PubMed:25962635 / 701-1546 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25962635","sourcedb":"PubMed","sourceid":"25962635","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25962635","text":"Genome-wide identification of transcripts associated with BRAT or with PUM in Drosophila embryos shows that they bind largely non-overlapping sets of mRNAs. BRAT binds mRNAs that encode proteins associated with a variety of functions, many of which are distinct from those implemented by PUM-associated transcripts. Computational analysis of in vitro and in vivo data identified a novel RNA motif recognized by BRAT that confers BRAT-mediated regulation in tissue culture cells. The regulatory status of BRAT-associated mRNAs suggests a prominent role for BRAT in post-transcriptional regulation, including a previously unidentified role in transcript degradation. Transcriptomic analysis of embryos lacking functional BRAT reveals an important role in mediating the decay of hundreds of maternal mRNAs during the maternal-to-zygotic transition.","tracks":[{"project":"GoldHamster","denotations":[{"id":"T190","span":{"begin":0,"end":6},"obj":"SO:0001026"},{"id":"T191","span":{"begin":58,"end":62},"obj":"PR:Q8MQJ9"},{"id":"T192","span":{"begin":71,"end":74},"obj":"PR:000001890"},{"id":"T193","span":{"begin":71,"end":74},"obj":"PR:000013492"},{"id":"T194","span":{"begin":71,"end":74},"obj":"PR:P25822"},{"id":"T195","span":{"begin":71,"end":74},"obj":"PR:P15941"},{"id":"T196","span":{"begin":71,"end":74},"obj":"P15941"},{"id":"T197","span":{"begin":78,"end":88},"obj":"2294143"},{"id":"T198","span":{"begin":78,"end":88},"obj":"504603"},{"id":"T199","span":{"begin":78,"end":88},"obj":"2294139"},{"id":"T200","span":{"begin":78,"end":88},"obj":"2294145"},{"id":"T201","span":{"begin":78,"end":88},"obj":"2294141"},{"id":"T202","span":{"begin":78,"end":88},"obj":"2294142"},{"id":"T203","span":{"begin":78,"end":88},"obj":"2294144"},{"id":"T204","span":{"begin":78,"end":88},"obj":"2294140"},{"id":"T205","span":{"begin":78,"end":88},"obj":"D004330"},{"id":"T206","span":{"begin":78,"end":88},"obj":"2080301"},{"id":"T207","span":{"begin":130,"end":141},"obj":"SO:0000068"},{"id":"T208","span":{"begin":157,"end":161},"obj":"PR:Q8MQJ9"},{"id":"T209","span":{"begin":186,"end":194},"obj":"CHEBI:36080"},{"id":"T210","span":{"begin":288,"end":291},"obj":"PR:000001890"},{"id":"T211","span":{"begin":288,"end":291},"obj":"PR:000013492"},{"id":"T212","span":{"begin":288,"end":291},"obj":"PR:P25822"},{"id":"T213","span":{"begin":288,"end":291},"obj":"PR:P15941"},{"id":"T214","span":{"begin":288,"end":291},"obj":"P15941"},{"id":"T215","span":{"begin":387,"end":390},"obj":"CHEBI:33697"},{"id":"T216","span":{"begin":387,"end":390},"obj":"D012313"},{"id":"T217","span":{"begin":387,"end":390},"obj":"GO:0005562"},{"id":"T219","span":{"begin":387,"end":396},"obj":"SO:0000715"},{"id":"T222","span":{"begin":411,"end":415},"obj":"PR:Q8MQJ9"},{"id":"T223","span":{"begin":429,"end":433},"obj":"PR:Q8MQJ9"},{"id":"T224","span":{"begin":443,"end":453},"obj":"GO:0065007"},{"id":"T225","span":{"begin":457,"end":463},"obj":"UBERON:0000479"},{"id":"T226","span":{"begin":504,"end":508},"obj":"PR:Q8MQJ9"},{"id":"T227","span":{"begin":556,"end":560},"obj":"PR:Q8MQJ9"},{"id":"T228","span":{"begin":585,"end":595},"obj":"GO:0065007"},{"id":"T229","span":{"begin":620,"end":632},"obj":"32644"},{"id":"T230","span":{"begin":641,"end":651},"obj":"SO:0000673"},{"id":"T231","span":{"begin":652,"end":663},"obj":"GO:0009056"},{"id":"T232","span":{"begin":719,"end":723},"obj":"PR:Q8MQJ9"},{"id":"T233","span":{"begin":834,"end":844},"obj":"SO:1000009"}],"attributes":[{"subj":"T190","pred":"source","obj":"GoldHamster"},{"subj":"T191","pred":"source","obj":"GoldHamster"},{"subj":"T192","pred":"source","obj":"GoldHamster"},{"subj":"T193","pred":"source","obj":"GoldHamster"},{"subj":"T194","pred":"source","obj":"GoldHamster"},{"subj":"T195","pred":"source","obj":"GoldHamster"},{"subj":"T196","pred":"source","obj":"GoldHamster"},{"subj":"T197","pred":"source","obj":"GoldHamster"},{"subj":"T198","pred":"source","obj":"GoldHamster"},{"subj":"T199","pred":"source","obj":"GoldHamster"},{"subj":"T200","pred":"source","obj":"GoldHamster"},{"subj":"T201","pred":"source","obj":"GoldHamster"},{"subj":"T202","pred":"source","obj":"GoldHamster"},{"subj":"T203","pred":"source","obj":"GoldHamster"},{"subj":"T204","pred":"source","obj":"GoldHamster"},{"subj":"T205","pred":"source","obj":"GoldHamster"},{"subj":"T206","pred":"source","obj":"GoldHamster"},{"subj":"T207","pred":"source","obj":"GoldHamster"},{"subj":"T208","pred":"source","obj":"GoldHamster"},{"subj":"T209","pred":"source","obj":"GoldHamster"},{"subj":"T210","pred":"source","obj":"GoldHamster"},{"subj":"T211","pred":"source","obj":"GoldHamster"},{"subj":"T212","pred":"source","obj":"GoldHamster"},{"subj":"T213","pred":"source","obj":"GoldHamster"},{"subj":"T214","pred":"source","obj":"GoldHamster"},{"subj":"T215","pred":"source","obj":"GoldHamster"},{"subj":"T216","pred":"source","obj":"GoldHamster"},{"subj":"T217","pred":"source","obj":"GoldHamster"},{"subj":"T219","pred":"source","obj":"GoldHamster"},{"subj":"T222","pred":"source","obj":"GoldHamster"},{"subj":"T223","pred":"source","obj":"GoldHamster"},{"subj":"T224","pred":"source","obj":"GoldHamster"},{"subj":"T225","pred":"source","obj":"GoldHamster"},{"subj":"T226","pred":"source","obj":"GoldHamster"},{"subj":"T227","pred":"source","obj":"GoldHamster"},{"subj":"T228","pred":"source","obj":"GoldHamster"},{"subj":"T229","pred":"source","obj":"GoldHamster"},{"subj":"T230","pred":"source","obj":"GoldHamster"},{"subj":"T231","pred":"source","obj":"GoldHamster"},{"subj":"T232","pred":"source","obj":"GoldHamster"},{"subj":"T233","pred":"source","obj":"GoldHamster"}]},{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T2","span":{"begin":0,"end":845},"obj":"RESULTS"}],"attributes":[{"subj":"T2","pred":"source","obj":"PubMed_Structured_Abstracts"}]},{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T5","span":{"begin":142,"end":146},"obj":"CVCL_WY71|Spontaneously_immortalized_cell_line|Oncorhynchus keta"},{"id":"T6","span":{"begin":211,"end":212},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T7","span":{"begin":379,"end":380},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T8","span":{"begin":535,"end":536},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T9","span":{"begin":607,"end":608},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T10","span":{"begin":732,"end":734},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T11","span":{"begin":732,"end":734},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"}],"attributes":[{"subj":"T5","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T6","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T7","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T8","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T9","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T10","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T11","pred":"source","obj":"Goldhamster2_Cellosaurus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"GoldHamster","color":"#b1ec93","default":true},{"id":"PubMed_Structured_Abstracts","color":"#ec93cb"},{"id":"Goldhamster2_Cellosaurus","color":"#93e5ec"}]}]}}