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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11027 0-10 GeneOrGeneProduct denotes Transgelin NCBIGene:6876
11028 45-62 DiseaseOrPhenotypicFeature denotes colorectal cancer MESH:D015179
11029 147-157 GeneOrGeneProduct denotes Transgelin NCBIGene:6876
11030 164-185 GeneOrGeneProduct denotes actin-binding protein NCBIGene:21345|NCBIGene:6876
11031 247-257 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11032 261-267 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
11033 364-369 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
11034 456-466 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11035 533-543 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11036 554-571 DiseaseOrPhenotypicFeature denotes colorectal cancer MESH:D015179
11037 573-576 DiseaseOrPhenotypicFeature denotes CRC MESH:D015179
11038 650-653 DiseaseOrPhenotypicFeature denotes CRC MESH:D015179
11039 680-690 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11040 776-781 OrganismTaxon denotes mouse NCBITaxon:10090
11041 848-858 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11042 977-987 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11043 991-994 CellLine denotes RKO NCBITaxon:9606
11044 1180-1195 DiseaseOrPhenotypicFeature denotes lung metastases MESH:D008175
11045 1203-1208 OrganismTaxon denotes mouse NCBITaxon:10090
11046 1262-1272 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11047 1287-1293 CellLine denotes HCT116 NCBITaxon:9606
11048 1346-1356 DiseaseOrPhenotypicFeature denotes metastases MESH:D009362
11049 1430-1440 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11050 1573-1578 GeneOrGeneProduct denotes actin NCBIGene:60
11051 1588-1609 GeneOrGeneProduct denotes cytoskeletal proteins NCBIGene:51361|NCBIGene:55740|NCBIGene:6876|NCBIGene:7145
11052 1641-1646 GeneOrGeneProduct denotes HOOK1 NCBIGene:51361
11053 1648-1655 GeneOrGeneProduct denotes SDCCAG8 NCBIGene:10806
11054 1657-1661 GeneOrGeneProduct denotes ENAH NCBIGene:55740
11055 1662-1666 GeneOrGeneProduct denotes Mena NCBIGene:55740
11056 1672-1676 GeneOrGeneProduct denotes TNS1 NCBIGene:7145
11057 1694-1697 GeneOrGeneProduct denotes EMB NCBIGene:133418
11058 1699-1705 GeneOrGeneProduct denotes BCL11B NCBIGene:64919
11059 1711-1716 GeneOrGeneProduct denotes PTPRD NCBIGene:5789
11060 1757-1767 GeneOrGeneProduct denotes transgelin NCBIGene:6876
11061 1802-1807 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-134 Sentence denotes Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.
T2 135-146 Sentence denotes BACKGROUND:
T3 147-225 Sentence denotes Transgelin is an actin-binding protein that promotes motility in normal cells.
T4 226-415 Sentence denotes Although the role of transgelin in cancer is controversial, a number of studies have shown that elevated levels correlate with aggressive tumor behavior, advanced stage, and poor prognosis.
T5 416-631 Sentence denotes Here we sought to determine the role of transgelin more directly by determining whether experimental manipulation of transgelin levels in colorectal cancer (CRC) cells led to changes in metastatic potential in vivo.
T6 632-640 Sentence denotes METHODS:
T7 641-825 Sentence denotes Isogenic CRC cell lines that differ in transgelin expression were characterized using in vitro assays of growth and invasiveness and a mouse tail vein assay of experimental metastasis.
T8 826-942 Sentence denotes Downstream effects of transgelin overexpression were investigated by gene expression profiling and quantitative PCR.
T9 943-951 Sentence denotes RESULTS:
T10 952-1114 Sentence denotes Stable overexpression of transgelin in RKO cells, which have low endogenous levels, led to increased invasiveness, growth at low density, and growth in soft agar.
T11 1115-1235 Sentence denotes Overexpression also led to an increase in the number and size of lung metastases in the mouse tail vein injection model.
T12 1236-1375 Sentence denotes Similarly, attenuation of transgelin expression in HCT116 cells, which have high endogenous levels, decreased metastases in the same model.
T13 1376-1610 Sentence denotes Investigation of mRNA expression patterns showed that transgelin overexpression altered the levels of approximately 250 other transcripts, with over-representation of genes that affect function of actin or other cytoskeletal proteins.
T14 1611-1717 Sentence denotes Changes included increases in HOOK1, SDCCAG8, ENAH/Mena, and TNS1 and decreases in EMB, BCL11B, and PTPRD.
T15 1718-1730 Sentence denotes CONCLUSIONS:
T16 1731-1867 Sentence denotes Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis.
T17 1868-1960 Sentence denotes Chronic overexpression influences steady-state levels of mRNAs for metastasis-related genes.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 776-781 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T3 1203-1208 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 45-62 DiseaseOrPhenotypicFeature denotes colorectal cancer 0005575
T2 56-62 DiseaseOrPhenotypicFeature denotes cancer 0004992
T3 261-267 DiseaseOrPhenotypicFeature denotes cancer 0004992
T4 554-571 DiseaseOrPhenotypicFeature denotes colorectal cancer 0005575
T5 565-571 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-10 GeneOrGeneProduct denotes Transgelin
T2 63-68 GeneOrGeneProduct denotes cells
T3 120-124 GeneOrGeneProduct denotes cell
T4 147-157 GeneOrGeneProduct denotes Transgelin
T5 164-185 GeneOrGeneProduct denotes actin-binding protein
T6 219-224 GeneOrGeneProduct denotes cells
T7 247-257 GeneOrGeneProduct denotes transgelin
T8 364-369 GeneOrGeneProduct denotes tumor
T9 370-378 GeneOrGeneProduct denotes behavior
T10 434-443 GeneOrGeneProduct denotes determine
T11 456-466 GeneOrGeneProduct denotes transgelin
T12 484-495 GeneOrGeneProduct denotes determining
T13 533-543 GeneOrGeneProduct denotes transgelin
T14 573-576 GeneOrGeneProduct denotes CRC
T15 578-583 GeneOrGeneProduct denotes cells
T16 632-639 GeneOrGeneProduct denotes METHODS
T17 650-653 GeneOrGeneProduct denotes CRC
T18 654-658 GeneOrGeneProduct denotes cell
T19 659-664 GeneOrGeneProduct denotes lines
T20 680-690 GeneOrGeneProduct denotes transgelin
T21 746-752 GeneOrGeneProduct denotes growth
T22 782-786 GeneOrGeneProduct denotes tail
T23 787-791 GeneOrGeneProduct denotes vein
T24 848-858 GeneOrGeneProduct denotes transgelin
T25 977-987 GeneOrGeneProduct denotes transgelin
T26 995-1000 GeneOrGeneProduct denotes cells
T27 1067-1073 GeneOrGeneProduct denotes growth
T28 1094-1100 GeneOrGeneProduct denotes growth
T29 1104-1108 GeneOrGeneProduct denotes soft
T30 1109-1113 GeneOrGeneProduct denotes agar
T31 1172-1176 GeneOrGeneProduct denotes size
T32 1180-1184 GeneOrGeneProduct denotes lung
T33 1209-1213 GeneOrGeneProduct denotes tail
T34 1214-1218 GeneOrGeneProduct denotes vein
T35 1236-1245 GeneOrGeneProduct denotes Similarly
T36 1247-1258 GeneOrGeneProduct denotes attenuation
T37 1262-1272 GeneOrGeneProduct denotes transgelin
T38 1294-1299 GeneOrGeneProduct denotes cells
T39 1312-1316 GeneOrGeneProduct denotes high
T40 1393-1397 GeneOrGeneProduct denotes mRNA
T41 1430-1440 GeneOrGeneProduct denotes transgelin
T42 1478-1491 GeneOrGeneProduct denotes approximately
T43 1496-1501 GeneOrGeneProduct denotes other
T44 1502-1513 GeneOrGeneProduct denotes transcripts
T45 1573-1578 GeneOrGeneProduct denotes actin
T46 1582-1587 GeneOrGeneProduct denotes other
T47 1588-1609 GeneOrGeneProduct denotes cytoskeletal proteins
T48 1641-1646 GeneOrGeneProduct denotes HOOK1
T49 1648-1655 GeneOrGeneProduct denotes SDCCAG8
T50 1657-1661 GeneOrGeneProduct denotes ENAH
T51 1662-1666 GeneOrGeneProduct denotes Mena
T52 1672-1676 GeneOrGeneProduct denotes TNS1
T53 1694-1697 GeneOrGeneProduct denotes EMB
T54 1699-1705 GeneOrGeneProduct denotes BCL11B
T55 1711-1716 GeneOrGeneProduct denotes PTPRD
T56 1757-1767 GeneOrGeneProduct denotes transgelin
T57 1802-1807 GeneOrGeneProduct denotes tumor
T58 1808-1812 GeneOrGeneProduct denotes cell
T59 1813-1821 GeneOrGeneProduct denotes behavior

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-10 GeneOrGeneProduct denotes Transgelin
T2 120-124 GeneOrGeneProduct denotes cell
T3 147-157 GeneOrGeneProduct denotes Transgelin
T4 164-185 GeneOrGeneProduct denotes actin-binding protein
T5 247-257 GeneOrGeneProduct denotes transgelin
T6 370-378 GeneOrGeneProduct denotes behavior
T7 456-466 GeneOrGeneProduct denotes transgelin
T8 533-543 GeneOrGeneProduct denotes transgelin
T9 654-658 GeneOrGeneProduct denotes cell
T10 659-664 GeneOrGeneProduct denotes lines
T11 680-690 GeneOrGeneProduct denotes transgelin
T12 746-752 GeneOrGeneProduct denotes growth
T13 782-786 GeneOrGeneProduct denotes tail
T14 787-791 GeneOrGeneProduct denotes vein
T15 848-858 GeneOrGeneProduct denotes transgelin
T16 977-987 GeneOrGeneProduct denotes transgelin
T17 1067-1073 GeneOrGeneProduct denotes growth
T18 1094-1100 GeneOrGeneProduct denotes growth
T19 1104-1108 GeneOrGeneProduct denotes soft
T20 1209-1213 GeneOrGeneProduct denotes tail
T21 1214-1218 GeneOrGeneProduct denotes vein
T22 1262-1272 GeneOrGeneProduct denotes transgelin
T23 1312-1316 GeneOrGeneProduct denotes high
T24 1393-1397 GeneOrGeneProduct denotes mRNA
T25 1430-1440 GeneOrGeneProduct denotes transgelin
T26 1496-1501 GeneOrGeneProduct denotes other
T27 1573-1578 GeneOrGeneProduct denotes actin
T28 1582-1587 GeneOrGeneProduct denotes other
T29 1588-1609 GeneOrGeneProduct denotes cytoskeletal proteins
T30 1641-1646 GeneOrGeneProduct denotes HOOK1
T31 1648-1655 GeneOrGeneProduct denotes SDCCAG8
T32 1657-1661 GeneOrGeneProduct denotes ENAH
T33 1662-1666 GeneOrGeneProduct denotes Mena
T34 1672-1676 GeneOrGeneProduct denotes TNS1
T35 1699-1705 GeneOrGeneProduct denotes BCL11B
T36 1711-1716 GeneOrGeneProduct denotes PTPRD
T37 1757-1767 GeneOrGeneProduct denotes transgelin
T38 1808-1812 GeneOrGeneProduct denotes cell
T39 1813-1821 GeneOrGeneProduct denotes behavior

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 776-781 OrganismTaxon denotes mouse
T2 1203-1208 OrganismTaxon denotes mouse

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 45-62 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T2 261-267 DiseaseOrPhenotypicFeature denotes cancer D009369
T3 364-369 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 554-571 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T5 573-576 DiseaseOrPhenotypicFeature denotes CRC D015179
T6 650-653 DiseaseOrPhenotypicFeature denotes CRC D015179
T7 814-824 DiseaseOrPhenotypicFeature denotes metastasis D009362
T8 1185-1195 DiseaseOrPhenotypicFeature denotes metastases D009362
T9 1346-1356 DiseaseOrPhenotypicFeature denotes metastases D009362
T10 1802-1807 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 1856-1866 DiseaseOrPhenotypicFeature denotes metastasis D009362
T12 1935-1945 DiseaseOrPhenotypicFeature denotes metastasis D009362

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-10 GeneOrGeneProduct denotes Transgelin
T2 147-157 GeneOrGeneProduct denotes Transgelin
T3 164-185 GeneOrGeneProduct denotes actin-binding protein
T4 247-257 GeneOrGeneProduct denotes transgelin
T5 456-466 GeneOrGeneProduct denotes transgelin
T6 533-543 GeneOrGeneProduct denotes transgelin
T7 680-690 GeneOrGeneProduct denotes transgelin
T8 848-858 GeneOrGeneProduct denotes transgelin
T9 977-987 GeneOrGeneProduct denotes transgelin
T10 1262-1272 GeneOrGeneProduct denotes transgelin
T11 1430-1440 GeneOrGeneProduct denotes transgelin
T12 1573-1578 GeneOrGeneProduct denotes actin
T13 1588-1609 GeneOrGeneProduct denotes cytoskeletal proteins
T14 1641-1646 GeneOrGeneProduct denotes HOOK1
T15 1648-1655 GeneOrGeneProduct denotes SDCCAG8
T16 1657-1661 GeneOrGeneProduct denotes ENAH
T17 1662-1666 GeneOrGeneProduct denotes Mena
T18 1672-1676 GeneOrGeneProduct denotes TNS1
T19 1699-1705 GeneOrGeneProduct denotes BCL11B
T20 1711-1716 GeneOrGeneProduct denotes PTPRD
T21 1757-1767 GeneOrGeneProduct denotes transgelin

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 45-62 DiseaseOrPhenotypicFeature denotes colorectal cancer 0024331|0005575
T3 364-369 DiseaseOrPhenotypicFeature denotes tumor 0005070
T4 554-571 DiseaseOrPhenotypicFeature denotes colorectal cancer 0024331|0005575
T6 573-576 DiseaseOrPhenotypicFeature denotes CRC 0024331|0005575
T8 650-653 DiseaseOrPhenotypicFeature denotes CRC 0024331|0005575
T10 1104-1108 DiseaseOrPhenotypicFeature denotes soft 0013894
T11 1180-1184 DiseaseOrPhenotypicFeature denotes lung 0021117
T12 1802-1807 DiseaseOrPhenotypicFeature denotes tumor 0005070

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 45-62 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T2 261-267 DiseaseOrPhenotypicFeature denotes cancer D009369
T3 364-369 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 554-571 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T5 573-576 DiseaseOrPhenotypicFeature denotes CRC DISEASE|D015179
T7 650-653 DiseaseOrPhenotypicFeature denotes CRC DISEASE|D015179
T9 814-824 DiseaseOrPhenotypicFeature denotes metastasis D009362
T10 1185-1195 DiseaseOrPhenotypicFeature denotes metastases D009362
T11 1346-1356 DiseaseOrPhenotypicFeature denotes metastases D009362
T12 1802-1807 DiseaseOrPhenotypicFeature denotes tumor D009369
T13 1856-1866 DiseaseOrPhenotypicFeature denotes metastasis D009362
T14 1935-1945 DiseaseOrPhenotypicFeature denotes metastasis D009362

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 991-994 CellLine denotes RKO CVCL_0504
T2 1287-1293 CellLine denotes HCT116 CVCL_0291

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 45-62 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T2 261-267 DiseaseOrPhenotypicFeature denotes cancer D009369
T3 364-369 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 554-571 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T5 573-576 DiseaseOrPhenotypicFeature denotes CRC DISEASE|D015179
T7 650-653 DiseaseOrPhenotypicFeature denotes CRC DISEASE|D015179
T9 1185-1195 DiseaseOrPhenotypicFeature denotes metastases D009362
T10 1346-1356 DiseaseOrPhenotypicFeature denotes metastases D009362
T11 1802-1807 DiseaseOrPhenotypicFeature denotes tumor D009369

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 1109-1113 ChemicalEntity denotes agar D000362|http://purl.obolibrary.org/obo/CHEBI_2509
T3 1694-1697 ChemicalEntity denotes EMB http://purl.obolibrary.org/obo/CHEBI_4877

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T2 1287-1293 CellLine denotes HCT116 CVCL_0291
T1 991-994 CellLine denotes RKO CVCL_0504
T3 1694-1697 ChemicalEntity denotes EMB http://purl.obolibrary.org/obo/CHEBI_4877
T83924 1109-1113 ChemicalEntity denotes agar D000362|http://purl.obolibrary.org/obo/CHEBI_2509
T21 1757-1767 GeneOrGeneProduct denotes transgelin
T20 1711-1716 GeneOrGeneProduct denotes PTPRD
T19 1699-1705 GeneOrGeneProduct denotes BCL11B
T18 1672-1676 GeneOrGeneProduct denotes TNS1
T17 1662-1666 GeneOrGeneProduct denotes Mena
T16 1657-1661 GeneOrGeneProduct denotes ENAH
T15 1648-1655 GeneOrGeneProduct denotes SDCCAG8
T14 1641-1646 GeneOrGeneProduct denotes HOOK1
T13 1588-1609 GeneOrGeneProduct denotes cytoskeletal proteins
T12 1573-1578 GeneOrGeneProduct denotes actin
T11 1430-1440 GeneOrGeneProduct denotes transgelin
T10 1262-1272 GeneOrGeneProduct denotes transgelin
T9 977-987 GeneOrGeneProduct denotes transgelin
T8 848-858 GeneOrGeneProduct denotes transgelin
T7 680-690 GeneOrGeneProduct denotes transgelin
T6 533-543 GeneOrGeneProduct denotes transgelin
T5 456-466 GeneOrGeneProduct denotes transgelin
T4 247-257 GeneOrGeneProduct denotes transgelin
T85099 164-185 GeneOrGeneProduct denotes actin-binding protein
T40233 147-157 GeneOrGeneProduct denotes Transgelin
T7432 0-10 GeneOrGeneProduct denotes Transgelin
T22124 1802-1807 DiseaseOrPhenotypicFeature denotes tumor D009369
T35580 1346-1356 DiseaseOrPhenotypicFeature denotes metastases D009362
T89019 1185-1195 DiseaseOrPhenotypicFeature denotes metastases D009362
T10693 650-653 DiseaseOrPhenotypicFeature denotes CRC D015179|DISEASE
T31075 573-576 DiseaseOrPhenotypicFeature denotes CRC D015179|DISEASE
T99040 554-571 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T72603 364-369 DiseaseOrPhenotypicFeature denotes tumor D009369
T89036 261-267 DiseaseOrPhenotypicFeature denotes cancer D009369
T20198 45-62 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T52620 1203-1208 OrganismTaxon denotes mouse
T22853 776-781 OrganismTaxon denotes mouse

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26847345-0#0#10#gene6876 147-157 gene6876 denotes Transgelin
26847345-0#45#62#diseaseC0009402 554-571 diseaseC0009402 denotes colorectal cancer
26847345-0#45#62#diseaseC1527249 554-571 diseaseC1527249 denotes colorectal cancer
26847345-11#26#36#gene6876 1757-1767 gene6876 denotes transgelin
26847345-11#125#135#diseaseC0027627 1856-1866 diseaseC0027627 denotes metastasis
0#10#gene687645#62#diseaseC0009402 26847345-0#0#10#gene6876 26847345-0#45#62#diseaseC0009402 associated_with Transgelin,colorectal cancer
0#10#gene687645#62#diseaseC1527249 26847345-0#0#10#gene6876 26847345-0#45#62#diseaseC1527249 associated_with Transgelin,colorectal cancer
26#36#gene6876125#135#diseaseC0027627 26847345-11#26#36#gene6876 26847345-11#125#135#diseaseC0027627 associated_with transgelin,metastasis