PubMed:2550128 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2550128","sourcedb":"PubMed","sourceid":"2550128","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2550128","text":"(1----3)-alpha-D-glucan from an alkaline extract of Agrocybe cylindracea, and antitumor activity of its O-(carboxymethyl)ated derivatives.\nThe structure of an alkali-soluble D-glucan (AG-AL) from the fruit body of Agrocybe cylindracea was investigated by a combination of chemical and spectroscopic methods indicating that it was a linear (1----3)-alpha-D-glucan (molecular weight, approximately 560,000), [alpha]20D +195 degrees (c 0.5, M sodium hydroxide). Both water-soluble and gelatinous products obtained by O-(carboxymethyl)ation of AG-AL showed potent antitumor activity against the solid form of Sarcoma 180 in mice, although the native D-glucan had little effect on the tumor.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":605,"end":612},"obj":"HP_0100242"},{"id":"T2","span":{"begin":680,"end":685},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":138},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":139,"end":458},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":459,"end":686},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":138},"obj":"Sentence"},{"id":"T2","span":{"begin":139,"end":458},"obj":"Sentence"},{"id":"T3","span":{"begin":459,"end":686},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":52,"end":72},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":214,"end":234},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":620,"end":624},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"64608"},{"id":"A2","pred":"db_id","subj":"T2","obj":"64608"},{"id":"A3","pred":"db_id","subj":"T3","obj":"10088"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":605,"end":612},"obj":"Disease"},{"id":"T2","span":{"begin":680,"end":685},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005089"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":605,"end":612},"obj":"Phenotype"},{"id":"T2","span":{"begin":680,"end":685},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0100242"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002664"},{"subj":"T1","pred":"source","obj":"HP-phenotype"},{"subj":"T2","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#da93ec","default":true},{"id":"sentences","color":"#93ecc0"},{"id":"NCBITAXON","color":"#eca693"},{"id":"mondo_disease","color":"#939aec"},{"id":"HP-phenotype","color":"#b4ec93"}]}]}}