PubMed:25962635 / 701-1546 JSONTXT

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{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T2","span":{"begin":0,"end":845},"obj":"RESULTS"}],"text":"Genome-wide identification of transcripts associated with BRAT or with PUM in Drosophila embryos shows that they bind largely non-overlapping sets of mRNAs. BRAT binds mRNAs that encode proteins associated with a variety of functions, many of which are distinct from those implemented by PUM-associated transcripts. Computational analysis of in vitro and in vivo data identified a novel RNA motif recognized by BRAT that confers BRAT-mediated regulation in tissue culture cells. The regulatory status of BRAT-associated mRNAs suggests a prominent role for BRAT in post-transcriptional regulation, including a previously unidentified role in transcript degradation. Transcriptomic analysis of embryos lacking functional BRAT reveals an important role in mediating the decay of hundreds of maternal mRNAs during the maternal-to-zygotic transition."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T5","span":{"begin":142,"end":146},"obj":"CVCL_WY71|Spontaneously_immortalized_cell_line|Oncorhynchus keta"},{"id":"T6","span":{"begin":211,"end":212},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T7","span":{"begin":379,"end":380},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T8","span":{"begin":535,"end":536},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T9","span":{"begin":607,"end":608},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T10","span":{"begin":732,"end":734},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T11","span":{"begin":732,"end":734},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"}],"text":"Genome-wide identification of transcripts associated with BRAT or with PUM in Drosophila embryos shows that they bind largely non-overlapping sets of mRNAs. BRAT binds mRNAs that encode proteins associated with a variety of functions, many of which are distinct from those implemented by PUM-associated transcripts. Computational analysis of in vitro and in vivo data identified a novel RNA motif recognized by BRAT that confers BRAT-mediated regulation in tissue culture cells. The regulatory status of BRAT-associated mRNAs suggests a prominent role for BRAT in post-transcriptional regulation, including a previously unidentified role in transcript degradation. Transcriptomic analysis of embryos lacking functional BRAT reveals an important role in mediating the decay of hundreds of maternal mRNAs during the maternal-to-zygotic transition."}