PubMed:25760041 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25760041","sourcedb":"PubMed","sourceid":"25760041","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25760041","text":"Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.\nProduction of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders. Earlier work has shown that interference with production of the transcription elongation protein SUPT4H results in decreased cellular capacity to transcribe mutant huntingtin gene (Htt) alleles containing long CAG expansions, but has little effect on expression of genes containing short CAG stretches. zQ175 and R6/2 are genetically engineered mouse strains whose genomes contain human HTT alleles that include greatly expanded CAG repeats and which are used as animal models for HD. Here we show that reduction of SUPT4H expression in brains of zQ175 mice by intracerebroventricular bolus injection of antisense 2'-O-methoxyethyl oligonucleotides (ASOs) directed against Supt4h, or in R6/2 mice by deletion of one copy of the Supt4h gene, results in a decrease in mRNA and protein encoded specifically by mutant Htt alleles. We further show that reduction of SUPT4H in mouse brains is associated with decreased HTT protein aggregation, and in R6/2 mice, also with prolonged lifespan and delay of the motor impairment that normally develops in these animals. Our findings support the view that targeting of SUPT4H function may be useful as a therapeutic countermeasure against HD.","tracks":[{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":31,"end":39},"obj":"UBERON:0000104"},{"id":"T2","span":{"begin":87,"end":97},"obj":"P42858"},{"id":"T3","span":{"begin":87,"end":97},"obj":"P42859"},{"id":"T4","span":{"begin":87,"end":97},"obj":"P51111"},{"id":"T5","span":{"begin":87,"end":97},"obj":"PR:000008840"},{"id":"T6","span":{"begin":87,"end":97},"obj":"P51112"},{"id":"T7","span":{"begin":98,"end":104},"obj":"SO:0001023"},{"id":"T8","span":{"begin":108,"end":114},"obj":"PR:P63272"},{"id":"T9","span":{"begin":108,"end":114},"obj":"PR:000030299"},{"id":"T10","span":{"begin":108,"end":114},"obj":"PR:P63271"},{"id":"T15","span":{"begin":140,"end":147},"obj":"SO:0000104"},{"id":"T14","span":{"begin":140,"end":147},"obj":"PR:000000001"},{"id":"T12","span":{"begin":140,"end":147},"obj":"CHEBI:36080"},{"id":"T13","span":{"begin":140,"end":147},"obj":"CHEBI:11122"},{"id":"T11","span":{"begin":140,"end":147},"obj":"GO:0003675"},{"id":"T16","span":{"begin":180,"end":193},"obj":"C097188"},{"id":"T17","span":{"begin":180,"end":193},"obj":"C097188"},{"id":"T18","span":{"begin":229,"end":242},"obj":"CHEBI:74953"},{"id":"T19","span":{"begin":243,"end":246},"obj":"CVCL_D569"},{"id":"T24","span":{"begin":264,"end":284},"obj":"D006816"},{"id":"T25","span":{"begin":264,"end":284},"obj":"D006816"},{"id":"T28","span":{"begin":356,"end":369},"obj":"D009468"},{"id":"T29","span":{"begin":356,"end":369},"obj":"D009468"},{"id":"T30","span":{"begin":445,"end":458},"obj":"GO:0006351"},{"id":"T35","span":{"begin":470,"end":477},"obj":"SO:0000104"},{"id":"T34","span":{"begin":470,"end":477},"obj":"PR:000000001"},{"id":"T31","span":{"begin":470,"end":477},"obj":"GO:0003675"},{"id":"T32","span":{"begin":470,"end":477},"obj":"CHEBI:36080"},{"id":"T33","span":{"begin":470,"end":477},"obj":"CHEBI:11122"},{"id":"T36","span":{"begin":478,"end":484},"obj":"PR:P63272"},{"id":"T37","span":{"begin":478,"end":484},"obj":"PR:000030299"},{"id":"T38","span":{"begin":478,"end":484},"obj":"PR:P63271"},{"id":"T39","span":{"begin":545,"end":555},"obj":"P42858"},{"id":"T40","span":{"begin":545,"end":555},"obj":"P42859"},{"id":"T41","span":{"begin":545,"end":555},"obj":"P51111"},{"id":"T42","span":{"begin":545,"end":555},"obj":"PR:000008840"},{"id":"T43","span":{"begin":545,"end":555},"obj":"P51112"},{"id":"T44","span":{"begin":556,"end":560},"obj":"SO:0000704"},{"id":"T45","span":{"begin":562,"end":565},"obj":"PR:P51111"},{"id":"T46","span":{"begin":562,"end":565},"obj":"PR:000015189"},{"id":"T47","span":{"begin":562,"end":565},"obj":"PR:Q76P24"},{"id":"T48","span":{"begin":562,"end":565},"obj":"PR:P31645"},{"id":"T49","span":{"begin":562,"end":565},"obj":"PR:P42859"},{"id":"T50","span":{"begin":562,"end":565},"obj":"PR:Q60857"},{"id":"T51","span":{"begin":562,"end":565},"obj":"PR:P42858"},{"id":"T52","span":{"begin":562,"end":565},"obj":"PR:000008840"},{"id":"T53","span":{"begin":591,"end":594},"obj":"CVCL_D569"},{"id":"T54","span":{"begin":669,"end":672},"obj":"CVCL_D569"},{"id":"T55","span":{"begin":715,"end":725},"obj":"SO:0000783"},{"id":"T56","span":{"begin":726,"end":731},"obj":"10090"},{"id":"T57","span":{"begin":726,"end":731},"obj":"D051379"},{"id":"T58","span":{"begin":732,"end":739},"obj":"D013180"},{"id":"T59","span":{"begin":732,"end":739},"obj":"D013180"},{"id":"T60","span":{"begin":762,"end":767},"obj":"D006801"},{"id":"T61","span":{"begin":768,"end":771},"obj":"PR:P51111"},{"id":"T62","span":{"begin":768,"end":771},"obj":"PR:000015189"},{"id":"T63","span":{"begin":768,"end":771},"obj":"PR:Q76P24"},{"id":"T64","span":{"begin":768,"end":771},"obj":"PR:P31645"},{"id":"T65","span":{"begin":768,"end":771},"obj":"PR:P42859"},{"id":"T66","span":{"begin":768,"end":771},"obj":"PR:Q60857"},{"id":"T67","span":{"begin":768,"end":771},"obj":"PR:P42858"},{"id":"T68","span":{"begin":768,"end":771},"obj":"PR:000008840"},{"id":"T69","span":{"begin":810,"end":813},"obj":"CVCL_D569"},{"id":"T70","span":{"begin":844,"end":850},"obj":"UBERON:3010325"},{"id":"T71","span":{"begin":844,"end":850},"obj":"UBERON:0000468"},{"id":"T72","span":{"begin":884,"end":893},"obj":"MOP:0000569"},{"id":"T73","span":{"begin":897,"end":903},"obj":"PR:P63272"},{"id":"T74","span":{"begin":897,"end":903},"obj":"PR:000030299"},{"id":"T75","span":{"begin":897,"end":903},"obj":"PR:P63271"},{"id":"T76","span":{"begin":934,"end":938},"obj":"PR:000005054"},{"id":"T78","span":{"begin":934,"end":938},"obj":"O89094"},{"id":"T77","span":{"begin":934,"end":938},"obj":"D051379"},{"id":"T79","span":{"begin":934,"end":938},"obj":"10095"},{"id":"T80","span":{"begin":966,"end":971},"obj":"UBERON:0012113"},{"id":"T81","span":{"begin":985,"end":994},"obj":"SO:0000077"},{"id":"T82","span":{"begin":1013,"end":1029},"obj":"CHEBI:7754"},{"id":"T83","span":{"begin":1013,"end":1029},"obj":"D009841"},{"id":"T84","span":{"begin":1013,"end":1029},"obj":"D009841"},{"id":"T85","span":{"begin":1054,"end":1060},"obj":"PR:P63272"},{"id":"T86","span":{"begin":1054,"end":1060},"obj":"PR:000030299"},{"id":"T87","span":{"begin":1054,"end":1060},"obj":"PR:P63271"},{"id":"T88","span":{"begin":1073,"end":1077},"obj":"PR:000005054"},{"id":"T90","span":{"begin":1073,"end":1077},"obj":"O89094"},{"id":"T89","span":{"begin":1073,"end":1077},"obj":"D051379"},{"id":"T91","span":{"begin":1073,"end":1077},"obj":"10095"},{"id":"T92","span":{"begin":1081,"end":1089},"obj":"SO:0000159"},{"id":"T93","span":{"begin":1109,"end":1115},"obj":"PR:P63272"},{"id":"T94","span":{"begin":1109,"end":1115},"obj":"PR:000030299"},{"id":"T95","span":{"begin":1109,"end":1115},"obj":"PR:P63271"},{"id":"T96","span":{"begin":1116,"end":1120},"obj":"SO:0000704"},{"id":"T99","span":{"begin":1147,"end":1151},"obj":"SO:0000234"},{"id":"T97","span":{"begin":1147,"end":1151},"obj":"D012333"},{"id":"T98","span":{"begin":1147,"end":1151},"obj":"CHEBI:33699"},{"id":"T100","span":{"begin":1156,"end":1163},"obj":"GO:0003675"},{"id":"T104","span":{"begin":1156,"end":1163},"obj":"SO:0000104"},{"id":"T103","span":{"begin":1156,"end":1163},"obj":"PR:000000001"},{"id":"T101","span":{"begin":1156,"end":1163},"obj":"CHEBI:36080"},{"id":"T102","span":{"begin":1156,"end":1163},"obj":"CHEBI:11122"},{"id":"T105","span":{"begin":1195,"end":1198},"obj":"PR:P51111"},{"id":"T106","span":{"begin":1195,"end":1198},"obj":"PR:000015189"},{"id":"T107","span":{"begin":1195,"end":1198},"obj":"PR:Q76P24"},{"id":"T108","span":{"begin":1195,"end":1198},"obj":"PR:P31645"},{"id":"T109","span":{"begin":1195,"end":1198},"obj":"PR:P42859"},{"id":"T110","span":{"begin":1195,"end":1198},"obj":"PR:Q60857"},{"id":"T111","span":{"begin":1195,"end":1198},"obj":"PR:P42858"},{"id":"T112","span":{"begin":1195,"end":1198},"obj":"PR:000008840"},{"id":"T113","span":{"begin":1229,"end":1238},"obj":"MOP:0000569"},{"id":"T114","span":{"begin":1242,"end":1248},"obj":"PR:P63272"},{"id":"T115","span":{"begin":1242,"end":1248},"obj":"PR:000030299"},{"id":"T116","span":{"begin":1242,"end":1248},"obj":"PR:P63271"},{"id":"T117","span":{"begin":1247,"end":1251},"obj":"CHEBI:13359"},{"id":"T118","span":{"begin":1252,"end":1257},"obj":"10090"},{"id":"T119","span":{"begin":1252,"end":1257},"obj":"D051379"},{"id":"T120","span":{"begin":1294,"end":1297},"obj":"PR:P51111"},{"id":"T121","span":{"begin":1294,"end":1297},"obj":"PR:000015189"},{"id":"T122","span":{"begin":1294,"end":1297},"obj":"PR:Q76P24"},{"id":"T123","span":{"begin":1294,"end":1297},"obj":"PR:P31645"},{"id":"T124","span":{"begin":1294,"end":1297},"obj":"PR:P42859"},{"id":"T125","span":{"begin":1294,"end":1297},"obj":"PR:Q60857"},{"id":"T126","span":{"begin":1294,"end":1297},"obj":"PR:P42858"},{"id":"T127","span":{"begin":1294,"end":1297},"obj":"PR:000008840"},{"id":"T132","span":{"begin":1298,"end":1305},"obj":"SO:0000104"},{"id":"T129","span":{"begin":1298,"end":1305},"obj":"CHEBI:36080"},{"id":"T130","span":{"begin":1298,"end":1305},"obj":"CHEBI:11122"},{"id":"T131","span":{"begin":1298,"end":1305},"obj":"PR:000000001"},{"id":"T128","span":{"begin":1298,"end":1305},"obj":"GO:0003675"},{"id":"T133","span":{"begin":1331,"end":1335},"obj":"PR:000005054"},{"id":"T135","span":{"begin":1331,"end":1335},"obj":"O89094"},{"id":"T134","span":{"begin":1331,"end":1335},"obj":"D051379"},{"id":"T136","span":{"begin":1331,"end":1335},"obj":"10095"},{"id":"T137","span":{"begin":1357,"end":1365},"obj":"UBERON:0000104"},{"id":"T138","span":{"begin":1489,"end":1495},"obj":"PR:P63272"},{"id":"T139","span":{"begin":1489,"end":1495},"obj":"PR:000030299"},{"id":"T140","span":{"begin":1489,"end":1495},"obj":"PR:P63271"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":339,"end":379},"obj":"HP_0000707"},{"id":"T2","span":{"begin":1370,"end":1388},"obj":"HP_0001270"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":125},"obj":"DRI_Background"},{"id":"T2","span":{"begin":126,"end":380},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":381,"end":683},"obj":"DRI_Background"},{"id":"T4","span":{"begin":684,"end":865},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":866,"end":1207},"obj":"DRI_Outcome"},{"id":"T6","span":{"begin":1208,"end":1440},"obj":"DRI_Outcome"},{"id":"T7","span":{"begin":1441,"end":1562},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"25760041-2#164#174#gene3064","span":{"begin":545,"end":555},"obj":"gene3064"},{"id":"25760041-2#481#483#diseaseC0020179","span":{"begin":862,"end":864},"obj":"diseaseC0020179"},{"id":"25760041-5#48#54#gene6827","span":{"begin":1489,"end":1495},"obj":"gene6827"},{"id":"25760041-5#118#120#diseaseC0020179","span":{"begin":1559,"end":1561},"obj":"diseaseC0020179"}],"relations":[{"id":"164#174#gene3064481#483#diseaseC0020179","pred":"associated_with","subj":"25760041-2#164#174#gene3064","obj":"25760041-2#481#483#diseaseC0020179"},{"id":"48#54#gene6827118#120#diseaseC0020179","pred":"associated_with","subj":"25760041-5#48#54#gene6827","obj":"25760041-5#118#120#diseaseC0020179"}],"attributes":[{"subj":"25760041-2#164#174#gene3064","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25760041-2#481#483#diseaseC0020179","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25760041-5#48#54#gene6827","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25760041-5#118#120#diseaseC0020179","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"c_corpus","color":"#dbec93","default":true},{"id":"PubmedHPO","color":"#e293ec"},{"id":"UseCases_ArguminSci_Discourse","color":"#93ecc8"},{"id":"DisGeNET5_gene_disease","color":"#ecae93"}]}]}}