PubMed:26791444
Annnotations
Glycan-Motif
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 38-49 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
T2 | 77-88 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | Chondroitin |
T3 | 200-224 | https://glytoucan.org/Structures/Glycans/G61418DU | denotes | N-acetyl-D-galactosamine |
T4 | 864-875 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
T5 | 1282-1293 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 38-49 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
T2 | 77-88 | Glycan_Motif | denotes | Chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
T3 | 200-224 | Glycan_Motif | denotes | N-acetyl-D-galactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61418DU |
T4 | 864-875 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
T5 | 1282-1293 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 38-49 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
T2 | 77-88 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | Chondroitin |
T3 | 864-875 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
T4 | 1282-1293 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 38-49 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
T2 | 77-88 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | Chondroitin |
T3 | 200-224 | https://glytoucan.org/Structures/Glycans/G61418DU | denotes | N-acetyl-D-galactosamine |
T4 | 864-875 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
T5 | 1282-1293 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-76 | Sentence | denotes | Sequence determination of synthesized chondroitin sulfate dodecasaccharides. |
TextSentencer_T2 | 77-225 | Sentence | denotes | Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine. |
TextSentencer_T3 | 226-334 | Sentence | denotes | The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. |
TextSentencer_T4 | 335-489 | Sentence | denotes | CS chains exhibit various biological and pathological functions by interacting with cytokines and growth factors and regulating their signal transduction. |
TextSentencer_T5 | 490-563 | Sentence | denotes | The fine structure of the CS chain defines its specific biological roles. |
TextSentencer_T6 | 564-725 | Sentence | denotes | However, structural analysis of CS has been restricted to disaccharide analysis, hampering the understanding of the structure-function relationship of CS chains. |
TextSentencer_T7 | 726-928 | Sentence | denotes | Here, we chemo-enzymatically synthesized CS dodecasaccharides having various sulfate modifications using a bioreactor system of bacterial chondroitin polymerase mutants and various CS sulfotransferases. |
TextSentencer_T8 | 929-1007 | Sentence | denotes | We developed a sequencing method for CS chains using the CS dodecasaccharides. |
TextSentencer_T9 | 1008-1578 | Sentence | denotes | The method consists of 1) labeling a reducing end with 3-aminopyridine (PA), 2) partial digestion of CS with testicular hyaluronidase, followed by separation of PA-conjugated oligosaccharides with different chain lengths, 3) limited digestion of these oligosaccharides with chondroitin lyase AC II into disaccharides, followed by labeling with 2-aminobenzamide, 4) CS disaccharide analysis using a dual-fluorescence HPLC system (reversed-phase ion pair and ion exchange chromatography), and 5) estimation of the composition by calculating individual disaccharide ratios. |
TextSentencer_T10 | 1579-1749 | Sentence | denotes | This CS chain sequencing allows characterization of CS-modifying enzymes and provides a useful tool toward understanding the structure-function relationship of CS chains. |
T1 | 0-76 | Sentence | denotes | Sequence determination of synthesized chondroitin sulfate dodecasaccharides. |
T2 | 77-225 | Sentence | denotes | Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine. |
T3 | 226-334 | Sentence | denotes | The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. |
T4 | 335-489 | Sentence | denotes | CS chains exhibit various biological and pathological functions by interacting with cytokines and growth factors and regulating their signal transduction. |
T5 | 490-563 | Sentence | denotes | The fine structure of the CS chain defines its specific biological roles. |
T6 | 564-725 | Sentence | denotes | However, structural analysis of CS has been restricted to disaccharide analysis, hampering the understanding of the structure-function relationship of CS chains. |
T7 | 726-928 | Sentence | denotes | Here, we chemo-enzymatically synthesized CS dodecasaccharides having various sulfate modifications using a bioreactor system of bacterial chondroitin polymerase mutants and various CS sulfotransferases. |
T8 | 929-1007 | Sentence | denotes | We developed a sequencing method for CS chains using the CS dodecasaccharides. |
T9 | 1008-1578 | Sentence | denotes | The method consists of 1) labeling a reducing end with 3-aminopyridine (PA), 2) partial digestion of CS with testicular hyaluronidase, followed by separation of PA-conjugated oligosaccharides with different chain lengths, 3) limited digestion of these oligosaccharides with chondroitin lyase AC II into disaccharides, followed by labeling with 2-aminobenzamide, 4) CS disaccharide analysis using a dual-fluorescence HPLC system (reversed-phase ion pair and ion exchange chromatography), and 5) estimation of the composition by calculating individual disaccharide ratios. |
T10 | 1579-1749 | Sentence | denotes | This CS chain sequencing allows characterization of CS-modifying enzymes and provides a useful tool toward understanding the structure-function relationship of CS chains. |
T1 | 0-76 | Sentence | denotes | Sequence determination of synthesized chondroitin sulfate dodecasaccharides. |
T2 | 77-225 | Sentence | denotes | Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine. |
T3 | 226-334 | Sentence | denotes | The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. |
T4 | 335-489 | Sentence | denotes | CS chains exhibit various biological and pathological functions by interacting with cytokines and growth factors and regulating their signal transduction. |
T5 | 490-563 | Sentence | denotes | The fine structure of the CS chain defines its specific biological roles. |
T6 | 564-725 | Sentence | denotes | However, structural analysis of CS has been restricted to disaccharide analysis, hampering the understanding of the structure-function relationship of CS chains. |
T7 | 726-928 | Sentence | denotes | Here, we chemo-enzymatically synthesized CS dodecasaccharides having various sulfate modifications using a bioreactor system of bacterial chondroitin polymerase mutants and various CS sulfotransferases. |
T8 | 929-1007 | Sentence | denotes | We developed a sequencing method for CS chains using the CS dodecasaccharides. |
T9 | 1008-1578 | Sentence | denotes | The method consists of 1) labeling a reducing end with 3-aminopyridine (PA), 2) partial digestion of CS with testicular hyaluronidase, followed by separation of PA-conjugated oligosaccharides with different chain lengths, 3) limited digestion of these oligosaccharides with chondroitin lyase AC II into disaccharides, followed by labeling with 2-aminobenzamide, 4) CS disaccharide analysis using a dual-fluorescence HPLC system (reversed-phase ion pair and ion exchange chromatography), and 5) estimation of the composition by calculating individual disaccharide ratios. |
T10 | 1579-1749 | Sentence | denotes | This CS chain sequencing allows characterization of CS-modifying enzymes and provides a useful tool toward understanding the structure-function relationship of CS chains. |
GlycoBiology-FMA
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 38-57 | FMAID:196838 | denotes | chondroitin sulfate |
_T2 | 38-57 | FMAID:82837 | denotes | chondroitin sulfate |
_T3 | 77-96 | FMAID:82837 | denotes | Chondroitin sulfate |
_T4 | 77-96 | FMAID:196838 | denotes | Chondroitin sulfate |
_T5 | 121-135 | FMAID:82785 | denotes | polysaccharide |
_T6 | 121-135 | FMAID:82746 | denotes | polysaccharide |
_T7 | 121-135 | FMAID:196735 | denotes | polysaccharide |
_T8 | 121-135 | FMAID:196779 | denotes | polysaccharide |
_T9 | 158-170 | FMAID:82744 | denotes | disaccharide |
_T10 | 158-170 | FMAID:196733 | denotes | disaccharide |
_T11 | 180-195 | FMAID:82798 | denotes | glucuronic acid |
_T12 | 180-195 | FMAID:196793 | denotes | glucuronic acid |
_T13 | 211-224 | FMAID:196787 | denotes | galactosamine |
_T14 | 211-224 | FMAID:82792 | denotes | galactosamine |
_T15 | 230-244 | FMAID:196735 | denotes | polysaccharide |
_T16 | 230-244 | FMAID:82785 | denotes | polysaccharide |
_T17 | 230-244 | FMAID:196779 | denotes | polysaccharide |
_T18 | 230-244 | FMAID:82746 | denotes | polysaccharide |
_T19 | 419-428 | FMAID:84050 | denotes | cytokines |
_T20 | 419-428 | FMAID:197972 | denotes | cytokines |
_T21 | 622-634 | FMAID:82744 | denotes | disaccharide |
_T22 | 622-634 | FMAID:196733 | denotes | disaccharide |
_T23 | 1183-1199 | FMAID:82742 | denotes | oligosaccharides |
_T24 | 1183-1199 | FMAID:196731 | denotes | oligosaccharides |
_T25 | 1260-1276 | FMAID:196731 | denotes | oligosaccharides |
_T26 | 1260-1276 | FMAID:82742 | denotes | oligosaccharides |
_T27 | 1311-1324 | FMAID:196733 | denotes | disaccharides |
_T28 | 1311-1324 | FMAID:82744 | denotes | disaccharides |
_T29 | 1376-1388 | FMAID:82744 | denotes | disaccharide |
_T30 | 1376-1388 | FMAID:196733 | denotes | disaccharide |
_T31 | 1520-1531 | FMAID:146309 | denotes | composition |
_T32 | 1520-1531 | FMAID:50603 | denotes | composition |
_T33 | 1558-1570 | FMAID:196733 | denotes | disaccharide |
_T34 | 1558-1570 | FMAID:82744 | denotes | disaccharide |
uniprot-human
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 98-100 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T2 | 335-337 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T3 | 516-518 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T4 | 596-598 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T5 | 715-717 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T6 | 767-769 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T7 | 907-909 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T8 | 966-968 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T9 | 986-988 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T10 | 1109-1111 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T11 | 1373-1375 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T12 | 1584-1586 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T13 | 1631-1633 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T14 | 1739-1741 | http://www.uniprot.org/uniprot/O75390 | denotes | CS |
T15 | 1080-1082 | http://www.uniprot.org/uniprot/P04746 | denotes | PA |
T16 | 1169-1171 | http://www.uniprot.org/uniprot/P04746 | denotes | PA |
T17 | 1080-1082 | http://www.uniprot.org/uniprot/Q9UL45 | denotes | PA |
T18 | 1169-1171 | http://www.uniprot.org/uniprot/Q9UL45 | denotes | PA |
T19 | 1300-1302 | http://www.uniprot.org/uniprot/Q13510 | denotes | AC |
uniprot-mouse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1080-1082 | http://www.uniprot.org/uniprot/P00688 | denotes | PA |
T2 | 1169-1171 | http://www.uniprot.org/uniprot/P00688 | denotes | PA |
T3 | 1300-1302 | http://www.uniprot.org/uniprot/Q9WV54 | denotes | AC |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 270-276 | http://purl.bioontology.org/ontology/STY/T096 | denotes | groups |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 50-57 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
T2 | 89-96 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
T3 | 262-269 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
T4 | 803-810 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
T5 | 433-439 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T6 | 452-462 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulating |
T7 | 452-475 | http://purl.obolibrary.org/obo/GO_0023051 | denotes | regulating their signal |
T8 | 452-488 | http://purl.obolibrary.org/obo/GO_0009967 | denotes | regulating their signal transduction |
T9 | 452-488 | http://purl.obolibrary.org/obo/GO_1903432 | denotes | regulating their signal transduction |
T10 | 452-488 | http://purl.obolibrary.org/obo/GO_1903939 | denotes | regulating their signal transduction |
T11 | 452-488 | http://purl.obolibrary.org/obo/GO_1900115 | denotes | regulating their signal transduction |
T12 | 452-488 | http://purl.obolibrary.org/obo/GO_1902847 | denotes | regulating their signal transduction |
T13 | 452-488 | http://purl.obolibrary.org/obo/GO_0009966 | denotes | regulating their signal transduction |
T14 | 452-488 | http://purl.obolibrary.org/obo/GO_0009968 | denotes | regulating their signal transduction |
T15 | 469-475 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signal |
T16 | 469-488 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signal transduction |
T17 | 476-488 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
T18 | 932-941 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | developed |
T19 | 1096-1105 | http://purl.obolibrary.org/obo/GO_0007586 | denotes | digestion |
T20 | 1241-1250 | http://purl.obolibrary.org/obo/GO_0007586 | denotes | digestion |
T21 | 1172-1182 | http://purl.obolibrary.org/obo/GO_0000746 | denotes | conjugated |
T22 | 1282-1302 | http://purl.obolibrary.org/obo/GO_0030341 | denotes | chondroitin lyase AC |
T23 | 1300-1302 | http://purl.obolibrary.org/obo/GO_0003987 | denotes | AC |
T24 | 1300-1302 | http://purl.obolibrary.org/obo/GO_0043884 | denotes | AC |
T25 | 1469-1477 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
GlycoBiology-Motifs
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 38-49 | http://rdf.glycoinfo.org/glycan/G00018MO | denotes | chondroitin |
T2 | 864-875 | http://rdf.glycoinfo.org/glycan/G00018MO | denotes | chondroitin |
T3 | 1282-1293 | http://rdf.glycoinfo.org/glycan/G00018MO | denotes | chondroitin |
T4 | 38-57 | http://rdf.glycoinfo.org/glycan/G00018MO | denotes | chondroitin sulfate |
GlycoBiology-Epitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-GlycoEpitope-B_T1 | 1034-1042 | id | denotes | labeling |
PD-GlycoEpitope-B_T2 | 1338-1346 | id | denotes | labeling |
PD-GlycoEpitope-B_T3 | 38-49 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
PD-GlycoEpitope-B_T4 | 77-88 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | Chondroitin |
PD-GlycoEpitope-B_T5 | 864-875 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
PD-GlycoEpitope-B_T6 | 1282-1293 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 38-49 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
T2 | 77-88 | Glycan | denotes | Chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
T3 | 864-875 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
T4 | 1282-1293 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 38-49 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
T2 | 77-88 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
T3 | 864-875 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
T4 | 1282-1293 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-76 | Sentence | denotes | Sequence determination of synthesized chondroitin sulfate dodecasaccharides. |
TextSentencer_T2 | 77-225 | Sentence | denotes | Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine. |
TextSentencer_T3 | 226-334 | Sentence | denotes | The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. |
TextSentencer_T4 | 335-489 | Sentence | denotes | CS chains exhibit various biological and pathological functions by interacting with cytokines and growth factors and regulating their signal transduction. |
TextSentencer_T5 | 490-563 | Sentence | denotes | The fine structure of the CS chain defines its specific biological roles. |
TextSentencer_T6 | 564-725 | Sentence | denotes | However, structural analysis of CS has been restricted to disaccharide analysis, hampering the understanding of the structure-function relationship of CS chains. |
TextSentencer_T7 | 726-928 | Sentence | denotes | Here, we chemo-enzymatically synthesized CS dodecasaccharides having various sulfate modifications using a bioreactor system of bacterial chondroitin polymerase mutants and various CS sulfotransferases. |
TextSentencer_T8 | 929-1007 | Sentence | denotes | We developed a sequencing method for CS chains using the CS dodecasaccharides. |
TextSentencer_T9 | 1008-1578 | Sentence | denotes | The method consists of 1) labeling a reducing end with 3-aminopyridine (PA), 2) partial digestion of CS with testicular hyaluronidase, followed by separation of PA-conjugated oligosaccharides with different chain lengths, 3) limited digestion of these oligosaccharides with chondroitin lyase AC II into disaccharides, followed by labeling with 2-aminobenzamide, 4) CS disaccharide analysis using a dual-fluorescence HPLC system (reversed-phase ion pair and ion exchange chromatography), and 5) estimation of the composition by calculating individual disaccharide ratios. |
TextSentencer_T10 | 1579-1749 | Sentence | denotes | This CS chain sequencing allows characterization of CS-modifying enzymes and provides a useful tool toward understanding the structure-function relationship of CS chains. |
T1 | 0-76 | Sentence | denotes | Sequence determination of synthesized chondroitin sulfate dodecasaccharides. |
T2 | 77-225 | Sentence | denotes | Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine. |
T3 | 226-334 | Sentence | denotes | The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. |
T4 | 335-489 | Sentence | denotes | CS chains exhibit various biological and pathological functions by interacting with cytokines and growth factors and regulating their signal transduction. |
T5 | 490-563 | Sentence | denotes | The fine structure of the CS chain defines its specific biological roles. |
T6 | 564-725 | Sentence | denotes | However, structural analysis of CS has been restricted to disaccharide analysis, hampering the understanding of the structure-function relationship of CS chains. |
T7 | 726-928 | Sentence | denotes | Here, we chemo-enzymatically synthesized CS dodecasaccharides having various sulfate modifications using a bioreactor system of bacterial chondroitin polymerase mutants and various CS sulfotransferases. |
T8 | 929-1007 | Sentence | denotes | We developed a sequencing method for CS chains using the CS dodecasaccharides. |
T9 | 1008-1578 | Sentence | denotes | The method consists of 1) labeling a reducing end with 3-aminopyridine (PA), 2) partial digestion of CS with testicular hyaluronidase, followed by separation of PA-conjugated oligosaccharides with different chain lengths, 3) limited digestion of these oligosaccharides with chondroitin lyase AC II into disaccharides, followed by labeling with 2-aminobenzamide, 4) CS disaccharide analysis using a dual-fluorescence HPLC system (reversed-phase ion pair and ion exchange chromatography), and 5) estimation of the composition by calculating individual disaccharide ratios. |
T10 | 1579-1749 | Sentence | denotes | This CS chain sequencing allows characterization of CS-modifying enzymes and provides a useful tool toward understanding the structure-function relationship of CS chains. |
T1 | 0-76 | Sentence | denotes | Sequence determination of synthesized chondroitin sulfate dodecasaccharides. |
T2 | 77-225 | Sentence | denotes | Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine. |
T3 | 226-334 | Sentence | denotes | The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. |
T4 | 335-489 | Sentence | denotes | CS chains exhibit various biological and pathological functions by interacting with cytokines and growth factors and regulating their signal transduction. |
T5 | 490-563 | Sentence | denotes | The fine structure of the CS chain defines its specific biological roles. |
T6 | 564-725 | Sentence | denotes | However, structural analysis of CS has been restricted to disaccharide analysis, hampering the understanding of the structure-function relationship of CS chains. |
T7 | 726-928 | Sentence | denotes | Here, we chemo-enzymatically synthesized CS dodecasaccharides having various sulfate modifications using a bioreactor system of bacterial chondroitin polymerase mutants and various CS sulfotransferases. |
T8 | 929-1007 | Sentence | denotes | We developed a sequencing method for CS chains using the CS dodecasaccharides. |
T9 | 1008-1578 | Sentence | denotes | The method consists of 1) labeling a reducing end with 3-aminopyridine (PA), 2) partial digestion of CS with testicular hyaluronidase, followed by separation of PA-conjugated oligosaccharides with different chain lengths, 3) limited digestion of these oligosaccharides with chondroitin lyase AC II into disaccharides, followed by labeling with 2-aminobenzamide, 4) CS disaccharide analysis using a dual-fluorescence HPLC system (reversed-phase ion pair and ion exchange chromatography), and 5) estimation of the composition by calculating individual disaccharide ratios. |
T10 | 1579-1749 | Sentence | denotes | This CS chain sequencing allows characterization of CS-modifying enzymes and provides a useful tool toward understanding the structure-function relationship of CS chains. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-76 | Sentence | denotes | Sequence determination of synthesized chondroitin sulfate dodecasaccharides. |
T2 | 77-225 | Sentence | denotes | Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine. |
T3 | 226-334 | Sentence | denotes | The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. |
T4 | 335-489 | Sentence | denotes | CS chains exhibit various biological and pathological functions by interacting with cytokines and growth factors and regulating their signal transduction. |
T5 | 490-563 | Sentence | denotes | The fine structure of the CS chain defines its specific biological roles. |
T6 | 564-725 | Sentence | denotes | However, structural analysis of CS has been restricted to disaccharide analysis, hampering the understanding of the structure-function relationship of CS chains. |
T7 | 726-928 | Sentence | denotes | Here, we chemo-enzymatically synthesized CS dodecasaccharides having various sulfate modifications using a bioreactor system of bacterial chondroitin polymerase mutants and various CS sulfotransferases. |
T8 | 929-1007 | Sentence | denotes | We developed a sequencing method for CS chains using the CS dodecasaccharides. |
T9 | 1008-1578 | Sentence | denotes | The method consists of 1) labeling a reducing end with 3-aminopyridine (PA), 2) partial digestion of CS with testicular hyaluronidase, followed by separation of PA-conjugated oligosaccharides with different chain lengths, 3) limited digestion of these oligosaccharides with chondroitin lyase AC II into disaccharides, followed by labeling with 2-aminobenzamide, 4) CS disaccharide analysis using a dual-fluorescence HPLC system (reversed-phase ion pair and ion exchange chromatography), and 5) estimation of the composition by calculating individual disaccharide ratios. |
T10 | 1579-1749 | Sentence | denotes | This CS chain sequencing allows characterization of CS-modifying enzymes and provides a useful tool toward understanding the structure-function relationship of CS chains. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 38-49 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
T2 | 77-88 | Glycan | denotes | Chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
T3 | 864-875 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
T4 | 1282-1293 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 38-49 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
T2 | 77-88 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
T3 | 864-875 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
T4 | 1282-1293 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |