PubMed:26647963 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/26647963","sourcedb":"PubMed","sourceid":"26647963","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/26647963","text":"A 3-day EGCG-supplementation reduces interstitial lactate concentration in skeletal muscle of overweight subjects.\nGreen tea, particularly epigallocatechin-3-gallate (EGCG), may affect body weight and composition, possibly by enhancing fat oxidation. The aim of this double-blind, randomized placebo-controlled cross-over study was to investigate whether 3-day supplementation with EGCG (282mg/day) stimulates fat oxidation and lipolysis in 24 overweight subjects (age = 30 ± 2yrs, BMI = 27.7 ± 0.3 kg/m(2)). Energy expenditure, substrate metabolism and circulating metabolites were determined during fasting and postprandial conditions. After 6 h, a fat biopsy was collected to examine gene expression. In 12 subjects, skeletal muscle glycerol, glucose and lactate concentrations were determined using microdialysis. EGCG-supplementation did not alter energy expenditure and substrate oxidation compared to placebo. Although EGCG reduced postprandial circulating glycerol concentrations (P = 0.015), no difference in skeletal muscle lipolysis was observed. Fasting (P = 0.001) and postprandial (P = 0.003) skeletal muscle lactate concentrations were reduced after EGCG-supplementation compared to placebo, despite similar tissue blood flow. Adipose tissue leptin (P = 0.05) and FAT/CD36 expression (P = 0.08) were increased after EGCG compared to placebo. In conclusion, 3-day EGCG-supplementation decreased postprandial plasma glycerol concentrations, but had no significant effects on skeletal muscle lipolysis and whole-body fat oxidation in overweight individuals. Furthermore, EGCG decreased skeletal muscle lactate concentrations, which suggest a shift towards a more oxidative muscle phenotype.","tracks":[{"project":"wangzhuo19_800_3","denotations":[{"id":"T1","span":{"begin":8,"end":12},"obj":"CI"},{"id":"T2","span":{"begin":167,"end":171},"obj":"CI"},{"id":"T3","span":{"begin":382,"end":386},"obj":"CI"},{"id":"T4","span":{"begin":818,"end":822},"obj":"CI"},{"id":"T5","span":{"begin":926,"end":930},"obj":"CI"},{"id":"T6","span":{"begin":1165,"end":1169},"obj":"CI"},{"id":"T7","span":{"begin":1331,"end":1335},"obj":"CI"},{"id":"T8","span":{"begin":1378,"end":1382},"obj":"CI"},{"id":"T9","span":{"begin":1583,"end":1587},"obj":"CI"},{"id":"T10","span":{"begin":139,"end":165},"obj":"CI"},{"id":"T11","span":{"begin":292,"end":299},"obj":"CI"},{"id":"T12","span":{"begin":908,"end":915},"obj":"CI"},{"id":"T13","span":{"begin":1198,"end":1205},"obj":"CI"},{"id":"T14","span":{"begin":1348,"end":1355},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T2","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T3","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T4","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T5","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T6","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T7","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T8","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T9","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T10","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T11","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T12","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T13","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T14","pred":"source","obj":"wangzhuo19_800_3"}]},{"project":"maxiaofeng52_800_3","denotations":[{"id":"T1","span":{"begin":139,"end":165},"obj":"CI"},{"id":"T2","span":{"begin":167,"end":171},"obj":"CI"},{"id":"T3","span":{"begin":8,"end":12},"obj":"CI"},{"id":"T4","span":{"begin":382,"end":386},"obj":"CI"},{"id":"T5","span":{"begin":818,"end":822},"obj":"CI"},{"id":"T6","span":{"begin":926,"end":930},"obj":"CI"},{"id":"T7","span":{"begin":1165,"end":1169},"obj":"CI"},{"id":"T8","span":{"begin":1331,"end":1335},"obj":"CI"},{"id":"T9","span":{"begin":1378,"end":1382},"obj":"CI"},{"id":"T10","span":{"begin":1583,"end":1587},"obj":"CI"},{"id":"T11","span":{"begin":908,"end":915},"obj":"CI"},{"id":"T12","span":{"begin":292,"end":299},"obj":"CI"},{"id":"T13","span":{"begin":1198,"end":1205},"obj":"CI"},{"id":"T14","span":{"begin":1348,"end":1355},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T2","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T3","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T4","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T5","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T6","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T7","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T8","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T9","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T10","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T11","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T12","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T13","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T14","pred":"source","obj":"maxiaofeng52_800_3"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":75,"end":90},"obj":"Body_part"},{"id":"T4","span":{"begin":236,"end":239},"obj":"Body_part"},{"id":"T5","span":{"begin":410,"end":413},"obj":"Body_part"},{"id":"T6","span":{"begin":651,"end":654},"obj":"Body_part"},{"id":"T7","span":{"begin":720,"end":735},"obj":"Body_part"},{"id":"T10","span":{"begin":1018,"end":1033},"obj":"Body_part"},{"id":"T13","span":{"begin":1107,"end":1122},"obj":"Body_part"},{"id":"T16","span":{"begin":1223,"end":1229},"obj":"Body_part"},{"id":"T17","span":{"begin":1230,"end":1235},"obj":"Body_part"},{"id":"T18","span":{"begin":1242,"end":1256},"obj":"Body_part"},{"id":"T19","span":{"begin":1422,"end":1428},"obj":"Body_part"},{"id":"T20","span":{"begin":1488,"end":1503},"obj":"Body_part"},{"id":"T23","span":{"begin":1518,"end":1528},"obj":"Body_part"},{"id":"T25","span":{"begin":1529,"end":1532},"obj":"Body_part"},{"id":"T26","span":{"begin":1598,"end":1613},"obj":"Body_part"},{"id":"T29","span":{"begin":1685,"end":1691},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"A2","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"A3","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0014895"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"A8","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"A9","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0014895"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"A11","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"A12","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0014895"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"A14","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"A15","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0014895"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"A21","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"A22","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0014895"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"A24","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0013702"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"A27","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"A28","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0014895"},{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"A30","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T6","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T7","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T10","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T13","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T16","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T17","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T18","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T19","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T20","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T23","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T25","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T26","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T29","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":75,"end":90},"obj":"Body_part"},{"id":"T2","span":{"begin":720,"end":735},"obj":"Body_part"},{"id":"T3","span":{"begin":1018,"end":1033},"obj":"Body_part"},{"id":"T4","span":{"begin":1107,"end":1122},"obj":"Body_part"},{"id":"T5","span":{"begin":1230,"end":1235},"obj":"Body_part"},{"id":"T7","span":{"begin":1242,"end":1256},"obj":"Body_part"},{"id":"T8","span":{"begin":1488,"end":1503},"obj":"Body_part"},{"id":"T9","span":{"begin":1598,"end":1613},"obj":"Body_part"},{"id":"T10","span":{"begin":1685,"end":1691},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000302"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000302"},{"id":"A3","pred":"mat_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MAT_0000302"},{"id":"A4","pred":"mat_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MAT_0000302"},{"id":"A5","pred":"mat_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MAT_0000083"},{"id":"A6","pred":"mat_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MAT_0000315"},{"id":"A7","pred":"mat_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MAT_0000015"},{"id":"A8","pred":"mat_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MAT_0000302"},{"id":"A9","pred":"mat_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MAT_0000302"},{"id":"A10","pred":"mat_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MAT_0000025"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"},{"subj":"T3","pred":"source","obj":"Anatomy-MAT"},{"subj":"T4","pred":"source","obj":"Anatomy-MAT"},{"subj":"T5","pred":"source","obj":"Anatomy-MAT"},{"subj":"T7","pred":"source","obj":"Anatomy-MAT"},{"subj":"T8","pred":"source","obj":"Anatomy-MAT"},{"subj":"T9","pred":"source","obj":"Anatomy-MAT"},{"subj":"T10","pred":"source","obj":"Anatomy-MAT"}]},{"project":"GlyCosmos15-HP","denotations":[{"id":"T1","span":{"begin":94,"end":104},"obj":"Phenotype"},{"id":"T2","span":{"begin":444,"end":454},"obj":"Phenotype"},{"id":"T3","span":{"begin":1546,"end":1556},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0025502"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0025502"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0025502"},{"subj":"T1","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T2","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T3","pred":"source","obj":"GlyCosmos15-HP"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"wangzhuo19_800_3","color":"#b5ec93","default":true},{"id":"maxiaofeng52_800_3","color":"#ec93cf"},{"id":"Anatomy-UBERON","color":"#93e9ec"},{"id":"Anatomy-MAT","color":"#ecd593"},{"id":"GlyCosmos15-HP","color":"#bb93ec"}]}]}}