> top > docs > PubMed:27149136 > annotations

PubMed:27149136 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-27 Sentence denotes Paraneoplastic Scleroderma:
TextSentencer_T2 28-48 Sentence denotes Are There Any Clues?
TextSentencer_T3 49-152 Sentence denotes Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported.
TextSentencer_T4 153-234 Sentence denotes We describe 4 patients with paraneoplastic scleroderma who were treated at the I.
TextSentencer_T5 235-328 Sentence denotes Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014.
TextSentencer_T6 329-473 Sentence denotes The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland.
TextSentencer_T7 474-736 Sentence denotes In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy.
TextSentencer_T8 737-950 Sentence denotes Sclerotization of the skin was described in association with lung cancer, carcinoid, plasma cell dyscrasia, cancer of the ovary, cervix, breast, esophagus, stomach, nasopharynx, melanoma, and sarcoma (1,2,5,7,10).
TextSentencer_T9 951-1043 Sentence denotes Symptoms may be induced by substances secreted by the tumor (hormones, cytokines, etc.) (9).
TextSentencer_T10 1044-1110 Sentence denotes Tumorous cells further induce cytotoxic and autoantibody response.
TextSentencer_T11 1111-1259 Sentence denotes Scleroderma is characterized by immunological dysregulation, vasculopathy, and hyperproduction of the extracellular matrix by activated fibroblasts.
TextSentencer_T12 1260-1547 Sentence denotes Endothelial, inflammatory, and mesenchymal cells produce cytokines, chemokines, and growth factors e.g. Interleukin-1 (IL1), Interleukin-6 (IL6), tumor necrosis factor alpha (TNF α), collagen alpha 1, connective tissue growth factor (CTGF) (3), and basic fibroblast growth factor (bFGF).
TextSentencer_T13 1548-1602 Sentence denotes This factor is also produced by lung cancer cells (4).
TextSentencer_T14 1603-1681 Sentence denotes The clinical picture of scleroderma and paraneoplastic scleroderma is similar.
TextSentencer_T15 1682-1756 Sentence denotes Diffuse thickening of the skin and/or sclerodermatous plaques can be seen.
TextSentencer_T16 1757-1813 Sentence denotes The histological picture is consistent with scleroderma.
TextSentencer_T17 1814-1961 Sentence denotes Capillaroscopy changes, antinuclear antibodies (ANA), sclerodactyly, and Raynaud phenomenon suggest the diagnosis of systemic scleroderma (SS) (4).
TextSentencer_T18 1962-2021 Sentence denotes Our patients did not fulfill enough of the criteria for SS.
TextSentencer_T19 2022-2134 Sentence denotes Both diffuse and localized scleroderma was seen in 3 patients and generalized localized scleroderma in one case.
TextSentencer_T20 2135-2256 Sentence denotes All patients had a histological picture consistent with scleroderma, negative ANA and ENA antibodies (Table 1, Figure 1).
TextSentencer_T21 2257-2391 Sentence denotes A 66-year-old woman presented with a 10 months history of sclerodermatous plaques on her neck, trunk, and upper and lower extremities.
TextSentencer_T22 2392-2451 Sentence denotes The skin on her breasts and cheeks was diffusely indurated.
TextSentencer_T23 2452-2731 Sentence denotes Examination showed thrombocytopenia, elevated transaminases, Cancer antigen 19-9 (Ca 19-9), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibodies, dysmotility of the lower part of esophagus, hepatosplenomegaly, cholecystolithiasis, and benign polyps of colon.
TextSentencer_T24 2732-2800 Sentence denotes She was given prednisone 40 mg/day but did not return for follow up.
TextSentencer_T25 2801-2916 Sentence denotes After 6 months she was diagnosed with cholangiogenic carcinoma with metastatic disease and died shortly afterwards.
TextSentencer_T26 2917-2992 Sentence denotes A 74-year-old woman had localized scleroderma on the trunk for three years.
TextSentencer_T27 2993-3090 Sentence denotes She was treated with procaine penicillin for positive borrelia Immunoglobulin M (IgM) antibodies.
TextSentencer_T28 3091-3288 Sentence denotes Her condition worsened suddenly with confluent scleroderma plaques on her trunk, extremities, and genital region, and vasoneurosis on her lower extremities; she was started on prednisone 35 mg/day.
TextSentencer_T29 3289-3329 Sentence denotes Examination revealed endometrial cancer.
TextSentencer_T30 3330-3419 Sentence denotes The patient underwent a hysterectomy, adnexectomy, and radiotherapy with curative effect.
TextSentencer_T31 3420-3525 Sentence denotes Scleroderma patches softened with residual hyperpigmentation, and prednisone was stopped two years later.
TextSentencer_T32 3526-3697 Sentence denotes A 80-year-old man had a month-long history of diffuse thickening and toughening of the skin on the forearms and lower legs and scleroderma patches on the thighs and shins.
TextSentencer_T33 3698-3824 Sentence denotes Examination revealed prostate adenocarcinoma, and therapy with antiandrogen bicalutamide and prednisone 15 mg/day was started.
TextSentencer_T34 3825-3978 Sentence denotes Two years after the diagnosis he continues with bicalutamide treatment, prednisone 5 mg q.a.d. and has residual toughening of the skin on his lower legs.
TextSentencer_T35 3979-4125 Sentence denotes A 62-year-old woman with seronegative rheumatoid arthritis presented with diffusely tough skin on her extremities and trunk, present for 2 months.
TextSentencer_T36 4126-4291 Sentence denotes Examination revealed cervicitis with a benign endometric polyp, cholecystolithiasis, borderline pulmonary hypertension, and a hormonally inactive suprarenal adenoma.
TextSentencer_T37 4292-4357 Sentence denotes She was given prednisone 40 mg/day and penicillamine with effect.
TextSentencer_T38 4358-4477 Sentence denotes In the 3rd year of therapy she has residual induration of her lower legs and a scleroderma plaque in the lumbar region.
TextSentencer_T39 4478-4522 Sentence denotes She is monitored for her suprarenal adenoma.
TextSentencer_T40 4523-4742 Sentence denotes Two patients had scleroderma at the same time as a malignant tumor; in one patient the localized scleroderma worsened rapidly at the time of the tumor diagnosis, and in one patient a clinically silent adenoma was found.
TextSentencer_T41 4743-4837 Sentence denotes Adrenal tissue can secrete molecules such as serotonine or bFGF involved in fibroplasia (3,6).
TextSentencer_T42 4838-5042 Sentence denotes One patient died of a metastatic disease, two patients after the successful treatment of the tumor, and the patient with suprarenal adenoma experienced softening of the skin and regression of scleroderma.
TextSentencer_T43 5043-5192 Sentence denotes Although paraneoplastic scleroderma is often classified as a pseudoscleroderma, we regard neoplasia as a distinct triggering impulse for scleroderma.
TextSentencer_T44 5193-5311 Sentence denotes Recently, an association between RNA polymerase I/III antibodies in systemic scleroderma and cancer was suggested (8).
TextSentencer_T45 5312-5386 Sentence denotes Such studies may confirm the true link between scleroderma and malignancy.
TextSentencer_T46 5387-5544 Sentence denotes These patients are characterized by older age, sudden onset, diffuse thickening of the skin, and/or generalized morphea with a concurrent neoplastic process.
TextSentencer_T47 5545-5611 Sentence denotes In the case of a successful tumor treatment, skin changes regress.
T1 0-27 Sentence denotes Paraneoplastic Scleroderma:
T2 28-48 Sentence denotes Are There Any Clues?
T3 49-152 Sentence denotes Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported.
T4 153-234 Sentence denotes We describe 4 patients with paraneoplastic scleroderma who were treated at the I.
T5 235-328 Sentence denotes Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014.
T6 329-473 Sentence denotes The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland.
T7 474-736 Sentence denotes In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy.
T8 737-950 Sentence denotes Sclerotization of the skin was described in association with lung cancer, carcinoid, plasma cell dyscrasia, cancer of the ovary, cervix, breast, esophagus, stomach, nasopharynx, melanoma, and sarcoma (1,2,5,7,10).
T9 951-1043 Sentence denotes Symptoms may be induced by substances secreted by the tumor (hormones, cytokines, etc.) (9).
T10 1044-1110 Sentence denotes Tumorous cells further induce cytotoxic and autoantibody response.
T11 1111-1259 Sentence denotes Scleroderma is characterized by immunological dysregulation, vasculopathy, and hyperproduction of the extracellular matrix by activated fibroblasts.
T12 1260-1547 Sentence denotes Endothelial, inflammatory, and mesenchymal cells produce cytokines, chemokines, and growth factors e.g. Interleukin-1 (IL1), Interleukin-6 (IL6), tumor necrosis factor alpha (TNF α), collagen alpha 1, connective tissue growth factor (CTGF) (3), and basic fibroblast growth factor (bFGF).
T13 1548-1602 Sentence denotes This factor is also produced by lung cancer cells (4).
T14 1603-1681 Sentence denotes The clinical picture of scleroderma and paraneoplastic scleroderma is similar.
T15 1682-1756 Sentence denotes Diffuse thickening of the skin and/or sclerodermatous plaques can be seen.
T16 1757-1813 Sentence denotes The histological picture is consistent with scleroderma.
T17 1814-1961 Sentence denotes Capillaroscopy changes, antinuclear antibodies (ANA), sclerodactyly, and Raynaud phenomenon suggest the diagnosis of systemic scleroderma (SS) (4).
T18 1962-2021 Sentence denotes Our patients did not fulfill enough of the criteria for SS.
T19 2022-2134 Sentence denotes Both diffuse and localized scleroderma was seen in 3 patients and generalized localized scleroderma in one case.
T20 2135-2256 Sentence denotes All patients had a histological picture consistent with scleroderma, negative ANA and ENA antibodies (Table 1, Figure 1).
T21 2257-2391 Sentence denotes A 66-year-old woman presented with a 10 months history of sclerodermatous plaques on her neck, trunk, and upper and lower extremities.
T22 2392-2451 Sentence denotes The skin on her breasts and cheeks was diffusely indurated.
T23 2452-2731 Sentence denotes Examination showed thrombocytopenia, elevated transaminases, Cancer antigen 19-9 (Ca 19-9), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibodies, dysmotility of the lower part of esophagus, hepatosplenomegaly, cholecystolithiasis, and benign polyps of colon.
T24 2732-2800 Sentence denotes She was given prednisone 40 mg/day but did not return for follow up.
T25 2801-2916 Sentence denotes After 6 months she was diagnosed with cholangiogenic carcinoma with metastatic disease and died shortly afterwards.
T26 2917-2992 Sentence denotes A 74-year-old woman had localized scleroderma on the trunk for three years.
T27 2993-3090 Sentence denotes She was treated with procaine penicillin for positive borrelia Immunoglobulin M (IgM) antibodies.
T28 3091-3288 Sentence denotes Her condition worsened suddenly with confluent scleroderma plaques on her trunk, extremities, and genital region, and vasoneurosis on her lower extremities; she was started on prednisone 35 mg/day.
T29 3289-3329 Sentence denotes Examination revealed endometrial cancer.
T30 3330-3419 Sentence denotes The patient underwent a hysterectomy, adnexectomy, and radiotherapy with curative effect.
T31 3420-3525 Sentence denotes Scleroderma patches softened with residual hyperpigmentation, and prednisone was stopped two years later.
T32 3526-3697 Sentence denotes A 80-year-old man had a month-long history of diffuse thickening and toughening of the skin on the forearms and lower legs and scleroderma patches on the thighs and shins.
T33 3698-3824 Sentence denotes Examination revealed prostate adenocarcinoma, and therapy with antiandrogen bicalutamide and prednisone 15 mg/day was started.
T34 3825-3978 Sentence denotes Two years after the diagnosis he continues with bicalutamide treatment, prednisone 5 mg q.a.d. and has residual toughening of the skin on his lower legs.
T35 3979-4125 Sentence denotes A 62-year-old woman with seronegative rheumatoid arthritis presented with diffusely tough skin on her extremities and trunk, present for 2 months.
T36 4126-4291 Sentence denotes Examination revealed cervicitis with a benign endometric polyp, cholecystolithiasis, borderline pulmonary hypertension, and a hormonally inactive suprarenal adenoma.
T37 4292-4357 Sentence denotes She was given prednisone 40 mg/day and penicillamine with effect.
T38 4358-4477 Sentence denotes In the 3rd year of therapy she has residual induration of her lower legs and a scleroderma plaque in the lumbar region.
T39 4478-4522 Sentence denotes She is monitored for her suprarenal adenoma.
T40 4523-4742 Sentence denotes Two patients had scleroderma at the same time as a malignant tumor; in one patient the localized scleroderma worsened rapidly at the time of the tumor diagnosis, and in one patient a clinically silent adenoma was found.
T41 4743-4837 Sentence denotes Adrenal tissue can secrete molecules such as serotonine or bFGF involved in fibroplasia (3,6).
T42 4838-5042 Sentence denotes One patient died of a metastatic disease, two patients after the successful treatment of the tumor, and the patient with suprarenal adenoma experienced softening of the skin and regression of scleroderma.
T43 5043-5192 Sentence denotes Although paraneoplastic scleroderma is often classified as a pseudoscleroderma, we regard neoplasia as a distinct triggering impulse for scleroderma.
T44 5193-5311 Sentence denotes Recently, an association between RNA polymerase I/III antibodies in systemic scleroderma and cancer was suggested (8).
T45 5312-5386 Sentence denotes Such studies may confirm the true link between scleroderma and malignancy.
T46 5387-5544 Sentence denotes These patients are characterized by older age, sudden onset, diffuse thickening of the skin, and/or generalized morphea with a concurrent neoplastic process.
T47 5545-5611 Sentence denotes In the case of a successful tumor treatment, skin changes regress.

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-27 Sentence denotes Paraneoplastic Scleroderma:
T2 28-48 Sentence denotes Are There Any Clues?
T3 49-152 Sentence denotes Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported.
T4 153-234 Sentence denotes We describe 4 patients with paraneoplastic scleroderma who were treated at the I.
T5 235-328 Sentence denotes Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014.
T6 329-473 Sentence denotes The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland.
T7 474-736 Sentence denotes In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy.
T8 737-950 Sentence denotes Sclerotization of the skin was described in association with lung cancer, carcinoid, plasma cell dyscrasia, cancer of the ovary, cervix, breast, esophagus, stomach, nasopharynx, melanoma, and sarcoma (1,2,5,7,10).
T9 951-1043 Sentence denotes Symptoms may be induced by substances secreted by the tumor (hormones, cytokines, etc.) (9).
T10 1044-1110 Sentence denotes Tumorous cells further induce cytotoxic and autoantibody response.
T11 1111-1259 Sentence denotes Scleroderma is characterized by immunological dysregulation, vasculopathy, and hyperproduction of the extracellular matrix by activated fibroblasts.
T12 1260-1547 Sentence denotes Endothelial, inflammatory, and mesenchymal cells produce cytokines, chemokines, and growth factors e.g. Interleukin-1 (IL1), Interleukin-6 (IL6), tumor necrosis factor alpha (TNF α), collagen alpha 1, connective tissue growth factor (CTGF) (3), and basic fibroblast growth factor (bFGF).
T13 1548-1602 Sentence denotes This factor is also produced by lung cancer cells (4).
T14 1603-1681 Sentence denotes The clinical picture of scleroderma and paraneoplastic scleroderma is similar.
T15 1682-1756 Sentence denotes Diffuse thickening of the skin and/or sclerodermatous plaques can be seen.
T16 1757-1813 Sentence denotes The histological picture is consistent with scleroderma.
T17 1814-1961 Sentence denotes Capillaroscopy changes, antinuclear antibodies (ANA), sclerodactyly, and Raynaud phenomenon suggest the diagnosis of systemic scleroderma (SS) (4).
T18 1962-2021 Sentence denotes Our patients did not fulfill enough of the criteria for SS.
T19 2022-2134 Sentence denotes Both diffuse and localized scleroderma was seen in 3 patients and generalized localized scleroderma in one case.
T20 2135-2256 Sentence denotes All patients had a histological picture consistent with scleroderma, negative ANA and ENA antibodies (Table 1, Figure 1).
T21 2257-2391 Sentence denotes A 66-year-old woman presented with a 10 months history of sclerodermatous plaques on her neck, trunk, and upper and lower extremities.
T22 2392-2451 Sentence denotes The skin on her breasts and cheeks was diffusely indurated.
T23 2452-2731 Sentence denotes Examination showed thrombocytopenia, elevated transaminases, Cancer antigen 19-9 (Ca 19-9), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibodies, dysmotility of the lower part of esophagus, hepatosplenomegaly, cholecystolithiasis, and benign polyps of colon.
T24 2732-2800 Sentence denotes She was given prednisone 40 mg/day but did not return for follow up.
T25 2801-2916 Sentence denotes After 6 months she was diagnosed with cholangiogenic carcinoma with metastatic disease and died shortly afterwards.
T26 2917-2992 Sentence denotes A 74-year-old woman had localized scleroderma on the trunk for three years.
T27 2993-3090 Sentence denotes She was treated with procaine penicillin for positive borrelia Immunoglobulin M (IgM) antibodies.
T28 3091-3288 Sentence denotes Her condition worsened suddenly with confluent scleroderma plaques on her trunk, extremities, and genital region, and vasoneurosis on her lower extremities; she was started on prednisone 35 mg/day.
T29 3289-3329 Sentence denotes Examination revealed endometrial cancer.
T30 3330-3419 Sentence denotes The patient underwent a hysterectomy, adnexectomy, and radiotherapy with curative effect.
T31 3420-3525 Sentence denotes Scleroderma patches softened with residual hyperpigmentation, and prednisone was stopped two years later.
T32 3526-3697 Sentence denotes A 80-year-old man had a month-long history of diffuse thickening and toughening of the skin on the forearms and lower legs and scleroderma patches on the thighs and shins.
T33 3698-3824 Sentence denotes Examination revealed prostate adenocarcinoma, and therapy with antiandrogen bicalutamide and prednisone 15 mg/day was started.
T34 3825-3978 Sentence denotes Two years after the diagnosis he continues with bicalutamide treatment, prednisone 5 mg q.a.d. and has residual toughening of the skin on his lower legs.
T35 3979-4125 Sentence denotes A 62-year-old woman with seronegative rheumatoid arthritis presented with diffusely tough skin on her extremities and trunk, present for 2 months.
T36 4126-4291 Sentence denotes Examination revealed cervicitis with a benign endometric polyp, cholecystolithiasis, borderline pulmonary hypertension, and a hormonally inactive suprarenal adenoma.
T37 4292-4357 Sentence denotes She was given prednisone 40 mg/day and penicillamine with effect.
T38 4358-4477 Sentence denotes In the 3rd year of therapy she has residual induration of her lower legs and a scleroderma plaque in the lumbar region.
T39 4478-4522 Sentence denotes She is monitored for her suprarenal adenoma.
T40 4523-4742 Sentence denotes Two patients had scleroderma at the same time as a malignant tumor; in one patient the localized scleroderma worsened rapidly at the time of the tumor diagnosis, and in one patient a clinically silent adenoma was found.
T41 4743-4837 Sentence denotes Adrenal tissue can secrete molecules such as serotonine or bFGF involved in fibroplasia (3,6).
T42 4838-5042 Sentence denotes One patient died of a metastatic disease, two patients after the successful treatment of the tumor, and the patient with suprarenal adenoma experienced softening of the skin and regression of scleroderma.
T43 5043-5192 Sentence denotes Although paraneoplastic scleroderma is often classified as a pseudoscleroderma, we regard neoplasia as a distinct triggering impulse for scleroderma.
T44 5193-5311 Sentence denotes Recently, an association between RNA polymerase I/III antibodies in systemic scleroderma and cancer was suggested (8).
T45 5312-5386 Sentence denotes Such studies may confirm the true link between scleroderma and malignancy.
T46 5387-5544 Sentence denotes These patients are characterized by older age, sudden onset, diffuse thickening of the skin, and/or generalized morphea with a concurrent neoplastic process.
T47 5545-5611 Sentence denotes In the case of a successful tumor treatment, skin changes regress.
T1 0-27 Sentence denotes Paraneoplastic Scleroderma:
T2 28-48 Sentence denotes Are There Any Clues?
T3 49-152 Sentence denotes Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported.
T4 153-234 Sentence denotes We describe 4 patients with paraneoplastic scleroderma who were treated at the I.
T5 235-328 Sentence denotes Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014.
T6 329-473 Sentence denotes The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland.
T7 474-736 Sentence denotes In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy.
T8 737-950 Sentence denotes Sclerotization of the skin was described in association with lung cancer, carcinoid, plasma cell dyscrasia, cancer of the ovary, cervix, breast, esophagus, stomach, nasopharynx, melanoma, and sarcoma (1,2,5,7,10).
T9 951-1043 Sentence denotes Symptoms may be induced by substances secreted by the tumor (hormones, cytokines, etc.) (9).
T10 1044-1110 Sentence denotes Tumorous cells further induce cytotoxic and autoantibody response.
T11 1111-1259 Sentence denotes Scleroderma is characterized by immunological dysregulation, vasculopathy, and hyperproduction of the extracellular matrix by activated fibroblasts.
T12 1260-1547 Sentence denotes Endothelial, inflammatory, and mesenchymal cells produce cytokines, chemokines, and growth factors e.g. Interleukin-1 (IL1), Interleukin-6 (IL6), tumor necrosis factor alpha (TNF α), collagen alpha 1, connective tissue growth factor (CTGF) (3), and basic fibroblast growth factor (bFGF).
T13 1548-1602 Sentence denotes This factor is also produced by lung cancer cells (4).
T14 1603-1681 Sentence denotes The clinical picture of scleroderma and paraneoplastic scleroderma is similar.
T15 1682-1756 Sentence denotes Diffuse thickening of the skin and/or sclerodermatous plaques can be seen.
T16 1757-1813 Sentence denotes The histological picture is consistent with scleroderma.
T17 1814-1961 Sentence denotes Capillaroscopy changes, antinuclear antibodies (ANA), sclerodactyly, and Raynaud phenomenon suggest the diagnosis of systemic scleroderma (SS) (4).
T18 1962-2021 Sentence denotes Our patients did not fulfill enough of the criteria for SS.
T19 2022-2134 Sentence denotes Both diffuse and localized scleroderma was seen in 3 patients and generalized localized scleroderma in one case.
T20 2135-2256 Sentence denotes All patients had a histological picture consistent with scleroderma, negative ANA and ENA antibodies (Table 1, Figure 1).
T21 2257-2391 Sentence denotes A 66-year-old woman presented with a 10 months history of sclerodermatous plaques on her neck, trunk, and upper and lower extremities.
T22 2392-2451 Sentence denotes The skin on her breasts and cheeks was diffusely indurated.
T23 2452-2731 Sentence denotes Examination showed thrombocytopenia, elevated transaminases, Cancer antigen 19-9 (Ca 19-9), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibodies, dysmotility of the lower part of esophagus, hepatosplenomegaly, cholecystolithiasis, and benign polyps of colon.
T24 2732-2800 Sentence denotes She was given prednisone 40 mg/day but did not return for follow up.
T25 2801-2916 Sentence denotes After 6 months she was diagnosed with cholangiogenic carcinoma with metastatic disease and died shortly afterwards.
T26 2917-2992 Sentence denotes A 74-year-old woman had localized scleroderma on the trunk for three years.
T27 2993-3090 Sentence denotes She was treated with procaine penicillin for positive borrelia Immunoglobulin M (IgM) antibodies.
T28 3091-3288 Sentence denotes Her condition worsened suddenly with confluent scleroderma plaques on her trunk, extremities, and genital region, and vasoneurosis on her lower extremities; she was started on prednisone 35 mg/day.
T29 3289-3329 Sentence denotes Examination revealed endometrial cancer.
T30 3330-3419 Sentence denotes The patient underwent a hysterectomy, adnexectomy, and radiotherapy with curative effect.
T31 3420-3525 Sentence denotes Scleroderma patches softened with residual hyperpigmentation, and prednisone was stopped two years later.
T32 3526-3697 Sentence denotes A 80-year-old man had a month-long history of diffuse thickening and toughening of the skin on the forearms and lower legs and scleroderma patches on the thighs and shins.
T33 3698-3824 Sentence denotes Examination revealed prostate adenocarcinoma, and therapy with antiandrogen bicalutamide and prednisone 15 mg/day was started.
T34 3825-3978 Sentence denotes Two years after the diagnosis he continues with bicalutamide treatment, prednisone 5 mg q.a.d. and has residual toughening of the skin on his lower legs.
T35 3979-4125 Sentence denotes A 62-year-old woman with seronegative rheumatoid arthritis presented with diffusely tough skin on her extremities and trunk, present for 2 months.
T36 4126-4291 Sentence denotes Examination revealed cervicitis with a benign endometric polyp, cholecystolithiasis, borderline pulmonary hypertension, and a hormonally inactive suprarenal adenoma.
T37 4292-4357 Sentence denotes She was given prednisone 40 mg/day and penicillamine with effect.
T38 4358-4477 Sentence denotes In the 3rd year of therapy she has residual induration of her lower legs and a scleroderma plaque in the lumbar region.
T39 4478-4522 Sentence denotes She is monitored for her suprarenal adenoma.
T40 4523-4742 Sentence denotes Two patients had scleroderma at the same time as a malignant tumor; in one patient the localized scleroderma worsened rapidly at the time of the tumor diagnosis, and in one patient a clinically silent adenoma was found.
T41 4743-4837 Sentence denotes Adrenal tissue can secrete molecules such as serotonine or bFGF involved in fibroplasia (3,6).
T42 4838-5042 Sentence denotes One patient died of a metastatic disease, two patients after the successful treatment of the tumor, and the patient with suprarenal adenoma experienced softening of the skin and regression of scleroderma.
T43 5043-5192 Sentence denotes Although paraneoplastic scleroderma is often classified as a pseudoscleroderma, we regard neoplasia as a distinct triggering impulse for scleroderma.
T44 5193-5311 Sentence denotes Recently, an association between RNA polymerase I/III antibodies in systemic scleroderma and cancer was suggested (8).
T45 5312-5386 Sentence denotes Such studies may confirm the true link between scleroderma and malignancy.
T46 5387-5544 Sentence denotes These patients are characterized by older age, sudden onset, diffuse thickening of the skin, and/or generalized morphea with a concurrent neoplastic process.
T47 5545-5611 Sentence denotes In the case of a successful tumor treatment, skin changes regress.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 467-472 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland
PD-UBERON-AE-B_T2 798-802 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 1580-1584 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T4 874-880 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 2408-2415 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breasts
PD-UBERON-AE-B_T6 882-891 http://purl.obolibrary.org/obo/UBERON_0001043 denotes esophagus
PD-UBERON-AE-B_T7 2652-2661 http://purl.obolibrary.org/obo/UBERON_0001043 denotes esophagus
PD-UBERON-AE-B_T8 893-900 http://purl.obolibrary.org/obo/UBERON_0000945 denotes stomach
PD-UBERON-AE-B_T9 902-913 http://purl.obolibrary.org/obo/UBERON_0001728 denotes nasopharynx
PD-UBERON-AE-B_T10 1291-1302 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T11 1461-1478 http://purl.obolibrary.org/obo/UBERON_0002384 denotes connective tissue
PD-UBERON-AE-B_T12 1472-1478 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T13 4751-4757 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T14 2346-2350 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T15 2352-2357 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T16 2970-2975 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T17 3165-3170 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T18 4097-4102 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T19 2420-2426 http://purl.obolibrary.org/obo/UBERON_0001567 denotes cheeks
PD-UBERON-AE-B_T20 2725-2730 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T21 3644-3648 http://purl.obolibrary.org/obo/UBERON_0000978 denotes legs
PD-UBERON-AE-B_T22 3973-3977 http://purl.obolibrary.org/obo/UBERON_0000978 denotes legs
PD-UBERON-AE-B_T23 4426-4430 http://purl.obolibrary.org/obo/UBERON_0000978 denotes legs

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 62-73 HP:0100324 denotes Scleroderma
TI1 15-26 HP:0100324 denotes Scleroderma
AB2 196-207 HP:0100324 denotes scleroderma
AB3 377-386 HP:0030731 denotes carcinoma
AB4 388-409 HP:0012114 denotes endometrial carcinoma
AB5 500-511 HP:0100324 denotes scleroderma
AB6 596-607 HP:0100324 denotes scleroderma
AB7 666-677 HP:0100324 denotes scleroderma
AB8 915-923 HP:0002861 denotes melanoma
AB9 929-936 HP:0100242 denotes sarcoma
AB10 1111-1122 HP:0100324 denotes Scleroderma
AB11 1627-1638 HP:0100324 denotes scleroderma
AB12 1658-1669 HP:0100324 denotes scleroderma
AB13 1801-1812 HP:0100324 denotes scleroderma
AB14 1868-1881 HP:0011838 denotes sclerodactyly
AB15 1887-1905 HP:0030880 denotes Raynaud phenomenon
AB16 1940-1951 HP:0100324 denotes scleroderma
AB17 2049-2060 HP:0100324 denotes scleroderma
AB18 2110-2121 HP:0100324 denotes scleroderma
AB19 2191-2202 HP:0100324 denotes scleroderma
AB20 2471-2487 HP:0001873 denotes thrombocytopenia
AB21 2663-2681 HP:0001433 denotes hepatosplenomegaly
AB22 2854-2863 HP:0030731 denotes carcinoma
AB23 2951-2962 HP:0100324 denotes scleroderma
AB24 3138-3149 HP:0100324 denotes scleroderma
AB25 3420-3431 HP:0100324 denotes Scleroderma
AB26 3653-3664 HP:0100324 denotes scleroderma
AB27 4017-4037 HP:0001370 denotes rheumatoid arthritis
AB28 4147-4157 HP:0030160 denotes cervicitis
AB29 4232-4244 HP:0000822 denotes hypertension
AB30 4437-4448 HP:0100324 denotes scleroderma
AB31 4540-4551 HP:0100324 denotes scleroderma
AB32 4620-4631 HP:0100324 denotes scleroderma
AB33 5030-5041 HP:0100324 denotes scleroderma
AB34 5067-5078 HP:0100324 denotes scleroderma
AB35 5180-5191 HP:0100324 denotes scleroderma
AB36 5270-5281 HP:0100324 denotes scleroderma
AB37 5359-5370 HP:0100324 denotes scleroderma
AB38 5499-5506 HP:0012344 denotes morphea

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 1931-1951 ORDO:90291 denotes systemic scleroderma
AB2 2039-2060 ORDO:90289 denotes localized scleroderma
AB3 2100-2121 ORDO:90289 denotes localized scleroderma
AB4 2941-2962 ORDO:90289 denotes localized scleroderma
AB5 4610-4631 ORDO:90289 denotes localized scleroderma
AB6 5261-5281 ORDO:90291 denotes systemic scleroderma

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 798-802 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 1580-1584 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 893-900 http://purl.obolibrary.org/obo/UBERON_0000945 denotes stomach
PD-UBERON-AE-B_T4 1291-1302 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T5 874-880 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 2408-2415 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breasts
PD-UBERON-AE-B_T7 1472-1478 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T8 4751-4757 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T9 3644-3648 http://purl.obolibrary.org/obo/UBERON_0000978 denotes legs
PD-UBERON-AE-B_T10 3973-3977 http://purl.obolibrary.org/obo/UBERON_0000978 denotes legs
PD-UBERON-AE-B_T11 4426-4430 http://purl.obolibrary.org/obo/UBERON_0000978 denotes legs
PD-UBERON-AE-B_T12 2346-2350 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T13 467-472 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland
PD-UBERON-AE-B_T14 882-891 http://purl.obolibrary.org/obo/UBERON_0001043 denotes esophagus
PD-UBERON-AE-B_T15 2652-2661 http://purl.obolibrary.org/obo/UBERON_0001043 denotes esophagus
PD-UBERON-AE-B_T16 902-913 http://purl.obolibrary.org/obo/UBERON_0001728 denotes nasopharynx
PD-UBERON-AE-B_T17 1461-1478 http://purl.obolibrary.org/obo/UBERON_0002384 denotes connective tissue
PD-UBERON-AE-B_T18 2352-2357 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T19 2970-2975 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T20 3165-3170 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T21 4097-4102 http://purl.obolibrary.org/obo/UBERON_0002100 denotes trunk
PD-UBERON-AE-B_T22 2420-2426 http://purl.obolibrary.org/obo/UBERON_0001567 denotes cheeks
PD-UBERON-AE-B_T23 2725-2730 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T24 4743-4757 http://purl.obolibrary.org/obo/UBERON_0018303 denotes Adrenal tissue