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PubMed:25760041 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 31-39 UBERON:0000104 denotes lifespan
T2 87-97 P42858 denotes huntingtin
T3 87-97 P42859 denotes huntingtin
T4 87-97 P51111 denotes huntingtin
T5 87-97 PR:000008840 denotes huntingtin
T6 87-97 P51112 denotes huntingtin
T7 98-104 SO:0001023 denotes allele
T8 108-114 PR:P63272 denotes supt4h
T9 108-114 PR:000030299 denotes supt4h
T10 108-114 PR:P63271 denotes supt4h
T15 140-147 SO:0000104 denotes protein
T14 140-147 PR:000000001 denotes protein
T12 140-147 CHEBI:36080 denotes protein
T13 140-147 CHEBI:11122 denotes protein
T11 140-147 GO:0003675 denotes protein
T16 180-193 C097188 denotes polyglutamine
T17 180-193 C097188 denotes polyglutamine
T18 229-242 CHEBI:74953 denotes trinucleotide
T19 243-246 CVCL_D569 denotes CAG
T24 264-284 D006816 denotes Huntington's disease
T25 264-284 D006816 denotes Huntington's disease
T28 356-369 D009468 denotes neuromuscular
T29 356-369 D009468 denotes neuromuscular
T30 445-458 GO:0006351 denotes transcription
T35 470-477 SO:0000104 denotes protein
T34 470-477 PR:000000001 denotes protein
T31 470-477 GO:0003675 denotes protein
T32 470-477 CHEBI:36080 denotes protein
T33 470-477 CHEBI:11122 denotes protein
T36 478-484 PR:P63272 denotes SUPT4H
T37 478-484 PR:000030299 denotes SUPT4H
T38 478-484 PR:P63271 denotes SUPT4H
T39 545-555 P42858 denotes huntingtin
T40 545-555 P42859 denotes huntingtin
T41 545-555 P51111 denotes huntingtin
T42 545-555 PR:000008840 denotes huntingtin
T43 545-555 P51112 denotes huntingtin
T44 556-560 SO:0000704 denotes gene
T45 562-565 PR:P51111 denotes Htt
T46 562-565 PR:000015189 denotes Htt
T47 562-565 PR:Q76P24 denotes Htt
T48 562-565 PR:P31645 denotes Htt
T49 562-565 PR:P42859 denotes Htt
T50 562-565 PR:Q60857 denotes Htt
T51 562-565 PR:P42858 denotes Htt
T52 562-565 PR:000008840 denotes Htt
T53 591-594 CVCL_D569 denotes CAG
T54 669-672 CVCL_D569 denotes CAG
T55 715-725 SO:0000783 denotes engineered
T56 726-731 10090 denotes mouse
T57 726-731 D051379 denotes mouse
T58 732-739 D013180 denotes strains
T59 732-739 D013180 denotes strains
T60 762-767 D006801 denotes human
T61 768-771 PR:P51111 denotes HTT
T62 768-771 PR:000015189 denotes HTT
T63 768-771 PR:Q76P24 denotes HTT
T64 768-771 PR:P31645 denotes HTT
T65 768-771 PR:P42859 denotes HTT
T66 768-771 PR:Q60857 denotes HTT
T67 768-771 PR:P42858 denotes HTT
T68 768-771 PR:000008840 denotes HTT
T69 810-813 CVCL_D569 denotes CAG
T70 844-850 UBERON:3010325 denotes animal
T71 844-850 UBERON:0000468 denotes animal
T72 884-893 MOP:0000569 denotes reduction
T73 897-903 PR:P63272 denotes SUPT4H
T74 897-903 PR:000030299 denotes SUPT4H
T75 897-903 PR:P63271 denotes SUPT4H
T76 934-938 PR:000005054 denotes mice
T78 934-938 O89094 denotes mice
T77 934-938 D051379 denotes mice
T79 934-938 10095 denotes mice
T80 966-971 UBERON:0012113 denotes bolus
T81 985-994 SO:0000077 denotes antisense
T82 1013-1029 CHEBI:7754 denotes oligonucleotides
T83 1013-1029 D009841 denotes oligonucleotides
T84 1013-1029 D009841 denotes oligonucleotides
T85 1054-1060 PR:P63272 denotes Supt4h
T86 1054-1060 PR:000030299 denotes Supt4h
T87 1054-1060 PR:P63271 denotes Supt4h
T88 1073-1077 PR:000005054 denotes mice
T90 1073-1077 O89094 denotes mice
T89 1073-1077 D051379 denotes mice
T91 1073-1077 10095 denotes mice
T92 1081-1089 SO:0000159 denotes deletion
T93 1109-1115 PR:P63272 denotes Supt4h
T94 1109-1115 PR:000030299 denotes Supt4h
T95 1109-1115 PR:P63271 denotes Supt4h
T96 1116-1120 SO:0000704 denotes gene
T99 1147-1151 SO:0000234 denotes mRNA
T97 1147-1151 D012333 denotes mRNA
T98 1147-1151 CHEBI:33699 denotes mRNA
T100 1156-1163 GO:0003675 denotes protein
T104 1156-1163 SO:0000104 denotes protein
T103 1156-1163 PR:000000001 denotes protein
T101 1156-1163 CHEBI:36080 denotes protein
T102 1156-1163 CHEBI:11122 denotes protein
T105 1195-1198 PR:P51111 denotes Htt
T106 1195-1198 PR:000015189 denotes Htt
T107 1195-1198 PR:Q76P24 denotes Htt
T108 1195-1198 PR:P31645 denotes Htt
T109 1195-1198 PR:P42859 denotes Htt
T110 1195-1198 PR:Q60857 denotes Htt
T111 1195-1198 PR:P42858 denotes Htt
T112 1195-1198 PR:000008840 denotes Htt
T113 1229-1238 MOP:0000569 denotes reduction
T114 1242-1248 PR:P63272 denotes SUPT4H
T115 1242-1248 PR:000030299 denotes SUPT4H
T116 1242-1248 PR:P63271 denotes SUPT4H
T117 1247-1251 CHEBI:13359 denotes H in
T118 1252-1257 10090 denotes mouse
T119 1252-1257 D051379 denotes mouse
T120 1294-1297 PR:P51111 denotes HTT
T121 1294-1297 PR:000015189 denotes HTT
T122 1294-1297 PR:Q76P24 denotes HTT
T123 1294-1297 PR:P31645 denotes HTT
T124 1294-1297 PR:P42859 denotes HTT
T125 1294-1297 PR:Q60857 denotes HTT
T126 1294-1297 PR:P42858 denotes HTT
T127 1294-1297 PR:000008840 denotes HTT
T132 1298-1305 SO:0000104 denotes protein
T129 1298-1305 CHEBI:36080 denotes protein
T130 1298-1305 CHEBI:11122 denotes protein
T131 1298-1305 PR:000000001 denotes protein
T128 1298-1305 GO:0003675 denotes protein
T133 1331-1335 PR:000005054 denotes mice
T135 1331-1335 O89094 denotes mice
T134 1331-1335 D051379 denotes mice
T136 1331-1335 10095 denotes mice
T137 1357-1365 UBERON:0000104 denotes lifespan
T138 1489-1495 PR:P63272 denotes SUPT4H
T139 1489-1495 PR:000030299 denotes SUPT4H
T140 1489-1495 PR:P63271 denotes SUPT4H

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 339-379 HP_0000707 denotes neurological and neuromuscular disorders
T2 1370-1388 HP_0001270 denotes delay of the motor

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-125 DRI_Background denotes Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.
T2 126-380 DRI_Challenge denotes Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders.
T3 381-683 DRI_Background denotes Earlier work has shown that interference with production of the transcription elongation protein SUPT4H results in decreased cellular capacity to transcribe mutant huntingtin gene (Htt) alleles containing long CAG expansions, but has little effect on expression of genes containing short CAG stretches.
T4 684-865 DRI_Outcome denotes zQ175 and R6/2 are genetically engineered mouse strains whose genomes contain human HTT alleles that include greatly expanded CAG repeats and which are used as animal models for HD.
T5 866-1207 DRI_Outcome denotes Here we show that reduction of SUPT4H expression in brains of zQ175 mice by intracerebroventricular bolus injection of antisense 2'-O-methoxyethyl oligonucleotides (ASOs) directed against Supt4h, or in R6/2 mice by deletion of one copy of the Supt4h gene, results in a decrease in mRNA and protein encoded specifically by mutant Htt alleles.
T6 1208-1440 DRI_Outcome denotes We further show that reduction of SUPT4H in mouse brains is associated with decreased HTT protein aggregation, and in R6/2 mice, also with prolonged lifespan and delay of the motor impairment that normally develops in these animals.
T7 1441-1562 DRI_Outcome denotes Our findings support the view that targeting of SUPT4H function may be useful as a therapeutic countermeasure against HD.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25760041-2#164#174#gene3064 545-555 gene3064 denotes huntingtin
25760041-2#481#483#diseaseC0020179 862-864 diseaseC0020179 denotes HD
25760041-5#48#54#gene6827 1489-1495 gene6827 denotes SUPT4H
25760041-5#118#120#diseaseC0020179 1559-1561 diseaseC0020179 denotes HD
164#174#gene3064481#483#diseaseC0020179 25760041-2#164#174#gene3064 25760041-2#481#483#diseaseC0020179 associated_with huntingtin,HD
48#54#gene6827118#120#diseaseC0020179 25760041-5#48#54#gene6827 25760041-5#118#120#diseaseC0020179 associated_with SUPT4H,HD