PubMed:26272609
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-169 | Sentence | denotes | Inhibition of oncogenic epidermal growth factor receptor kinase triggers release of exosome-like extracellular vesicles and impacts their phosphoprotein and DNA content. |
| T2 | 170-256 | Sentence | denotes | Cancer cells emit extracellular vesicles (EVs) containing unique molecular signatures. |
| T3 | 257-394 | Sentence | denotes | Here, we report that the oncogenic EGF receptor (EGFR) and its inhibitors reprogram phosphoproteomes and cargo of tumor cell-derived EVs. |
| T4 | 395-592 | Sentence | denotes | Thus, phosphorylated EGFR (P-EGFR) and several other receptor tyrosine kinases can be detected in EVs purified from plasma of tumor-bearing mice and from conditioned media of cultured cancer cells. |
| T5 | 593-877 | Sentence | denotes | Treatment of EGFR-driven tumor cells with second generation EGFR kinase inhibitors (EKIs), including CI-1033 and PF-00299804 but not with anti-EGFR antibody (Cetuximab) or etoposide, triggers a burst in emission of exosome-like EVs containing EGFR, P-EGFR, and genomic DNA (exo-gDNA). |
| T6 | 878-999 | Sentence | denotes | The EV release can be attenuated by treatment with inhibitors of exosome biogenesis (GW4869) and caspase pathways (ZVAD). |
| T7 | 1000-1163 | Sentence | denotes | The content of P-EGFR isoforms (Tyr-845, Tyr-1068, and Tyr-1173), ERK, and AKT varies between cells and their corresponding EVs and as a function of EKI treatment. |
| T8 | 1164-1285 | Sentence | denotes | Immunocapture experiments reveal the presence of EGFR and exo-gDNA within the same EV population following EKI treatment. |
| T9 | 1286-1435 | Sentence | denotes | These findings suggest that targeted agents may induce cancer cells to change the EV emission profiles reflective of drug-related therapeutic stress. |
| T10 | 1436-1534 | Sentence | denotes | We suggest that EV-based assays may serve as companion diagnostics for targeted anticancer agents. |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 170-176 | Disease | denotes | Cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T2 | 371-376 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 521-526 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 579-585 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T5 | 618-623 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 1341-1347 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 535-539 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 24-40 | Body_part | denotes | epidermal growth | http://purl.obolibrary.org/obo/UBERON_0000021 |
| T2 | 84-91 | Body_part | denotes | exosome | http://purl.obolibrary.org/obo/GO_0070062 |
| T3 | 97-119 | Body_part | denotes | extracellular vesicles | http://purl.obolibrary.org/obo/GO_1903561 |
| T4 | 188-210 | Body_part | denotes | extracellular vesicles | http://purl.obolibrary.org/obo/GO_1903561 |
| T5 | 212-215 | Body_part | denotes | EVs | http://purl.obolibrary.org/obo/GO_1903561 |
| T6 | 390-393 | Body_part | denotes | EVs | http://purl.obolibrary.org/obo/GO_1903561 |
| T7 | 493-496 | Body_part | denotes | EVs | http://purl.obolibrary.org/obo/GO_1903561 |
| T8 | 511-517 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T9 | 808-815 | Body_part | denotes | exosome | http://purl.obolibrary.org/obo/GO_0070062 |
| T10 | 821-824 | Body_part | denotes | EVs | http://purl.obolibrary.org/obo/GO_1903561 |
| T11 | 943-950 | Body_part | denotes | exosome | http://purl.obolibrary.org/obo/GO_0070062 |
| T12 | 1124-1127 | Body_part | denotes | EVs | http://purl.obolibrary.org/obo/GO_1903561 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 170-176 | Phenotype | denotes | Cancer | HP:0002664 |
| T2 | 371-376 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 521-526 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 579-585 | Phenotype | denotes | cancer | HP:0002664 |
| T5 | 618-623 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 1341-1347 | Phenotype | denotes | cancer | HP:0002664 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 170-182 | Cell | denotes | Cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 371-381 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
| T3 | 579-591 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T4 | 618-629 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
| T5 | 1341-1353 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |