PubMed:28411266
Annnotations
test-210614
| Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
|---|---|---|---|---|---|
| 28411266_0 | 1276-1284 | ProteinMutation | denotes | p.A1369S | rs757110 |
| 28411266_1 | 929-937 | ProteinMutation | denotes | p.A1369S | rs757110 |
| 28411266_2 | 478-486 | ProteinMutation | denotes | p.A1369S | rs757110 |
PubTator4TogoVar
| Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
|---|---|---|---|---|---|
| 28411266_0 | 1276-1284 | ProteinMutation | denotes | p.A1369S | rs757110 |
| 28411266_1 | 929-937 | ProteinMutation | denotes | p.A1369S | rs757110 |
| 28411266_2 | 478-486 | ProteinMutation | denotes | p.A1369S | rs757110 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T5 | 655-924 | Sentence | denotes | Using individual-level data from 120,286 participants in the UK Biobank and summary association results from four large-scale genome-wide association studies, we examined the impact of this variant on cardiometabolic traits, type 2 diabetes, and coronary heart disease. |
| T1 | 0-92 | Sentence | denotes | Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease. |
| T2 | 93-242 | Sentence | denotes | Despite widespread clinical use in the treatment of type 2 diabetes, the impact of sulfonylurea therapy on cardiovascular outcomes remains uncertain. |
| T3 | 243-382 | Sentence | denotes | Studies of naturally occurring genetic variation can be used to anticipate the expected clinical consequences of a pharmacological therapy. |
| T4 | 383-654 | Sentence | denotes | A common missense variant in the gene encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S) promotes closure of the target channel of sulfonylurea therapy and is associated with increased insulin secretion, thus mimicking the effects of sulfonylurea therapy. |
| T6 | 925-1073 | Sentence | denotes | The p.A1369S variant was associated with a significantly lower risk of type 2 diabetes (odds ratio [OR] 0.93; 95% CI 0.91, 0.95; P = 1.2 × 10(-11)). |
| T7 | 1074-1262 | Sentence | denotes | The variant was associated with increased BMI (+0.062 kg/m(2); 95% CI 0.037, 0.086; P = 8.1 × 10(-7)) but lower waist-to-hip ratio adjusted for BMI, a marker of abdominal fat distribution. |
| T8 | 1263-1393 | Sentence | denotes | Furthermore, p.A1369S was associated with a reduced risk of coronary heart disease (OR 0.98; 95% CI 0.96, 0.99; P = 5.9 × 10(-4)). |
| T9 | 1394-1550 | Sentence | denotes | These results suggest that, despite a known association with increased weight, long-term sulfonylurea therapy may reduce the risk of coronary heart disease. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 12695 | 25-46 | GeneOrGeneProduct | denotes | Sulfonylurea Receptor | NCBIGene:6833 |
| 12696 | 48-63 | DiseaseOrPhenotypicFeature | denotes | Type 2 Diabetes | MESH:D003924 |
| 12697 | 69-91 | DiseaseOrPhenotypicFeature | denotes | Coronary Heart Disease | MESH:D003324 |
| 12698 | 145-160 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | MESH:D003924 |
| 12699 | 176-188 | ChemicalEntity | denotes | sulfonylurea | MESH:D013453 |
| 12700 | 449-470 | GeneOrGeneProduct | denotes | sulfonylurea receptor | NCBIGene:6833 |
| 12701 | 472-477 | GeneOrGeneProduct | denotes | ABCC8 | NCBIGene:6833 |
| 12702 | 478-486 | SequenceVariant | denotes | p.A1369S | DBSNP:rs757110 |
| 12703 | 530-542 | ChemicalEntity | denotes | sulfonylurea | MESH:D013453 |
| 12704 | 584-591 | GeneOrGeneProduct | denotes | insulin | NCBIGene:3630 |
| 12705 | 633-645 | ChemicalEntity | denotes | sulfonylurea | MESH:D013453 |
| 12706 | 880-895 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | MESH:D003924 |
| 12707 | 901-923 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | MESH:D003324 |
| 12708 | 929-937 | SequenceVariant | denotes | p.A1369S | DBSNP:rs757110 |
| 12709 | 996-1011 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | MESH:D003924 |
| 12710 | 1276-1284 | SequenceVariant | denotes | p.A1369S | DBSNP:rs757110 |
| 12711 | 1323-1345 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | MESH:D003324 |
| 12712 | 1483-1495 | ChemicalEntity | denotes | sulfonylurea | MESH:D013453 |
| 12713 | 1527-1549 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | MESH:D003324 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 78-91 | DiseaseOrPhenotypicFeature | denotes | Heart Disease | 0005267 |
| T2 | 910-923 | DiseaseOrPhenotypicFeature | denotes | heart disease | 0005267 |
| T3 | 1332-1345 | DiseaseOrPhenotypicFeature | denotes | heart disease | 0005267 |
| T4 | 1536-1549 | DiseaseOrPhenotypicFeature | denotes | heart disease | 0005267 |
LitCoin-SeqVar
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 478-486 | SequenceVariant | denotes | p.A1369S |
| T2 | 929-937 | SequenceVariant | denotes | p.A1369S |
| T3 | 1276-1284 | SequenceVariant | denotes | p.A1369S |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 25-46 | GeneOrGeneProduct | denotes | Sulfonylurea Receptor |
| T2 | 48-54 | GeneOrGeneProduct | denotes | Type 2 |
| T3 | 55-63 | GeneOrGeneProduct | denotes | Diabetes |
| T4 | 78-83 | GeneOrGeneProduct | denotes | Heart |
| T5 | 145-151 | GeneOrGeneProduct | denotes | type 2 |
| T6 | 152-160 | GeneOrGeneProduct | denotes | diabetes |
| T7 | 166-172 | GeneOrGeneProduct | denotes | impact |
| T8 | 392-400 | GeneOrGeneProduct | denotes | missense |
| T9 | 449-470 | GeneOrGeneProduct | denotes | sulfonylurea receptor |
| T10 | 472-477 | GeneOrGeneProduct | denotes | ABCC8 |
| T11 | 584-591 | GeneOrGeneProduct | denotes | insulin |
| T12 | 592-601 | GeneOrGeneProduct | denotes | secretion |
| T13 | 769-774 | GeneOrGeneProduct | denotes | large |
| T14 | 830-836 | GeneOrGeneProduct | denotes | impact |
| T15 | 872-878 | GeneOrGeneProduct | denotes | traits |
| T16 | 880-886 | GeneOrGeneProduct | denotes | type 2 |
| T17 | 887-895 | GeneOrGeneProduct | denotes | diabetes |
| T18 | 910-915 | GeneOrGeneProduct | denotes | heart |
| T19 | 996-1002 | GeneOrGeneProduct | denotes | type 2 |
| T20 | 1003-1011 | GeneOrGeneProduct | denotes | diabetes |
| T21 | 1186-1191 | GeneOrGeneProduct | denotes | waist |
| T22 | 1235-1244 | GeneOrGeneProduct | denotes | abdominal |
| T23 | 1245-1261 | GeneOrGeneProduct | denotes | fat distribution |
| T24 | 1307-1314 | GeneOrGeneProduct | denotes | reduced |
| T25 | 1332-1337 | GeneOrGeneProduct | denotes | heart |
| T26 | 1375-1382 | GeneOrGeneProduct | denotes | P = 5.9 |
| T27 | 1473-1477 | GeneOrGeneProduct | denotes | long |
| T28 | 1478-1482 | GeneOrGeneProduct | denotes | term |
| T29 | 1508-1514 | GeneOrGeneProduct | denotes | reduce |
| T30 | 1536-1541 | GeneOrGeneProduct | denotes | heart |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 25-46 | GeneOrGeneProduct | denotes | Sulfonylurea Receptor |
| T2 | 48-54 | GeneOrGeneProduct | denotes | Type 2 |
| T3 | 55-63 | GeneOrGeneProduct | denotes | Diabetes |
| T4 | 78-83 | GeneOrGeneProduct | denotes | Heart |
| T5 | 145-151 | GeneOrGeneProduct | denotes | type 2 |
| T6 | 152-160 | GeneOrGeneProduct | denotes | diabetes |
| T7 | 166-172 | GeneOrGeneProduct | denotes | impact |
| T8 | 449-470 | GeneOrGeneProduct | denotes | sulfonylurea receptor |
| T9 | 472-477 | GeneOrGeneProduct | denotes | ABCC8 |
| T10 | 584-591 | GeneOrGeneProduct | denotes | insulin |
| T11 | 769-774 | GeneOrGeneProduct | denotes | large |
| T12 | 830-836 | GeneOrGeneProduct | denotes | impact |
| T13 | 872-878 | GeneOrGeneProduct | denotes | traits |
| T14 | 880-886 | GeneOrGeneProduct | denotes | type 2 |
| T15 | 887-895 | GeneOrGeneProduct | denotes | diabetes |
| T16 | 910-915 | GeneOrGeneProduct | denotes | heart |
| T17 | 996-1002 | GeneOrGeneProduct | denotes | type 2 |
| T18 | 1003-1011 | GeneOrGeneProduct | denotes | diabetes |
| T19 | 1235-1244 | GeneOrGeneProduct | denotes | abdominal |
| T20 | 1245-1261 | GeneOrGeneProduct | denotes | fat distribution |
| T21 | 1307-1314 | GeneOrGeneProduct | denotes | reduced |
| T22 | 1332-1337 | GeneOrGeneProduct | denotes | heart |
| T23 | 1375-1382 | GeneOrGeneProduct | denotes | P = 5.9 |
| T24 | 1478-1482 | GeneOrGeneProduct | denotes | term |
| T25 | 1536-1541 | GeneOrGeneProduct | denotes | heart |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 48-63 | DiseaseOrPhenotypicFeature | denotes | Type 2 Diabetes | D003924 |
| T2 | 69-91 | DiseaseOrPhenotypicFeature | denotes | Coronary Heart Disease | D003327 |
| T3 | 145-160 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T4 | 880-895 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T5 | 901-923 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
| T6 | 996-1011 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T7 | 1323-1345 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
| T8 | 1527-1549 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 25-46 | GeneOrGeneProduct | denotes | Sulfonylurea Receptor |
| T2 | 449-470 | GeneOrGeneProduct | denotes | sulfonylurea receptor |
| T3 | 472-477 | GeneOrGeneProduct | denotes | ABCC8 |
| T4 | 1245-1261 | GeneOrGeneProduct | denotes | fat distribution |
| T5 | 1375-1382 | GeneOrGeneProduct | denotes | P = 5.9 |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 48-63 | DiseaseOrPhenotypicFeature | denotes | Type 2 Diabetes | 0005148 |
| T2 | 69-91 | DiseaseOrPhenotypicFeature | denotes | Coronary Heart Disease | 0005010 |
| T3 | 145-160 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | 0005148 |
| T4 | 292-295 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T5 | 880-895 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | 0005148 |
| T6 | 901-923 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | 0005010 |
| T7 | 996-1011 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | 0005148 |
| T8 | 1323-1345 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | 0005010 |
| T9 | 1527-1549 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | 0005010 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 48-63 | DiseaseOrPhenotypicFeature | denotes | Type 2 Diabetes | D003924 |
| T2 | 69-91 | DiseaseOrPhenotypicFeature | denotes | Coronary Heart Disease | D003327 |
| T3 | 145-160 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T4 | 880-895 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T5 | 901-923 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
| T6 | 996-1011 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T7 | 1323-1345 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
| T8 | 1527-1549 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 48-63 | DiseaseOrPhenotypicFeature | denotes | Type 2 Diabetes | D003924 |
| T2 | 69-91 | DiseaseOrPhenotypicFeature | denotes | Coronary Heart Disease | D003327 |
| T3 | 145-160 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T4 | 880-895 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T5 | 901-923 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
| T6 | 996-1011 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 |
| T7 | 1323-1345 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
| T8 | 1527-1549 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 25-37 | ChemicalEntity | denotes | Sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_26831 |
| T2 | 176-188 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_76983|http://purl.obolibrary.org/obo/CHEBI_26831 |
| T4 | 449-461 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_76983|http://purl.obolibrary.org/obo/CHEBI_26831 |
| T6 | 530-542 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_76983|http://purl.obolibrary.org/obo/CHEBI_26831 |
| T8 | 633-645 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_76983|http://purl.obolibrary.org/obo/CHEBI_26831 |
| T10 | 1483-1495 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_76983|http://purl.obolibrary.org/obo/CHEBI_26831 |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T10 | 1483-1495 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_26831|http://purl.obolibrary.org/obo/CHEBI_76983 | |
| T8 | 633-645 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_26831|http://purl.obolibrary.org/obo/CHEBI_76983 | |
| T6 | 530-542 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_26831|http://purl.obolibrary.org/obo/CHEBI_76983 | |
| T4 | 449-461 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_26831|http://purl.obolibrary.org/obo/CHEBI_76983 | |
| T2 | 176-188 | ChemicalEntity | denotes | sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_26831|http://purl.obolibrary.org/obo/CHEBI_76983 | |
| T1 | 25-37 | ChemicalEntity | denotes | Sulfonylurea | http://purl.obolibrary.org/obo/CHEBI_26831 | |
| T5 | 1375-1382 | GeneOrGeneProduct | denotes | P = 5.9 | ||
| T34673 | 1245-1261 | GeneOrGeneProduct | denotes | fat distribution | ||
| T3 | 472-477 | GeneOrGeneProduct | denotes | ABCC8 | ||
| T77245 | 449-470 | GeneOrGeneProduct | denotes | sulfonylurea receptor | ||
| T56263 | 25-46 | GeneOrGeneProduct | denotes | Sulfonylurea Receptor | ||
| T84515 | 1527-1549 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 | |
| T7 | 1323-1345 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 | |
| T86714 | 996-1011 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 | |
| T4049 | 901-923 | DiseaseOrPhenotypicFeature | denotes | coronary heart disease | D003327 | |
| T92003 | 880-895 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 | |
| T76323 | 145-160 | DiseaseOrPhenotypicFeature | denotes | type 2 diabetes | D003924 | |
| T76869 | 69-91 | DiseaseOrPhenotypicFeature | denotes | Coronary Heart Disease | D003327 | |
| T56295 | 48-63 | DiseaseOrPhenotypicFeature | denotes | Type 2 Diabetes | D003924 | |
| T3532 | 1276-1284 | SequenceVariant | denotes | p.A1369S | ||
| T71982 | 929-937 | SequenceVariant | denotes | p.A1369S | ||
| T78896 | 478-486 | SequenceVariant | denotes | p.A1369S |