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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Helminth infections and type 2 diabetes: a cluster-randomized placebo controlled SUGARSPIN trial in Nangapanda, Flores, Indonesia.
T2 131-142 Sentence denotes BACKGROUND:
T3 143-231 Sentence denotes Insulin resistance is a strong predictor of the development of type 2 diabetes mellitus.
T4 232-397 Sentence denotes Chronic helminth infections might protect against insulin resistance via a caloric restriction state and indirectly via T-helper-2 polarization of the immune system.
T5 398-495 Sentence denotes Therefore the elimination of helminths might remove this beneficial effect on insulin resistance.
T6 496-511 Sentence denotes METHODS/DESIGN:
T7 512-902 Sentence denotes To determine whether soil-transmitted helminth infections are associated with a better whole-body insulin sensitivity and whether this protection is reversible by anthelmintic treatment, a household-based cluster-randomized, double blind, placebo-controlled trial was conducted in the area of Nangapanda on Flores Island, Indonesia, an area endemic for soil-transmitted helminth infections.
T8 903-1091 Sentence denotes The trial incorporates three monthly treatment with albendazole or matching placebo for one year, whereby each treatment round consists of three consecutive days of supervised drug intake.
T9 1092-1191 Sentence denotes The presence of soil-transmitted helminths will be evaluated in faeces using microscopy and/or PCR.
T10 1192-1542 Sentence denotes The primary outcome of the study will be changes in insulin resistance as assessed by HOMA-IR, while the secondary outcomes will be changes in body mass index, waist circumference, fasting blood glucose, 2 h-glucose levels after oral glucose tolerance test, HbA1c, serum lipid levels, immunological parameters, and efficacy of anthelmintic treatment.
T11 1543-1554 Sentence denotes DISCUSSION:
T12 1555-1642 Sentence denotes The study will provide data on the effect of helminth infections on insulin resistance.
T13 1643-1858 Sentence denotes It will assess the relationship between helminth infection status and immune responses as well as metabolic parameters, allowing the establishment of a link between inflammation and whole-body metabolic homeostasis.
T14 1859-1950 Sentence denotes In addition, it will give information on anthelmintic treatment efficacy and effectiveness.
T15 1951-1970 Sentence denotes TRIAL REGISTRATION:
T16 1971-2075 Sentence denotes This study has been approved by the ethical committee of Faculty of Medicine Universitas Indonesia (ref:
T17 2076-2216 Sentence denotes 549/H2.F1/ETIK/2013), and has been filed by the ethics committee of Leiden University Medical Center, clinical trial number: ISRCTN75636394.
T18 2217-2311 Sentence denotes The study is reported in accordance with the CONSORT guidelines for cluster-randomised trials.
T1 0-130 Sentence denotes Helminth infections and type 2 diabetes: a cluster-randomized placebo controlled SUGARSPIN trial in Nangapanda, Flores, Indonesia.
T2 131-142 Sentence denotes BACKGROUND:
T3 143-231 Sentence denotes Insulin resistance is a strong predictor of the development of type 2 diabetes mellitus.
T4 232-397 Sentence denotes Chronic helminth infections might protect against insulin resistance via a caloric restriction state and indirectly via T-helper-2 polarization of the immune system.
T5 398-495 Sentence denotes Therefore the elimination of helminths might remove this beneficial effect on insulin resistance.
T6 496-511 Sentence denotes METHODS/DESIGN:
T7 512-902 Sentence denotes To determine whether soil-transmitted helminth infections are associated with a better whole-body insulin sensitivity and whether this protection is reversible by anthelmintic treatment, a household-based cluster-randomized, double blind, placebo-controlled trial was conducted in the area of Nangapanda on Flores Island, Indonesia, an area endemic for soil-transmitted helminth infections.
T8 903-1091 Sentence denotes The trial incorporates three monthly treatment with albendazole or matching placebo for one year, whereby each treatment round consists of three consecutive days of supervised drug intake.
T9 1092-1191 Sentence denotes The presence of soil-transmitted helminths will be evaluated in faeces using microscopy and/or PCR.
T10 1192-1542 Sentence denotes The primary outcome of the study will be changes in insulin resistance as assessed by HOMA-IR, while the secondary outcomes will be changes in body mass index, waist circumference, fasting blood glucose, 2 h-glucose levels after oral glucose tolerance test, HbA1c, serum lipid levels, immunological parameters, and efficacy of anthelmintic treatment.
T11 1543-1554 Sentence denotes DISCUSSION:
T12 1555-1642 Sentence denotes The study will provide data on the effect of helminth infections on insulin resistance.
T13 1643-1858 Sentence denotes It will assess the relationship between helminth infection status and immune responses as well as metabolic parameters, allowing the establishment of a link between inflammation and whole-body metabolic homeostasis.
T14 1859-1950 Sentence denotes In addition, it will give information on anthelmintic treatment efficacy and effectiveness.
T15 1951-1970 Sentence denotes TRIAL REGISTRATION:
T16 1971-2075 Sentence denotes This study has been approved by the ethical committee of Faculty of Medicine Universitas Indonesia (ref:
T17 2076-2216 Sentence denotes 549/H2.F1/ETIK/2013), and has been filed by the ethics committee of Leiden University Medical Center, clinical trial number: ISRCTN75636394.
T18 2217-2311 Sentence denotes The study is reported in accordance with the CONSORT guidelines for cluster-randomised trials.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 143-161 HP_0000855 denotes Insulin resistance
T2 213-230 HP_0000819 denotes diabetes mellitus
T3 282-300 HP_0000855 denotes insulin resistance
T4 476-494 HP_0000855 denotes insulin resistance