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PubMed:26808467 JSONTXT

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test-210614

Id Subject Object Predicate Lexical cue proteinmutation
26808467_0 6-12 ProteinMutation denotes G2019S rs34637584
26808467_1 334-349 ProteinMutation denotes Gly 2019 to Ser rs34637584
26808467_2 1289-1295 ProteinMutation denotes G2019S rs34637584
26808467_3 1084-1090 ProteinMutation denotes G2019S rs34637584
26808467_4 943-949 ProteinMutation denotes G2019S rs34637584
26808467_5 688-694 ProteinMutation denotes G2019S rs34637584
26808467_6 351-357 ProteinMutation denotes G2019S rs34637584

PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
26808467_0 6-12 ProteinMutation denotes G2019S rs34637584
26808467_1 334-349 ProteinMutation denotes Gly 2019 to Ser rs34637584
26808467_2 1289-1295 ProteinMutation denotes G2019S rs34637584
26808467_3 1084-1090 ProteinMutation denotes G2019S rs34637584
26808467_4 943-949 ProteinMutation denotes G2019S rs34637584
26808467_5 688-694 ProteinMutation denotes G2019S rs34637584
26808467_6 351-357 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q5S006 denotes LRRK2
T2 0-5 PR:000003033 denotes LRRK2
T3 0-5 PR:Q5S007 denotes LRRK2
T4 13-23 SO:0000781 denotes transgenic
T5 13-28 10090 denotes transgenic mice
T6 13-28 D008822 denotes transgenic mice
T7 24-28 PR:000005054 denotes mice
T9 24-28 O89094 denotes mice
T11 47-61 D004198 denotes susceptibility
T12 47-61 D004198 denotes susceptibility
T14 65-109 D015632 denotes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
T15 65-109 D015632 denotes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
T16 65-109 CHEBI:17963 denotes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
T25 111-115 PR:000013454 denotes MPTP
T27 111-115 Q06180 denotes MPTP
T26 111-115 D015632 denotes MPTP
T28 111-115 D015632 denotes MPTP
T29 111-115 CHEBI:17963 denotes MPTP
T31 154-161 6308 denotes leucine
T32 154-161 SO:0001437 denotes leucine
T30 154-161 CHEBI:15603 denotes leucine
T33 154-161 D007930 denotes leucine
T34 154-161 CHEBI:25017 denotes leucine
T35 154-161 D007930 denotes leucine
T36 167-173 SO:0001068 denotes repeat
T37 184-189 PR:Q5S006 denotes LRRK2
T38 184-189 PR:000003033 denotes LRRK2
T39 184-189 PR:Q5S007 denotes LRRK2
T40 221-231 D000067562 denotes late onset
T41 221-231 D000067562 denotes late onset
T42 232-250 C566739 denotes autosomal dominant
T45 259-276 D010300 denotes Parkinson disease
T46 259-276 D010300 denotes Parkinson disease
T49 291-306 GO:0016301 denotes kinase activity
T50 318-330 SO:1000002 denotes substitution
T52 334-337 SO:0001443 denotes Gly
T54 334-337 CVCL_R733 denotes Gly
T51 334-337 CHEBI:15428 denotes Gly
T53 334-337 CHEBI:46740 denotes Gly
T55 334-337 CHEBI:32722 denotes Gly
T56 334-337 CHEBI:46738 denotes Gly
T57 334-337 CHEBI:29947 denotes Gly
T58 334-337 CHEBI:32508 denotes Gly
T59 334-337 CHEBI:32721 denotes Gly
T60 343-349 CVCL_U692 denotes to Ser
T67 346-349 SO:0001444 denotes Ser
T65 346-349 Q62230 denotes Ser
T66 346-349 PR:000001931 denotes Ser
T69 346-349 PR:P18168 denotes Ser
T61 346-349 CHEBI:32838 denotes Ser
T62 346-349 CHEBI:32839 denotes Ser
T64 346-349 CHEBI:29999 denotes Ser
T68 346-349 CHEBI:17115 denotes Ser
T63 346-349 GO:0005790 denotes Ser
T70 378-386 SO:0000109 denotes mutation
T71 401-407 SO:0000417 denotes domain
T72 411-416 PR:Q5S006 denotes LRRK2
T73 411-416 PR:000003033 denotes LRRK2
T74 411-416 PR:Q5S007 denotes LRRK2
T75 418-440 D020022 denotes Genetic predisposition
T76 418-440 D020022 denotes Genetic predisposition
T77 459-465 CHEBI:27026 denotes toxins
T78 484-498 D004198 denotes susceptibility
T79 484-498 D004198 denotes susceptibility
T80 572-577 PR:Q5S006 denotes LRRK2
T81 572-577 PR:000003033 denotes LRRK2
T82 572-577 PR:Q5S007 denotes LRRK2
T83 591-605 D004198 denotes susceptibility
T84 591-605 D004198 denotes susceptibility
T85 623-629 CHEBI:27026 denotes toxins
T86 655-665 SO:0000781 denotes transgenic
T87 655-670 10090 denotes transgenic mice
T88 655-670 D008822 denotes transgenic mice
T89 666-670 PR:000005054 denotes mice
T91 666-670 O89094 denotes mice
T93 682-687 D006801 denotes human
T94 705-714 SO:0000817 denotes wild type
T95 720-725 PR:Q5S006 denotes LRRK2
T96 720-725 PR:000003033 denotes LRRK2
T97 720-725 PR:Q5S007 denotes LRRK2
T98 747-752 CHEBI:27026 denotes toxin
T99 747-754 Q9GV72 denotes toxin 1
T100 747-754 P68426 denotes toxin 1
T101 747-754 Q8T3S7 denotes toxin 1
T102 747-754 P15223 denotes toxin 1
T103 747-754 P01533 denotes toxin 1
T104 747-754 A7L035 denotes toxin 1
T105 747-754 A9JX75 denotes toxin 1
T106 753-797 D015632 denotes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
T107 753-797 D015632 denotes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
T108 753-797 CHEBI:17963 denotes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
T117 799-803 PR:000013454 denotes MPTP
T119 799-803 Q06180 denotes MPTP
T118 799-803 D015632 denotes MPTP
T120 799-803 D015632 denotes MPTP
T121 799-803 CHEBI:17963 denotes MPTP
T122 806-810 PR:000013454 denotes MPTP
T124 806-810 Q06180 denotes MPTP
T123 806-810 D015632 denotes MPTP
T125 806-810 D015632 denotes MPTP
T126 806-810 CHEBI:17963 denotes MPTP
T128 851-859 10962 denotes tyrosine
T132 851-859 SO:0001446 denotes tyrosine
T135 851-871 A0A060X6Z0 denotes tyrosine hydroxylase
T134 851-871 D014446 denotes tyrosine hydroxylase
T137 896-926 UBERON:0001966 denotes substantia nigra pars compacta
T138 896-926 UBERON:0001965 denotes substantia nigra pars compacta
T139 913-917 PR:P07814 denotes pars
T140 913-917 PR:000007144 denotes pars
T142 928-932 PR:Q9U9R7 denotes SNpc
T143 928-932 UBERON:0001965 denotes SNpc
T144 937-942 PR:Q5S006 denotes LRRK2
T145 937-942 PR:000003033 denotes LRRK2
T146 937-942 PR:Q5S007 denotes LRRK2
T147 950-960 SO:0000781 denotes transgenic
T148 950-965 10090 denotes transgenic mice
T149 950-965 D008822 denotes transgenic mice
T150 961-965 PR:000005054 denotes mice
T152 961-965 O89094 denotes mice
T154 982-987 PR:Q5S006 denotes LRRK2
T155 982-987 PR:000003033 denotes LRRK2
T156 982-987 PR:Q5S007 denotes LRRK2
T157 1006-1010 PR:000005054 denotes mice
T159 1006-1010 O89094 denotes mice
T158 1006-1010 D051379 denotes mice
T160 1006-1010 10095 denotes mice
T165 1030-1038 3628 denotes dopamine
T161 1030-1038 CHEBI:59905 denotes dopamine
T162 1030-1038 CHEBI:18243 denotes dopamine
T163 1030-1038 D004298 denotes dopamine
T164 1030-1038 D004298 denotes dopamine
T166 1066-1074 UBERON:0002435 denotes striatum
T167 1066-1074 UBERON:0005383 denotes striatum
T168 1078-1083 PR:Q5S006 denotes LRRK2
T169 1078-1083 PR:000003033 denotes LRRK2
T170 1078-1083 PR:Q5S007 denotes LRRK2
T171 1091-1095 PR:000005054 denotes mice
T173 1091-1095 O89094 denotes mice
T172 1091-1095 D051379 denotes mice
T174 1091-1095 10095 denotes mice
T175 1117-1122 PR:Q5S006 denotes LRRK2
T176 1117-1122 PR:000003033 denotes LRRK2
T177 1117-1122 PR:Q5S007 denotes LRRK2
T178 1126-1130 PR:000005054 denotes mice
T180 1126-1130 O89094 denotes mice
T179 1126-1130 D051379 denotes mice
T181 1126-1130 10095 denotes mice
T182 1159-1163 PR:000013454 denotes MPTP
T184 1159-1163 Q06180 denotes MPTP
T183 1159-1163 D015632 denotes MPTP
T185 1159-1163 D015632 denotes MPTP
T186 1159-1163 CHEBI:17963 denotes MPTP
T187 1263-1275 GO:0009405 denotes pathogenesis
T188 1296-1304 SO:0000109 denotes mutation
T189 1308-1313 PR:Q5S006 denotes LRRK2
T190 1308-1313 PR:000003033 denotes LRRK2
T191 1308-1313 PR:Q5S007 denotes LRRK2
T192 1328-1342 D004198 denotes susceptibility
T193 1328-1342 D004198 denotes susceptibility
T198 1346-1354 3628 denotes dopamine
T194 1346-1354 CHEBI:59905 denotes dopamine
T195 1346-1354 CHEBI:18243 denotes dopamine
T196 1346-1354 D004298 denotes dopamine
T197 1346-1354 D004298 denotes dopamine
T199 1377-1383 CHEBI:27026 denotes toxins

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 141-282 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of late onset autosomal dominant form of Parkinson disease (PD).
T2 283-417 DRI_Background denotes Gain of kinase activity due to the substitution of Gly 2019 to Ser (G2019S) is the most common mutation in the kinase domain of LRRK2.
T3 418-526 DRI_Background denotes Genetic predisposition and environmental toxins contribute to the susceptibility of neurodegeneration in PD.
T4 527-805 DRI_Challenge denotes To identify whether the genetic mutations in LRRK2 increase the susceptibility to environmental toxins in PD models, we exposed transgenic mice expressing human G2019S mutant or wild type (WT) LRRK2 to the environmental toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
T5 806-936 DRI_Background denotes MPTP treatment resulted in a greater loss of tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta (SNpc) in
T6 950-1011 DRI_Background denotes transgenic mice compared to the LRRK2 WT overexpressing mice.
T7 1012-1077 DRI_Background denotes Similarly loss of dopamine levels were greater in the striatum of
T8 1091-1164 DRI_Background denotes mice when compared to the LRRK2 WT mice when both were treated with MPTP.
T9 1165-1384 DRI_Background denotes This study suggests a likely interaction between genetic and environmental risk factors in the PD pathogenesis and that the G2019S mutation in LRRK2 increases the susceptibility of dopamine neurons to PD-causing toxins.