PubMed:28007005 JSONTXT

{"project":"yangbin123xm_800_3","denotations":[{"id":"T1","span":{"begin":50,"end":72},"obj":"DP"},{"id":"T2","span":{"begin":263,"end":285},"obj":"DP"},{"id":"T3","span":{"begin":287,"end":290},"obj":"DP"},{"id":"T4","span":{"begin":394,"end":397},"obj":"DP"},{"id":"T5","span":{"begin":1367,"end":1370},"obj":"DP"},{"id":"T6","span":{"begin":33,"end":42},"obj":"CI"},{"id":"T7","span":{"begin":158,"end":167},"obj":"CI"},{"id":"T8","span":{"begin":483,"end":492},"obj":"CI"},{"id":"T9","span":{"begin":949,"end":958},"obj":"CI"},{"id":"T10","span":{"begin":1301,"end":1310},"obj":"CI"}],"text":"Analgesic effect of topical oral capsaicin gel in burning mouth syndrome.\nOBJECTIVE: To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS).\nMATERIAL AND METHODS: This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days. A visual analogue scale (VAS) was used to assess the severity of pain five times during the intervention period.\nRESULTS: 18 patients completed the intervention. Their VAS score at baseline was 5.5 ± 0.6 cm (mean ± SD). Treatment with the two concentrations of capsaicin gels significantly improved the burning/stinging symptoms assessed on VAS compared with baseline (p = 0.002). There was no statistically significant difference between the two concentrations of the gels on relieving symptoms. Four patients dropped out during the intervention period due to gastrointestinal side-effects.\nCONCLUSIONS: Topical capsaicin might be an alternative for the short-term treatment of BMS. However, further studies are needed to investigate especially the gastro-intestinal side-effects which may limit its long-term use."}

{"project":"chenxin_473849_800_3","denotations":[{"id":"T1","span":{"begin":263,"end":285},"obj":"DP"},{"id":"T2","span":{"begin":50,"end":72},"obj":"DP"},{"id":"T3","span":{"begin":287,"end":290},"obj":"DP"},{"id":"T4","span":{"begin":394,"end":397},"obj":"DP"},{"id":"T5","span":{"begin":1367,"end":1370},"obj":"DP"},{"id":"T6","span":{"begin":483,"end":492},"obj":"CI"},{"id":"T7","span":{"begin":33,"end":42},"obj":"CI"},{"id":"T8","span":{"begin":158,"end":167},"obj":"CI"},{"id":"T9","span":{"begin":949,"end":958},"obj":"CI"},{"id":"T10","span":{"begin":1301,"end":1310},"obj":"CI"}],"text":"Analgesic effect of topical oral capsaicin gel in burning mouth syndrome.\nOBJECTIVE: To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS).\nMATERIAL AND METHODS: This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days. A visual analogue scale (VAS) was used to assess the severity of pain five times during the intervention period.\nRESULTS: 18 patients completed the intervention. Their VAS score at baseline was 5.5 ± 0.6 cm (mean ± SD). Treatment with the two concentrations of capsaicin gels significantly improved the burning/stinging symptoms assessed on VAS compared with baseline (p = 0.002). There was no statistically significant difference between the two concentrations of the gels on relieving symptoms. Four patients dropped out during the intervention period due to gastrointestinal side-effects.\nCONCLUSIONS: Topical capsaicin might be an alternative for the short-term treatment of BMS. However, further studies are needed to investigate especially the gastro-intestinal side-effects which may limit its long-term use."}