PubMed:25230104 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25230104","sourcedb":"PubMed","sourceid":"25230104","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25230104","text":"Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.\nUNLABELLED: Inflammatory bowel diseases (IBDs) are chronic and progressive inflammatory disorders of the gastrointestinal tract. In IBD, protein serological biomarkers could be relevant tools for assessing disease activity, performing early-stage diagnosis and managing the treatment. Using the interleukin-10 knockout (IL-10(-/-)) mouse, a model that develops a time-dependent IBD-like disorder that predominates in the colon; we performed longitudinal studies of circulating protein biomarkers in IBD. Circulating protein profiles in serum samples collected from 30-, 93-, to 135-day-old IL-10(-/-) mice were investigated using two-dimensional differential gel electrophoresis and MALDI-TOF/TOF tandem mass spectrometry. A total of 15 different proteins were identified and confirmed by ELISA and Western blot to be differentially accumulated in serum samples from mid- to late-stage IL-10(-/-) mice compared to early non-inflamed IL-10(-/-) mice. The use of another model of colitis and an extra-intestinal inflammation model validated this biomarker panel and demonstrated that comprised some global inflammatory markers, some intestinal inflammation-specific markers and some chronic intestinal inflammation markers. Statistical analyses using misclassification error rate charts validated the use of these identified proteins as powerful biomarkers of colitis. Unlike standard biomarker screening studies, our analyses identified a panel of proteins that allowed the definition of protein signatures that reflect colitis status.\nBIOLOGICAL SIGNIFICANCE: Crohn's disease (CD) and ulcerative colitis (UC) are the most common inflammatory bowel diseases (IBDs) occurring in humans. The major current diagnosis tool is colonoscopy, which is invasive and could lead to false diagnosis. The emergence of serological biomarkers enables the use of new diagnosis tools such as protein signatures for IBD diagnosis/management. Using 2D-DIGE coupled to mass spectrometry, our longitudinal study in a mouse model of colitis identified a signature of protein biomarkers for specific stages of disease.","tracks":[{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":95},"obj":"Sentence"},{"id":"T3","span":{"begin":96,"end":212},"obj":"Sentence"},{"id":"T4","span":{"begin":213,"end":368},"obj":"Sentence"},{"id":"T5","span":{"begin":369,"end":587},"obj":"Sentence"},{"id":"T6","span":{"begin":588,"end":806},"obj":"Sentence"},{"id":"T7","span":{"begin":807,"end":1033},"obj":"Sentence"},{"id":"T8","span":{"begin":1034,"end":1305},"obj":"Sentence"},{"id":"T9","span":{"begin":1306,"end":1450},"obj":"Sentence"},{"id":"T10","span":{"begin":1451,"end":1618},"obj":"Sentence"},{"id":"T11","span":{"begin":1619,"end":1643},"obj":"Sentence"},{"id":"T12","span":{"begin":1644,"end":1768},"obj":"Sentence"},{"id":"T13","span":{"begin":1769,"end":1870},"obj":"Sentence"},{"id":"T14","span":{"begin":1871,"end":2006},"obj":"Sentence"},{"id":"T15","span":{"begin":2007,"end":2178},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":95},"obj":"Sentence"},{"id":"T3","span":{"begin":96,"end":212},"obj":"Sentence"},{"id":"T4","span":{"begin":213,"end":368},"obj":"Sentence"},{"id":"T5","span":{"begin":369,"end":587},"obj":"Sentence"},{"id":"T6","span":{"begin":588,"end":806},"obj":"Sentence"},{"id":"T7","span":{"begin":807,"end":1033},"obj":"Sentence"},{"id":"T8","span":{"begin":1034,"end":1305},"obj":"Sentence"},{"id":"T9","span":{"begin":1306,"end":1450},"obj":"Sentence"},{"id":"T10","span":{"begin":1451,"end":1618},"obj":"Sentence"},{"id":"T11","span":{"begin":1619,"end":1643},"obj":"Sentence"},{"id":"T12","span":{"begin":1644,"end":1768},"obj":"Sentence"},{"id":"T13","span":{"begin":1769,"end":1870},"obj":"Sentence"},{"id":"T14","span":{"begin":1871,"end":2006},"obj":"Sentence"},{"id":"T15","span":{"begin":2007,"end":2178},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":505,"end":510},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T2","span":{"begin":1083,"end":1093},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T3","span":{"begin":1215,"end":1225},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T4","span":{"begin":1273,"end":1283},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T3","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T4","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":95},"obj":"Sentence"},{"id":"T3","span":{"begin":96,"end":212},"obj":"Sentence"},{"id":"T4","span":{"begin":213,"end":368},"obj":"Sentence"},{"id":"T5","span":{"begin":369,"end":587},"obj":"Sentence"},{"id":"T6","span":{"begin":588,"end":806},"obj":"Sentence"},{"id":"T7","span":{"begin":807,"end":1033},"obj":"Sentence"},{"id":"T8","span":{"begin":1034,"end":1305},"obj":"Sentence"},{"id":"T9","span":{"begin":1306,"end":1450},"obj":"Sentence"},{"id":"T10","span":{"begin":1451,"end":1618},"obj":"Sentence"},{"id":"T11","span":{"begin":1619,"end":1643},"obj":"Sentence"},{"id":"T12","span":{"begin":1644,"end":1768},"obj":"Sentence"},{"id":"T13","span":{"begin":1769,"end":1870},"obj":"Sentence"},{"id":"T14","span":{"begin":1871,"end":2006},"obj":"Sentence"},{"id":"T15","span":{"begin":2007,"end":2178},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":95},"obj":"Sentence"},{"id":"T3","span":{"begin":96,"end":212},"obj":"Sentence"},{"id":"T4","span":{"begin":213,"end":368},"obj":"Sentence"},{"id":"T5","span":{"begin":369,"end":587},"obj":"Sentence"},{"id":"T6","span":{"begin":588,"end":806},"obj":"Sentence"},{"id":"T7","span":{"begin":807,"end":1033},"obj":"Sentence"},{"id":"T8","span":{"begin":1034,"end":1305},"obj":"Sentence"},{"id":"T9","span":{"begin":1306,"end":1450},"obj":"Sentence"},{"id":"T10","span":{"begin":1451,"end":1618},"obj":"Sentence"},{"id":"T11","span":{"begin":1619,"end":1643},"obj":"Sentence"},{"id":"T12","span":{"begin":1644,"end":1768},"obj":"Sentence"},{"id":"T13","span":{"begin":1769,"end":1870},"obj":"Sentence"},{"id":"T14","span":{"begin":1871,"end":2006},"obj":"Sentence"},{"id":"T15","span":{"begin":2007,"end":2178},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":172,"end":211},"obj":"HP_0011024"},{"id":"T2","span":{"begin":172,"end":211},"obj":"HP_0002012"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":56,"end":82},"obj":"Disease"},{"id":"T2","span":{"begin":96,"end":123},"obj":"Disease"},{"id":"T3","span":{"begin":125,"end":129},"obj":"Disease"},{"id":"T4","span":{"begin":159,"end":181},"obj":"Disease"},{"id":"T5","span":{"begin":216,"end":219},"obj":"Disease"},{"id":"T7","span":{"begin":462,"end":465},"obj":"Disease"},{"id":"T9","span":{"begin":583,"end":586},"obj":"Disease"},{"id":"T11","span":{"begin":1062,"end":1069},"obj":"Disease"},{"id":"T12","span":{"begin":1083,"end":1106},"obj":"Disease"},{"id":"T13","span":{"begin":1215,"end":1238},"obj":"Disease"},{"id":"T14","span":{"begin":1273,"end":1296},"obj":"Disease"},{"id":"T15","span":{"begin":1442,"end":1449},"obj":"Disease"},{"id":"T16","span":{"begin":1603,"end":1610},"obj":"Disease"},{"id":"T17","span":{"begin":1644,"end":1659},"obj":"Disease"},{"id":"T18","span":{"begin":1661,"end":1663},"obj":"Disease"},{"id":"T19","span":{"begin":1669,"end":1687},"obj":"Disease"},{"id":"T21","span":{"begin":1689,"end":1691},"obj":"Disease"},{"id":"T22","span":{"begin":1713,"end":1740},"obj":"Disease"},{"id":"T23","span":{"begin":1742,"end":1746},"obj":"Disease"},{"id":"T24","span":{"begin":1981,"end":1984},"obj":"Disease"},{"id":"T26","span":{"begin":2094,"end":2101},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005052"},{"id":"A6","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005052"},{"id":"A8","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005052"},{"id":"A10","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005292"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0002269"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0002269"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0002269"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005292"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005292"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005011"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005011"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005101"},{"id":"A20","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0009960"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0005101"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0005052"},{"id":"A25","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0005292"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T5","pred":"source","obj":"mondo_disease"},{"subj":"T7","pred":"source","obj":"mondo_disease"},{"subj":"T9","pred":"source","obj":"mondo_disease"},{"subj":"T11","pred":"source","obj":"mondo_disease"},{"subj":"T12","pred":"source","obj":"mondo_disease"},{"subj":"T13","pred":"source","obj":"mondo_disease"},{"subj":"T14","pred":"source","obj":"mondo_disease"},{"subj":"T15","pred":"source","obj":"mondo_disease"},{"subj":"T16","pred":"source","obj":"mondo_disease"},{"subj":"T17","pred":"source","obj":"mondo_disease"},{"subj":"T18","pred":"source","obj":"mondo_disease"},{"subj":"T19","pred":"source","obj":"mondo_disease"},{"subj":"T21","pred":"source","obj":"mondo_disease"},{"subj":"T22","pred":"source","obj":"mondo_disease"},{"subj":"T23","pred":"source","obj":"mondo_disease"},{"subj":"T24","pred":"source","obj":"mondo_disease"},{"subj":"T26","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":416,"end":421},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":685,"end":689},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":981,"end":985},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1028,"end":1032},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":2079,"end":2084},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"10088"},{"id":"A2","pred":"db_id","subj":"T1","obj":"10090"},{"id":"A3","pred":"db_id","subj":"T3","obj":"10088"},{"id":"A4","pred":"db_id","subj":"T4","obj":"10088"},{"id":"A5","pred":"db_id","subj":"T5","obj":"10088"},{"id":"A6","pred":"db_id","subj":"T6","obj":"10088"},{"id":"A7","pred":"db_id","subj":"T6","obj":"10090"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"},{"subj":"T4","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"},{"subj":"T6","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":505,"end":510},"obj":"Body_part"},{"id":"T2","span":{"begin":1083,"end":1093},"obj":"Body_part"},{"id":"T3","span":{"begin":1215,"end":1225},"obj":"Body_part"},{"id":"T4","span":{"begin":1273,"end":1283},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"A3","pred":"mat_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"A4","pred":"mat_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"},{"subj":"T3","pred":"source","obj":"Anatomy-MAT"},{"subj":"T4","pred":"source","obj":"Anatomy-MAT"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":69,"end":74},"obj":"Body_part"},{"id":"T2","span":{"begin":109,"end":114},"obj":"Body_part"},{"id":"T3","span":{"begin":189,"end":211},"obj":"Body_part"},{"id":"T4","span":{"begin":505,"end":510},"obj":"Body_part"},{"id":"T5","span":{"begin":1726,"end":1731},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0005409"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":56,"end":82},"obj":"Phenotype"},{"id":"T2","span":{"begin":96,"end":123},"obj":"Phenotype"},{"id":"T3","span":{"begin":125,"end":129},"obj":"Phenotype"},{"id":"T4","span":{"begin":1062,"end":1069},"obj":"Phenotype"},{"id":"T5","span":{"begin":1083,"end":1106},"obj":"Phenotype"},{"id":"T6","span":{"begin":1215,"end":1238},"obj":"Phenotype"},{"id":"T7","span":{"begin":1273,"end":1296},"obj":"Phenotype"},{"id":"T8","span":{"begin":1442,"end":1449},"obj":"Phenotype"},{"id":"T9","span":{"begin":1603,"end":1610},"obj":"Phenotype"},{"id":"T10","span":{"begin":1644,"end":1659},"obj":"Phenotype"},{"id":"T11","span":{"begin":1661,"end":1663},"obj":"Phenotype"},{"id":"T12","span":{"begin":1669,"end":1687},"obj":"Phenotype"},{"id":"T13","span":{"begin":1689,"end":1691},"obj":"Phenotype"},{"id":"T14","span":{"begin":1713,"end":1740},"obj":"Phenotype"},{"id":"T15","span":{"begin":1742,"end":1746},"obj":"Phenotype"},{"id":"T16","span":{"begin":2094,"end":2101},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002037"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002037"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0002037"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0002583"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"HP:4000055"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"HP:4000055"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"HP:4000055"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"HP:0002583"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"HP:0002583"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"HP:0100280"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"HP:0100280"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"HP:0100279"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"HP:0100279"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"HP:0002037"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"HP:0002037"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"HP:0002583"},{"subj":"T1","pred":"source","obj":"HP-phenotype"},{"subj":"T2","pred":"source","obj":"HP-phenotype"},{"subj":"T3","pred":"source","obj":"HP-phenotype"},{"subj":"T4","pred":"source","obj":"HP-phenotype"},{"subj":"T5","pred":"source","obj":"HP-phenotype"},{"subj":"T6","pred":"source","obj":"HP-phenotype"},{"subj":"T7","pred":"source","obj":"HP-phenotype"},{"subj":"T8","pred":"source","obj":"HP-phenotype"},{"subj":"T9","pred":"source","obj":"HP-phenotype"},{"subj":"T10","pred":"source","obj":"HP-phenotype"},{"subj":"T11","pred":"source","obj":"HP-phenotype"},{"subj":"T12","pred":"source","obj":"HP-phenotype"},{"subj":"T13","pred":"source","obj":"HP-phenotype"},{"subj":"T14","pred":"source","obj":"HP-phenotype"},{"subj":"T15","pred":"source","obj":"HP-phenotype"},{"subj":"T16","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#ec93ac","default":true},{"id":"Glycosmos6-MAT","color":"#93c6ec"},{"id":"Inflammaging","color":"#e0ec93"},{"id":"PubmedHPO","color":"#de93ec"},{"id":"mondo_disease","color":"#93ecc3"},{"id":"NCBITAXON","color":"#eca993"},{"id":"Anatomy-MAT","color":"#9396ec"},{"id":"Anatomy-UBERON","color":"#b0ec93"},{"id":"HP-phenotype","color":"#ec93ca"}]}]}}