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sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.
T2 84-95 Sentence denotes UNLABELLED:
T3 96-212 Sentence denotes Inflammatory bowel diseases (IBDs) are chronic and progressive inflammatory disorders of the gastrointestinal tract.
T4 213-368 Sentence denotes In IBD, protein serological biomarkers could be relevant tools for assessing disease activity, performing early-stage diagnosis and managing the treatment.
T5 369-587 Sentence denotes Using the interleukin-10 knockout (IL-10(-/-)) mouse, a model that develops a time-dependent IBD-like disorder that predominates in the colon; we performed longitudinal studies of circulating protein biomarkers in IBD.
T6 588-806 Sentence denotes Circulating protein profiles in serum samples collected from 30-, 93-, to 135-day-old IL-10(-/-) mice were investigated using two-dimensional differential gel electrophoresis and MALDI-TOF/TOF tandem mass spectrometry.
T7 807-1033 Sentence denotes A total of 15 different proteins were identified and confirmed by ELISA and Western blot to be differentially accumulated in serum samples from mid- to late-stage IL-10(-/-) mice compared to early non-inflamed IL-10(-/-) mice.
T8 1034-1305 Sentence denotes The use of another model of colitis and an extra-intestinal inflammation model validated this biomarker panel and demonstrated that comprised some global inflammatory markers, some intestinal inflammation-specific markers and some chronic intestinal inflammation markers.
T9 1306-1450 Sentence denotes Statistical analyses using misclassification error rate charts validated the use of these identified proteins as powerful biomarkers of colitis.
T10 1451-1618 Sentence denotes Unlike standard biomarker screening studies, our analyses identified a panel of proteins that allowed the definition of protein signatures that reflect colitis status.
T11 1619-1643 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T12 1644-1768 Sentence denotes Crohn's disease (CD) and ulcerative colitis (UC) are the most common inflammatory bowel diseases (IBDs) occurring in humans.
T13 1769-1870 Sentence denotes The major current diagnosis tool is colonoscopy, which is invasive and could lead to false diagnosis.
T14 1871-2006 Sentence denotes The emergence of serological biomarkers enables the use of new diagnosis tools such as protein signatures for IBD diagnosis/management.
T15 2007-2178 Sentence denotes Using 2D-DIGE coupled to mass spectrometry, our longitudinal study in a mouse model of colitis identified a signature of protein biomarkers for specific stages of disease.
T1 0-83 Sentence denotes Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.
T2 84-95 Sentence denotes UNLABELLED:
T3 96-212 Sentence denotes Inflammatory bowel diseases (IBDs) are chronic and progressive inflammatory disorders of the gastrointestinal tract.
T4 213-368 Sentence denotes In IBD, protein serological biomarkers could be relevant tools for assessing disease activity, performing early-stage diagnosis and managing the treatment.
T5 369-587 Sentence denotes Using the interleukin-10 knockout (IL-10(-/-)) mouse, a model that develops a time-dependent IBD-like disorder that predominates in the colon; we performed longitudinal studies of circulating protein biomarkers in IBD.
T6 588-806 Sentence denotes Circulating protein profiles in serum samples collected from 30-, 93-, to 135-day-old IL-10(-/-) mice were investigated using two-dimensional differential gel electrophoresis and MALDI-TOF/TOF tandem mass spectrometry.
T7 807-1033 Sentence denotes A total of 15 different proteins were identified and confirmed by ELISA and Western blot to be differentially accumulated in serum samples from mid- to late-stage IL-10(-/-) mice compared to early non-inflamed IL-10(-/-) mice.
T8 1034-1305 Sentence denotes The use of another model of colitis and an extra-intestinal inflammation model validated this biomarker panel and demonstrated that comprised some global inflammatory markers, some intestinal inflammation-specific markers and some chronic intestinal inflammation markers.
T9 1306-1450 Sentence denotes Statistical analyses using misclassification error rate charts validated the use of these identified proteins as powerful biomarkers of colitis.
T10 1451-1618 Sentence denotes Unlike standard biomarker screening studies, our analyses identified a panel of proteins that allowed the definition of protein signatures that reflect colitis status.
T11 1619-1643 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T12 1644-1768 Sentence denotes Crohn's disease (CD) and ulcerative colitis (UC) are the most common inflammatory bowel diseases (IBDs) occurring in humans.
T13 1769-1870 Sentence denotes The major current diagnosis tool is colonoscopy, which is invasive and could lead to false diagnosis.
T14 1871-2006 Sentence denotes The emergence of serological biomarkers enables the use of new diagnosis tools such as protein signatures for IBD diagnosis/management.
T15 2007-2178 Sentence denotes Using 2D-DIGE coupled to mass spectrometry, our longitudinal study in a mouse model of colitis identified a signature of protein biomarkers for specific stages of disease.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 505-510 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T2 1083-1093 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T3 1215-1225 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T4 1273-1283 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.
T2 84-95 Sentence denotes UNLABELLED:
T3 96-212 Sentence denotes Inflammatory bowel diseases (IBDs) are chronic and progressive inflammatory disorders of the gastrointestinal tract.
T4 213-368 Sentence denotes In IBD, protein serological biomarkers could be relevant tools for assessing disease activity, performing early-stage diagnosis and managing the treatment.
T5 369-587 Sentence denotes Using the interleukin-10 knockout (IL-10(-/-)) mouse, a model that develops a time-dependent IBD-like disorder that predominates in the colon; we performed longitudinal studies of circulating protein biomarkers in IBD.
T6 588-806 Sentence denotes Circulating protein profiles in serum samples collected from 30-, 93-, to 135-day-old IL-10(-/-) mice were investigated using two-dimensional differential gel electrophoresis and MALDI-TOF/TOF tandem mass spectrometry.
T7 807-1033 Sentence denotes A total of 15 different proteins were identified and confirmed by ELISA and Western blot to be differentially accumulated in serum samples from mid- to late-stage IL-10(-/-) mice compared to early non-inflamed IL-10(-/-) mice.
T8 1034-1305 Sentence denotes The use of another model of colitis and an extra-intestinal inflammation model validated this biomarker panel and demonstrated that comprised some global inflammatory markers, some intestinal inflammation-specific markers and some chronic intestinal inflammation markers.
T9 1306-1450 Sentence denotes Statistical analyses using misclassification error rate charts validated the use of these identified proteins as powerful biomarkers of colitis.
T10 1451-1618 Sentence denotes Unlike standard biomarker screening studies, our analyses identified a panel of proteins that allowed the definition of protein signatures that reflect colitis status.
T11 1619-1643 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T12 1644-1768 Sentence denotes Crohn's disease (CD) and ulcerative colitis (UC) are the most common inflammatory bowel diseases (IBDs) occurring in humans.
T13 1769-1870 Sentence denotes The major current diagnosis tool is colonoscopy, which is invasive and could lead to false diagnosis.
T14 1871-2006 Sentence denotes The emergence of serological biomarkers enables the use of new diagnosis tools such as protein signatures for IBD diagnosis/management.
T15 2007-2178 Sentence denotes Using 2D-DIGE coupled to mass spectrometry, our longitudinal study in a mouse model of colitis identified a signature of protein biomarkers for specific stages of disease.
T1 0-83 Sentence denotes Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.
T2 84-95 Sentence denotes UNLABELLED:
T3 96-212 Sentence denotes Inflammatory bowel diseases (IBDs) are chronic and progressive inflammatory disorders of the gastrointestinal tract.
T4 213-368 Sentence denotes In IBD, protein serological biomarkers could be relevant tools for assessing disease activity, performing early-stage diagnosis and managing the treatment.
T5 369-587 Sentence denotes Using the interleukin-10 knockout (IL-10(-/-)) mouse, a model that develops a time-dependent IBD-like disorder that predominates in the colon; we performed longitudinal studies of circulating protein biomarkers in IBD.
T6 588-806 Sentence denotes Circulating protein profiles in serum samples collected from 30-, 93-, to 135-day-old IL-10(-/-) mice were investigated using two-dimensional differential gel electrophoresis and MALDI-TOF/TOF tandem mass spectrometry.
T7 807-1033 Sentence denotes A total of 15 different proteins were identified and confirmed by ELISA and Western blot to be differentially accumulated in serum samples from mid- to late-stage IL-10(-/-) mice compared to early non-inflamed IL-10(-/-) mice.
T8 1034-1305 Sentence denotes The use of another model of colitis and an extra-intestinal inflammation model validated this biomarker panel and demonstrated that comprised some global inflammatory markers, some intestinal inflammation-specific markers and some chronic intestinal inflammation markers.
T9 1306-1450 Sentence denotes Statistical analyses using misclassification error rate charts validated the use of these identified proteins as powerful biomarkers of colitis.
T10 1451-1618 Sentence denotes Unlike standard biomarker screening studies, our analyses identified a panel of proteins that allowed the definition of protein signatures that reflect colitis status.
T11 1619-1643 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T12 1644-1768 Sentence denotes Crohn's disease (CD) and ulcerative colitis (UC) are the most common inflammatory bowel diseases (IBDs) occurring in humans.
T13 1769-1870 Sentence denotes The major current diagnosis tool is colonoscopy, which is invasive and could lead to false diagnosis.
T14 1871-2006 Sentence denotes The emergence of serological biomarkers enables the use of new diagnosis tools such as protein signatures for IBD diagnosis/management.
T15 2007-2178 Sentence denotes Using 2D-DIGE coupled to mass spectrometry, our longitudinal study in a mouse model of colitis identified a signature of protein biomarkers for specific stages of disease.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 172-211 HP_0011024 denotes disorders of the gastrointestinal tract
T2 172-211 HP_0002012 denotes disorders of the gastrointestinal tract

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 56-82 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T2 96-123 Disease denotes Inflammatory bowel diseases http://purl.obolibrary.org/obo/MONDO_0005265
T3 125-129 Disease denotes IBDs http://purl.obolibrary.org/obo/MONDO_0005265
T4 159-181 Disease denotes inflammatory disorders http://purl.obolibrary.org/obo/MONDO_0021166
T5 216-219 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T7 462-465 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T9 583-586 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T11 1062-1069 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T12 1083-1106 Disease denotes intestinal inflammation http://purl.obolibrary.org/obo/MONDO_0002269
T13 1215-1238 Disease denotes intestinal inflammation http://purl.obolibrary.org/obo/MONDO_0002269
T14 1273-1296 Disease denotes intestinal inflammation http://purl.obolibrary.org/obo/MONDO_0002269
T15 1442-1449 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T16 1603-1610 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T17 1644-1659 Disease denotes Crohn's disease http://purl.obolibrary.org/obo/MONDO_0005011
T18 1661-1663 Disease denotes CD http://purl.obolibrary.org/obo/MONDO_0005011
T19 1669-1687 Disease denotes ulcerative colitis http://purl.obolibrary.org/obo/MONDO_0005101|http://purl.obolibrary.org/obo/MONDO_0009960
T21 1689-1691 Disease denotes UC http://purl.obolibrary.org/obo/MONDO_0005101
T22 1713-1740 Disease denotes inflammatory bowel diseases http://purl.obolibrary.org/obo/MONDO_0005265
T23 1742-1746 Disease denotes IBDs http://purl.obolibrary.org/obo/MONDO_0005265
T24 1981-1984 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T26 2094-2101 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 416-421 OrganismTaxon denotes mouse 10088|10090
T3 685-689 OrganismTaxon denotes mice 10088
T4 981-985 OrganismTaxon denotes mice 10088
T5 1028-1032 OrganismTaxon denotes mice 10088
T6 2079-2084 OrganismTaxon denotes mouse 10088|10090

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 505-510 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T2 1083-1093 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T3 1215-1225 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T4 1273-1283 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 69-74 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T2 109-114 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T3 189-211 Body_part denotes gastrointestinal tract http://purl.obolibrary.org/obo/UBERON_0005409
T4 505-510 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T5 1726-1731 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 56-82 Phenotype denotes inflammatory bowel disease HP:0002037
T2 96-123 Phenotype denotes Inflammatory bowel diseases HP:0002037
T3 125-129 Phenotype denotes IBDs HP:0002037
T4 1062-1069 Phenotype denotes colitis HP:0002583
T5 1083-1106 Phenotype denotes intestinal inflammation HP:4000055
T6 1215-1238 Phenotype denotes intestinal inflammation HP:4000055
T7 1273-1296 Phenotype denotes intestinal inflammation HP:4000055
T8 1442-1449 Phenotype denotes colitis HP:0002583
T9 1603-1610 Phenotype denotes colitis HP:0002583
T10 1644-1659 Phenotype denotes Crohn's disease HP:0100280
T11 1661-1663 Phenotype denotes CD HP:0100280
T12 1669-1687 Phenotype denotes ulcerative colitis HP:0100279
T13 1689-1691 Phenotype denotes UC HP:0100279
T14 1713-1740 Phenotype denotes inflammatory bowel diseases HP:0002037
T15 1742-1746 Phenotype denotes IBDs HP:0002037
T16 2094-2101 Phenotype denotes colitis HP:0002583