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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 750-757 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 759-762 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T3 867-877 Glycan_Motif denotes hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T4 879-881 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T5 897-899 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T6 1150-1153 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T7 1256-1259 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T8 1331-1333 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T9 1386-1405 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 750-757 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 867-877 https://glytoucan.org/Structures/Glycans/G00017MO denotes hyaluronan
T3 1386-1405 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs.
T2 126-251 Sentence denotes Glycosaminoglycans (GAGs) have therapeutic potential in areas ranging from angiogenesis, inflammation, hemostasis and cancer.
T3 252-391 Sentence denotes GAG bioactivity is conferred by intrinsic structural features, such as disaccharide composition, glycosidic linkages and sulfation pattern.
T4 392-550 Sentence denotes Unfortunately, the in vitro enzymatic synthesis of defined GAGs is quite restricted by a limited understanding of current GAG synthases and modifying enzymes.
T5 551-696 Sentence denotes Our work provides insights into GAG-active enzymes through the creation of sulfated oligosaccharides, a new polysaccharide and chimeric polymers.
T6 697-948 Sentence denotes We show that a C6-sulfonated uridine diphospho (UDP)-glucose (Glc) derivative, sulfoquinovose, can be used as an uronic acid donor, but not as a hexosamine donor, to cap hyaluronan (HA) chains by the HA synthase from the microbe Pasteurella multocida.
T7 949-1097 Sentence denotes However, the two heparosan (HEP) synthases from the same species, PmHS1 and PmHS2, could not employ the UDP-sulfoquinovose under similar conditions.
T8 1098-1265 Sentence denotes Serendipitously, we found that PmHS2 co-polymerized Glc with glucuronic acid (GlcA), creating a novel HEP-like polymer we named hepbiuronic acid [-4-GlcAβ1-4-Glcα1-]n.
T9 1266-1592 Sentence denotes In addition, we created chimeric block polymers composed of both HA and HEP segments; in these reactions GlcA-, but not N-acetylglucosamine-(GlcNAc), terminated GAG acceptors were recognized by their noncognate synthase for further extension, likely due to the common β-linkage connecting GlcA to GlcNAc in both of these GAGs.
T10 1593-1718 Sentence denotes Overall, these GAG constructs provide new tools for studying biology and offer potential for future sugar-based therapeutics.
T1 0-125 Sentence denotes Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs.
T2 126-251 Sentence denotes Glycosaminoglycans (GAGs) have therapeutic potential in areas ranging from angiogenesis, inflammation, hemostasis and cancer.
T3 252-391 Sentence denotes GAG bioactivity is conferred by intrinsic structural features, such as disaccharide composition, glycosidic linkages and sulfation pattern.
T4 392-550 Sentence denotes Unfortunately, the in vitro enzymatic synthesis of defined GAGs is quite restricted by a limited understanding of current GAG synthases and modifying enzymes.
T5 551-696 Sentence denotes Our work provides insights into GAG-active enzymes through the creation of sulfated oligosaccharides, a new polysaccharide and chimeric polymers.
T6 697-948 Sentence denotes We show that a C6-sulfonated uridine diphospho (UDP)-glucose (Glc) derivative, sulfoquinovose, can be used as an uronic acid donor, but not as a hexosamine donor, to cap hyaluronan (HA) chains by the HA synthase from the microbe Pasteurella multocida.
T7 949-1097 Sentence denotes However, the two heparosan (HEP) synthases from the same species, PmHS1 and PmHS2, could not employ the UDP-sulfoquinovose under similar conditions.
T8 1098-1265 Sentence denotes Serendipitously, we found that PmHS2 co-polymerized Glc with glucuronic acid (GlcA), creating a novel HEP-like polymer we named hepbiuronic acid [-4-GlcAβ1-4-Glcα1-]n.
T9 1266-1592 Sentence denotes In addition, we created chimeric block polymers composed of both HA and HEP segments; in these reactions GlcA-, but not N-acetylglucosamine-(GlcNAc), terminated GAG acceptors were recognized by their noncognate synthase for further extension, likely due to the common β-linkage connecting GlcA to GlcNAc in both of these GAGs.
T10 1593-1718 Sentence denotes Overall, these GAG constructs provide new tools for studying biology and offer potential for future sugar-based therapeutics.

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 1386-1405 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T2 1407-1413 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 1563-1569 chem:24139 denotes GlcNAc

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs.
TextSentencer_T2 126-251 Sentence denotes Glycosaminoglycans (GAGs) have therapeutic potential in areas ranging from angiogenesis, inflammation, hemostasis and cancer.
TextSentencer_T3 252-391 Sentence denotes GAG bioactivity is conferred by intrinsic structural features, such as disaccharide composition, glycosidic linkages and sulfation pattern.
TextSentencer_T4 392-550 Sentence denotes Unfortunately, the in vitro enzymatic synthesis of defined GAGs is quite restricted by a limited understanding of current GAG synthases and modifying enzymes.
TextSentencer_T5 551-696 Sentence denotes Our work provides insights into GAG-active enzymes through the creation of sulfated oligosaccharides, a new polysaccharide and chimeric polymers.
TextSentencer_T6 697-948 Sentence denotes We show that a C6-sulfonated uridine diphospho (UDP)-glucose (Glc) derivative, sulfoquinovose, can be used as an uronic acid donor, but not as a hexosamine donor, to cap hyaluronan (HA) chains by the HA synthase from the microbe Pasteurella multocida.
TextSentencer_T7 949-1097 Sentence denotes However, the two heparosan (HEP) synthases from the same species, PmHS1 and PmHS2, could not employ the UDP-sulfoquinovose under similar conditions.
TextSentencer_T8 1098-1265 Sentence denotes Serendipitously, we found that PmHS2 co-polymerized Glc with glucuronic acid (GlcA), creating a novel HEP-like polymer we named hepbiuronic acid [-4-GlcAβ1-4-Glcα1-]n.
TextSentencer_T9 1266-1592 Sentence denotes In addition, we created chimeric block polymers composed of both HA and HEP segments; in these reactions GlcA-, but not N-acetylglucosamine-(GlcNAc), terminated GAG acceptors were recognized by their noncognate synthase for further extension, likely due to the common β-linkage connecting GlcA to GlcNAc in both of these GAGs.
TextSentencer_T10 1593-1718 Sentence denotes Overall, these GAG constructs provide new tools for studying biology and offer potential for future sugar-based therapeutics.
T1 0-125 Sentence denotes Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs.
T2 126-251 Sentence denotes Glycosaminoglycans (GAGs) have therapeutic potential in areas ranging from angiogenesis, inflammation, hemostasis and cancer.
T3 252-391 Sentence denotes GAG bioactivity is conferred by intrinsic structural features, such as disaccharide composition, glycosidic linkages and sulfation pattern.
T4 392-550 Sentence denotes Unfortunately, the in vitro enzymatic synthesis of defined GAGs is quite restricted by a limited understanding of current GAG synthases and modifying enzymes.
T5 551-696 Sentence denotes Our work provides insights into GAG-active enzymes through the creation of sulfated oligosaccharides, a new polysaccharide and chimeric polymers.
T6 697-948 Sentence denotes We show that a C6-sulfonated uridine diphospho (UDP)-glucose (Glc) derivative, sulfoquinovose, can be used as an uronic acid donor, but not as a hexosamine donor, to cap hyaluronan (HA) chains by the HA synthase from the microbe Pasteurella multocida.
T7 949-1097 Sentence denotes However, the two heparosan (HEP) synthases from the same species, PmHS1 and PmHS2, could not employ the UDP-sulfoquinovose under similar conditions.
T8 1098-1265 Sentence denotes Serendipitously, we found that PmHS2 co-polymerized Glc with glucuronic acid (GlcA), creating a novel HEP-like polymer we named hepbiuronic acid [-4-GlcAβ1-4-Glcα1-]n.
T9 1266-1592 Sentence denotes In addition, we created chimeric block polymers composed of both HA and HEP segments; in these reactions GlcA-, but not N-acetylglucosamine-(GlcNAc), terminated GAG acceptors were recognized by their noncognate synthase for further extension, likely due to the common β-linkage connecting GlcA to GlcNAc in both of these GAGs.
T10 1593-1718 Sentence denotes Overall, these GAG constructs provide new tools for studying biology and offer potential for future sugar-based therapeutics.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 215-227 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 244-250 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 926-947 OrganismTaxon denotes Pasteurella multocida 747

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 37-42 Body_part denotes space http://purl.obolibrary.org/obo/UBERON_0000464
T2 1342-1350 Body_part denotes segments http://purl.obolibrary.org/obo/UBERON_0000914
T3 1498-1507 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 244-250 Phenotype denotes cancer HP:0002664