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GoldHamster

Id Subject Object Predicate Lexical cue
T3 0-12 3008 denotes Cyclosporine
T5 0-14 D016572 denotes Cyclosporine A
T6 0-14 D016572 denotes Cyclosporine A
T7 32-35 D011085 denotes PCO
T8 36-45 GO:0009058 denotes formation
T9 67-76 GO:0016236 denotes autophagy
T10 67-76 GO:0006914 denotes autophagy
T11 86-96 GO:0008219 denotes cell death
T14 145-157 3008 denotes Cyclosporine
T16 145-159 D016572 denotes Cyclosporine A
T17 145-159 D016572 denotes Cyclosporine A
T19 161-164 PR:Q8CFD5 denotes CsA
T20 161-164 PR:000007170 denotes CsA
T22 161-164 P08796 denotes CsA
T23 161-164 PR:Q13216 denotes CsA
T21 161-164 CHEBI:55379 denotes CsA
T18 161-164 D003057 denotes CsA
T24 183-187 CHEBI:23888 denotes drug
T25 220-229 UBERON:0001353 denotes posterior
T26 230-237 GO:0042603 denotes capsule
T27 230-237 UBERON:0003893 denotes capsule
T28 230-251 D058442 denotes capsule opacification
T29 230-251 D058442 denotes capsule opacification
T30 253-256 D011085 denotes PCO
T31 272-278 UBERON:0003674 denotes canine
T33 315-318 PR:Q8CFD5 denotes CsA
T34 315-318 PR:000007170 denotes CsA
T36 315-318 P08796 denotes CsA
T37 315-318 PR:Q13216 denotes CsA
T35 315-318 CHEBI:55379 denotes CsA
T32 315-318 D003057 denotes CsA
T38 327-337 GO:0008219 denotes cell death
T39 339-345 UBERON:0003674 denotes Canine
T40 346-350 UBERON:0000965 denotes lens
T41 346-350 UBERON:0005389 denotes lens
T42 369-372 CL:0002138 denotes LEC
T44 369-372 PR:Q9LJR2 denotes LEC
T43 369-372 UBERON:0007225 denotes LEC
T46 392-395 PR:Q8CFD5 denotes CsA
T47 392-395 PR:000007170 denotes CsA
T49 392-395 P08796 denotes CsA
T50 392-395 PR:Q13216 denotes CsA
T48 392-395 CHEBI:55379 denotes CsA
T45 392-395 D003057 denotes CsA
T51 411-425 GO:0016477 denotes cell migration
T52 427-440 UBERON:2000098 denotes proliferation
T54 480-483 PR:Q8CFD5 denotes CsA
T55 480-483 PR:000007170 denotes CsA
T57 480-483 P08796 denotes CsA
T58 480-483 PR:Q13216 denotes CsA
T56 480-483 CHEBI:55379 denotes CsA
T53 480-483 D003057 denotes CsA
T59 492-495 CL:0002138 denotes LEC
T61 492-495 PR:Q9LJR2 denotes LEC
T60 492-495 UBERON:0007225 denotes LEC
T62 519-527 CHEBI:10545 denotes electron
T66 540-543 GO:0097197 denotes TEM
T63 540-543 PR:000016500 denotes TEM
T64 540-543 Q9H2S6 denotes TEM
T67 540-543 Q9EP64 denotes TEM
T68 540-543 Q9ESC2 denotes TEM
T65 540-543 CVCL_E844 denotes TEM
T69 540-543 CHEBI:27919 denotes TEM
T70 615-624 GO:0016236 denotes autophagy
T71 615-624 GO:0006914 denotes autophagy
T72 615-635 CHEBI:88230 denotes autophagy inhibitors
T74 665-675 GO:0008219 denotes cell death
T75 677-681 UBERON:0000965 denotes Lens
T76 677-681 UBERON:0005389 denotes Lens
T77 682-690 D002214 denotes capsules
T78 711-717 UBERON:0003674 denotes canine
T80 718-725 UBERON:0008979 denotes cadaver
T79 718-725 D002102 denotes cadaver
T81 718-725 D002102 denotes cadaver
T82 755-758 D011085 denotes PCO
T83 760-764 UBERON:0000965 denotes Lens
T84 760-764 UBERON:0005389 denotes Lens
T85 765-773 D002214 denotes capsules
T87 792-795 PR:Q8CFD5 denotes CsA
T88 792-795 PR:000007170 denotes CsA
T90 792-795 P08796 denotes CsA
T91 792-795 PR:Q13216 denotes CsA
T89 792-795 CHEBI:55379 denotes CsA
T86 792-795 D003057 denotes CsA
T93 909-913 CHEBI:23888 denotes drug
T95 915-918 PR:Q8CFD5 denotes CsA
T96 915-918 PR:000007170 denotes CsA
T98 915-918 P08796 denotes CsA
T99 915-918 PR:Q13216 denotes CsA
T97 915-918 CHEBI:55379 denotes CsA
T94 915-918 D003057 denotes CsA
T102 927-930 PR:Q9LJR2 denotes LEC
T101 927-930 UBERON:0007225 denotes LEC
T100 927-930 CL:0002138 denotes LEC
T104 986-989 PR:Q8CFD5 denotes CsA
T105 986-989 PR:000007170 denotes CsA
T107 986-989 P08796 denotes CsA
T108 986-989 PR:Q13216 denotes CsA
T106 986-989 CHEBI:55379 denotes CsA
T103 986-989 D003057 denotes CsA
T109 998-1001 CL:0002138 denotes LEC
T111 998-1001 PR:Q9LJR2 denotes LEC
T110 998-1001 UBERON:0007225 denotes LEC
T112 1027-1033 CHEBI:33252 denotes nuclei
T114 1053-1062 GO:0000785 denotes chromatin
T113 1053-1062 D002843 denotes chromatin
T117 1119-1122 CVCL_E844 denotes TEM
T115 1119-1122 PR:000016500 denotes TEM
T116 1119-1122 Q9H2S6 denotes TEM
T119 1119-1122 Q9EP64 denotes TEM
T120 1119-1122 Q9ESC2 denotes TEM
T118 1119-1122 GO:0097197 denotes TEM
T121 1119-1122 CHEBI:27919 denotes TEM
T122 1148-1151 P82160 denotes LC3
T127 1155-1162 SO:0000104 denotes protein
T126 1155-1162 PR:000000001 denotes protein
T123 1155-1162 GO:0003675 denotes protein
T124 1155-1162 CHEBI:36080 denotes protein
T125 1155-1162 CHEBI:11122 denotes protein
T129 1178-1193 D000165 denotes acridine orange
T130 1178-1193 D000165 denotes acridine orange
T131 1178-1193 CHEBI:87346 denotes acridine orange
T132 1178-1193 CHEBI:51739 denotes acridine orange
T133 1187-1193 127424 denotes orange
T135 1220-1223 PR:Q8CFD5 denotes CsA
T136 1220-1223 PR:000007170 denotes CsA
T138 1220-1223 P08796 denotes CsA
T139 1220-1223 PR:Q13216 denotes CsA
T137 1220-1223 CHEBI:55379 denotes CsA
T134 1220-1223 D003057 denotes CsA
T142 1284-1293 P55866 denotes caspase-3
T143 1284-1293 Q8MJC3 denotes caspase-3
T144 1284-1293 Q2PFV2 denotes caspase-3
T145 1284-1293 Q08DY9 denotes caspase-3
T146 1284-1293 Q5IS54 denotes caspase-3
T147 1284-1293 Q8MKI5 denotes caspase-3
T148 1284-1293 PR:000002312 denotes caspase-3
T149 1284-1293 Q8MJU1 denotes caspase-3
T150 1284-1293 Q60431 denotes caspase-3
T151 1284-1293 P42574 denotes caspase-3
T152 1284-1293 Q5IS99 denotes caspase-3
T153 1284-1293 Q95ND5 denotes caspase-3
T154 1284-1293 P70677 denotes caspase-3
T155 1284-1293 P55213 denotes caspase-3
T141 1284-1293 D053148 denotes caspase-3
T157 1310-1313 PR:Q8CFD5 denotes CsA
T158 1310-1313 PR:000007170 denotes CsA
T160 1310-1313 P08796 denotes CsA
T161 1310-1313 PR:Q13216 denotes CsA
T159 1310-1313 CHEBI:55379 denotes CsA
T156 1310-1313 D003057 denotes CsA
T164 1322-1325 PR:Q9LJR2 denotes LEC
T163 1322-1325 UBERON:0007225 denotes LEC
T162 1322-1325 CL:0002138 denotes LEC
T165 1327-1331 UBERON:0000965 denotes Lens
T166 1327-1331 UBERON:0005389 denotes Lens
T167 1332-1340 D002214 denotes capsules
T174 1382-1385 PR:Q8CFD5 denotes CsA
T175 1382-1385 PR:000007170 denotes CsA
T177 1382-1385 P08796 denotes CsA
T178 1382-1385 PR:Q13216 denotes CsA
T176 1382-1385 CHEBI:55379 denotes CsA
T173 1382-1385 D003057 denotes CsA
T179 1427-1430 D011085 denotes PCO
T180 1431-1440 GO:0009058 denotes formation
T181 1452-1456 CHEBI:23888 denotes drug
T182 1476-1479 D011085 denotes PCO
T183 1524-1533 GO:0009058 denotes formation
T184 1582-1585 P82160 denotes LC3
T186 1618-1621 PR:Q8CFD5 denotes CsA
T187 1618-1621 PR:000007170 denotes CsA
T189 1618-1621 P08796 denotes CsA
T190 1618-1621 PR:Q13216 denotes CsA
T188 1618-1621 CHEBI:55379 denotes CsA
T185 1618-1621 D003057 denotes CsA
T191 1631-1634 CL:0002138 denotes LEC
T193 1631-1634 PR:Q9LJR2 denotes LEC
T192 1631-1634 UBERON:0007225 denotes LEC
T194 1645-1654 GO:0016236 denotes autophagy
T195 1645-1654 GO:0006914 denotes autophagy
T196 1687-1691 UBERON:0000965 denotes lens
T197 1687-1691 UBERON:0005389 denotes lens
T199 1706-1709 PR:Q8CFD5 denotes CsA
T200 1706-1709 PR:000007170 denotes CsA
T202 1706-1709 P08796 denotes CsA
T203 1706-1709 PR:Q13216 denotes CsA
T201 1706-1709 CHEBI:55379 denotes CsA
T198 1706-1709 D003057 denotes CsA
T204 1718-1727 GO:0097194 denotes apoptosis
T205 1718-1727 GO:0006915 denotes apoptosis
T207 1767-1770 PR:Q8CFD5 denotes CsA
T208 1767-1770 PR:000007170 denotes CsA
T210 1767-1770 P08796 denotes CsA
T211 1767-1770 PR:Q13216 denotes CsA
T209 1767-1770 CHEBI:55379 denotes CsA
T206 1767-1770 D003057 denotes CsA
T212 1771-1775 CHEBI:23888 denotes drug
T213 6-9 D011085 denotes por
T214 10-19 GO:0009058 denotes ne A prev

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 98-338 DRI_Approach denotes The purpose of this study was to determine the Cyclosporine A (CsA) dose and minimum drug delivery time needed to prevent posterior capsule opacification (PCO) in an ex vivo canine model and evaluate the mechanism of CsA-induced cell death.
T2 339-479 DRI_Background denotes Canine lens epithelial cells (LEC) were treated with CsA and changes in cell migration, proliferation, and density were monitored over time.
T3 480-676 DRI_Background denotes CsA-treated LEC underwent transmission electron microscopy (TEM), immunofluorescence, and immunoblotting in the presence or absence of autophagy inhibitors to evaluate the mechanism of cell death.
T4 677-759 DRI_Outcome denotes Lens capsules were harvested from canine cadaver eyes for an ex vivo model of PCO.
T5 760-914 DRI_Approach denotes Lens capsules were treated with CsA for 1, 2, 3, 4, 5, 6, or 7 days, and subsequently maintained in culture for a total of 28 days in the absence of drug.
T6 915-968 DRI_Approach denotes CsA reduced LEC viability in a dose dependent manner.
T7 969-1147 DRI_Outcome denotes Morphologically, CsA-treated LEC were swollen, had intact nuclei, lacked peripheral chromatin condensation, and demonstrated prominent vacuolization; TEM revealed autophagosomes.
T8 1148-1238 DRI_Background denotes LC3-II protein expression and acridine orange fluorescence increased in CsA-treated cells.
T9 1239-1326 DRI_Background denotes A small non-significant induction of cleaved caspase-3 was observed in CsA-treated LEC.
T10 1481-1692 DRI_Challenge denotes This study finds that morphologic changes, formation of acidic vesicles, and increased expression of LC3-II supports the hypothesis that CsA mediates LEC death via autophagy; this is a novel finding in the lens.
T11 1693-1740 DRI_Background denotes Induction of CsA-induced apoptosis was minimal.
T12 1741-1817 DRI_Approach denotes Six days of intracapsular CsA drug delivery prevented ex vivo PCO formation.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 13-14 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T2 158-159 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T3 197-201 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T4 261-263 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T5 261-263 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T6 400-407 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T7 474-478 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T8 540-543 CVCL_E844|Transformed_cell_line|Homo sapiens denotes TEM
T9 735-737 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T10 735-737 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T11 800-807 CVCL_HE67|Factor-dependent_cell_line|Mus musculus denotes 1, 2, 3
T12 809-813 CVCL_E420|Transformed_cell_line|Homo sapiens denotes 4, 5
T13 815-820 CVCL_VN30|Cancer_cell_line|Homo sapiens denotes 6, or
T14 872-873 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T15 944-945 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 1119-1122 CVCL_E844|Transformed_cell_line|Homo sapiens denotes TEM
T17 1239-1240 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T18 1357-1362 CVCL_VN30|Cancer_cell_line|Homo sapiens denotes 6, or
T19 1379-1381 CVCL_F566|Transformed_cell_line|Homo sapiens denotes mL
T20 1379-1381 CVCL_W799|Cancer_cell_line|Homo sapiens denotes mL
T21 1393-1394 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T22 1515-1522 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T23 1664-1665 CVCL_6479|Finite_cell_line|Mus musculus denotes a

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1672-1691 HP_0000517 denotes finding in the lens