> top > docs > PubMed:26088564 > annotations

PubMed:26088564 JSONTXT

Annnotations TAB JSON ListView MergeView

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 437-451 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl-Lewis X

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 437-451 Glycan_Motif denotes sialyl-Lewis X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
TextSentencer_T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
TextSentencer_T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
TextSentencer_T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
TextSentencer_T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
TextSentencer_T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
TextSentencer_T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
TextSentencer_T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
TextSentencer_T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
TextSentencer_T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
TextSentencer_T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
TextSentencer_T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 437-451 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl-Lewis X
T2 444-451 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 437-451 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl-Lewis X
T2 444-451 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis X

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 41-53 FMAID:62925 denotes glycoprotein
_T2 41-53 FMAID:167256 denotes glycoprotein
_T3 128-140 FMAID:167256 denotes glycoprotein
_T4 128-140 FMAID:62925 denotes glycoprotein
_T5 168-174 FMAID:162307 denotes plasma
_T6 175-187 FMAID:167256 denotes glycoprotein
_T7 175-187 FMAID:62925 denotes glycoprotein
_T8 493-501 FMAID:61795 denotes selectin
_T9 493-501 FMAID:165243 denotes selectin
_T10 502-510 FMAID:67257 denotes proteins
_T11 502-510 FMAID:165447 denotes proteins
_T12 1037-1043 FMAID:50596 denotes points
_T13 1037-1043 FMAID:146304 denotes points
_T14 1234-1241 FMAID:165447 denotes protein
_T15 1234-1241 FMAID:67257 denotes protein
_T16 1367-1376 FMAID:165656 denotes compounds
_T17 1367-1376 FMAID:67745 denotes compounds
_T18 1453-1462 FMAID:61795 denotes selectins
_T19 1453-1462 FMAID:165243 denotes selectins
_T20 1488-1494 FMAID:30332 denotes latter
_T21 1488-1494 FMAID:171168 denotes latter
_T22 1646-1651 FMAID:146304 denotes point
_T23 1646-1651 FMAID:50596 denotes point
_T24 1685-1698 FMAID:82737 denotes carbohydrates
_T25 1685-1698 FMAID:197276 denotes carbohydrates

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 322-328 http://purl.bioontology.org/ontology/STY/T051 denotes events
T2 338-344 http://purl.bioontology.org/ontology/STY/T051 denotes events
T3 746-765 http://purl.bioontology.org/ontology/STY/T039 denotes biological function

GO-BP

Id Subject Object Predicate Lexical cue
T1 100-112 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 1749-1761 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3 202-214 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T4 931-943 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T5 1083-1096 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 410-421 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylated
T7 1408-1420 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylation
T8 437-443 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl

GO-MF

Id Subject Object Predicate Lexical cue
T1 488-492 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T2 1277-1284 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1442-1449 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 1562-1569 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 488-492 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T6 1277-1284 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 1442-1449 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 1562-1569 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 488-492 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T10 1277-1284 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T11 1442-1449 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T12 1562-1569 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 488-492 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T14 1277-1284 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15 1442-1449 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16 1562-1569 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T17 493-501 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T18 1453-1462 http://purl.obolibrary.org/obo/GO_0030246 denotes selectins
T19 1270-1276 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 27-32 http://edamontology.org/topic_2815 denotes human
T2 79-95 http://edamontology.org/topic_3375 denotes pharmacokinetics
T3 114-119 http://edamontology.org/topic_2815 denotes Human
T4 162-167 http://edamontology.org/topic_2815 denotes human
T5 263-279 http://edamontology.org/topic_3375 denotes pharmacokinetics
T6 502-510 http://edamontology.org/topic_0078 denotes proteins
T7 544-560 http://edamontology.org/topic_3400 denotes immunomodulation
T8 697-719 http://edamontology.org/topic_0081 denotes its structural biology
T9 701-719 http://edamontology.org/topic_1317 denotes structural biology
T10 712-719 http://edamontology.org/topic_3070 denotes biology
T11 1104-1125 http://edamontology.org/topic_0694 denotes s secondary structure
T12 1104-1125 http://edamontology.org/topic_3542 denotes s secondary structure
T13 1145-1160 http://edamontology.org/topic_2828 denotes crystallography
T14 1234-1241 http://edamontology.org/topic_0078 denotes protein
T15 1234-1250 http://edamontology.org/topic_0176 denotes protein dynamics
T16 1685-1698 http://edamontology.org/topic_0152 denotes carbohydrates
T17 1728-1744 http://edamontology.org/topic_3375 denotes pharmacokinetics

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 0-10 http://edamontology.org/data_0883 denotes Structural
T2 142-145 http://edamontology.org/format_3693 denotes AGP
T3 234-237 http://edamontology.org/format_3693 denotes AGP
T4 502-510 http://edamontology.org/format_1208 denotes proteins
T5 502-510 http://edamontology.org/data_1467 denotes proteins
T6 578-587 http://edamontology.org/data_0883 denotes structure
T7 606-609 http://edamontology.org/format_3693 denotes AGP
T8 619-627 http://edamontology.org/data_2048 denotes reported
T9 701-711 http://edamontology.org/data_0883 denotes structural
T10 843-853 http://edamontology.org/data_0883 denotes structural
T11 883-886 http://edamontology.org/format_3693 denotes AGP
T12 901-911 http://edamontology.org/data_0883 denotes structural
T13 1032-1036 http://edamontology.org/data_0006 denotes data
T14 1100-1103 http://edamontology.org/format_3693 denotes AGP
T15 1104-1125 http://edamontology.org/operation_2488 denotes s secondary structure
T16 1104-1125 http://edamontology.org/data_0880 denotes s secondary structure
T17 1106-1125 http://edamontology.org/data_2881 denotes secondary structure
T18 1106-1125 http://edamontology.org/data_2081 denotes secondary structure
T19 1106-1125 http://edamontology.org/data_0880 denotes secondary structure
T20 1106-1125 http://edamontology.org/operation_0500 denotes secondary structure
T21 1106-1125 http://edamontology.org/operation_2482 denotes secondary structure
T22 1106-1125 http://edamontology.org/data_2973 denotes secondary structure
T23 1106-1125 http://edamontology.org/data_2880 denotes secondary structure
T24 1106-1125 http://edamontology.org/data_2366 denotes secondary structure
T25 1116-1125 http://edamontology.org/data_0883 denotes structure
T26 1234-1241 http://edamontology.org/data_1467 denotes protein
T27 1234-1241 http://edamontology.org/format_1208 denotes protein
T28 1266-1269 http://edamontology.org/format_3693 denotes AGP
T29 1270-1289 http://edamontology.org/operation_0482 denotes ligand-binding site
T30 1424-1427 http://edamontology.org/format_3693 denotes AGP
T31 1428-1437 http://edamontology.org/data_0883 denotes structure
T32 1715-1718 http://edamontology.org/format_3693 denotes AGP

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1488-1494 http://purl.obolibrary.org/obo/MAT_0000488 denotes latter

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 437-449 http://rdf.glycoinfo.org/glycan/G00053MO denotes sialyl-Lewis
T2 437-451 http://rdf.glycoinfo.org/glycan/G00054MO denotes sialyl-Lewis X
T3 444-449 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T4 444-451 http://rdf.glycoinfo.org/glycan/G00051MO denotes Lewis X

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 493-501 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T2 493-501 https://acgg.asia/db/lfdb/LfDB0043 denotes selectin
Lectin_T3 493-501 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 437-449 http://www.glycoepitope.jp/epitopes/EP0008 denotes sialyl-Lewis
PD-GlycoEpitope-B_T2 437-451 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl-Lewis X
PD-GlycoEpitope-B_T3 444-451 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis X

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 100-112 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 1749-1761 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 444-451 Glycan denotes Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 437-451 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl-Lewis X http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 100-112 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 1749-1761 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 27-32 OrganismTaxon denotes human 9606
T2 114-119 OrganismTaxon denotes Human 9606
T3 162-167 OrganismTaxon denotes human 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 168-174 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
TextSentencer_T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
TextSentencer_T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
TextSentencer_T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
TextSentencer_T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
TextSentencer_T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
TextSentencer_T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
TextSentencer_T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
TextSentencer_T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
TextSentencer_T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
TextSentencer_T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
TextSentencer_T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue glycosmos_id image
T1 444-451 Glycan denotes Lewis X https://glycosmos.org/glycans/show/G00051MO https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 437-451 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl-Lewis X http://www.glycoepitope.jp/epitopes/EP0012

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 27-32 OrganismTaxon denotes human 9606
T2 114-119 OrganismTaxon denotes Human 9606
T3 162-167 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 168-174 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969