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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 88-341 DRI_Background denotes In response to hypoxia and other stress, the sympathetic (adrenergic) nervous system regulates arterial contractility and blood flow, partly through differential activities of the alpha1 (α1) - adrenergic receptor (AR) subtypes (α1A-, α1B-, and α1D-AR).
T2 342-559 DRI_Approach denotes Thus, we tested the hypothesis that with acclimatization to long-term hypoxia (LTH), contractility of middle cerebral arteries (MCA) is regulated by changes in expression and activation of the specific α1-AR subtypes.
T3 560-698 DRI_Approach denotes We conducted experiments in MCA from adult normoxic sheep maintained near sea level (300 m) and those exposed to LTH (110 days at 3801 m).
T4 699-844 DRI_Approach denotes Following acclimatization to LTH, ovine MCA showed a 20% reduction (n = 5; P<0.05) in the maximum tension achieved by 10-5 M phenylephrine (PHE).
T5 845-1029 DRI_Outcome denotes LTH-acclimatized cerebral arteries also demonstrated a statistically significant (P<0.05) inhibition of PHE-induced contractility in the presence of specific α1-AR subtype antagonists.
T6 1030-1177 DRI_Outcome denotes Importantly, compared to normoxic vessels, there was significantly greater (P<0.05) α1B-AR subtype mRNA and protein levels in LTH acclimatized MCA.
T7 1178-1359 DRI_Outcome denotes Also, our results demonstrate that extracellular regulated kinase 1 and 2 (ERK1/2)-mediated negative feedback regulation of PHE-induced contractility is modulated by α1B-AR subtype.
T8 1360-1454 DRI_Background denotes Overall, in ovine MCA, LTH produces profound effects on α1-AR subtype expression and function.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 250-260 CVCL_C410|Hybridoma|Mus musculus denotes activities
T2 319-320 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T3 325-326 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T4 335-339 CVCL_W749|Transformed_cell_line|Homo sapiens denotes D-AR
T5 348-350 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T6 470-473 CVCL_ZC21|Cancer_cell_line|Homo sapiens denotes MCA
T7 491-498 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T8 517-527 CVCL_C410|Hybridoma|Mus musculus denotes activation
T9 560-562 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T10 588-591 CVCL_ZC21|Cancer_cell_line|Homo sapiens denotes MCA
T11 739-742 CVCL_ZC21|Cancer_cell_line|Homo sapiens denotes MCA
T12 750-754 CVCL_1940|Cancer_cell_line|Mus musculus denotes a 20
T13 750-754 CVCL_Z353|Spontaneously_immortalized_cell_line|Aedes aegypti denotes a 20
T14 750-751 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T15 752-754 CVCL_J923|Hybridoma|Mus musculus denotes 20
T16 898-899 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T17 1116-1117 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T18 1173-1176 CVCL_ZC21|Cancer_cell_line|Homo sapiens denotes MCA
T19 1246-1251 CVCL_B527|Embryonic_stem_cell|Homo sapiens denotes and 2
T20 1346-1347 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T21 1378-1381 CVCL_ZC21|Cancer_cell_line|Homo sapiens denotes MCA

GoldHamster

Id Subject Object Predicate Lexical cue
T2 0-15 UBERON:0004449 denotes Cerebral artery
T1 0-15 D002539 denotes Cerebral artery
T3 0-15 D002539 denotes Cerebral artery
T5 16-21 CHEBI:30216 denotes alpha
T6 16-23 PR:P0CY06 denotes alpha-1
T7 56-60 original_id denotes term
T11 91-110 GO:0001666 denotes response to hypoxia
T12 103-110 D000860 denotes hypoxia
T13 103-110 D000860 denotes hypoxia
T15 158-172 UBERON:0001016 denotes nervous system
T14 158-172 D009422 denotes nervous system
T16 158-172 D009422 denotes nervous system
T17 268-273 CHEBI:30216 denotes alpha
T18 268-274 PR:P0CY06 denotes alpha1
T23 282-301 D011941 denotes adrenergic receptor
T41 407-411 original_id denotes term
T42 412-419 D000860 denotes hypoxia
T43 412-419 D000860 denotes hypoxia
T44 460-468 UBERON:0001637 denotes arteries
T46 470-473 P60254 denotes MCA
T45 470-473 CHEBI:34342 denotes MCA
T47 478-487 SO:0000119 denotes regulated
T53 588-591 P60254 denotes MCA
T52 588-591 CHEBI:34342 denotes MCA
T54 597-602 UBERON:0007023 denotes adult
T55 612-617 9940 denotes sheep
T56 612-617 D012756 denotes sheep
T57 634-637 PR:000000735 denotes sea
T58 733-738 D012757 denotes ovine
T59 733-738 D012757 denotes ovine
T61 739-742 P60254 denotes MCA
T60 739-742 CHEBI:34342 denotes MCA
T64 756-765 MOP:0000569 denotes reduction
T67 824-837 8163 denotes phenylephrine
T65 824-837 D010656 denotes phenylephrine
T66 824-837 CHEBI:8093 denotes phenylephrine
T68 824-837 D010656 denotes phenylephrine
T71 839-842 SO:0001441 denotes PHE
T69 839-842 CHEBI:32501 denotes PHE
T70 839-842 CHEBI:29997 denotes PHE
T72 839-842 CHEBI:17295 denotes PHE
T73 839-842 CHEBI:32496 denotes PHE
T74 839-842 CHEBI:28044 denotes PHE
T75 871-879 UBERON:0001637 denotes arteries
T78 949-952 SO:0001441 denotes PHE
T76 949-952 CHEBI:32501 denotes PHE
T77 949-952 CHEBI:29997 denotes PHE
T79 949-952 CHEBI:17295 denotes PHE
T80 949-952 CHEBI:32496 denotes PHE
T81 949-952 CHEBI:28044 denotes PHE
T86 1017-1028 CHEBI:48706 denotes antagonists
T97 1129-1133 SO:0000234 denotes mRNA
T95 1129-1133 D012333 denotes mRNA
T96 1129-1133 CHEBI:33699 denotes mRNA
T98 1138-1145 GO:0003675 denotes protein
T101 1138-1145 PR:000000001 denotes protein
T102 1138-1145 SO:0000104 denotes protein
T99 1138-1145 CHEBI:36080 denotes protein
T100 1138-1145 CHEBI:11122 denotes protein
T104 1173-1176 P60254 denotes MCA
T103 1173-1176 CHEBI:34342 denotes MCA
T105 1213-1226 GO:0005576 denotes extracellular
T106 1227-1236 SO:0000119 denotes regulated
T111 1253-1257 Q63844 denotes ERK1
T112 1253-1257 P27361 denotes ERK1
T113 1253-1257 P21708 denotes ERK1
T114 1253-1257 PR:000000104 denotes ERK1
T115 1253-1257 PR:P42525 denotes ERK1
T116 1253-1257 Q5A1D3 denotes ERK1
T117 1253-1257 P42525 denotes ERK1
T118 1253-1257 PR:P27361 denotes ERK1
T119 1253-1257 PR:P21708 denotes ERK1
T121 1253-1257 PR:Q63844 denotes ERK1
T122 1253-1257 C4YGK0 denotes ERK1
T123 1253-1257 PR:Q5A1D3 denotes ERK1
T120 1253-1257 GO:0004707 denotes ERK1
T124 1288-1298 GO:0065007 denotes regulation
T127 1302-1305 SO:0001441 denotes PHE
T125 1302-1305 CHEBI:32501 denotes PHE
T126 1302-1305 CHEBI:29997 denotes PHE
T128 1302-1305 CHEBI:17295 denotes PHE
T129 1302-1305 CHEBI:32496 denotes PHE
T130 1302-1305 CHEBI:28044 denotes PHE
T139 1372-1377 D012757 denotes ovine
T140 1372-1377 D012757 denotes ovine
T142 1378-1381 P60254 denotes MCA
T141 1378-1381 CHEBI:34342 denotes MCA

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 192-205 HP_0001371 denotes contractility
T2 427-440 HP_0001371 denotes contractility
T3 961-974 HP_0001371 denotes contractility
T4 1314-1327 HP_0001371 denotes contractility