PubMed:27729412 / 1322-1830 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/27729412","sourcedb":"PubMed","sourceid":"27729412","text":"We conclude that reduced adiponectin expression under high-fat dietary conditions is dependent on 1) increased ALDH1A1 expression in adipocytes, which does not increase all-trans-retinoic acid levels; 2) further RAR ligand-induced, WAT-selective, increased retinoic acid response element-mediated signaling; and 3) RAR ligand-dependent reduction of adiponectin expression.-Landrier, J.-F., Kasiri, E., Karkeni, E., Mihály, J., Béke, G., Weiss, K., Lucas, R., Aydemir, G., Salles, J., Walrand, S., de Lera, A.","tracks":[{"project":"LitCoin-entities","denotations":[{"id":"11633","span":{"begin":25,"end":36},"obj":"GeneOrGeneProduct"},{"id":"11634","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"11635","span":{"begin":179,"end":192},"obj":"ChemicalEntity"},{"id":"11636","span":{"begin":212,"end":215},"obj":"GeneOrGeneProduct"},{"id":"11637","span":{"begin":257,"end":270},"obj":"ChemicalEntity"},{"id":"11638","span":{"begin":315,"end":318},"obj":"GeneOrGeneProduct"},{"id":"11639","span":{"begin":349,"end":360},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A35","pred":"db_id","subj":"11633","obj":"NCBIGene:11450"},{"id":"A36","pred":"db_id","subj":"11634","obj":"NCBIGene:11668"},{"id":"A37","pred":"db_id","subj":"11635","obj":"MESH:D014212"},{"id":"A38","pred":"db_id","subj":"11636","obj":"NCBIGene:19401"},{"id":"A39","pred":"db_id","subj":"11636","obj":"NCBIGene:19411"},{"id":"A40","pred":"db_id","subj":"11636","obj":"NCBIGene:20181"},{"id":"A41","pred":"db_id","subj":"11637","obj":"MESH:D014212"},{"id":"A42","pred":"db_id","subj":"11638","obj":"NCBIGene:19401"},{"id":"A43","pred":"db_id","subj":"11638","obj":"NCBIGene:19411"},{"id":"A44","pred":"db_id","subj":"11638","obj":"NCBIGene:20181"},{"id":"A45","pred":"db_id","subj":"11639","obj":"NCBIGene:11450"},{"subj":"11633","pred":"source","obj":"LitCoin-entities"},{"subj":"11634","pred":"source","obj":"LitCoin-entities"},{"subj":"11635","pred":"source","obj":"LitCoin-entities"},{"subj":"11636","pred":"source","obj":"LitCoin-entities"},{"subj":"11637","pred":"source","obj":"LitCoin-entities"},{"subj":"11638","pred":"source","obj":"LitCoin-entities"},{"subj":"11639","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":508},"obj":"Sentence"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T53","span":{"begin":17,"end":24},"obj":"GeneOrGeneProduct"},{"id":"T54","span":{"begin":25,"end":36},"obj":"GeneOrGeneProduct"},{"id":"T55","span":{"begin":54,"end":58},"obj":"GeneOrGeneProduct"},{"id":"T56","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T57","span":{"begin":169,"end":178},"obj":"GeneOrGeneProduct"},{"id":"T58","span":{"begin":188,"end":192},"obj":"GeneOrGeneProduct"},{"id":"T59","span":{"begin":212,"end":215},"obj":"GeneOrGeneProduct"},{"id":"T60","span":{"begin":223,"end":230},"obj":"GeneOrGeneProduct"},{"id":"T61","span":{"begin":266,"end":270},"obj":"GeneOrGeneProduct"},{"id":"T62","span":{"begin":288,"end":296},"obj":"GeneOrGeneProduct"},{"id":"T63","span":{"begin":308,"end":313},"obj":"GeneOrGeneProduct"},{"id":"T64","span":{"begin":315,"end":318},"obj":"GeneOrGeneProduct"},{"id":"T65","span":{"begin":349,"end":360},"obj":"GeneOrGeneProduct"},{"id":"T66","span":{"begin":448,"end":453},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T53","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T54","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T55","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T56","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T57","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T58","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T59","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T60","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T61","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T62","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T63","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T64","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T65","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T66","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T36","span":{"begin":17,"end":24},"obj":"GeneOrGeneProduct"},{"id":"T37","span":{"begin":25,"end":36},"obj":"GeneOrGeneProduct"},{"id":"T38","span":{"begin":54,"end":58},"obj":"GeneOrGeneProduct"},{"id":"T39","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T40","span":{"begin":169,"end":178},"obj":"GeneOrGeneProduct"},{"id":"T41","span":{"begin":188,"end":192},"obj":"GeneOrGeneProduct"},{"id":"T42","span":{"begin":266,"end":270},"obj":"GeneOrGeneProduct"},{"id":"T43","span":{"begin":349,"end":360},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T36","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T37","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T38","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T39","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T40","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T41","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T42","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T43","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T15","span":{"begin":25,"end":36},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":169,"end":178},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":257,"end":279},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":349,"end":360},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T7","span":{"begin":232,"end":235},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0004255"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T21","span":{"begin":25,"end":36},"obj":"ChemicalEntity"},{"id":"T22","span":{"begin":59,"end":70},"obj":"ChemicalEntity"},{"id":"T23","span":{"begin":169,"end":192},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":257,"end":270},"obj":"ChemicalEntity"},{"id":"T26","span":{"begin":349,"end":360},"obj":"ChemicalEntity"}],"attributes":[{"id":"A21","pred":"ID:","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_81572"},{"id":"A22","pred":"ID:","subj":"T22","obj":"D004041"},{"id":"A23","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_15367"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D014212"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_26536"},{"id":"A26","pred":"ID:","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_81572"},{"subj":"T21","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T26","span":{"begin":349,"end":360},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":257,"end":270},"obj":"ChemicalEntity"},{"id":"T23","span":{"begin":169,"end":192},"obj":"ChemicalEntity"},{"id":"T22","span":{"begin":59,"end":70},"obj":"ChemicalEntity"},{"id":"T21","span":{"begin":25,"end":36},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":349,"end":360},"obj":"GeneOrGeneProduct"},{"id":"T80019","span":{"begin":257,"end":279},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":169,"end":178},"obj":"GeneOrGeneProduct"},{"id":"T12417","span":{"begin":111,"end":118},"obj":"GeneOrGeneProduct"},{"id":"T3544","span":{"begin":25,"end":36},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A26","pred":"ID:","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_81572"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_26536"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D014212"},{"id":"A23","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_15367"},{"id":"A22","pred":"ID:","subj":"T22","obj":"D004041"},{"id":"A21","pred":"ID:","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_81572"},{"subj":"T26","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T24","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T23","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T22","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T21","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T19","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T80019","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T17","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12417","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3544","pred":"source","obj":"LitCoin-training-merged"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-entities","color":"#9393ec","default":true},{"id":"LitCoin-sentences","color":"#acec93"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ec93c7"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#93e1ec"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#ecdd93"},{"id":"LitCoin_Mondo_095","color":"#c393ec"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#93eca9"},{"id":"LitCoin-training-merged","color":"#ec9396"}]}]}}