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PubMed:2535495 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes Chemical evidence for covalent linkages of a semi-synthetic glycoconjugate vaccine for Haemophilus influenzae type B disease.
TextSentencer_T2 126-271 Sentence denotes We have defined the nature of the covalent linkages in a Haemophilus influenzae type b oligosaccharide-CRM197 conjugate vaccine, designated HbOC.
TextSentencer_T3 272-434 Sentence denotes The conjugate was acid hydrolyzed to release a novel amino-acid derivative, N epsilon-(2-hydroxyethyl)lysine (OHEt-Lys), identifiable with an amino-acid analyzer.
TextSentencer_T4 435-701 Sentence denotes This amino-acid derivative was formed by reduction of Schiff bases formed between H. influenzae type b oligosaccharides (HbO) and the lysyl epsilon-amino groups of CRM197 (a non-toxic, cross-reactive variant of diphtheria toxin), followed by acid hydrolysis of HbOC.
TextSentencer_T5 702-886 Sentence denotes Quantification of OHEt-Lys per CRM197 molecule allowed the determination of a covalency ratio, a useful parameter for evaluating the stoichiometry and consistency of HbOC preparations.
TextSentencer_T6 887-1091 Sentence denotes Covalent association between HbO and CRM197 was also demonstrated by the coincidence of immunoreactivity of gel-electrophoresed HbOC on a Western blot probed with anti-CRM197 and anti-saccharide antisera.
T1 0-125 Sentence denotes Chemical evidence for covalent linkages of a semi-synthetic glycoconjugate vaccine for Haemophilus influenzae type B disease.
T2 126-271 Sentence denotes We have defined the nature of the covalent linkages in a Haemophilus influenzae type b oligosaccharide-CRM197 conjugate vaccine, designated HbOC.
T3 272-434 Sentence denotes The conjugate was acid hydrolyzed to release a novel amino-acid derivative, N epsilon-(2-hydroxyethyl)lysine (OHEt-Lys), identifiable with an amino-acid analyzer.
T4 435-701 Sentence denotes This amino-acid derivative was formed by reduction of Schiff bases formed between H. influenzae type b oligosaccharides (HbO) and the lysyl epsilon-amino groups of CRM197 (a non-toxic, cross-reactive variant of diphtheria toxin), followed by acid hydrolysis of HbOC.
T5 702-886 Sentence denotes Quantification of OHEt-Lys per CRM197 molecule allowed the determination of a covalency ratio, a useful parameter for evaluating the stoichiometry and consistency of HbOC preparations.
T6 887-1091 Sentence denotes Covalent association between HbO and CRM197 was also demonstrated by the coincidence of immunoreactivity of gel-electrophoresed HbOC on a Western blot probed with anti-CRM197 and anti-saccharide antisera.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 99-109 Disease denotes influenzae http://purl.obolibrary.org/obo/MONDO_0005812
T2 195-205 Disease denotes influenzae http://purl.obolibrary.org/obo/MONDO_0005812
T3 520-530 Disease denotes influenzae http://purl.obolibrary.org/obo/MONDO_0005812
T4 646-656 Disease denotes diphtheria http://purl.obolibrary.org/obo/MONDO_0005504

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 87-109 OrganismTaxon denotes Haemophilus influenzae 727
T2 183-205 OrganismTaxon denotes Haemophilus influenzae 727

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 350-357 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T2 575-582 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025