PubMed:28398555 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/28398555","sourcedb":"PubMed","sourceid":"28398555","text":"Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.\nDystonia is a neurological movement disorder that forces the body into twisting, repetitive movements or sometimes painful abnormal postures. With the advent of next-generation sequencing technologies, the homozygous mutations T71N and A190T in the neuronal calcium sensor (NCS) hippocalcin were identified as the genetic cause of primary isolated dystonia (DYT2 dystonia). However, the effect of these mutations on the physiological role of hippocalcin has not yet been elucidated. Using a multidisciplinary approach, we demonstrated that hippocalcin oligomerises in a calcium-dependent manner and binds to voltage-gated calcium channels. Mutations T71N and A190T in hippocalcin did not affect stability, calcium-binding affinity or translocation to cellular membranes (Ca2+/myristoyl switch). We obtained the first crystal structure of hippocalcin and alignment with other NCS proteins showed significant variability in the orientation of the C-terminal part of the molecule, the region expected to be important for target binding. We demonstrated that the disease-causing mutations did not affect the structure of the protein, however both mutants showed a defect in oligomerisation. In addition, we observed an increased calcium influx in KCl-depolarised cells expressing mutated hippocalcin, mostly driven by N-type voltage-gated calcium channels. Our data demonstrate that the dystonia-causing mutations strongly affect hippocalcin cellular functions which suggest a central role for perturbed calcium signalling in DYT2 dystonia.","tracks":[{"project":"LitCoin-entities","denotations":[{"id":"12662","span":{"begin":47,"end":58},"obj":"GeneOrGeneProduct"},{"id":"12663","span":{"begin":83,"end":88},"obj":"OrganismTaxon"},{"id":"12664","span":{"begin":89,"end":97},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12665","span":{"begin":99,"end":107},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12666","span":{"begin":113,"end":143},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12667","span":{"begin":326,"end":330},"obj":"SequenceVariant"},{"id":"12668","span":{"begin":335,"end":340},"obj":"SequenceVariant"},{"id":"12669","span":{"begin":348,"end":371},"obj":"GeneOrGeneProduct"},{"id":"12670","span":{"begin":373,"end":376},"obj":"GeneOrGeneProduct"},{"id":"12671","span":{"begin":378,"end":389},"obj":"GeneOrGeneProduct"},{"id":"12672","span":{"begin":430,"end":455},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12673","span":{"begin":457,"end":461},"obj":"GeneOrGeneProduct"},{"id":"12674","span":{"begin":462,"end":470},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12675","span":{"begin":541,"end":552},"obj":"GeneOrGeneProduct"},{"id":"12676","span":{"begin":639,"end":650},"obj":"GeneOrGeneProduct"},{"id":"12677","span":{"begin":669,"end":676},"obj":"ChemicalEntity"},{"id":"12678","span":{"begin":707,"end":737},"obj":"GeneOrGeneProduct"},{"id":"12679","span":{"begin":749,"end":753},"obj":"SequenceVariant"},{"id":"12680","span":{"begin":758,"end":763},"obj":"SequenceVariant"},{"id":"12681","span":{"begin":767,"end":778},"obj":"GeneOrGeneProduct"},{"id":"12682","span":{"begin":805,"end":812},"obj":"ChemicalEntity"},{"id":"12683","span":{"begin":870,"end":874},"obj":"ChemicalEntity"},{"id":"12684","span":{"begin":937,"end":948},"obj":"GeneOrGeneProduct"},{"id":"12685","span":{"begin":974,"end":977},"obj":"GeneOrGeneProduct"},{"id":"12686","span":{"begin":1324,"end":1331},"obj":"ChemicalEntity"},{"id":"12687","span":{"begin":1342,"end":1345},"obj":"ChemicalEntity"},{"id":"12688","span":{"begin":1383,"end":1394},"obj":"GeneOrGeneProduct"},{"id":"12689","span":{"begin":1413,"end":1450},"obj":"GeneOrGeneProduct"},{"id":"12690","span":{"begin":1482,"end":1490},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12691","span":{"begin":1525,"end":1536},"obj":"GeneOrGeneProduct"},{"id":"12692","span":{"begin":1599,"end":1606},"obj":"ChemicalEntity"},{"id":"12693","span":{"begin":1621,"end":1625},"obj":"GeneOrGeneProduct"},{"id":"12694","span":{"begin":1626,"end":1634},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A15","pred":"db_id","subj":"12676","obj":"NCBIGene:3208"},{"id":"A24","pred":"db_id","subj":"12685","obj":"NCBIGene:3208"},{"id":"A6","pred":"db_id","subj":"12667","obj":"DBSNP:rs775863165"},{"id":"A4","pred":"db_id","subj":"12665","obj":"MESH:D004421"},{"id":"A8","pred":"db_id","subj":"12669","obj":"NCBIGene:3208"},{"id":"A16","pred":"db_id","subj":"12677","obj":"MESH:D002118"},{"id":"A17","pred":"db_id","subj":"12678","obj":"NCBIGene:783"},{"id":"A10","pred":"db_id","subj":"12671","obj":"NCBIGene:3208"},{"id":"A18","pred":"db_id","subj":"12679","obj":"DBSNP:rs775863165"},{"id":"A25","pred":"db_id","subj":"12686","obj":"MESH:D002118"},{"id":"A9","pred":"db_id","subj":"12670","obj":"NCBIGene:3208"},{"id":"A22","pred":"db_id","subj":"12683","obj":"MESH:D000069285"},{"id":"A26","pred":"db_id","subj":"12687","obj":"MESH:D011189"},{"id":"A1","pred":"db_id","subj":"12662","obj":"NCBIGene:3208"},{"id":"A7","pred":"db_id","subj":"12668","obj":"DBSNP:rs550921485"},{"id":"A28","pred":"db_id","subj":"12689","obj":"NCBIGene:774"},{"id":"A32","pred":"db_id","subj":"12693","obj":"NCBIGene:3208"},{"id":"A14","pred":"db_id","subj":"12675","obj":"NCBIGene:3208"},{"id":"A2","pred":"db_id","subj":"12663","obj":"NCBITaxon:9606"},{"id":"A3","pred":"db_id","subj":"12664","obj":"MESH:D004421"},{"id":"A11","pred":"db_id","subj":"12672","obj":"MESH:D004421"},{"id":"A21","pred":"db_id","subj":"12682","obj":"MESH:D002118"},{"id":"A33","pred":"db_id","subj":"12694","obj":"MESH:D004421"},{"id":"A5","pred":"db_id","subj":"12666","obj":"MESH:D009069"},{"id":"A31","pred":"db_id","subj":"12692","obj":"MESH:D002118"},{"id":"A19","pred":"db_id","subj":"12680","obj":"DBSNP:rs550921485"},{"id":"A12","pred":"db_id","subj":"12673","obj":"NCBIGene:3208"},{"id":"A20","pred":"db_id","subj":"12681","obj":"NCBIGene:3208"},{"id":"A27","pred":"db_id","subj":"12688","obj":"NCBIGene:3208"},{"id":"A13","pred":"db_id","subj":"12674","obj":"MESH:D004421"},{"id":"A23","pred":"db_id","subj":"12684","obj":"NCBIGene:3208"},{"id":"A29","pred":"db_id","subj":"12690","obj":"MESH:D004421"},{"id":"A30","pred":"db_id","subj":"12691","obj":"NCBIGene:3208"},{"subj":"12662","pred":"source","obj":"LitCoin-entities"},{"subj":"12663","pred":"source","obj":"LitCoin-entities"},{"subj":"12664","pred":"source","obj":"LitCoin-entities"},{"subj":"12665","pred":"source","obj":"LitCoin-entities"},{"subj":"12666","pred":"source","obj":"LitCoin-entities"},{"subj":"12667","pred":"source","obj":"LitCoin-entities"},{"subj":"12668","pred":"source","obj":"LitCoin-entities"},{"subj":"12669","pred":"source","obj":"LitCoin-entities"},{"subj":"12670","pred":"source","obj":"LitCoin-entities"},{"subj":"12671","pred":"source","obj":"LitCoin-entities"},{"subj":"12672","pred":"source","obj":"LitCoin-entities"},{"subj":"12673","pred":"source","obj":"LitCoin-entities"},{"subj":"12674","pred":"source","obj":"LitCoin-entities"},{"subj":"12675","pred":"source","obj":"LitCoin-entities"},{"subj":"12676","pred":"source","obj":"LitCoin-entities"},{"subj":"12677","pred":"source","obj":"LitCoin-entities"},{"subj":"12678","pred":"source","obj":"LitCoin-entities"},{"subj":"12679","pred":"source","obj":"LitCoin-entities"},{"subj":"12680","pred":"source","obj":"LitCoin-entities"},{"subj":"12681","pred":"source","obj":"LitCoin-entities"},{"subj":"12682","pred":"source","obj":"LitCoin-entities"},{"subj":"12683","pred":"source","obj":"LitCoin-entities"},{"subj":"12684","pred":"source","obj":"LitCoin-entities"},{"subj":"12685","pred":"source","obj":"LitCoin-entities"},{"subj":"12686","pred":"source","obj":"LitCoin-entities"},{"subj":"12687","pred":"source","obj":"LitCoin-entities"},{"subj":"12688","pred":"source","obj":"LitCoin-entities"},{"subj":"12689","pred":"source","obj":"LitCoin-entities"},{"subj":"12690","pred":"source","obj":"LitCoin-entities"},{"subj":"12691","pred":"source","obj":"LitCoin-entities"},{"subj":"12692","pred":"source","obj":"LitCoin-entities"},{"subj":"12693","pred":"source","obj":"LitCoin-entities"},{"subj":"12694","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T2","span":{"begin":99,"end":240},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":98},"obj":"Sentence"},{"id":"T3","span":{"begin":241,"end":472},"obj":"Sentence"},{"id":"T4","span":{"begin":473,"end":581},"obj":"Sentence"},{"id":"T5","span":{"begin":582,"end":738},"obj":"Sentence"},{"id":"T6","span":{"begin":739,"end":893},"obj":"Sentence"},{"id":"T7","span":{"begin":894,"end":1132},"obj":"Sentence"},{"id":"T8","span":{"begin":1133,"end":1285},"obj":"Sentence"},{"id":"T9","span":{"begin":1286,"end":1451},"obj":"Sentence"},{"id":"T10","span":{"begin":1452,"end":1635},"obj":"Sentence"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"},{"subj":"T9","pred":"source","obj":"LitCoin-sentences"},{"subj":"T10","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":83,"end":88},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:9606"},{"subj":"T1","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"}]},{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":326,"end":330},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":335,"end":340},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":749,"end":753},"obj":"SequenceVariant"},{"id":"T4","span":{"begin":758,"end":763},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T2","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T3","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T4","pred":"source","obj":"LitCoin-SeqVar"}]},{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":126,"end":143},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":348,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":438,"end":455},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005395"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0004466"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0015494"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":47,"end":58},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":59,"end":66},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":149,"end":155},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":170,"end":178},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":214,"end":221},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":316,"end":325},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":348,"end":371},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":373,"end":376},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":378,"end":389},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":457,"end":461},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":502,"end":511},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":541,"end":552},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":639,"end":650},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":664,"end":668},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":698,"end":703},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":707,"end":737},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":739,"end":748},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":767,"end":778},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":805,"end":820},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":833,"end":846},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":870,"end":873},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":885,"end":891},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":937,"end":948},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":968,"end":973},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":974,"end":977},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":978,"end":986},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1044,"end":1054},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1055,"end":1059},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1124,"end":1131},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1174,"end":1183},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1220,"end":1227},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1242,"end":1249},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":1259,"end":1265},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":1358,"end":1363},"obj":"GeneOrGeneProduct"},{"id":"T35","span":{"begin":1375,"end":1382},"obj":"GeneOrGeneProduct"},{"id":"T36","span":{"begin":1383,"end":1394},"obj":"GeneOrGeneProduct"},{"id":"T37","span":{"begin":1420,"end":1450},"obj":"GeneOrGeneProduct"},{"id":"T38","span":{"begin":1499,"end":1508},"obj":"GeneOrGeneProduct"},{"id":"T39","span":{"begin":1525,"end":1536},"obj":"GeneOrGeneProduct"},{"id":"T40","span":{"begin":1621,"end":1625},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T31","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T32","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T33","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T34","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T35","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T36","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T37","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T38","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T39","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T40","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":89,"end":97},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":99,"end":107},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":126,"end":143},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":447,"end":455},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":462,"end":470},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1482,"end":1490},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1626,"end":1634},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"#label","subj":"T7","obj":"D004421"},{"id":"A2","pred":"#label","subj":"T2","obj":"D004421"},{"id":"A3","pred":"#label","subj":"T3","obj":"D009069"},{"id":"A5","pred":"#label","subj":"T5","obj":"D004421"},{"id":"A1","pred":"#label","subj":"T1","obj":"D004421"},{"id":"A4","pred":"#label","subj":"T4","obj":"D004421"},{"id":"A6","pred":"#label","subj":"T6","obj":"D004421"},{"subj":"T1","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T2","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T3","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T7","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":83,"end":88},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":357,"end":364},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":373,"end":376},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":669,"end":676},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":721,"end":728},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":805,"end":812},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":875,"end":884},"obj":"ChemicalEntity"},{"id":"T15","span":{"begin":974,"end":977},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":1324,"end":1331},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":1342,"end":1345},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":1434,"end":1441},"obj":"ChemicalEntity"},{"id":"T23","span":{"begin":1599,"end":1606},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D002118"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D002118"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A13","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_53203"},{"id":"A14","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_25456"},{"id":"A15","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_53203"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D002118"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A10","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D002118"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A7","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A20","pred":"ID:","subj":"T20","obj":"D002118"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D002118"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A18","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A23","pred":"ID:","subj":"T23","obj":"D002118"},{"id":"A24","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A25","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A19","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_32588"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T16","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T19","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T20","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":47,"end":58},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":348,"end":371},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":373,"end":376},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":378,"end":389},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":457,"end":461},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":541,"end":552},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":639,"end":650},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":707,"end":737},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":767,"end":778},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":805,"end":820},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":833,"end":846},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":885,"end":891},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":937,"end":948},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":968,"end":973},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":974,"end":977},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1044,"end":1054},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1124,"end":1131},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1220,"end":1227},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1383,"end":1394},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1420,"end":1450},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1525,"end":1536},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1621,"end":1625},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":89,"end":97},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":99,"end":107},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":126,"end":143},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":447,"end":455},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":462,"end":470},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1158,"end":1165},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1482,"end":1490},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1626,"end":1634},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A8","pred":"originalLabel","subj":"T8","obj":"D004421"},{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D004421"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D004421"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D004421"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D004421"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D009069"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D004421"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D004194"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":89,"end":97},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":99,"end":107},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":126,"end":143},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":438,"end":455},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":457,"end":461},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":462,"end":470},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1259,"end":1265},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1482,"end":1490},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1621,"end":1625},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1626,"end":1634},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0003441"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0009141"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0003441"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0003441"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0003441"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0003441"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0015494"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0009141"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005395"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0008568"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T6","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T8","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T9","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T10","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":47,"end":58},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":348,"end":371},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":373,"end":376},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":378,"end":389},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":457,"end":461},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":541,"end":552},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":639,"end":650},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":707,"end":737},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":767,"end":778},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":937,"end":948},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":974,"end":977},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1383,"end":1394},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1420,"end":1450},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1525,"end":1536},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1621,"end":1625},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":89,"end":97},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":99,"end":107},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":126,"end":143},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":447,"end":455},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":462,"end":470},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1158,"end":1165},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1482,"end":1490},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1626,"end":1634},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"ID:","subj":"T4","obj":"D004421"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D004421"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D009069"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D004421"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D004421"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D004421"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D004421"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D004194"},{"subj":"T1","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T2","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T3","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T5","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T7","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T8","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T23","span":{"begin":1599,"end":1606},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":1434,"end":1441},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":1342,"end":1345},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":1324,"end":1331},"obj":"ChemicalEntity"},{"id":"T15","span":{"begin":974,"end":977},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":875,"end":884},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":805,"end":812},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":721,"end":728},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":669,"end":676},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":373,"end":376},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":357,"end":364},"obj":"ChemicalEntity"},{"id":"T2194","span":{"begin":1621,"end":1625},"obj":"GeneOrGeneProduct"},{"id":"T27411","span":{"begin":1525,"end":1536},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1420,"end":1450},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1383,"end":1394},"obj":"GeneOrGeneProduct"},{"id":"T74980","span":{"begin":974,"end":977},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":937,"end":948},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":767,"end":778},"obj":"GeneOrGeneProduct"},{"id":"T28299","span":{"begin":707,"end":737},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":639,"end":650},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":541,"end":552},"obj":"GeneOrGeneProduct"},{"id":"T41634","span":{"begin":457,"end":461},"obj":"GeneOrGeneProduct"},{"id":"T33976","span":{"begin":378,"end":389},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":373,"end":376},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":348,"end":371},"obj":"GeneOrGeneProduct"},{"id":"T98032","span":{"begin":47,"end":58},"obj":"GeneOrGeneProduct"},{"id":"T76179","span":{"begin":1626,"end":1634},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T78573","span":{"begin":1482,"end":1490},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19724","span":{"begin":462,"end":470},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T89605","span":{"begin":447,"end":455},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T82986","span":{"begin":126,"end":143},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T32476","span":{"begin":99,"end":107},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11177","span":{"begin":89,"end":97},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7056","span":{"begin":83,"end":88},"obj":"OrganismTaxon"},{"id":"T26514","span":{"begin":758,"end":763},"obj":"SequenceVariant"},{"id":"T22121","span":{"begin":749,"end":753},"obj":"SequenceVariant"},{"id":"T91846","span":{"begin":335,"end":340},"obj":"SequenceVariant"},{"id":"T86809","span":{"begin":326,"end":330},"obj":"SequenceVariant"}],"attributes":[{"id":"A15","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_53203"},{"id":"A18","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D002118"},{"id":"A36153","pred":"#label","subj":"T19724","obj":"D004421"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A20","pred":"ID:","subj":"T20","obj":"D002118"},{"id":"A46688","pred":"#label","subj":"T11177","obj":"D004421"},{"id":"A25","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A24","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A23","pred":"ID:","subj":"T23","obj":"D002118"},{"id":"A14","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_25456"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D002118"},{"id":"A7","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D002118"},{"id":"A24213","pred":"#label","subj":"T76179","obj":"D004421"},{"id":"A97855","pred":"#label","subj":"T32476","obj":"D004421"},{"id":"A30948","pred":"#label","subj":"T78573","obj":"D004421"},{"id":"A13","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D002118"},{"id":"A10","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D002118"},{"id":"A19","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_32588"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_53203"},{"id":"A68592","pred":"#label","subj":"T89605","obj":"D004421"},{"id":"A13767","pred":"#label","subj":"T82986","obj":"D009069"},{"subj":"T23","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T20","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T19","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T16","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T15","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T14","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2194","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T27411","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T13","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T74980","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T28299","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T41634","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T33976","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T98032","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T76179","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T78573","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T19724","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T89605","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T82986","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T32476","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11177","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7056","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T26514","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T22121","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T91846","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T86809","pred":"source","obj":"LitCoin-training-merged"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-entities","color":"#ec93c7","default":true},{"id":"LitCoin-sentences","color":"#93e1ec"},{"id":"LitCoin-entities-OrganismTaxon-PD","color":"#ecdd93"},{"id":"LitCoin-SeqVar","color":"#c393ec"},{"id":"LitCoin_Mondo","color":"#93eca9"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ec9397"},{"id":"LitCoin-MONDO_bioort2019","color":"#93b1ec"},{"id":"LitCoin-NCBITaxon-2","color":"#cbec93"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#ec93e5"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#93ecd9"},{"id":"LitCoin-Disease-MeSH","color":"#ecbf93"},{"id":"LitCoin_Mondo_095","color":"#a593ec"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#9aec93"},{"id":"LitCoin-MeSH-Disease-2","color":"#ec93b5"},{"id":"LitCoin-training-merged","color":"#93cfec"}]}]}}