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PubMed:26408820 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-152 Sentence denotes Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer.
TextSentencer_T2 153-267 Sentence denotes The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field.
TextSentencer_T3 268-476 Sentence denotes Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis.
TextSentencer_T4 477-631 Sentence denotes Modified proteins that are immunogenic and stimulate cellular and humoral immune responses are being studied to develop early detection markers of cancer.
TextSentencer_T5 632-799 Sentence denotes This study has probed the structural alternations; leading to the formation of adducts and aggregates, in histone H2A upon in vitro modification by methylglyoxal (MG).
TextSentencer_T6 800-904 Sentence denotes The immunogenicity of modified histone H2A and its binding with cancer autoantibodies was also assessed.
TextSentencer_T7 905-1095 Sentence denotes MG induced lysine side chain modifications, blocking of free amino groups and the formation of condensed cross structures in histone H2A; and its effect was inhibited by carbonyl scavengers.
TextSentencer_T8 1096-1337 Sentence denotes It led to the adduct formation and generation of N-epsilon-(carboxyethyl)lysine (CEL) and its decomposition forms as revealed by Matrix-assisted laser desorption ionization-mass spectrometry, high-performance liquid chromatography and LC-MS.
TextSentencer_T9 1338-1467 Sentence denotes MG-H2A showed amorphous aggregate formation under electron microscopy and altered binding with DNA in circular dichroism studies.
TextSentencer_T10 1468-1643 Sentence denotes The modified histone elicited high titer immunogen-specific antibodies in rabbits when compared with the native, thus pointing toward the generation of neo-epitopes in MG-H2A.
TextSentencer_T11 1644-1830 Sentence denotes The autoantibodies derived from cancer patients exhibited enhanced binding with MG-H2A as compared with the native histone in enzyme-linked immunosorbent assay and gel retardation assay.
TextSentencer_T12 1831-1907 Sentence denotes This reflects sharing of epitopes on MG-H2A and histones in cancer patients.
TextSentencer_T13 1908-2018 Sentence denotes The neo-epitopes on H2A may be responsible for induction and elevated levels of antibodies in cancer patients.
TextSentencer_T14 2019-2118 Sentence denotes Thus, MG-H2A may be considered as potential antigenic candidate for auto-immune response in cancer.
T1 0-152 Sentence denotes Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer.
T2 153-267 Sentence denotes The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field.
T3 268-476 Sentence denotes Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis.
T4 477-631 Sentence denotes Modified proteins that are immunogenic and stimulate cellular and humoral immune responses are being studied to develop early detection markers of cancer.
T5 632-799 Sentence denotes This study has probed the structural alternations; leading to the formation of adducts and aggregates, in histone H2A upon in vitro modification by methylglyoxal (MG).
T6 800-904 Sentence denotes The immunogenicity of modified histone H2A and its binding with cancer autoantibodies was also assessed.
T7 905-1095 Sentence denotes MG induced lysine side chain modifications, blocking of free amino groups and the formation of condensed cross structures in histone H2A; and its effect was inhibited by carbonyl scavengers.
T8 1096-1337 Sentence denotes It led to the adduct formation and generation of N-epsilon-(carboxyethyl)lysine (CEL) and its decomposition forms as revealed by Matrix-assisted laser desorption ionization-mass spectrometry, high-performance liquid chromatography and LC-MS.
T9 1338-1467 Sentence denotes MG-H2A showed amorphous aggregate formation under electron microscopy and altered binding with DNA in circular dichroism studies.
T10 1468-1643 Sentence denotes The modified histone elicited high titer immunogen-specific antibodies in rabbits when compared with the native, thus pointing toward the generation of neo-epitopes in MG-H2A.
T11 1644-1830 Sentence denotes The autoantibodies derived from cancer patients exhibited enhanced binding with MG-H2A as compared with the native histone in enzyme-linked immunosorbent assay and gel retardation assay.
T12 1831-1907 Sentence denotes This reflects sharing of epitopes on MG-H2A and histones in cancer patients.
T13 1908-2018 Sentence denotes The neo-epitopes on H2A may be responsible for induction and elevated levels of antibodies in cancer patients.
T14 2019-2118 Sentence denotes Thus, MG-H2A may be considered as potential antigenic candidate for auto-immune response in cancer.
T1 0-152 Sentence denotes Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer.
T2 153-267 Sentence denotes The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field.
T3 268-476 Sentence denotes Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis.
T4 477-631 Sentence denotes Modified proteins that are immunogenic and stimulate cellular and humoral immune responses are being studied to develop early detection markers of cancer.
T5 632-799 Sentence denotes This study has probed the structural alternations; leading to the formation of adducts and aggregates, in histone H2A upon in vitro modification by methylglyoxal (MG).
T6 800-904 Sentence denotes The immunogenicity of modified histone H2A and its binding with cancer autoantibodies was also assessed.
T7 905-1095 Sentence denotes MG induced lysine side chain modifications, blocking of free amino groups and the formation of condensed cross structures in histone H2A; and its effect was inhibited by carbonyl scavengers.
T8 1096-1337 Sentence denotes It led to the adduct formation and generation of N-epsilon-(carboxyethyl)lysine (CEL) and its decomposition forms as revealed by Matrix-assisted laser desorption ionization-mass spectrometry, high-performance liquid chromatography and LC-MS.
T9 1338-1467 Sentence denotes MG-H2A showed amorphous aggregate formation under electron microscopy and altered binding with DNA in circular dichroism studies.
T10 1468-1643 Sentence denotes The modified histone elicited high titer immunogen-specific antibodies in rabbits when compared with the native, thus pointing toward the generation of neo-epitopes in MG-H2A.
T11 1644-1830 Sentence denotes The autoantibodies derived from cancer patients exhibited enhanced binding with MG-H2A as compared with the native histone in enzyme-linked immunosorbent assay and gel retardation assay.
T12 1831-1907 Sentence denotes This reflects sharing of epitopes on MG-H2A and histones in cancer patients.
T13 1908-2018 Sentence denotes The neo-epitopes on H2A may be responsible for induction and elevated levels of antibodies in cancer patients.
T14 2019-2118 Sentence denotes Thus, MG-H2A may be considered as potential antigenic candidate for auto-immune response in cancer.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T50 1648-1662 FMAID:167180 denotes autoantibodies
_T1 22-29 FMAID:74413 denotes histone
_T2 22-29 FMAID:176874 denotes histone
_T3 22-33 FMAID:84129 denotes histone H2A
_T4 22-33 FMAID:198090 denotes histone H2A
_T5 22-33 FMAID:84130 denotes histone H2A
_T6 22-33 FMAID:198088 denotes histone H2A
_T7 30-33 FMAID:198089 denotes H2A
_T8 174-181 FMAID:67257 denotes protein
_T9 174-181 FMAID:165447 denotes protein
_T10 300-308 FMAID:165447 denotes proteins
_T11 300-308 FMAID:67257 denotes proteins
_T12 471-475 FMAID:12520 denotes axis
_T13 471-475 FMAID:101260 denotes axis
_T14 486-494 FMAID:67257 denotes proteins
_T15 486-494 FMAID:165447 denotes proteins
_T16 738-745 FMAID:176874 denotes histone
_T17 738-745 FMAID:74413 denotes histone
_T18 738-749 FMAID:198088 denotes histone H2A
_T19 738-749 FMAID:84129 denotes histone H2A
_T20 738-749 FMAID:198090 denotes histone H2A
_T21 738-749 FMAID:84130 denotes histone H2A
_T22 746-749 FMAID:198089 denotes H2A
_T23 831-838 FMAID:74413 denotes histone
_T24 831-838 FMAID:176874 denotes histone
_T25 831-842 FMAID:84129 denotes histone H2A
_T26 831-842 FMAID:198088 denotes histone H2A
_T27 831-842 FMAID:84130 denotes histone H2A
_T28 831-842 FMAID:198090 denotes histone H2A
_T29 839-842 FMAID:198089 denotes H2A
_T30 871-885 FMAID:167180 denotes autoantibodies
_T31 916-922 FMAID:82758 denotes lysine
_T32 916-922 FMAID:196747 denotes lysine
_T33 1030-1037 FMAID:176874 denotes histone
_T34 1030-1037 FMAID:74413 denotes histone
_T35 1030-1041 FMAID:84130 denotes histone H2A
_T36 1030-1041 FMAID:198090 denotes histone H2A
_T37 1030-1041 FMAID:198088 denotes histone H2A
_T38 1030-1041 FMAID:84129 denotes histone H2A
_T39 1038-1041 FMAID:198089 denotes H2A
_T40 1169-1175 FMAID:82758 denotes lysine
_T41 1169-1175 FMAID:196747 denotes lysine
_T42 1305-1311 FMAID:85815 denotes liquid
_T43 1341-1344 FMAID:198089 denotes H2A
_T44 1481-1488 FMAID:176874 denotes histone
_T45 1481-1488 FMAID:74413 denotes histone
_T46 1528-1538 FMAID:167180 denotes antibodies
_T47 1586-1594 FMAID:50596 denotes pointing
_T48 1586-1594 FMAID:146304 denotes pointing
_T49 1639-1642 FMAID:198089 denotes H2A
_T51 1727-1730 FMAID:198089 denotes H2A
_T52 1759-1766 FMAID:176874 denotes histone
_T53 1759-1766 FMAID:74413 denotes histone
_T54 1871-1874 FMAID:198089 denotes H2A
_T55 1879-1887 FMAID:74413 denotes histones
_T56 1879-1887 FMAID:176874 denotes histones
_T57 1928-1931 FMAID:198089 denotes H2A
_T58 1988-1998 FMAID:167180 denotes antibodies
_T59 2028-2031 FMAID:198089 denotes H2A

uniprot-human

Id Subject Object Predicate Lexical cue
T1 22-33 http://www.uniprot.org/uniprot/P04908 denotes histone H2A
T2 738-749 http://www.uniprot.org/uniprot/P04908 denotes histone H2A
T3 831-842 http://www.uniprot.org/uniprot/P04908 denotes histone H2A
T4 1030-1041 http://www.uniprot.org/uniprot/P04908 denotes histone H2A
T5 1871-1887 http://www.uniprot.org/uniprot/P04908 denotes H2A and histones
T6 413-416 http://www.uniprot.org/uniprot/P51606 denotes AGE
T7 465-469 http://www.uniprot.org/uniprot/Q9UQ07 denotes RAGE
T8 465-469 http://www.uniprot.org/uniprot/Q3L1R6 denotes RAGE
T9 1177-1180 http://www.uniprot.org/uniprot/P19835 denotes CEL
T10 1334-1336 http://www.uniprot.org/uniprot/Q99707 denotes MS

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 413-416 http://www.uniprot.org/uniprot/P82343 denotes AGE
T2 1334-1336 http://www.uniprot.org/uniprot/A6H5Y3 denotes MS

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 145-151 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 199-205 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T3 418-427 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T4 624-630 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T5 864-870 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T6 972-978 http://purl.bioontology.org/ontology/STY/T096 denotes groups
T7 1241-1246 http://purl.bioontology.org/ontology/NCBITAXON/62990 denotes laser
T8 1388-1396 http://purl.bioontology.org/ontology/NCBITAXON/68518 denotes electron
T9 1676-1682 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T10 1891-1897 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T11 2002-2008 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T12 2111-2117 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer

GO-BP

Id Subject Object Predicate Lexical cue
T1 126-141 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T2 551-567 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T3 174-195 http://purl.obolibrary.org/obo/GO_0036211 denotes protein modifications
T4 287-308 http://purl.obolibrary.org/obo/GO_0018158 denotes oxidation of proteins
T5 413-416 http://purl.obolibrary.org/obo/GO_0007568 denotes AGE
T6 530-538 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T7 543-567 http://purl.obolibrary.org/obo/GO_0002922 denotes humoral immune responses
T8 543-567 http://purl.obolibrary.org/obo/GO_0002921 denotes humoral immune responses
T9 543-567 http://purl.obolibrary.org/obo/GO_0002920 denotes humoral immune responses
T10 543-567 http://purl.obolibrary.org/obo/GO_0006959 denotes humoral immune responses
T11 589-596 http://purl.obolibrary.org/obo/GO_0032502 denotes develop
T12 698-707 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T13 987-996 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T14 1117-1126 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T15 1372-1381 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

GO-MF

Id Subject Object Predicate Lexical cue
T1 851-858 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 1420-1427 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1711-1718 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 851-858 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T5 1420-1427 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 1711-1718 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 851-858 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T8 1420-1427 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 1711-1718 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 851-858 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11 1420-1427 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12 1711-1718 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13 1420-1436 http://purl.obolibrary.org/obo/GO_0003677 denotes binding with DNA
T14 1420-1436 http://purl.obolibrary.org/obo/GO_0003680 denotes binding with DNA
T15 1528-1538 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T16 1988-1998 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T17 1702-1718 http://purl.obolibrary.org/obo/GO_0035326 denotes enhanced binding

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 67-78 http://edamontology.org/topic_2830 denotes immunogenic
T2 145-151 http://edamontology.org/topic_2640 denotes cancer
T3 174-181 http://edamontology.org/topic_0078 denotes protein
T4 174-195 http://edamontology.org/topic_0601 denotes protein modifications
T5 174-195 http://edamontology.org/topic_3537 denotes protein modifications
T6 199-205 http://edamontology.org/topic_2640 denotes cancer
T7 300-308 http://edamontology.org/topic_0078 denotes proteins
T8 413-416 http://edamontology.org/topic_3399 denotes AGE
T9 486-494 http://edamontology.org/topic_0078 denotes proteins
T10 504-515 http://edamontology.org/topic_2830 denotes immunogenic
T11 578-585 http://edamontology.org/topic_3678 denotes studied
T12 624-630 http://edamontology.org/topic_2640 denotes cancer
T13 637-642 http://edamontology.org/topic_3678 denotes study
T14 647-653 http://edamontology.org/topic_0632 denotes probed
T15 804-818 http://edamontology.org/topic_2830 denotes immunogenicity
T16 864-870 http://edamontology.org/topic_2640 denotes cancer
T17 1269-1286 http://edamontology.org/topic_0134 denotes mass spectrometry
T18 1269-1286 http://edamontology.org/topic_3520 denotes mass spectrometry
T19 1388-1407 http://edamontology.org/topic_0611 denotes electron microscopy
T20 1397-1407 http://edamontology.org/topic_3382 denotes microscopy
T21 1459-1466 http://edamontology.org/topic_3678 denotes studies
T22 1509-1518 http://edamontology.org/topic_2830 denotes immunogen
T23 1676-1682 http://edamontology.org/topic_2640 denotes cancer
T24 1891-1897 http://edamontology.org/topic_2640 denotes cancer
T25 2002-2008 http://edamontology.org/topic_2640 denotes cancer
T26 2063-2072 http://edamontology.org/topic_2830 denotes antigenic
T27 2111-2117 http://edamontology.org/topic_2640 denotes cancer

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 0-10 http://edamontology.org/data_0883 denotes Structural
T2 51-59 http://edamontology.org/operation_3429 denotes generate
T3 174-181 http://edamontology.org/format_1208 denotes protein
T4 174-181 http://edamontology.org/data_1467 denotes protein
T5 174-198 http://edamontology.org/data_2618 denotes protein modifications in
T6 300-308 http://edamontology.org/data_1467 denotes proteins
T7 300-308 http://edamontology.org/format_1208 denotes proteins
T8 486-494 http://edamontology.org/data_1467 denotes proteins
T9 486-494 http://edamontology.org/format_1208 denotes proteins
T10 603-612 http://edamontology.org/operation_2423 denotes detection
T11 658-668 http://edamontology.org/data_0883 denotes structural
T12 698-707 http://edamontology.org/operation_0335 denotes formation
T13 698-707 http://edamontology.org/format_1915 denotes formation
T14 987-996 http://edamontology.org/format_1915 denotes formation
T15 987-996 http://edamontology.org/operation_0335 denotes formation
T16 1016-1026 http://edamontology.org/data_0883 denotes structures
T17 1016-1029 http://edamontology.org/data_1070 denotes structures in
T18 1117-1126 http://edamontology.org/format_1915 denotes formation
T19 1117-1126 http://edamontology.org/operation_0335 denotes formation
T20 1131-1141 http://edamontology.org/operation_3429 denotes generation
T21 1177-1180 http://edamontology.org/format_1638 denotes CEL
T22 1225-1231 http://edamontology.org/data_2082 denotes Matrix
T23 1269-1286 http://edamontology.org/data_3147 denotes mass spectrometry
T24 1269-1286 http://edamontology.org/data_2536 denotes mass spectrometry
T25 1372-1381 http://edamontology.org/format_1915 denotes formation
T26 1372-1381 http://edamontology.org/operation_0335 denotes formation
T27 1388-1407 http://edamontology.org/data_0941 denotes electron microscopy
T28 1388-1411 http://edamontology.org/data_1079 denotes electron microscopy and
T29 1606-1616 http://edamontology.org/operation_3429 denotes generation

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 145-151 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 199-205 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 624-630 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 864-870 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T5 1177-1180 Disease denotes CEL http://purl.obolibrary.org/obo/MONDO_0006147
T6 1676-1682 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T7 1891-1897 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T8 2002-2008 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T9 2111-2117 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 145-151 Phenotype denotes cancer HP:0002664
T2 199-205 Phenotype denotes cancer HP:0002664
T3 315-331 Phenotype denotes oxidative stress HP:0025464
T4 624-630 Phenotype denotes cancer HP:0002664
T5 864-870 Phenotype denotes cancer HP:0002664
T6 1676-1682 Phenotype denotes cancer HP:0002664
T7 1891-1897 Phenotype denotes cancer HP:0002664
T8 2002-2008 Phenotype denotes cancer HP:0002664
T9 2111-2117 Phenotype denotes cancer HP:0002664

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1084-1094 OrganismTaxon denotes scavengers 30848
T2 1542-1549 OrganismTaxon denotes rabbits 9986

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 471-475 Body_part denotes axis http://purl.obolibrary.org/obo/UBERON_0001093

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1147-1154 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025