PubMed:26269594
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-111 | Sentence | denotes | Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3. |
| T2 | 112-240 | Sentence | denotes | Postpartum mammary gland involution is the physiological process by which the lactating gland returns to its pre-pregnant state. |
| T3 | 241-391 | Sentence | denotes | In rodent models, the microenvironment of mammary gland involution is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. |
| T4 | 392-530 | Sentence | denotes | Therefore, a deeper understanding of the physiological regulation of involution may provide in-depth information on breast cancer therapy. |
| T5 | 531-621 | Sentence | denotes | We herein identified Nucling as an important regulator of involution of the mammary gland. |
| T6 | 622-738 | Sentence | denotes | A knock-out mouse model was generated and revealed that postpartum involution were impaired in mice lacking Nucling. |
| T7 | 739-955 | Sentence | denotes | Involution is normally associated with an increase in the activation of NF-κB and STAT3, which is required for the organized regulation of involution, and was observed in WT glands, but not in the absence of Nucling. |
| T8 | 956-1106 | Sentence | denotes | Furthermore, the loss of Nucling led to the suppression of Calpain-1, IL-6, and C/EBPδ factors, which are known to be essential for normal involution. |
| T9 | 1107-1261 | Sentence | denotes | The number of M2 macrophages, which are crucial for epithelial cell death and adipocyte repopulation after weaning, was also reduced in Nucling-KO glands. |
| T10 | 1262-1439 | Sentence | denotes | Taken together, the results of the present study demonstrated that Nucling played an important role in mammary gland involution by regulating NF-κB and STAT3 signaling pathways. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 56-69 | http://purl.obolibrary.org/obo/MAT_0000073 | denotes | mammary gland |
| T2 | 64-69 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
| T3 | 123-136 | http://purl.obolibrary.org/obo/MAT_0000073 | denotes | mammary gland |
| T4 | 131-136 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
| T5 | 200-205 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
| T6 | 283-296 | http://purl.obolibrary.org/obo/MAT_0000073 | denotes | mammary gland |
| T7 | 291-296 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
| T8 | 607-620 | http://purl.obolibrary.org/obo/MAT_0000073 | denotes | mammary gland |
| T9 | 615-620 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
| T10 | 913-919 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | glands |
| T11 | 1254-1260 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | glands |
| T12 | 1365-1378 | http://purl.obolibrary.org/obo/MAT_0000073 | denotes | mammary gland |
| T13 | 1373-1378 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 341-346 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 508-521 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 56-69 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/MAT_0000073 |
| T2 | 123-136 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/MAT_0000073 |
| T3 | 200-205 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/MAT_0000021 |
| T4 | 283-296 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/MAT_0000073 |
| T5 | 607-620 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/MAT_0000073 |
| T6 | 913-919 | Body_part | denotes | glands | http://purl.obolibrary.org/obo/MAT_0000021 |
| T7 | 1254-1260 | Body_part | denotes | glands | http://purl.obolibrary.org/obo/MAT_0000021 |
| T8 | 1365-1378 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/MAT_0000073 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 341-346 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 508-521 | Phenotype | denotes | breast cancer | HP:0003002 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 634-639 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 717-721 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 56-69 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200 |
| T3 | 123-136 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200 |
| T5 | 200-205 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/UBERON_0002530 |
| T6 | 283-296 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200 |
| T8 | 508-514 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T9 | 607-620 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200 |
| T11 | 1124-1135 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T12 | 1159-1174 | Body_part | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL_0000066 |
| T13 | 1185-1194 | Body_part | denotes | adipocyte | http://purl.obolibrary.org/obo/CL_0000136 |
| T14 | 1365-1378 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 341-351 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
| T2 | 1121-1135 | Cell | denotes | M2 macrophages | http://purl.obolibrary.org/obo/CL:0000890 |
| T3 | 1159-1174 | Cell | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL:0000066 |
| T4 | 1185-1194 | Cell | denotes | adipocyte | http://purl.obolibrary.org/obo/CL:0000136 |