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PubMed:27371349 / 0-1365 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells.
T2 127-209 Sentence denotes Protein degradation by the proteasome generates functional intracellular peptides.
T3 210-350 Sentence denotes Pep5, a peptide derived from Cyclin D2, induces cell death in tumor cell lines and reduces the volume of rat C6 glioblastoma tumors in vivo.
T4 351-501 Sentence denotes Here, we chose the human MDA-MB-231 breast cancer cells to evaluate the mechanism of cell death induced by pep5 in different phases of the cell cycle.
T5 502-669 Sentence denotes Fluorescently labeled pep5, monitored by real time confocal microscopy, entered the MDA-MB-231 cells 3min after application and localized to the nucleus and cytoplasm.
T6 670-825 Sentence denotes Pep5-induced cell death was increased when the MDA-MB-231 cell population was arrested at the G1/S transition or in S phase compared to asynchronous cells.
T7 826-964 Sentence denotes Pep5 induced permanent extracellular signal-regulated kinase (ERK1/2) phosphorylation in MDA-MB-231 cells synchronized in G1/S or S phase.
T8 965-1154 Sentence denotes Affinity chromatography followed by mass spectrometry identified CLIC1 and Plectin as the only two proteins that interacted with pep5 in both asynchronous and synchronized MDA-MB-231 cells.
T9 1155-1357 Sentence denotes These interactions could explain the long-lasting ERK1/2 phosphorylation and the cytoskeleton perturbations in the MDA-MB-231 cells, in which the stress fibers' integrity is affected by pep5 treatments.
T1 0-126 Sentence denotes A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells.
T2 127-209 Sentence denotes Protein degradation by the proteasome generates functional intracellular peptides.
T3 210-350 Sentence denotes Pep5, a peptide derived from Cyclin D2, induces cell death in tumor cell lines and reduces the volume of rat C6 glioblastoma tumors in vivo.
T4 351-501 Sentence denotes Here, we chose the human MDA-MB-231 breast cancer cells to evaluate the mechanism of cell death induced by pep5 in different phases of the cell cycle.
T5 502-669 Sentence denotes Fluorescently labeled pep5, monitored by real time confocal microscopy, entered the MDA-MB-231 cells 3min after application and localized to the nucleus and cytoplasm.
T6 670-825 Sentence denotes Pep5-induced cell death was increased when the MDA-MB-231 cell population was arrested at the G1/S transition or in S phase compared to asynchronous cells.
T7 826-964 Sentence denotes Pep5 induced permanent extracellular signal-regulated kinase (ERK1/2) phosphorylation in MDA-MB-231 cells synchronized in G1/S or S phase.
T8 965-1154 Sentence denotes Affinity chromatography followed by mass spectrometry identified CLIC1 and Plectin as the only two proteins that interacted with pep5 in both asynchronous and synchronized MDA-MB-231 cells.
T9 1155-1357 Sentence denotes These interactions could explain the long-lasting ERK1/2 phosphorylation and the cytoskeleton perturbations in the MDA-MB-231 cells, in which the stress fibers' integrity is affected by pep5 treatments.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 106-119 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 272-277 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 322-334 Disease denotes glioblastoma http://purl.obolibrary.org/obo/MONDO_0018177|http://purl.obolibrary.org/obo/MONDO_0020690
T5 335-341 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T6 387-400 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 315-318 OrganismTaxon denotes rat 10114|10116
T3 370-375 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 45-55 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T2 106-112 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 186-199 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T4 387-393 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 490-500 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T6 647-654 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T8 659-668 Body_part denotes cytoplasm http://purl.obolibrary.org/obo/GO_0005737
T9 849-862 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T10 1236-1248 Body_part denotes cytoskeleton http://purl.obolibrary.org/obo/GO_0005856

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 106-119 Phenotype denotes breast cancer HP:0003002
T2 272-277 Phenotype denotes tumor HP:0002664
T3 322-334 Phenotype denotes glioblastoma HP:0012174
T4 387-400 Phenotype denotes breast cancer HP:0003002

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 113-125 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 272-282 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T3 394-406 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064