| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-191 |
Sentence |
denotes |
Reliable confirmation of antibodies to human immunodeficiency virus type 1 (HIV-1) with an enzyme-linked immunoassay using recombinant antigens derived from the HIV-1 gag, pol, and env genes. |
| TextSentencer_T2 |
192-568 |
Sentence |
denotes |
An enzyme-linked immunoassay (ELISA) using six recombinant proteins corresponding to large segments of the human immunodeficiency virus type 1 (HIV-1) gag, pol, and env gene products (HIVAGEN; SmithKline Bio-Science Laboratories, Van Nuys, Calif.) was developed to confirm the presence of antibodies to HIV-1 in sera reactive in the whole-cell-derived virion screening ELISAs. |
| TextSentencer_T3 |
569-794 |
Sentence |
denotes |
Serum samples for testing were obtained from healthy seronegative blood donors and from the different categories of HIV-infected individuals (asymptomatic, acquired immunodeficiency syndrome [AIDS]-related complex, and AIDS). |
| TextSentencer_T4 |
795-1061 |
Sentence |
denotes |
A positive reaction was defined as reactivity against an env and at least one other (either gag or pol) HIV-1 gene product; negative was defined as no reaction with any antigen; and indeterminate was defined as reactivity with gag or pol (or both) or with env alone. |
| TextSentencer_T5 |
1062-1218 |
Sentence |
denotes |
None of the 1,180 serum samples from healthy seronegative blood donors gave a positive result, and only 49 of these samples (4%) gave indeterminate results. |
| TextSentencer_T6 |
1219-1499 |
Sentence |
denotes |
The recombinant HIV-1 antigen ELISA panel identified seropositive individuals with a high degree of accuracy, as a positive reaction was seen with 99.3% of asymptomatic healthy seropositive individuals, 98.1% of patients with AIDS-related complex, and 90.4% of patients with AIDS. |
| TextSentencer_T7 |
1500-1571 |
Sentence |
denotes |
None of the 725 HIV-1-seropositive subjects had a negative test result. |
| TextSentencer_T8 |
1572-1794 |
Sentence |
denotes |
Reactivity with the Kp41 antigen, corresponding to an amino-terminal portion of the gp41 envelope glycoprotein, by itself demonstrated 100% sensitivity and specificity in distinguishing seronegative from seropositive sera. |
| TextSentencer_T9 |
1795-1943 |
Sentence |
denotes |
A subset of seronegative and seropositive samples were tested both with the recombinant HIV-1 antigen ELISA panel and by Western blot (Du Pont Co.). |
| TextSentencer_T10 |
1944-2143 |
Sentence |
denotes |
The recombinant HIV-1 antigen ELISA panel accurately identified more seropositive and seronegative samples and had fewer indeterminate results than did Western blot (interpreted by Du Pont criteria). |
| T1 |
0-191 |
Sentence |
denotes |
Reliable confirmation of antibodies to human immunodeficiency virus type 1 (HIV-1) with an enzyme-linked immunoassay using recombinant antigens derived from the HIV-1 gag, pol, and env genes. |
| T2 |
192-568 |
Sentence |
denotes |
An enzyme-linked immunoassay (ELISA) using six recombinant proteins corresponding to large segments of the human immunodeficiency virus type 1 (HIV-1) gag, pol, and env gene products (HIVAGEN; SmithKline Bio-Science Laboratories, Van Nuys, Calif.) was developed to confirm the presence of antibodies to HIV-1 in sera reactive in the whole-cell-derived virion screening ELISAs. |
| T3 |
569-794 |
Sentence |
denotes |
Serum samples for testing were obtained from healthy seronegative blood donors and from the different categories of HIV-infected individuals (asymptomatic, acquired immunodeficiency syndrome [AIDS]-related complex, and AIDS). |
| T4 |
795-1061 |
Sentence |
denotes |
A positive reaction was defined as reactivity against an env and at least one other (either gag or pol) HIV-1 gene product; negative was defined as no reaction with any antigen; and indeterminate was defined as reactivity with gag or pol (or both) or with env alone. |
| T5 |
1062-1218 |
Sentence |
denotes |
None of the 1,180 serum samples from healthy seronegative blood donors gave a positive result, and only 49 of these samples (4%) gave indeterminate results. |
| T6 |
1219-1499 |
Sentence |
denotes |
The recombinant HIV-1 antigen ELISA panel identified seropositive individuals with a high degree of accuracy, as a positive reaction was seen with 99.3% of asymptomatic healthy seropositive individuals, 98.1% of patients with AIDS-related complex, and 90.4% of patients with AIDS. |
| T7 |
1500-1571 |
Sentence |
denotes |
None of the 725 HIV-1-seropositive subjects had a negative test result. |
| T8 |
1572-1794 |
Sentence |
denotes |
Reactivity with the Kp41 antigen, corresponding to an amino-terminal portion of the gp41 envelope glycoprotein, by itself demonstrated 100% sensitivity and specificity in distinguishing seronegative from seropositive sera. |
| T9 |
1795-1943 |
Sentence |
denotes |
A subset of seronegative and seropositive samples were tested both with the recombinant HIV-1 antigen ELISA panel and by Western blot (Du Pont Co.). |
| T10 |
1944-2143 |
Sentence |
denotes |
The recombinant HIV-1 antigen ELISA panel accurately identified more seropositive and seronegative samples and had fewer indeterminate results than did Western blot (interpreted by Du Pont criteria). |
