PubMed:28624519 / 1632-2410 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T2 0-778 BIOLOGICAL SIGNIFICANCE denotes Bombyx mori nucleopolyhedrovirus (BmNPV) is highly pathogenic, causing serious losses in sericulture every year. However, the molecular mechanisms of BmNPV infection and host defence remain unclear. Here we combined quantitative proteomic, bioinformatics, RT-qPCR and Western blotting analyses and found that BmNPV invasion causes complex protein alterations in the larval midgut, and that these changes are related to cytoskeleton, immune response, apoptosis, ubiquitination, translation, ion transport, endocytosis and endopeptidase activity. Five important differentially expression proteins were validation by independent approaches. These finding will help address the molecular mechanisms of silkworm resistance to BmNPV and provide a molecular target for resisting BmNPV.

sentences

Id Subject Object Predicate Lexical cue
T12 0-112 Sentence denotes Bombyx mori nucleopolyhedrovirus (BmNPV) is highly pathogenic, causing serious losses in sericulture every year.
T13 113-198 Sentence denotes However, the molecular mechanisms of BmNPV infection and host defence remain unclear.
T14 199-544 Sentence denotes Here we combined quantitative proteomic, bioinformatics, RT-qPCR and Western blotting analyses and found that BmNPV invasion causes complex protein alterations in the larval midgut, and that these changes are related to cytoskeleton, immune response, apoptosis, ubiquitination, translation, ion transport, endocytosis and endopeptidase activity.
T15 545-637 Sentence denotes Five important differentially expression proteins were validation by independent approaches.
T16 638-778 Sentence denotes These finding will help address the molecular mechanisms of silkworm resistance to BmNPV and provide a molecular target for resisting BmNPV.
T12 0-112 Sentence denotes Bombyx mori nucleopolyhedrovirus (BmNPV) is highly pathogenic, causing serious losses in sericulture every year.
T13 113-198 Sentence denotes However, the molecular mechanisms of BmNPV infection and host defence remain unclear.
T14 199-544 Sentence denotes Here we combined quantitative proteomic, bioinformatics, RT-qPCR and Western blotting analyses and found that BmNPV invasion causes complex protein alterations in the larval midgut, and that these changes are related to cytoskeleton, immune response, apoptosis, ubiquitination, translation, ion transport, endocytosis and endopeptidase activity.
T15 545-637 Sentence denotes Five important differentially expression proteins were validation by independent approaches.
T16 638-778 Sentence denotes These finding will help address the molecular mechanisms of silkworm resistance to BmNPV and provide a molecular target for resisting BmNPV.

silkworm

Id Subject Object Predicate Lexical cue
T18 0-32 Species:271108 denotes Bombyx mori nucleopolyhedrovirus
T19 34-39 Species:271108 denotes BmNPV
T20 150-155 Species:271108 denotes BmNPV
T21 156-165 Disease:MESH:D007239 denotes infection
T22 309-314 Species:271108 denotes BmNPV
T23 698-706 Species:7091 denotes silkworm
T24 721-726 Species:271108 denotes BmNPV
T25 772-777 Species:271108 denotes BmNPV

silkwormbase

Id Subject Object Predicate Lexical cue
T18 0-32 Species:271108 denotes Bombyx mori nucleopolyhedrovirus
T19 34-39 Species:271108 denotes BmNPV
T20 150-155 Species:271108 denotes BmNPV
T21 156-165 Disease:MESH:D007239 denotes infection
T22 309-314 Species:271108 denotes BmNPV
T23 698-706 Species:7091 denotes silkworm
T24 721-726 Species:271108 denotes BmNPV
T25 772-777 Species:271108 denotes BmNPV

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T2 156-165 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T15 0-32 OrganismTaxon denotes Bombyx mori nucleopolyhedrovirus 271108
T16 34-39 OrganismTaxon denotes BmNPV 271108
T17 150-155 OrganismTaxon denotes BmNPV 271108
T18 309-314 OrganismTaxon denotes BmNPV 271108
T19 698-706 OrganismTaxon denotes silkworm 7091
T20 721-726 OrganismTaxon denotes BmNPV 271108
T21 772-777 OrganismTaxon denotes BmNPV 271108

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 373-379 Body_part denotes midgut http://purl.obolibrary.org/obo/UBERON_0001045
T4 419-431 Body_part denotes cytoskeleton http://purl.obolibrary.org/obo/GO_0005856