PubMed:26719025 JSONTXT

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"26719025-3#62#65#gene3439","span":{"begin":516,"end":519},"obj":"gene3439"},{"id":"26719025-3#62#65#gene3447","span":{"begin":516,"end":519},"obj":"gene3447"},{"id":"26719025-3#82#97#diseaseC0042769","span":{"begin":536,"end":551},"obj":"diseaseC0042769"}],"relations":[{"id":"62#65#gene343982#97#diseaseC0042769","pred":"associated_with","subj":"26719025-3#62#65#gene3439","obj":"26719025-3#82#97#diseaseC0042769"},{"id":"62#65#gene344782#97#diseaseC0042769","pred":"associated_with","subj":"26719025-3#62#65#gene3447","obj":"26719025-3#82#97#diseaseC0042769"}],"text":"Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.\nThe BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T132","span":{"begin":516,"end":519},"obj":"gene:3439"},{"id":"T133","span":{"begin":536,"end":551},"obj":"disease:C0042769"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T132","obj":"T133"},{"id":"R2","pred":"associated_with","subj":"T132","obj":"T133"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.\nThe BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":112},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":113,"end":333},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":334,"end":453},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":454,"end":701},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":702,"end":868},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":869,"end":1059},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":112},"obj":"Sentence"},{"id":"T2","span":{"begin":113,"end":333},"obj":"Sentence"},{"id":"T3","span":{"begin":334,"end":453},"obj":"Sentence"},{"id":"T4","span":{"begin":454,"end":701},"obj":"Sentence"},{"id":"T5","span":{"begin":702,"end":868},"obj":"Sentence"},{"id":"T6","span":{"begin":869,"end":1059},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.\nThe BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":446,"end":452},"obj":"http://purl.obolibrary.org/obo/UBERON_0002548"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":975,"end":986},"obj":"http://purl.obolibrary.org/obo/UBERON_3010224"}],"text":"Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.\nThe BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":975,"end":986},"obj":"http://purl.obolibrary.org/obo/UBERON_3010224"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":446,"end":452},"obj":"http://purl.obolibrary.org/obo/UBERON_0002548"}],"text":"Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.\nThe BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms."}