PubMed:25372662 / 0-740 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25372662","sourcedb":"PubMed","sourceid":"25372662","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25372662","text":"Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by exome-seq.\nAcute respiratory distress syndrome (ARDS) is a lung condition characterized by impaired gas exchange with systemic release of inflammatory mediators, causing pulmonary inflammation, vascular leak and hypoxemia. Existing biomarkers have limited effectiveness as diagnostic and therapeutic targets. To identify disease-associating variants in ARDS patients, whole-exome sequencing was performed on 96 ARDS patients, detecting 1,382,399 SNPs. By comparing these exome data to those of the 1000 Genomes Project, we identified a number of single nucleotide polymorphisms (SNP) which are potentially associated with ARDS. 5","tracks":[{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":121},"obj":"Sentence"},{"id":"T2","span":{"begin":122,"end":333},"obj":"Sentence"},{"id":"T3","span":{"begin":334,"end":419},"obj":"Sentence"},{"id":"T4","span":{"begin":420,"end":562},"obj":"Sentence"},{"id":"T5","span":{"begin":563,"end":738},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":121},"obj":"Sentence"},{"id":"T2","span":{"begin":122,"end":333},"obj":"Sentence"},{"id":"T3","span":{"begin":334,"end":419},"obj":"Sentence"},{"id":"T4","span":{"begin":420,"end":562},"obj":"Sentence"},{"id":"T5","span":{"begin":563,"end":738},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":128,"end":148},"obj":"HP_0002098"},{"id":"T2","span":{"begin":323,"end":332},"obj":"HP_0012418"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Inflammaging","color":"#ec93d2","default":true},{"id":"PubmedHPO","color":"#93ecec"}]}]}}