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PubMed:28747658 / 428-942 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T4 0-514 Sentence denotes Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha).

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
13222 28-79 SequenceVariant denotes Arginine (R) to Glycine (G) mutation at position 76 p|SUB|R|76|G
13223 104-107 GeneOrGeneProduct denotes p17 NCBIGene:155348
13224 107-111 SequenceVariant denotes R76G p|SUB|R|76|G
13225 124-128 SequenceVariant denotes S75X p|SUB|S|75|X
13226 260-264 GeneOrGeneProduct denotes PTEN NCBIGene:5728
13227 265-269 GeneOrGeneProduct denotes PI3K NCBIGene:5291
13228 270-273 GeneOrGeneProduct denotes Akt NCBIGene:207
13229 347-353 GeneOrGeneProduct denotes CASP-9 NCBIGene:842
13230 355-361 GeneOrGeneProduct denotes CASP-7 NCBIGene:840
13231 363-369 GeneOrGeneProduct denotes DFF-45 NCBIGene:1676
13232 371-374 GeneOrGeneProduct denotes NPM NCBIGene:4869
13233 376-381 GeneOrGeneProduct denotes YWHAZ NCBIGene:7534
13234 383-386 GeneOrGeneProduct denotes Src NCBIGene:6714
13235 388-392 GeneOrGeneProduct denotes PAX2 NCBIGene:5076
13236 394-399 GeneOrGeneProduct denotes MAPK8 NCBIGene:5599
13237 427-433 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
13238 447-451 GeneOrGeneProduct denotes CDK1 NCBIGene:983
13239 453-457 GeneOrGeneProduct denotes CDK2 NCBIGene:1017
13240 459-463 GeneOrGeneProduct denotes CDK8 NCBIGene:1024
13241 465-470 GeneOrGeneProduct denotes CHEK1 NCBIGene:1111
13242 472-477 GeneOrGeneProduct denotes CHEK2 NCBIGene:11200
13243 479-489 GeneOrGeneProduct denotes GSK-3 beta NCBIGene:2932
13244 491-494 GeneOrGeneProduct denotes NPM NCBIGene:4869
13245 496-500 GeneOrGeneProduct denotes PAK1 NCBIGene:5058
13246 502-512 GeneOrGeneProduct denotes PP2C-alpha NCBIGene:5494

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T2 427-433 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T2 124-128 SequenceVariant denotes S75X

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T8 56-64 GeneOrGeneProduct denotes mutation
T9 138-144 GeneOrGeneProduct denotes is per
T10 173-177 GeneOrGeneProduct denotes cell
T11 206-219 GeneOrGeneProduct denotes viral protein
T12 242-252 GeneOrGeneProduct denotes activation
T13 260-264 GeneOrGeneProduct denotes PTEN
T14 265-269 GeneOrGeneProduct denotes PI3K
T15 313-334 GeneOrGeneProduct denotes involved in apoptosis
T16 347-353 GeneOrGeneProduct denotes CASP-9
T17 355-361 GeneOrGeneProduct denotes CASP-7
T18 363-369 GeneOrGeneProduct denotes DFF-45
T19 376-381 GeneOrGeneProduct denotes YWHAZ
T20 388-392 GeneOrGeneProduct denotes PAX2
T21 394-399 GeneOrGeneProduct denotes MAPK8
T22 402-412 GeneOrGeneProduct denotes cell cycle
T23 447-451 GeneOrGeneProduct denotes CDK1
T24 453-457 GeneOrGeneProduct denotes CDK2
T25 459-463 GeneOrGeneProduct denotes CDK8
T26 465-470 GeneOrGeneProduct denotes CHEK1
T27 472-477 GeneOrGeneProduct denotes CHEK2
T28 479-489 GeneOrGeneProduct denotes GSK-3 beta
T29 496-500 GeneOrGeneProduct denotes PAK1
T30 502-512 GeneOrGeneProduct denotes PP2C-alpha

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T5 173-177 GeneOrGeneProduct denotes cell
T6 206-219 GeneOrGeneProduct denotes viral protein
T7 260-264 GeneOrGeneProduct denotes PTEN
T8 265-269 GeneOrGeneProduct denotes PI3K
T9 313-334 GeneOrGeneProduct denotes involved in apoptosis
T10 347-353 GeneOrGeneProduct denotes CASP-9
T11 355-361 GeneOrGeneProduct denotes CASP-7
T12 363-369 GeneOrGeneProduct denotes DFF-45
T13 376-381 GeneOrGeneProduct denotes YWHAZ
T14 388-392 GeneOrGeneProduct denotes PAX2
T15 394-399 GeneOrGeneProduct denotes MAPK8
T16 402-412 GeneOrGeneProduct denotes cell cycle
T17 447-451 GeneOrGeneProduct denotes CDK1
T18 453-457 GeneOrGeneProduct denotes CDK2
T19 459-463 GeneOrGeneProduct denotes CDK8
T20 465-470 GeneOrGeneProduct denotes CHEK1
T21 472-477 GeneOrGeneProduct denotes CHEK2
T22 479-489 GeneOrGeneProduct denotes GSK-3 beta
T23 496-500 GeneOrGeneProduct denotes PAK1
T24 502-512 GeneOrGeneProduct denotes PP2C-alpha

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T2 427-433 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T2 206-219 GeneOrGeneProduct denotes viral protein
T3 260-264 GeneOrGeneProduct denotes PTEN
T4 265-269 GeneOrGeneProduct denotes PI3K
T5 270-273 GeneOrGeneProduct denotes Akt
T6 313-334 GeneOrGeneProduct denotes involved in apoptosis
T7 347-353 GeneOrGeneProduct denotes CASP-9
T8 355-361 GeneOrGeneProduct denotes CASP-7
T9 363-369 GeneOrGeneProduct denotes DFF-45
T10 376-381 GeneOrGeneProduct denotes YWHAZ
T11 388-392 GeneOrGeneProduct denotes PAX2
T12 394-399 GeneOrGeneProduct denotes MAPK8
T13 447-451 GeneOrGeneProduct denotes CDK1
T14 453-457 GeneOrGeneProduct denotes CDK2
T15 459-463 GeneOrGeneProduct denotes CDK8
T16 465-470 GeneOrGeneProduct denotes CHEK1
T17 472-477 GeneOrGeneProduct denotes CHEK2
T18 479-489 GeneOrGeneProduct denotes GSK-3 beta
T19 496-500 GeneOrGeneProduct denotes PAK1
T20 502-512 GeneOrGeneProduct denotes PP2C-alpha

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T5 427-433 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T4 427-433 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 28-36 ChemicalEntity denotes Arginine http://purl.obolibrary.org/obo/CHEBI_29016
T2 44-51 ChemicalEntity denotes Glycine http://purl.obolibrary.org/obo/CHEBI_15428

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T2 44-51 ChemicalEntity denotes Glycine http://purl.obolibrary.org/obo/CHEBI_15428
T1 28-36 ChemicalEntity denotes Arginine http://purl.obolibrary.org/obo/CHEBI_29016
T20 502-512 GeneOrGeneProduct denotes PP2C-alpha
T19 496-500 GeneOrGeneProduct denotes PAK1
T18 479-489 GeneOrGeneProduct denotes GSK-3 beta
T17 472-477 GeneOrGeneProduct denotes CHEK2
T16 465-470 GeneOrGeneProduct denotes CHEK1
T15 459-463 GeneOrGeneProduct denotes CDK8
T14 453-457 GeneOrGeneProduct denotes CDK2
T13 447-451 GeneOrGeneProduct denotes CDK1
T12 394-399 GeneOrGeneProduct denotes MAPK8
T11 388-392 GeneOrGeneProduct denotes PAX2
T10 376-381 GeneOrGeneProduct denotes YWHAZ
T9 363-369 GeneOrGeneProduct denotes DFF-45
T8 355-361 GeneOrGeneProduct denotes CASP-7
T7 347-353 GeneOrGeneProduct denotes CASP-9
T6 313-334 GeneOrGeneProduct denotes involved in apoptosis
T88995 270-273 GeneOrGeneProduct denotes Akt
T4 265-269 GeneOrGeneProduct denotes PI3K
T49561 260-264 GeneOrGeneProduct denotes PTEN
T33109 206-219 GeneOrGeneProduct denotes viral protein
T40648 427-433 DiseaseOrPhenotypicFeature denotes cancer D009369
T29712 124-128 SequenceVariant denotes S75X

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T2 427-433 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T2 427-433 Phenotype denotes cancer HP:0002664

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 44-51 OrganismTaxon denotes Glycine 3846

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 94-102 Body_part denotes backbone http://purl.obolibrary.org/obo/UBERON_0001130
T4 171-177 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T5 402-412 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T4 169-177 Cell denotes a B-cell http://purl.obolibrary.org/obo/CL:4023097
T5 171-177 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236