PubMed:28411266 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/28411266","sourcedb":"PubMed","sourceid":"28411266","text":"Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease.\nDespite widespread clinical use in the treatment of type 2 diabetes, the impact of sulfonylurea therapy on cardiovascular outcomes remains uncertain. Studies of naturally occurring genetic variation can be used to anticipate the expected clinical consequences of a pharmacological therapy. A common missense variant in the gene encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S) promotes closure of the target channel of sulfonylurea therapy and is associated with increased insulin secretion, thus mimicking the effects of sulfonylurea therapy. Using individual-level data from 120,286 participants in the UK Biobank and summary association results from four large-scale genome-wide association studies, we examined the impact of this variant on cardiometabolic traits, type 2 diabetes, and coronary heart disease. The p.A1369S variant was associated with a significantly lower risk of type 2 diabetes (odds ratio [OR] 0.93; 95% CI 0.91, 0.95; P = 1.2 × 10(-11)). The variant was associated with increased BMI (+0.062 kg/m(2); 95% CI 0.037, 0.086; P = 8.1 × 10(-7)) but lower waist-to-hip ratio adjusted for BMI, a marker of abdominal fat distribution. Furthermore, p.A1369S was associated with a reduced risk of coronary heart disease (OR 0.98; 95% CI 0.96, 0.99; P = 5.9 × 10(-4)). These results suggest that, despite a known association with increased weight, long-term sulfonylurea therapy may reduce the risk of coronary heart disease.","tracks":[{"project":"test-210614","denotations":[{"id":"28411266_0","span":{"begin":1276,"end":1284},"obj":"ProteinMutation"},{"id":"28411266_1","span":{"begin":929,"end":937},"obj":"ProteinMutation"},{"id":"28411266_2","span":{"begin":478,"end":486},"obj":"ProteinMutation"}],"attributes":[{"id":"28411266_0_ProteinMutation","pred":"proteinmutation","subj":"28411266_0","obj":"rs757110"},{"id":"28411266_1_ProteinMutation","pred":"proteinmutation","subj":"28411266_1","obj":"rs757110"},{"id":"28411266_2_ProteinMutation","pred":"proteinmutation","subj":"28411266_2","obj":"rs757110"},{"subj":"28411266_0","pred":"source","obj":"test-210614"},{"subj":"28411266_1","pred":"source","obj":"test-210614"},{"subj":"28411266_2","pred":"source","obj":"test-210614"}]},{"project":"PubTator4TogoVar","denotations":[{"id":"28411266_0","span":{"begin":1276,"end":1284},"obj":"ProteinMutation"},{"id":"28411266_1","span":{"begin":929,"end":937},"obj":"ProteinMutation"},{"id":"28411266_2","span":{"begin":478,"end":486},"obj":"ProteinMutation"}],"attributes":[{"id":"28411266_0_ProteinMutation","pred":"proteinmutation","subj":"28411266_0","obj":"rs757110"},{"id":"28411266_1_ProteinMutation","pred":"proteinmutation","subj":"28411266_1","obj":"rs757110"},{"id":"28411266_2_ProteinMutation","pred":"proteinmutation","subj":"28411266_2","obj":"rs757110"},{"subj":"28411266_0","pred":"source","obj":"PubTator4TogoVar"},{"subj":"28411266_1","pred":"source","obj":"PubTator4TogoVar"},{"subj":"28411266_2","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T5","span":{"begin":655,"end":924},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T2","span":{"begin":93,"end":242},"obj":"Sentence"},{"id":"T3","span":{"begin":243,"end":382},"obj":"Sentence"},{"id":"T4","span":{"begin":383,"end":654},"obj":"Sentence"},{"id":"T6","span":{"begin":925,"end":1073},"obj":"Sentence"},{"id":"T7","span":{"begin":1074,"end":1262},"obj":"Sentence"},{"id":"T8","span":{"begin":1263,"end":1393},"obj":"Sentence"},{"id":"T9","span":{"begin":1394,"end":1550},"obj":"Sentence"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"},{"subj":"T9","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities","denotations":[{"id":"12695","span":{"begin":25,"end":46},"obj":"GeneOrGeneProduct"},{"id":"12696","span":{"begin":48,"end":63},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12697","span":{"begin":69,"end":91},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12698","span":{"begin":145,"end":160},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12699","span":{"begin":176,"end":188},"obj":"ChemicalEntity"},{"id":"12700","span":{"begin":449,"end":470},"obj":"GeneOrGeneProduct"},{"id":"12701","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"12702","span":{"begin":478,"end":486},"obj":"SequenceVariant"},{"id":"12703","span":{"begin":530,"end":542},"obj":"ChemicalEntity"},{"id":"12704","span":{"begin":584,"end":591},"obj":"GeneOrGeneProduct"},{"id":"12705","span":{"begin":633,"end":645},"obj":"ChemicalEntity"},{"id":"12706","span":{"begin":880,"end":895},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12707","span":{"begin":901,"end":923},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12708","span":{"begin":929,"end":937},"obj":"SequenceVariant"},{"id":"12709","span":{"begin":996,"end":1011},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12710","span":{"begin":1276,"end":1284},"obj":"SequenceVariant"},{"id":"12711","span":{"begin":1323,"end":1345},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12712","span":{"begin":1483,"end":1495},"obj":"ChemicalEntity"},{"id":"12713","span":{"begin":1527,"end":1549},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A9","pred":"db_id","subj":"12703","obj":"MESH:D013453"},{"id":"A5","pred":"db_id","subj":"12699","obj":"MESH:D013453"},{"id":"A14","pred":"db_id","subj":"12708","obj":"DBSNP:rs757110"},{"id":"A19","pred":"db_id","subj":"12713","obj":"MESH:D003324"},{"id":"A7","pred":"db_id","subj":"12701","obj":"NCBIGene:6833"},{"id":"A4","pred":"db_id","subj":"12698","obj":"MESH:D003924"},{"id":"A15","pred":"db_id","subj":"12709","obj":"MESH:D003924"},{"id":"A8","pred":"db_id","subj":"12702","obj":"DBSNP:rs757110"},{"id":"A2","pred":"db_id","subj":"12696","obj":"MESH:D003924"},{"id":"A17","pred":"db_id","subj":"12711","obj":"MESH:D003324"},{"id":"A1","pred":"db_id","subj":"12695","obj":"NCBIGene:6833"},{"id":"A10","pred":"db_id","subj":"12704","obj":"NCBIGene:3630"},{"id":"A6","pred":"db_id","subj":"12700","obj":"NCBIGene:6833"},{"id":"A11","pred":"db_id","subj":"12705","obj":"MESH:D013453"},{"id":"A18","pred":"db_id","subj":"12712","obj":"MESH:D013453"},{"id":"A16","pred":"db_id","subj":"12710","obj":"DBSNP:rs757110"},{"id":"A12","pred":"db_id","subj":"12706","obj":"MESH:D003924"},{"id":"A3","pred":"db_id","subj":"12697","obj":"MESH:D003324"},{"id":"A13","pred":"db_id","subj":"12707","obj":"MESH:D003324"},{"subj":"12695","pred":"source","obj":"LitCoin-entities"},{"subj":"12696","pred":"source","obj":"LitCoin-entities"},{"subj":"12697","pred":"source","obj":"LitCoin-entities"},{"subj":"12698","pred":"source","obj":"LitCoin-entities"},{"subj":"12699","pred":"source","obj":"LitCoin-entities"},{"subj":"12700","pred":"source","obj":"LitCoin-entities"},{"subj":"12701","pred":"source","obj":"LitCoin-entities"},{"subj":"12702","pred":"source","obj":"LitCoin-entities"},{"subj":"12703","pred":"source","obj":"LitCoin-entities"},{"subj":"12704","pred":"source","obj":"LitCoin-entities"},{"subj":"12705","pred":"source","obj":"LitCoin-entities"},{"subj":"12706","pred":"source","obj":"LitCoin-entities"},{"subj":"12707","pred":"source","obj":"LitCoin-entities"},{"subj":"12708","pred":"source","obj":"LitCoin-entities"},{"subj":"12709","pred":"source","obj":"LitCoin-entities"},{"subj":"12710","pred":"source","obj":"LitCoin-entities"},{"subj":"12711","pred":"source","obj":"LitCoin-entities"},{"subj":"12712","pred":"source","obj":"LitCoin-entities"},{"subj":"12713","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":78,"end":91},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":910,"end":923},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":1332,"end":1345},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1536,"end":1549},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005267"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005267"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005267"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005267"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo"}]},{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":478,"end":486},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":929,"end":937},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":1276,"end":1284},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T2","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T3","pred":"source","obj":"LitCoin-SeqVar"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":25,"end":46},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":48,"end":54},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":55,"end":63},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":78,"end":83},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":145,"end":151},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":152,"end":160},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":166,"end":172},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":392,"end":400},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":449,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":584,"end":591},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":592,"end":601},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":769,"end":774},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":830,"end":836},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":872,"end":878},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":880,"end":886},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":887,"end":895},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":910,"end":915},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":996,"end":1002},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1003,"end":1011},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1186,"end":1191},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1235,"end":1244},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1245,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1307,"end":1314},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1332,"end":1337},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1375,"end":1382},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1473,"end":1477},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1478,"end":1482},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1508,"end":1514},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1536,"end":1541},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":25,"end":46},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":48,"end":54},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":55,"end":63},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":78,"end":83},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":145,"end":151},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":152,"end":160},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":166,"end":172},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":449,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":584,"end":591},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":769,"end":774},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":830,"end":836},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":872,"end":878},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":880,"end":886},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":887,"end":895},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":910,"end":915},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":996,"end":1002},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1003,"end":1011},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1235,"end":1244},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1245,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1307,"end":1314},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1332,"end":1337},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1375,"end":1382},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1478,"end":1482},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1536,"end":1541},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":48,"end":63},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":69,"end":91},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":145,"end":160},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":880,"end":895},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":901,"end":923},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":996,"end":1011},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1323,"end":1345},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1527,"end":1549},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D003924"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D003327"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D003924"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D003924"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D003327"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D003924"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D003327"},{"id":"A8","pred":"originalLabel","subj":"T8","obj":"D003327"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":25,"end":46},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":449,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":1245,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":1375,"end":1382},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":48,"end":63},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":69,"end":91},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":145,"end":160},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":292,"end":295},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":880,"end":895},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":901,"end":923},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":996,"end":1011},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1323,"end":1345},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1527,"end":1549},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005148"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005010"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005148"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0012833"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005148"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005010"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005148"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005010"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0005010"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T6","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T8","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T9","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":48,"end":63},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":69,"end":91},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":145,"end":160},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":880,"end":895},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":901,"end":923},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":996,"end":1011},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1323,"end":1345},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1527,"end":1549},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D003924"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D003327"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D003924"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D003924"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D003327"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D003924"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D003327"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D003327"},{"subj":"T1","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T2","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T3","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T5","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T7","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T8","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":48,"end":63},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":69,"end":91},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":145,"end":160},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":880,"end":895},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":901,"end":923},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":996,"end":1011},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1323,"end":1345},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1527,"end":1549},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D003924"},{"id":"A2","pred":"#label","subj":"T2","obj":"D003327"},{"id":"A3","pred":"#label","subj":"T3","obj":"D003924"},{"id":"A4","pred":"#label","subj":"T4","obj":"D003924"},{"id":"A5","pred":"#label","subj":"T5","obj":"D003327"},{"id":"A6","pred":"#label","subj":"T6","obj":"D003924"},{"id":"A7","pred":"#label","subj":"T7","obj":"D003327"},{"id":"A8","pred":"#label","subj":"T8","obj":"D003327"},{"subj":"T1","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T2","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T3","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T7","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T8","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":25,"end":37},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":176,"end":188},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":449,"end":461},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":530,"end":542},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":633,"end":645},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":1483,"end":1495},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A3","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A6","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A8","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A11","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T10","span":{"begin":1483,"end":1495},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":633,"end":645},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":530,"end":542},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":449,"end":461},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":176,"end":188},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":25,"end":37},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":1375,"end":1382},"obj":"GeneOrGeneProduct"},{"id":"T34673","span":{"begin":1245,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":472,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T77245","span":{"begin":449,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T56263","span":{"begin":25,"end":46},"obj":"GeneOrGeneProduct"},{"id":"T84515","span":{"begin":1527,"end":1549},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1323,"end":1345},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T86714","span":{"begin":996,"end":1011},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4049","span":{"begin":901,"end":923},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T92003","span":{"begin":880,"end":895},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T76323","span":{"begin":145,"end":160},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T76869","span":{"begin":69,"end":91},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T56295","span":{"begin":48,"end":63},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3532","span":{"begin":1276,"end":1284},"obj":"SequenceVariant"},{"id":"T71982","span":{"begin":929,"end":937},"obj":"SequenceVariant"},{"id":"T78896","span":{"begin":478,"end":486},"obj":"SequenceVariant"}],"attributes":[{"id":"A11","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A8","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A6","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A3","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_76983"},{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_26831"},{"id":"A13709","pred":"#label","subj":"T84515","obj":"D003327"},{"id":"A37610","pred":"#label","subj":"T7","obj":"D003327"},{"id":"A18793","pred":"#label","subj":"T86714","obj":"D003924"},{"id":"A70495","pred":"#label","subj":"T4049","obj":"D003327"},{"id":"A28656","pred":"#label","subj":"T92003","obj":"D003924"},{"id":"A54167","pred":"#label","subj":"T76323","obj":"D003924"},{"id":"A52898","pred":"#label","subj":"T76869","obj":"D003327"},{"id":"A32806","pred":"#label","subj":"T56295","obj":"D003924"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T34673","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T77245","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T56263","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T84515","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T86714","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4049","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T92003","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T76323","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T76869","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T56295","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3532","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T71982","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T78896","pred":"source","obj":"LitCoin-training-merged"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"test-210614","color":"#cdec93","default":true},{"id":"PubTator4TogoVar","color":"#ec93e7"},{"id":"LitCoin-sentences","color":"#93ecd6"},{"id":"LitCoin-entities","color":"#ecbc93"},{"id":"LitCoin_Mondo","color":"#a293ec"},{"id":"LitCoin-SeqVar","color":"#9dec93"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ec93b7"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#93d1ec"},{"id":"LitCoin-Disease-MeSH","color":"#ebec93"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#d293ec"},{"id":"LitCoin_Mondo_095","color":"#93ecb8"},{"id":"LitCoin-MeSH-Disease-2","color":"#ec9e93"},{"id":"LitCoin-MONDO_bioort2019","color":"#93a1ec"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#bbec93"},{"id":"LitCoin-training-merged","color":"#ec93d5"}]}]}}