PubMed:27845370
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 86-109 | Disease | denotes | oral submucous fibrosis | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T2 | 111-134 | Disease | denotes | Oral submucous fibrosis | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T3 | 136-139 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T4 | 156-178 | Disease | denotes | precancerous condition | http://purl.obolibrary.org/obo/MONDO_0021074 |
| T5 | 348-351 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T6 | 553-556 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T7 | 594-597 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T8 | 704-707 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T9 | 881-884 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T10 | 1223-1226 | Disease | denotes | SMA | http://purl.obolibrary.org/obo/MONDO_0019079 |
| T11 | 1379-1384 | Disease | denotes | wound | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T12 | 1665-1668 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 477-485 | Body_part | denotes | stemness | http://purl.obolibrary.org/obo/MAT_0000239 |
| T2 | 1200-1213 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-15 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T2 | 447-453 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T3 | 584-590 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T4 | 668-674 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T5 | 794-800 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T6 | 1002-1008 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T7 | 1086-1092 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T8 | 1244-1250 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T9 | 1309-1315 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T10 | 1529-1535 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 9-15 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T2 | 447-453 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T3 | 584-590 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T4 | 668-674 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T5 | 794-800 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T6 | 1002-1008 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T7 | 1086-1092 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T8 | 1244-1250 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T9 | 1309-1315 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T10 | 1529-1535 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 86-109 | Disease | denotes | oral submucous fibrosis | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T2 | 111-134 | Disease | denotes | Oral submucous fibrosis | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T3 | 136-139 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T4 | 156-178 | Disease | denotes | precancerous condition | http://purl.obolibrary.org/obo/MONDO_0021074 |
| T5 | 348-351 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T6 | 553-556 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T7 | 594-597 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T8 | 704-707 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T9 | 881-884 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
| T10 | 1223-1226 | Disease | denotes | SMA | http://purl.obolibrary.org/obo/MONDO_0019079 |
| T11 | 1379-1384 | Disease | denotes | wound | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T12 | 1665-1668 | Disease | denotes | OSF | http://purl.obolibrary.org/obo/MONDO_0018166 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 851-856 | OrganismTaxon | denotes | areca | 115440 |
| T2 | 1031-1036 | OrganismTaxon | denotes | human | 9606 |
| T3 | 1635-1640 | OrganismTaxon | denotes | areca | 115440 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1059-1070 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 279-285 | Body_part | denotes | lamina | http://purl.obolibrary.org/obo/UBERON_0000957|http://purl.obolibrary.org/obo/UBERON_0004529|http://purl.obolibrary.org/obo/UBERON_0022303 |
| T4 | 914-925 | Body_part | denotes | oral mucosa | http://purl.obolibrary.org/obo/UBERON_0003729 |
| T5 | 1059-1070 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T6 | 1200-1213 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/UBERON_0001135 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 477-485 | Body_part | denotes | stemness | http://purl.obolibrary.org/obo/MAT_0000239 |
| T2 | 1200-1213 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-110 | Sentence | denotes | Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis. |
| T2 | 111-318 | Sentence | denotes | Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina properia and epithelial atrophy. |
| T3 | 319-387 | Sentence | denotes | The pathologic mechanisms of OSF still need to be further clarified. |
| T4 | 388-565 | Sentence | denotes | In the study, we investigated the functional expression of SSEA-4, which is a well-known stemness marker, in myofibroblast activity and the clinical significance in OSF tissues. |
| T5 | 566-644 | Sentence | denotes | The expression of SSEA-4 in OSF was evaluated by immunohistochemical staining. |
| T6 | 645-753 | Sentence | denotes | Functional analysis of SSEA-4 on myofibroblast activity of OSF was achieved by lentiviral silencing ST3GAL2. |
| T7 | 754-934 | Sentence | denotes | Immunohisitochemistry demonstrated that SSEA-4 expression was significantly higher expression in areca quid chewing-associated OSF tissues than those of normal oral mucosa tissues. |
| T8 | 935-1078 | Sentence | denotes | From flow cytometry analysis, arecoline dose-dependently activated SSEA-4 expression in primary human normal buccal mucosal fibroblasts (BMFs). |
| T9 | 1079-1267 | Sentence | denotes | Sorted SSEA-4-positive cells from fibrotic BMFs (fBMFs) have higher colony-forming unit, collagen gel contraction, and α-smooth muscle actin (α-SMA) expression than SSEA-4-negative subset. |
| T10 | 1268-1404 | Sentence | denotes | Knockdown of ST3GAL2 in fBMFs suppressed SSEA-4 expression, collagen contraction, migration, invasiveness, and wound healing capability. |
| T11 | 1405-1507 | Sentence | denotes | Consistently, silencing ST3GAL2 was found to repress arecoline-induced myofibroblast activity in BMFs. |
| T12 | 1508-1669 | Sentence | denotes | The study highlights SSEA-4 as a critical marker for therapeutic intervention to mediate myofibroblast transdifferentiation in areca quid chewing-associated OSF. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-15 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T2 | 447-453 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T3 | 584-590 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T4 | 668-674 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T5 | 794-800 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T6 | 1002-1008 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T7 | 1086-1092 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T8 | 1244-1250 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T9 | 1309-1315 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T10 | 1529-1535 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 9-15 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T2 | 447-453 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T3 | 584-590 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T4 | 668-674 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T5 | 794-800 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T6 | 1002-1008 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T7 | 1086-1092 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T8 | 1244-1250 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T9 | 1309-1315 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T10 | 1529-1535 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 851-856 | OrganismTaxon | denotes | areca | 115440 |
| T2 | 1031-1036 | OrganismTaxon | denotes | human | 9606 |
| T3 | 1635-1640 | OrganismTaxon | denotes | areca | 115440 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 279-285 | Body_part | denotes | lamina | http://purl.obolibrary.org/obo/UBERON_0000957|http://purl.obolibrary.org/obo/UBERON_0004529|http://purl.obolibrary.org/obo/UBERON_0022303 |
| T4 | 914-925 | Body_part | denotes | oral mucosa | http://purl.obolibrary.org/obo/UBERON_0003729 |
| T5 | 1059-1070 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T6 | 1200-1213 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/UBERON_0001135 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1059-1070 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |