PubMed:26546614
Annnotations
PubTator4TogoVar
Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
---|---|---|---|---|---|
26546614_0 | 678-684 | ProteinMutation | denotes | G2019S | rs34637584 |
26546614_1 | 834-840 | ProteinMutation | denotes | R1441G | rs33939927 |
26546614_2 | 987-993 | ProteinMutation | denotes | G2019S | rs34637584 |
26546614_3 | 1016-1022 | ProteinMutation | denotes | G2019S | rs34637584 |
26546614_4 | 1202-1208 | ProteinMutation | denotes | G2019S | rs34637584 |
26546614_5 | 1263-1269 | ProteinMutation | denotes | G2019S | rs34637584 |
26546614_6 | 1433-1439 | ProteinMutation | denotes | G2019S | rs34637584 |
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-15 | D048948 | denotes | 14-3-3 Proteins |
T3 | 32-37 | PR:Q5S006 | denotes | LRRK2 |
T4 | 32-37 | PR:000003033 | denotes | LRRK2 |
T5 | 32-37 | PR:Q5S007 | denotes | LRRK2 |
T6 | 38-53 | GO:0016301 | denotes | kinase activity |
T7 | 58-65 | GO:0043005 | denotes | neurite |
T9 | 91-98 | 6308 | denotes | leucine |
T10 | 91-98 | SO:0001437 | denotes | leucine |
T8 | 91-98 | CHEBI:15603 | denotes | leucine |
T11 | 91-98 | D007930 | denotes | leucine |
T12 | 91-98 | CHEBI:25017 | denotes | leucine |
T13 | 91-98 | D007930 | denotes | leucine |
T14 | 104-110 | SO:0001068 | denotes | repeat |
T15 | 121-126 | PR:Q5S006 | denotes | LRRK2 |
T16 | 121-126 | PR:000003033 | denotes | LRRK2 |
T17 | 121-126 | PR:Q5S007 | denotes | LRRK2 |
T22 | 173-192 | D010300 | denotes | Parkinson's disease |
T23 | 173-192 | D010300 | denotes | Parkinson's disease |
T26 | 203-208 | PR:Q5S006 | denotes | LRRK2 |
T27 | 203-208 | PR:000003033 | denotes | LRRK2 |
T28 | 203-208 | PR:Q5S007 | denotes | LRRK2 |
T29 | 249-254 | PR:Q5S006 | denotes | LRRK2 |
T30 | 249-254 | PR:000003033 | denotes | LRRK2 |
T31 | 249-254 | PR:Q5S007 | denotes | LRRK2 |
T32 | 267-276 | SO:0000119 | denotes | regulated |
T33 | 322-331 | SO:0000856 | denotes | conserved |
T34 | 332-347 | D048948 | denotes | 14-3-3 proteins |
T36 | 408-418 | GO:0008219 | denotes | cell death |
T37 | 453-458 | PR:Q5S006 | denotes | LRRK2 |
T38 | 453-458 | PR:000003033 | denotes | LRRK2 |
T39 | 453-458 | PR:Q5S007 | denotes | LRRK2 |
T40 | 527-532 | PR:Q5S006 | denotes | LRRK2 |
T41 | 527-532 | PR:000003033 | denotes | LRRK2 |
T42 | 527-532 | PR:Q5S007 | denotes | LRRK2 |
T43 | 541-548 | GO:0043005 | denotes | neurite |
T44 | 564-579 | GO:0016301 | denotes | kinase activity |
T45 | 624-631 | GO:0043005 | denotes | neurite |
T46 | 663-666 | SO:0000153 | denotes | BAC |
T47 | 667-677 | SO:0000781 | denotes | transgenic |
T48 | 685-690 | PR:Q5S006 | denotes | LRRK2 |
T49 | 685-690 | PR:000003033 | denotes | LRRK2 |
T50 | 685-690 | PR:Q5S007 | denotes | LRRK2 |
T51 | 691-695 | PR:000005054 | denotes | mice |
T53 | 691-695 | O89094 | denotes | mice |
T52 | 691-695 | D051379 | denotes | mice |
T54 | 691-695 | 10095 | denotes | mice |
T55 | 713-722 | SO:0000817 | denotes | wild-type |
T56 | 774-781 | GO:0043005 | denotes | neurite |
T57 | 819-822 | SO:0000153 | denotes | BAC |
T58 | 823-833 | SO:0000781 | denotes | transgenic |
T59 | 841-846 | PR:Q5S006 | denotes | LRRK2 |
T60 | 841-846 | PR:000003033 | denotes | LRRK2 |
T61 | 841-846 | PR:Q5S007 | denotes | LRRK2 |
T62 | 847-851 | PR:000005054 | denotes | mice |
T64 | 847-851 | O89094 | denotes | mice |
T63 | 847-851 | D051379 | denotes | mice |
T65 | 847-851 | 10095 | denotes | mice |
T66 | 894-897 | PR:Q8UVK2 | denotes | pan |
T67 | 905-914 | CHEBI:35222 | denotes | inhibitor |
T68 | 915-923 | C443131 | denotes | difopein |
T69 | 927-944 | SO:0002052 | denotes | dominant-negative |
T70 | 969-976 | GO:0043005 | denotes | neurite |
T71 | 994-999 | PR:Q5S006 | denotes | LRRK2 |
T72 | 994-999 | PR:000003033 | denotes | LRRK2 |
T73 | 994-999 | PR:Q5S007 | denotes | LRRK2 |
T74 | 1023-1028 | PR:Q5S006 | denotes | LRRK2 |
T75 | 1023-1028 | PR:000003033 | denotes | LRRK2 |
T76 | 1023-1028 | PR:Q5S007 | denotes | LRRK2 |
T77 | 1075-1090 | GO:0016301 | denotes | kinase activity |
T78 | 1125-1130 | PR:Q5S006 | denotes | LRRK2 |
T79 | 1125-1130 | PR:000003033 | denotes | LRRK2 |
T80 | 1125-1130 | PR:Q5S007 | denotes | LRRK2 |
T81 | 1131-1146 | GO:0016301 | denotes | kinase activity |
T82 | 1183-1198 | GO:0016301 | denotes | kinase activity |
T83 | 1209-1214 | PR:Q5S006 | denotes | LRRK2 |
T84 | 1209-1214 | PR:000003033 | denotes | LRRK2 |
T85 | 1209-1214 | PR:Q5S007 | denotes | LRRK2 |
T86 | 1222-1230 | C443131 | denotes | difopein |
T87 | 1244-1259 | GO:0016301 | denotes | kinase activity |
T88 | 1270-1275 | PR:Q5S006 | denotes | LRRK2 |
T89 | 1270-1275 | PR:000003033 | denotes | LRRK2 |
T90 | 1270-1275 | PR:Q5S007 | denotes | LRRK2 |
T91 | 1310-1315 | PR:Q5S006 | denotes | LRRK2 |
T92 | 1310-1315 | PR:000003033 | denotes | LRRK2 |
T93 | 1310-1315 | PR:Q5S007 | denotes | LRRK2 |
T94 | 1316-1331 | GO:0016301 | denotes | kinase activity |
T95 | 1348-1355 | SO:0100018 | denotes | binding |
T96 | 1348-1355 | SO:0001091 | denotes | binding |
T97 | 1348-1355 | GO:0005488 | denotes | binding |
T98 | 1372-1377 | PR:Q5S006 | denotes | LRRK2 |
T99 | 1372-1377 | PR:000003033 | denotes | LRRK2 |
T100 | 1372-1377 | PR:Q5S007 | denotes | LRRK2 |
T101 | 1399-1406 | GO:0043005 | denotes | neurite |
T102 | 1421-1429 | C443131 | denotes | difopein |
T103 | 1440-1445 | PR:Q5S006 | denotes | LRRK2 |
T104 | 1440-1445 | PR:000003033 | denotes | LRRK2 |
T105 | 1440-1445 | PR:Q5S007 | denotes | LRRK2 |
T106 | 1470-1475 | PR:Q5S006 | denotes | LRRK2 |
T107 | 1470-1475 | PR:000003033 | denotes | LRRK2 |
T108 | 1470-1475 | PR:Q5S007 | denotes | LRRK2 |
T109 | 1483-1493 | CHEBI:35222 | denotes | inhibitors |
T110 | 1549-1554 | PR:Q5S006 | denotes | LRRK2 |
T111 | 1549-1554 | PR:000003033 | denotes | LRRK2 |
T112 | 1549-1554 | PR:Q5S007 | denotes | LRRK2 |
T113 | 1589-1594 | PR:Q5S006 | denotes | LRRK2 |
T114 | 1589-1594 | PR:000003033 | denotes | LRRK2 |
T115 | 1589-1594 | PR:Q5S007 | denotes | LRRK2 |
T116 | 1605-1614 | MOP:0000569 | denotes | reduction |
T117 | 1618-1633 | GO:0016301 | denotes | kinase activity |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-77 | DRI_Background | denotes | 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. |
T2 | 78-244 | DRI_Approach | denotes | Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of inherited Parkinson's disease (PD), and LRRK2 is a risk factor for idiopathic PD. |
T3 | 245-300 | DRI_Background | denotes | How LRRK2 function is regulated is not well understood. |
T4 | 301-459 | DRI_Background | denotes | Recently, the highly conserved 14-3-3 proteins, which play a key role in many cellular functions including cell death, have been shown to interact with LRRK2. |
T5 | 460-580 | DRI_Approach | denotes | In this study, we investigated whether 14-3-3s can regulate mutant LRRK2-induced neurite shortening and kinase activity. |
T6 | 581-730 | DRI_Background | denotes | In the presence of 14-3-3θ overexpression, neurite length of primary neurons from BAC transgenic G2019S-LRRK2 mice returned back to wild-type levels. |
T7 | 731-852 | DRI_Background | denotes | Similarly, 14-3-3θ overexpression reversed neurite shortening in neuronal cultures from BAC transgenic R1441G-LRRK2 mice. |
T8 | 853-926 | DRI_Background | denotes | Conversely, inhibition of 14-3-3s by the pan-14-3-3 inhibitor difopein or |
T9 | 927-952 | Token_Label.OUTSIDE | denotes | dominant-negative 14-3-3θ |
T10 | 953-1009 | DRI_Background | denotes | further reduced neurite length in G2019S-LRRK2 cultures. |
T11 | 1010-1147 | DRI_Background | denotes | Since G2019S-LRRK2 toxicity is likely mediated through increased kinase activity, we examined 14-3-3θ's effects on LRRK2 kinase activity. |
T12 | 1148-1276 | DRI_Background | denotes | 14-3-3θ overexpression reduced the kinase activity of G2019S-LRRK2, while difopein promoted the kinase activity of G2019S-LRRK2. |
T13 | 1277-1378 | DRI_Challenge | denotes | The ability of 14-3-3θ to reduce LRRK2 kinase activity required direct binding of 14-3-3θ with LRRK2. |
T14 | 1379-1494 | DRI_Background | denotes | The potentiation of neurite shortening by difopein in G2019S-LRRK2 neurons was reversed by LRRK2 kinase inhibitors. |
T15 | 1495-1634 | DRI_Approach | denotes | Taken together, we conclude that 14-3-3θ can regulate LRRK2 and reduce the toxicity of mutant LRRK2 through a reduction of kinase activity. |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 78-244 | DRI_Approach | denotes | Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of inherited Parkinson's disease (PD), and LRRK2 is a risk factor for idiopathic PD. |
T2 | 245-300 | DRI_Background | denotes | How LRRK2 function is regulated is not well understood. |
T3 | 301-459 | DRI_Background | denotes | Recently, the highly conserved 14-3-3 proteins, which play a key role in many cellular functions including cell death, have been shown to interact with LRRK2. |
T4 | 460-580 | DRI_Approach | denotes | In this study, we investigated whether 14-3-3s can regulate mutant LRRK2-induced neurite shortening and kinase activity. |
T5 | 581-730 | DRI_Background | denotes | In the presence of 14-3-3θ overexpression, neurite length of primary neurons from BAC transgenic G2019S-LRRK2 mice returned back to wild-type levels. |
T6 | 731-852 | DRI_Background | denotes | Similarly, 14-3-3θ overexpression reversed neurite shortening in neuronal cultures from BAC transgenic R1441G-LRRK2 mice. |
T7 | 853-926 | DRI_Background | denotes | Conversely, inhibition of 14-3-3s by the pan-14-3-3 inhibitor difopein or |
T8 | 953-1009 | DRI_Background | denotes | further reduced neurite length in G2019S-LRRK2 cultures. |
T9 | 1010-1147 | DRI_Background | denotes | Since G2019S-LRRK2 toxicity is likely mediated through increased kinase activity, we examined 14-3-3θ's effects on LRRK2 kinase activity. |
T10 | 1148-1276 | DRI_Background | denotes | 14-3-3θ overexpression reduced the kinase activity of G2019S-LRRK2, while difopein promoted the kinase activity of G2019S-LRRK2. |
T11 | 1277-1378 | DRI_Challenge | denotes | The ability of 14-3-3θ to reduce LRRK2 kinase activity required direct binding of 14-3-3θ with LRRK2. |
T12 | 1379-1494 | DRI_Background | denotes | The potentiation of neurite shortening by difopein in G2019S-LRRK2 neurons was reversed by LRRK2 kinase inhibitors. |
T13 | 1495-1634 | DRI_Approach | denotes | Taken together, we conclude that 14-3-3θ can regulate LRRK2 and reduce the toxicity of mutant LRRK2 through a reduction of kinase activity. |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
26546614-1#13#41#gene120892 | 91-119 | gene120892 | denotes | leucine-rich repeat kinase 2 |
26546614-1#43#48#gene120892 | 121-126 | gene120892 | denotes | LRRK2 |
26546614-1#125#130#gene120892 | 203-208 | gene120892 | denotes | LRRK2 |
26546614-1#95#114#diseaseC0030567 | 173-192 | diseaseC0030567 | denotes | Parkinson's disease |
26546614-1#116#118#diseaseC0030567 | 194-196 | diseaseC0030567 | denotes | PD |
26546614-1#163#165#diseaseC0030567 | 241-243 | diseaseC0030567 | denotes | PD |
26546614-1#95#114#diseaseC0030567 | 173-192 | diseaseC0030567 | denotes | Parkinson's disease |
26546614-1#116#118#diseaseC0030567 | 194-196 | diseaseC0030567 | denotes | PD |
26546614-1#163#165#diseaseC0030567 | 241-243 | diseaseC0030567 | denotes | PD |
26546614-1#95#114#diseaseC0030567 | 173-192 | diseaseC0030567 | denotes | Parkinson's disease |
26546614-1#116#118#diseaseC0030567 | 194-196 | diseaseC0030567 | denotes | PD |
26546614-1#163#165#diseaseC0030567 | 241-243 | diseaseC0030567 | denotes | PD |
13#41#gene12089295#114#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,Parkinson's disease |
13#41#gene120892116#118#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,PD |
13#41#gene120892163#165#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,PD |
13#41#gene12089295#114#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,Parkinson's disease |
13#41#gene120892116#118#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,PD |
13#41#gene120892163#165#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,PD |
13#41#gene12089295#114#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,Parkinson's disease |
13#41#gene120892116#118#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,PD |
13#41#gene120892163#165#diseaseC0030567 | 26546614-1#13#41#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | leucine-rich repeat kinase 2,PD |
43#48#gene12089295#114#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | LRRK2,Parkinson's disease |
43#48#gene120892116#118#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | LRRK2,PD |
43#48#gene120892163#165#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | LRRK2,PD |
43#48#gene12089295#114#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | LRRK2,Parkinson's disease |
43#48#gene120892116#118#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | LRRK2,PD |
43#48#gene120892163#165#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | LRRK2,PD |
43#48#gene12089295#114#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | LRRK2,Parkinson's disease |
43#48#gene120892116#118#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | LRRK2,PD |
43#48#gene120892163#165#diseaseC0030567 | 26546614-1#43#48#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | LRRK2,PD |
125#130#gene12089295#114#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | LRRK2,Parkinson's disease |
125#130#gene120892116#118#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | LRRK2,PD |
125#130#gene120892163#165#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | LRRK2,PD |
125#130#gene12089295#114#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | LRRK2,Parkinson's disease |
125#130#gene120892116#118#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | LRRK2,PD |
125#130#gene120892163#165#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | LRRK2,PD |
125#130#gene12089295#114#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#95#114#diseaseC0030567 | associated_with | LRRK2,Parkinson's disease |
125#130#gene120892116#118#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#116#118#diseaseC0030567 | associated_with | LRRK2,PD |
125#130#gene120892163#165#diseaseC0030567 | 26546614-1#125#130#gene120892 | 26546614-1#163#165#diseaseC0030567 | associated_with | LRRK2,PD |