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PubMed:26269587 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide.
T2 108-258 Sentence denotes Hydrogen sulfide (H2S) is increasingly recognized to modulate physiological processes in mammals through mechanisms that are currently under scrutiny.
T3 259-310 Sentence denotes H2S is not able to react with reduced thiols (RSH).
T4 311-396 Sentence denotes However, H2S, more precisely HS(-), is able to react with oxidized thiol derivatives.
T5 397-547 Sentence denotes We performed a systematic study of the reactivity of HS(-) toward symmetric low molecular weight disulfides (RSSR) and mixed albumin (HSA) disulfides.
T6 548-669 Sentence denotes Correlations with thiol acidity and computational modeling showed that the reaction occurs through a concerted mechanism.
T7 670-821 Sentence denotes Comparison with analogous reactions of thiolates indicated that the intrinsic reactivity of HS(-) is 1 order of magnitude lower than that of thiolates.
T8 822-883 Sentence denotes In addition, H2S is able to react with sulfenic acids (RSOH).
T9 884-977 Sentence denotes The rate constant of the reaction of H2S with the sulfenic acid formed in HSA was determined.
T10 978-1114 Sentence denotes Both reactions of H2S with disulfides and sulfenic acids yield persulfides (RSSH), recently identified post-translational modifications.
T11 1115-1361 Sentence denotes The formation of this derivative in HSA was determined, and the rate constants of its reactions with a reporter disulfide and with peroxynitrite revealed that persulfides are better nucleophiles than thiols, which is consistent with the α effect.
T12 1362-1479 Sentence denotes Experiments with cells in culture showed that treatment with hydrogen peroxide enhanced the formation of persulfides.
T13 1480-1518 Sentence denotes Biological implications are discussed.
T14 1519-1810 Sentence denotes Our results give light on the mechanisms of persulfide formation and provide quantitative evidence for the high nucleophilicity of these novel derivatives, setting the stage for understanding the contribution of the reactions of H2S with oxidized thiol derivatives to H2S effector processes.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 531-534 Disease denotes HSA http://purl.obolibrary.org/obo/MONDO_0011848
T2 958-961 Disease denotes HSA http://purl.obolibrary.org/obo/MONDO_0011848
T3 1151-1154 Disease denotes HSA http://purl.obolibrary.org/obo/MONDO_0011848