end":433},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"#label","subj":"T4","obj":"D009369"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-Chemical-MeSH-CHEBI

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":28,"end":36},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":44,"end":51},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_29016"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

LitCoin-training-merged

{"project":"LitCoin-training-merged","denotations":[{"id":"T2","span":{"begin":44,"end":51},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":28,"end":36},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":502,"end":512},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":496,"end":500},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":479,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":459,"end":463},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":453,"end":457},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":447,"end":451},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":394,"end":399},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":388,"end":392},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":376,"end":381},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":363,"end":369},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":355,"end":361},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":347,"end":353},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":313,"end":334},"obj":"GeneOrGeneProduct"},{"id":"T88995","span":{"begin":270,"end":273},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":265,"end":269},"obj":"GeneOrGeneProduct"},{"id":"T49561","span":{"begin":260,"end":264},"obj":"GeneOrGeneProduct"},{"id":"T33109","span":{"begin":206,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T40648","span":{"begin":427,"end":433},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T29712","span":{"begin":124,"end":128},"obj":"SequenceVariant"}],"attributes":[{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"},{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_29016"},{"id":"A96010","pred":"#label","subj":"T40648","obj":"D009369"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

mondo_disease

{"project":"mondo_disease","denotations":[{"id":"T2","span":{"begin":427,"end":433},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

GlyCosmos15-HP

{"project":"GlyCosmos15-HP","denotations":[{"id":"T2","span":{"begin":427,"end":433},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002664"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

NCBITAXON

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":44,"end":51},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"3846"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

Anatomy-UBERON

{"project":"Anatomy-UBERON","denotations":[{"id":"T3","span":{"begin":94,"end":102},"obj":"Body_part"},{"id":"T4","span":{"begin":171,"end":177},"obj":"Body_part"},{"id":"T5","span":{"begin":402,"end":412},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001130"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_2000098"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

Glycosmos15-CL

{"project":"Glycosmos15-CL","denotations":[{"id":"T4","span":{"begin":169,"end":177},"obj":"Cell"},{"id":"T5","span":{"begin":171,"end":177},"obj":"Cell"}],"attributes":[{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:4023097"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000236"}],"text":"Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha)."}

PubMed:28747658 / 428-942 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed:28747658 / 428-942 JSON TXT