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PubMed:27794539 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
27794539_0 6-12 ProteinMutation denotes R1441C rs33939927
27794539_1 463-469 ProteinMutation denotes R1441C rs33939927
27794539_2 542-548 ProteinMutation denotes R1441C rs33939927
27794539_3 1290-1296 ProteinMutation denotes R1441C rs33939927
27794539_4 1365-1371 ProteinMutation denotes R1441C rs33939927
27794539_5 1707-1713 ProteinMutation denotes R1441C rs33939927
27794539_6 1814-1820 ProteinMutation denotes R1441C rs33939927

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 D006801 denotes Human
T2 13-18 PR:Q5S006 denotes LRRK2
T3 13-18 PR:000003033 denotes LRRK2
T4 13-18 PR:Q5S007 denotes LRRK2
T5 33-49 GO:0008021 denotes synaptic vesicle
T7 50-58 D020543 denotes proteome
T8 84-94 2294143 denotes Drosophila
T9 84-94 504603 denotes Drosophila
T10 84-94 2294139 denotes Drosophila
T11 84-94 2294145 denotes Drosophila
T12 84-94 2294141 denotes Drosophila
T13 84-94 2294142 denotes Drosophila
T14 84-94 2294144 denotes Drosophila
T15 84-94 2294140 denotes Drosophila
T16 84-94 D004330 denotes Drosophila
T17 84-94 2080301 denotes Drosophila
T22 104-123 D010300 denotes Parkinson's disease
T23 104-123 D010300 denotes Parkinson's disease
T27 138-145 6308 denotes leucine
T28 138-145 SO:0001437 denotes leucine
T26 138-145 CHEBI:15603 denotes leucine
T29 138-145 D007930 denotes leucine
T30 138-145 CHEBI:25017 denotes leucine
T31 138-145 D007930 denotes leucine
T32 151-157 SO:0001068 denotes repeat
T33 168-173 PR:Q5S006 denotes LRRK2
T34 168-173 PR:000003033 denotes LRRK2
T35 168-173 PR:Q5S007 denotes LRRK2
T36 181-191 D000067562 denotes late-onset
T37 181-191 D000067562 denotes late-onset
T38 193-211 C566739 denotes autosomal dominant
T43 221-240 D010300 denotes Parkinson`s disease
T44 221-240 D010300 denotes Parkinson`s disease
T47 267-272 PR:Q5S006 denotes LRRK2
T48 267-272 PR:000003033 denotes LRRK2
T49 267-272 PR:Q5S007 denotes LRRK2
T50 322-327 PR:Q5S006 denotes LRRK2
T51 322-327 PR:000003033 denotes LRRK2
T52 322-327 PR:Q5S007 denotes LRRK2
T56 346-353 PR:000000001 denotes protein
T57 346-353 SO:0000104 denotes protein
T53 346-353 GO:0003675 denotes protein
T58 346-360 D011494 denotes protein kinase
T59 393-408 GO:0016301 denotes kinase activity
T60 470-478 SO:0000109 denotes mutation
T61 486-492 D020558 denotes GTPase
T62 493-499 SO:0000417 denotes domain
T63 503-508 PR:Q5S006 denotes LRRK2
T64 503-508 PR:000003033 denotes LRRK2
T65 503-508 PR:Q5S007 denotes LRRK2
T66 523-528 D006801 denotes human
T67 529-538 SO:0000817 denotes wild-type
T68 549-554 PR:Q5S006 denotes LRRK2
T69 549-554 PR:000003033 denotes LRRK2
T70 549-554 PR:Q5S007 denotes LRRK2
T71 582-592 2294143 denotes Drosophila
T72 582-592 504603 denotes Drosophila
T73 582-592 2294139 denotes Drosophila
T74 582-592 2294145 denotes Drosophila
T75 582-592 2294141 denotes Drosophila
T76 582-592 2294142 denotes Drosophila
T77 582-592 2294144 denotes Drosophila
T78 582-592 2294140 denotes Drosophila
T79 582-592 D004330 denotes Drosophila
T80 582-592 2080301 denotes Drosophila
T81 774-779 PR:Q5S006 denotes LRRK2
T82 774-779 PR:000003033 denotes LRRK2
T83 774-779 PR:Q5S007 denotes LRRK2
T84 850-858 CHEBI:36080 denotes proteins
T85 870-875 UBERON:6110636 denotes brain
T86 870-875 UBERON:0000955 denotes brain
T87 954-970 GO:0008021 denotes synaptic vesicle
T89 971-979 CHEBI:36080 denotes proteins
T91 996-1011 P47191 denotes synaptotagmin-1
T92 996-1011 P46096 denotes synaptotagmin-1
T94 996-1011 P21707 denotes synaptotagmin-1
T95 996-1011 P48018 denotes synaptotagmin-1
T96 996-1011 P34693 denotes synaptotagmin-1
T97 996-1011 P21521 denotes synaptotagmin-1
T98 996-1011 P41823 denotes synaptotagmin-1
T99 996-1011 Q60HC0 denotes synaptotagmin-1
T100 996-1011 Q9SKR2 denotes synaptotagmin-1
T101 996-1011 PR:000015894 denotes synaptotagmin-1
T102 996-1011 Q5R4J5 denotes synaptotagmin-1
T103 996-1011 P21579 denotes synaptotagmin-1
T104 996-1011 A0A075F932 denotes synaptotagmin-1
T93 996-1011 D050863 denotes synaptotagmin-1
T108 1013-1024 PR:000015792 denotes syntaxin-1A
T109 1013-1024 A8WVD0 denotes syntaxin-1A
T110 1013-1024 O35526 denotes syntaxin-1A
T111 1013-1024 Q24547 denotes syntaxin-1A
T113 1013-1024 Q16623 denotes syntaxin-1A
T114 1013-1024 Q5R4L2 denotes syntaxin-1A
T115 1013-1024 P32850 denotes syntaxin-1A
T116 1013-1024 P32851 denotes syntaxin-1A
T112 1013-1024 D050827 denotes syntaxin-1A
T120 1029-1033 PR:P25228 denotes Rab3
T121 1029-1033 PR:Q94986 denotes Rab3
T122 1038-1047 UBERON:0000955 denotes the brain
T125 1056-1061 PR:Q5S006 denotes LRRK2
T126 1056-1061 PR:000003033 denotes LRRK2
T127 1056-1061 PR:Q5S007 denotes LRRK2
T128 1141-1156 GO:0016310 denotes phosphorylation
T129 1171-1179 CHEBI:36080 denotes proteins
T132 1191-1205 Q62910 denotes synaptojanin-1
T133 1191-1205 PR:000015882 denotes synaptojanin-1
T134 1191-1205 O18964 denotes synaptojanin-1
T135 1191-1205 Q8CHC4 denotes synaptojanin-1
T137 1191-1205 O43426 denotes synaptojanin-1
T136 1191-1205 C097702 denotes synaptojanin-1
T138 1207-1211 PR:P25961 denotes pThr
T139 1207-1211 PR:Q03431 denotes pThr
T140 1207-1211 PR:P41593 denotes pThr
T141 1207-1211 PR:000013430 denotes pThr
T142 1207-1211 UBERON:0034747 denotes pThr
T143 1225-1236 GO:0005874 denotes microtubule
T145 1225-1262 Q9W596 denotes microtubule-associated protein futsch
T150 1248-1255 SO:0000104 denotes protein
T147 1248-1255 CHEBI:36080 denotes protein
T148 1248-1255 CHEBI:11122 denotes protein
T146 1248-1255 GO:0003675 denotes protein
T152 1277-1286 UBERON:0000955 denotes the brain
T155 1297-1303 PR:Q5S007 denotes hLRRK2
T156 1304-1309 D004175 denotes flies
T157 1322-1337 GO:0016310 denotes phosphorylation
T158 1341-1346 D006801 denotes human
T161 1347-1361 Q62910 denotes synaptojanin-1
T162 1347-1361 PR:000015882 denotes synaptojanin-1
T163 1347-1361 O18964 denotes synaptojanin-1
T164 1347-1361 Q8CHC4 denotes synaptojanin-1
T166 1347-1361 O43426 denotes synaptojanin-1
T165 1347-1361 C097702 denotes synaptojanin-1
T167 1372-1378 PR:Q5S007 denotes hLRRK2
T168 1433-1442 P03632 denotes A protein
T169 1433-1442 P09676 denotes A protein
T170 1433-1442 P25243 denotes A protein
T171 1433-1442 P25244 denotes A protein
T172 1433-1442 O64306 denotes A protein
T173 1433-1442 P07394 denotes A protein
T174 1433-1442 P07928 denotes A protein
T175 1433-1442 P35823 denotes A protein
T176 1433-1442 P03610 denotes A protein
T177 1433-1442 P15966 denotes A protein
T178 1433-1442 P98005 denotes A protein
T180 1435-1442 CHEBI:36080 denotes protein
T181 1435-1442 CHEBI:11122 denotes protein
T179 1435-1442 GO:0003675 denotes protein
T184 1435-1462 SO:0001093 denotes protein-protein interaction
T188 1443-1450 PR:000000001 denotes protein
T186 1443-1450 CHEBI:36080 denotes protein
T187 1443-1450 CHEBI:11122 denotes protein
T185 1443-1450 GO:0003675 denotes protein
T190 1481-1486 UBERON:6110636 denotes brain
T191 1481-1486 UBERON:0000955 denotes brain
T192 1501-1506 PR:Q5S006 denotes LRRK2
T193 1501-1506 PR:000003033 denotes LRRK2
T194 1501-1506 PR:Q5S007 denotes LRRK2
T195 1543-1551 CHEBI:36080 denotes proteins
T198 1563-1577 Q62910 denotes synaptojanin-1
T199 1563-1577 PR:000015882 denotes synaptojanin-1
T200 1563-1577 O18964 denotes synaptojanin-1
T201 1563-1577 Q8CHC4 denotes synaptojanin-1
T203 1563-1577 O43426 denotes synaptojanin-1
T202 1563-1577 C097702 denotes synaptojanin-1
T204 1656-1666 2294143 denotes Drosophila
T205 1656-1666 504603 denotes Drosophila
T206 1656-1666 2294139 denotes Drosophila
T207 1656-1666 2294145 denotes Drosophila
T208 1656-1666 2294141 denotes Drosophila
T209 1656-1666 2294142 denotes Drosophila
T210 1656-1666 2294144 denotes Drosophila
T211 1656-1666 2294140 denotes Drosophila
T212 1656-1666 D004330 denotes Drosophila
T213 1656-1666 2080301 denotes Drosophila
T214 1667-1672 UBERON:6110636 denotes brain
T215 1667-1672 UBERON:0000955 denotes brain
T216 1714-1720 PR:Q5S007 denotes hLRRK2
T217 1821-1829 SO:0000109 denotes mutation
T218 1849-1854 PR:Q5S006 denotes LRRK2
T219 1849-1854 PR:000003033 denotes LRRK2
T220 1849-1854 PR:Q5S007 denotes LRRK2
T221 1855-1861 D020558 denotes GTPase
T222 1862-1868 SO:0000417 denotes domain
T223 1890-1905 GO:0016310 denotes phosphorylation
T224 1912-1920 CHEBI:36080 denotes proteins
T225 1924-1933 UBERON:0000955 denotes the brain

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 125-321 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Parkinson`s disease (PD) and variation at the LRRK2 locus contributes to the risk for idiopathic PD.
T2 322-409 DRI_Background denotes LRRK2 can function as a protein kinase and mutations lead to increased kinase activity.
T3 410-541 DRI_Challenge denotes To elucidate the pathophysiological mechanism of the R1441C mutation in the GTPase domain of LRRK2, we expressed human wild-type or
T4 555-746 DRI_Challenge denotes in dopaminergic neurons of Drosophila and observe reduced locomotor activity, impaired survival and an age-dependent degeneration of dopaminergic neurons thereby creating a new PD-like model.
T5 747-876 DRI_Approach denotes To explore the function of LRRK2 variants in vivo, we performed mass spectrometry and quantified 3,616 proteins in the fly brain.
T6 877-1072 DRI_Outcome denotes We identify several differentially-expressed cytoskeletal, mitochondrial and synaptic vesicle proteins (SV), including synaptotagmin-1, syntaxin-1A and Rab3, in the brain of this LRRK2 fly model.
T7 1073-1289 DRI_Outcome denotes In addition, a global phosphoproteome analysis reveals the enhanced phosphorylation of several SV proteins, including synaptojanin-1 (pThr1131) and the microtubule-associated protein futsch (pSer4106) in the brain of
T8 1304-1310 DRI_Outcome denotes flies.
T9 1311-1364 DRI_Background denotes The direct phosphorylation of human synaptojanin-1 by
T10 1379-1432 DRI_Background denotes could further be confirmed by in vitro kinase assays.
T11 1433-1594 DRI_Outcome denotes A protein-protein interaction screen in the fly brain confirms that LRRK2 robustly interacts with numerous SV proteins, including synaptojanin-1 and EndophilinA.
T12 1595-1706 DRI_Outcome denotes Our proteomic, phosphoproteomic and interactome study in the Drosophila brain provides a systematic analyses of
T13 1745-1770 DRI_Outcome denotes mechanisms in this model.
T14 1771-1934 DRI_Outcome denotes We demonstrate for the first time that the R1441C mutation located within the LRRK2 GTPase domain induces the enhanced phosphorylation of SV proteins in the brain.