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GoldHamster

Id Subject Object Predicate Lexical cue
T1 15-28 GO:0005576 denotes extracellular
T5 29-48 CHEBI:37397 denotes chondroitin sulfate
T6 29-48 D002809 denotes chondroitin sulfate
T7 29-48 D002809 denotes chondroitin sulfate
T9 117-124 CHEBI:16189 denotes sulfate
T10 125-138 CHEBI:37396 denotes proteoglycans
T11 125-138 D011509 denotes proteoglycans
T12 125-138 D011509 denotes proteoglycans
T13 169-179 D014714 denotes vertebrate
T14 253-263 GO:0065007 denotes regulation
T17 686-692 CVCL_E025 denotes Cancer
T15 686-692 D009369 denotes Cancer
T16 686-692 D009369 denotes Cancer
T18 686-701 39395 denotes Cancer borealis
T19 771-782 GO:0042592 denotes homeostasis
T22 847-855 UBERON:0000045 denotes ganglion
T20 847-855 D045888 denotes ganglion
T21 847-855 D045888 denotes ganglion
T23 872-886 P34059 denotes chondroitinase
T24 872-886 Q8WNQ7 denotes chondroitinase
T25 872-886 Q32KJ6 denotes chondroitinase
T26 872-886 Q571E4 denotes chondroitinase
T27 872-886 PR:000007817 denotes chondroitinase
T28 872-886 Q32KH5 denotes chondroitinase
T30 872-886 R4J7Z9 denotes chondroitinase
T29 872-886 GO:0043890 denotes chondroitinase
T31 872-890 D019765 denotes chondroitinase ABC
T32 887-890 PR:P30750 denotes ABC
T34 887-890 PR:000023218 denotes ABC
T35 962-968 GO:0048511 denotes rhythm
T36 1103-1109 GO:0048511 denotes rhythm
T37 1141-1147 GO:0048511 denotes rhythm
T39 1297-1317 GO:0031012 denotes extracellular matrix
T40 1311-1317 UBERON:0027368 denotes matrix

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 105-286 DRI_Background denotes Chondroitin sulfate proteoglycans (CSPGs) are widely studied in vertebrate systems and are known to play a key role in development, plasticity, and regulation of cortical circuitry.
T2 287-458 DRI_Challenge denotes The mechanistic details of this role are still elusive, but increasingly central to the investigation is the homeostatic balance between network excitation and inhibition.
T3 459-591 DRI_Challenge denotes Studying a simpler neuronal circuit may prove advantageous for discovering the mechanistic details of the cellular effects of CSPGs.
T4 592-783 DRI_Approach denotes In this study we used a well-established model of homeostatic change after injury in the crab Cancer borealis to show first evidence that CSPGs are necessary for network activity homeostasis.
T5 784-1066 DRI_Outcome denotes We degraded CSPGs in the pyloric circuit of the stomatogastric ganglion with the enzyme chondroitinase ABC (chABC) and found that removal of CSPGs does not influence the ongoing rhythm of the pyloric circuit but does limit its capacity for recovery after a networkwide perturbation.
T6 1067-1168 DRI_Outcome denotes Without CSPGs, the postperturbation rhythm is slower than in controls and rhythm recovery is delayed.
T7 1169-1452 DRI_Background denotes In addition to providing a new model system for the study of CSPGs, this study suggests a wider role for CSPGs, and perhaps the extracellular matrix in general, beyond simply plastic reorganization (as observed in mammals) and into a foundational regulatory role of neural circuitry.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 76-84 CVCL_C410|Hybridoma|Mus musculus denotes activity
T2 210-211 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 468-469 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 495-498 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T5 606-608 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T6 614-615 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 654-660 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T8 686-692 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes Cancer
T9 762-770 CVCL_C410|Hybridoma|Mus musculus denotes activity
T10 784-786 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T11 1039-1040 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 1194-1195 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T13 1257-1258 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 1401-1402 CVCL_6479|Finite_cell_line|Mus musculus denotes a