PubMed:26033936
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 138-154 | Cell | denotes | eukaryotic cells | http://purl.obolibrary.org/obo/CL:0000255 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-64 | Sentence | denotes | Glycosaminoglycans affect heparanase location in CHO cell lines. |
| TextSentencer_T2 | 65-134 | Sentence | denotes | Glycosaminoglycans (GAG) play a ubiquitous role in tissues and cells. |
| TextSentencer_T3 | 135-253 | Sentence | denotes | In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-β-glucuronidase called heparanase-1 (HPSE). |
| TextSentencer_T4 | 254-422 | Sentence | denotes | HS oligosaccharides generated by the action of HPSE intensify the activity of signaling molecules, activating inflammatory response, tumor metastasis, and angiogenesis. |
| TextSentencer_T5 | 423-580 | Sentence | denotes | The aim of the present study was to understand if sulfated GAG could modulate HPSE, since the mechanisms that regulate HPSE have not been completely defined. |
| TextSentencer_T6 | 581-755 | Sentence | denotes | CHO-K1 cells were treated with 4-methylumbelliferone (4-MU) and sodium chlorate, to promote total inhibition of GAG synthesis, and reduce the sulfation pattern, respectively. |
| TextSentencer_T7 | 756-889 | Sentence | denotes | The GAG profile of the wild CHO-K1 cells and CHO-745, deficient in xylosyltransferase, was determined after [(35)S]-sulfate labeling. |
| TextSentencer_T8 | 890-974 | Sentence | denotes | HPSE expression was determined via real-time quantitative polymerase chain reaction. |
| TextSentencer_T9 | 975-1086 | Sentence | denotes | Total ablation of GAG with 4-MU in CHO-K1 inhibited HPSE expression, while the lack of sulfation had no effect. |
| TextSentencer_T10 | 1087-1155 | Sentence | denotes | Interestingly, 4-MU had no effect in CHO-745 cells for these assays. |
| TextSentencer_T11 | 1156-1370 | Sentence | denotes | In addition, a different enzyme location was observed in CHO-K1 wild-type cells, which presents HPSE mainly in the extracellular matrix, in comparison with the CHO-745 mutant cells, which is found in the cytoplasm. |
| TextSentencer_T12 | 1371-1477 | Sentence | denotes | In view of our results, we can conclude that GAG are essential modulators of HPSE expression and location. |
| TextSentencer_T13 | 1478-1563 | Sentence | denotes | Therefore, GAG profile could impact cell behavior mediated by the regulation of HPSE. |
| T1 | 0-64 | Sentence | denotes | Glycosaminoglycans affect heparanase location in CHO cell lines. |
| T2 | 65-134 | Sentence | denotes | Glycosaminoglycans (GAG) play a ubiquitous role in tissues and cells. |
| T3 | 135-253 | Sentence | denotes | In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-β-glucuronidase called heparanase-1 (HPSE). |
| T4 | 254-422 | Sentence | denotes | HS oligosaccharides generated by the action of HPSE intensify the activity of signaling molecules, activating inflammatory response, tumor metastasis, and angiogenesis. |
| T5 | 423-580 | Sentence | denotes | The aim of the present study was to understand if sulfated GAG could modulate HPSE, since the mechanisms that regulate HPSE have not been completely defined. |
| T6 | 581-755 | Sentence | denotes | CHO-K1 cells were treated with 4-methylumbelliferone (4-MU) and sodium chlorate, to promote total inhibition of GAG synthesis, and reduce the sulfation pattern, respectively. |
| T7 | 756-889 | Sentence | denotes | The GAG profile of the wild CHO-K1 cells and CHO-745, deficient in xylosyltransferase, was determined after [(35)S]-sulfate labeling. |
| T8 | 890-974 | Sentence | denotes | HPSE expression was determined via real-time quantitative polymerase chain reaction. |
| T9 | 975-1086 | Sentence | denotes | Total ablation of GAG with 4-MU in CHO-K1 inhibited HPSE expression, while the lack of sulfation had no effect. |
| T10 | 1087-1155 | Sentence | denotes | Interestingly, 4-MU had no effect in CHO-745 cells for these assays. |
| T11 | 1156-1370 | Sentence | denotes | In addition, a different enzyme location was observed in CHO-K1 wild-type cells, which presents HPSE mainly in the extracellular matrix, in comparison with the CHO-745 mutant cells, which is found in the cytoplasm. |
| T12 | 1371-1477 | Sentence | denotes | In view of our results, we can conclude that GAG are essential modulators of HPSE expression and location. |
| T13 | 1478-1563 | Sentence | denotes | Therefore, GAG profile could impact cell behavior mediated by the regulation of HPSE. |
| T1 | 0-64 | Sentence | denotes | Glycosaminoglycans affect heparanase location in CHO cell lines. |
| T2 | 65-134 | Sentence | denotes | Glycosaminoglycans (GAG) play a ubiquitous role in tissues and cells. |
| T3 | 135-253 | Sentence | denotes | In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-β-glucuronidase called heparanase-1 (HPSE). |
| T4 | 254-422 | Sentence | denotes | HS oligosaccharides generated by the action of HPSE intensify the activity of signaling molecules, activating inflammatory response, tumor metastasis, and angiogenesis. |
| T5 | 423-580 | Sentence | denotes | The aim of the present study was to understand if sulfated GAG could modulate HPSE, since the mechanisms that regulate HPSE have not been completely defined. |
| T6 | 581-755 | Sentence | denotes | CHO-K1 cells were treated with 4-methylumbelliferone (4-MU) and sodium chlorate, to promote total inhibition of GAG synthesis, and reduce the sulfation pattern, respectively. |
| T7 | 756-889 | Sentence | denotes | The GAG profile of the wild CHO-K1 cells and CHO-745, deficient in xylosyltransferase, was determined after [(35)S]-sulfate labeling. |
| T8 | 890-974 | Sentence | denotes | HPSE expression was determined via real-time quantitative polymerase chain reaction. |
| T9 | 975-1086 | Sentence | denotes | Total ablation of GAG with 4-MU in CHO-K1 inhibited HPSE expression, while the lack of sulfation had no effect. |
| T10 | 1087-1155 | Sentence | denotes | Interestingly, 4-MU had no effect in CHO-745 cells for these assays. |
| T11 | 1156-1370 | Sentence | denotes | In addition, a different enzyme location was observed in CHO-K1 wild-type cells, which presents HPSE mainly in the extracellular matrix, in comparison with the CHO-745 mutant cells, which is found in the cytoplasm. |
| T12 | 1371-1477 | Sentence | denotes | In view of our results, we can conclude that GAG are essential modulators of HPSE expression and location. |
| T13 | 1478-1563 | Sentence | denotes | Therefore, GAG profile could impact cell behavior mediated by the regulation of HPSE. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 156-171 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 173-175 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T3 | 254-256 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 0-18 | FMAID:63011 | denotes | Glycosaminoglycans |
| _T2 | 0-18 | FMAID:167395 | denotes | Glycosaminoglycans |
| _T3 | 65-83 | FMAID:63011 | denotes | Glycosaminoglycans |
| _T4 | 65-83 | FMAID:167395 | denotes | Glycosaminoglycans |
| _T5 | 85-88 | FMAID:167404 | denotes | GAG |
| _T6 | 116-123 | FMAID:256050 | denotes | tissues |
| _T7 | 124-133 | FMAID:200932 | denotes | and cells |
| _T8 | 124-133 | FMAID:86471 | denotes | and cells |
| _T9 | 128-133 | FMAID:169002 | denotes | cells |
| _T10 | 128-133 | FMAID:68646 | denotes | cells |
| _T11 | 149-154 | FMAID:68646 | denotes | cells |
| _T12 | 149-154 | FMAID:169002 | denotes | cells |
| _T13 | 156-163 | FMAID:67110 | denotes | heparan |
| _T14 | 156-163 | FMAID:165191 | denotes | heparan |
| _T15 | 156-171 | FMAID:167405 | denotes | heparan sulfate |
| _T16 | 156-171 | FMAID:63023 | denotes | heparan sulfate |
| _T17 | 257-273 | FMAID:82742 | denotes | oligosaccharides |
| _T18 | 257-273 | FMAID:196731 | denotes | oligosaccharides |
| _T19 | 482-485 | FMAID:167404 | denotes | GAG |
| _T20 | 588-593 | FMAID:169002 | denotes | cells |
| _T21 | 588-593 | FMAID:68646 | denotes | cells |
| _T22 | 693-696 | FMAID:167404 | denotes | GAG |
| _T23 | 760-763 | FMAID:167404 | denotes | GAG |
| _T24 | 791-796 | FMAID:169002 | denotes | cells |
| _T25 | 791-796 | FMAID:68646 | denotes | cells |
| _T26 | 993-996 | FMAID:167404 | denotes | GAG |
| _T27 | 1132-1137 | FMAID:169002 | denotes | cells |
| _T28 | 1132-1137 | FMAID:68646 | denotes | cells |
| _T29 | 1230-1235 | FMAID:169002 | denotes | cells |
| _T30 | 1230-1235 | FMAID:68646 | denotes | cells |
| _T31 | 1271-1291 | FMAID:165194 | denotes | extracellular matrix |
| _T32 | 1271-1291 | FMAID:265717 | denotes | extracellular matrix |
| _T33 | 1331-1336 | FMAID:68646 | denotes | cells |
| _T34 | 1331-1336 | FMAID:169002 | denotes | cells |
| _T35 | 1360-1369 | FMAID:164989 | denotes | cytoplasm |
| _T36 | 1360-1369 | FMAID:66835 | denotes | cytoplasm |
| _T37 | 1360-1369 | FMAID:165187 | denotes | cytoplasm |
| _T38 | 1416-1419 | FMAID:167404 | denotes | GAG |
| _T39 | 1489-1492 | FMAID:167404 | denotes | GAG |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 26-36 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | heparanase |
| T2 | 233-245 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | heparanase-1 |
| T3 | 247-251 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T4 | 301-305 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T5 | 501-505 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T6 | 542-546 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T7 | 890-894 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T8 | 1027-1031 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T9 | 1252-1256 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T10 | 1448-1452 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T11 | 1558-1562 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HPSE |
| T12 | 210-225 | http://www.uniprot.org/uniprot/P08236 | denotes | β-glucuronidase |
| T13 | 585-587 | http://www.uniprot.org/uniprot/P04264 | denotes | K1 |
| T14 | 788-790 | http://www.uniprot.org/uniprot/P04264 | denotes | K1 |
| T15 | 1014-1016 | http://www.uniprot.org/uniprot/P04264 | denotes | K1 |
| T16 | 1217-1219 | http://www.uniprot.org/uniprot/P04264 | denotes | K1 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 26-36 | http://www.uniprot.org/uniprot/Q6YGZ1 | denotes | heparanase |
| T2 | 233-243 | http://www.uniprot.org/uniprot/Q6YGZ1 | denotes | heparanase |
| T3 | 210-225 | http://www.uniprot.org/uniprot/P12265 | denotes | β-glucuronidase |
| T4 | 585-587 | http://www.uniprot.org/uniprot/P04104 | denotes | K1 |
| T5 | 788-790 | http://www.uniprot.org/uniprot/P04104 | denotes | K1 |
| T6 | 1014-1016 | http://www.uniprot.org/uniprot/P04104 | denotes | K1 |
| T7 | 1217-1219 | http://www.uniprot.org/uniprot/P04104 | denotes | K1 |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 116-123 | http://purl.bioontology.org/ontology/STY/T024 | denotes | tissues |
| T2 | 128-133 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T3 | 138-148 | http://purl.bioontology.org/ontology/NCBITAXON/2759 | denotes | eukaryotic |
| T4 | 149-154 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T5 | 517-527 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanisms |
| T6 | 588-593 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T7 | 637-639 | http://purl.bioontology.org/ontology/NCBITAXON/10088 | denotes | MU |
| T8 | 791-796 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T9 | 1004-1006 | http://purl.bioontology.org/ontology/NCBITAXON/10088 | denotes | MU |
| T10 | 1104-1106 | http://purl.bioontology.org/ontology/NCBITAXON/10088 | denotes | MU |
| T11 | 1132-1137 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T12 | 1230-1235 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T13 | 1331-1336 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T14 | 1519-1527 | http://purl.bioontology.org/ontology/STY/T053 | denotes | behavior |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 49-52 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T2 | 581-584 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T3 | 784-787 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T4 | 801-804 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T5 | 1010-1013 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T6 | 1124-1127 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T7 | 1213-1216 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T8 | 1316-1319 | http://purl.obolibrary.org/obo/GO_0043848 | denotes | CHO |
| T9 | 164-171 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T10 | 473-481 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfated |
| T11 | 723-732 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfation |
| T12 | 1062-1071 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfation |
| T13 | 190-198 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degraded |
| T14 | 332-341 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T15 | 353-385 | http://purl.obolibrary.org/obo/GO_0002675 | denotes | activating inflammatory response |
| T16 | 353-385 | http://purl.obolibrary.org/obo/GO_0002678 | denotes | activating inflammatory response |
| T17 | 353-385 | http://purl.obolibrary.org/obo/GO_0050729 | denotes | activating inflammatory response |
| T18 | 364-385 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T19 | 409-421 | http://purl.obolibrary.org/obo/GO_0001525 | denotes | angiogenesis |
| T20 | 533-541 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulate |
| T21 | 1544-1554 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T22 | 697-706 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T23 | 1519-1527 | http://purl.obolibrary.org/obo/GO_0007610 | denotes | behavior |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 53-57 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T2 | 128-133 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T3 | 149-154 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T4 | 588-593 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T5 | 791-796 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T6 | 1132-1137 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7 | 1230-1235 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 1331-1336 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T9 | 1271-1284 | http://purl.obolibrary.org/obo/GO_0005576 | denotes | extracellular |
| T10 | 1271-1291 | http://purl.obolibrary.org/obo/GO_0031012 | denotes | extracellular matrix |
| T11 | 1360-1369 | http://purl.obolibrary.org/obo/GO_0005737 | denotes | cytoplasm |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 116-123 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 156-171 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| PD-GlycoEpitope-B_T2 | 880-888 | id | denotes | labeling |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 116-123 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 387-392 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 387-392 | Phenotype | denotes | tumor | HP:0002664 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 138-154 | Body_part | denotes | eukaryotic cells | http://purl.obolibrary.org/obo/CL_0000255 |
| T2 | 1271-1291 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T3 | 1360-1369 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |