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PubMed:26260790 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate.
T2 116-238 Sentence denotes Endurance exercise training induces substantial adaptive cardiac modifications such as left ventricular hypertrophy (LVH).
T3 239-389 Sentence denotes Simultaneously to the development of LVH, adipose tissue (AT) lipolysis becomes elevated upon endurance training to cope with enhanced energy demands.
T4 390-519 Sentence denotes In this study, we investigated the impact of adipose tissue lipolysis on the development of exercise-induced cardiac hypertrophy.
T5 520-639 Sentence denotes Mice deficient for adipose triglyceride lipase (Atgl) in AT (atATGL-KO) were challenged with chronic treadmill running.
T6 640-787 Sentence denotes Exercise-induced AT lipolytic activity was significantly reduced in atATGL-KO mice accompanied by the absence of a plasma fatty acid (FA) increase.
T7 788-972 Sentence denotes These processes were directly associated with a prominent attenuation of myocardial FA uptake in atATGL-KO and a significant reduction of the cardiac hypertrophic response to exercise.
T8 973-1149 Sentence denotes FA serum profiling revealed palmitoleic acid (C16:1n7) as a new molecular co-mediator of exercise-induced cardiac hypertrophy by inducing nonproliferative cardiomyocyte growth.
T9 1150-1242 Sentence denotes In parallel, serum FA analysis and echocardiography were performed in 25 endurance athletes.
T10 1243-1409 Sentence denotes In consonance, the serum C16:1n7 palmitoleate level exhibited a significantly positive correlation with diastolic interventricular septum thickness in those athletes.
T11 1410-1512 Sentence denotes No correlation existed between linoleic acid (18:2n6) and diastolic interventricular septum thickness.
T12 1513-1738 Sentence denotes Collectively, our data provide the first evidence that adipose tissue lipolysis directly promotes the development of exercise-induced cardiac hypertrophy involving the lipokine C16:1n7 palmitoleate as a molecular co-mediator.
T13 1739-1900 Sentence denotes The identification of a lipokine involved in physiological cardiac growth may help to develop future lipid-based therapies for pathological LVH or heart failure.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 0-14 http://purl.obolibrary.org/obo/MAT_0000015 denotes Adipose Tissue
T2 281-295 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T3 435-449 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T4 1568-1582 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T5 1886-1891 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1886-1899 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 520-524 OrganismTaxon denotes Mice 10088
T2 718-722 OrganismTaxon denotes mice 10088
T3 836-845 OrganismTaxon denotes prominent 37571
T4 1233-1241 OrganismTaxon denotes athletes 1337349
T5 1400-1408 OrganismTaxon denotes athletes 1337349

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-14 Body_part denotes Adipose Tissue http://purl.obolibrary.org/obo/UBERON_0001013
T2 281-295 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T3 435-449 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T4 539-546 Body_part denotes adipose http://purl.obolibrary.org/obo/UBERON_0001013
T5 755-761 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T6 1128-1141 Body_part denotes cardiomyocyte http://purl.obolibrary.org/obo/CL_0000746
T7 1357-1380 Body_part denotes interventricular septum http://purl.obolibrary.org/obo/UBERON_0002094
T8 1478-1501 Body_part denotes interventricular septum http://purl.obolibrary.org/obo/UBERON_0002094
T9 1568-1582 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T10 1886-1891 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 0-14 Body_part denotes Adipose Tissue http://purl.obolibrary.org/obo/MAT_0000015
T2 281-295 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/MAT_0000015
T3 435-449 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/MAT_0000015
T4 1568-1582 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/MAT_0000015
T5 1886-1891 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 203-231 Phenotype denotes left ventricular hypertrophy HP:0001712
T2 233-236 Phenotype denotes LVH HP:0001712
T3 276-279 Phenotype denotes LVH HP:0001712
T4 1879-1882 Phenotype denotes LVH HP:0001712
T5 1886-1899 Phenotype denotes heart failure HP:0001635

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1128-1141 Cell denotes cardiomyocyte http://purl.obolibrary.org/obo/CL:0000746