PubMed:25156158
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 107-122 | DRI_Approach | denotes | The Frog Embryo |
| T2 | 151-222 | DRI_Approach | denotes | (FETAX) was used to assess the teratogenic potential of two tocolytics. |
| T3 | 223-321 | DRI_Background | denotes | Embryos of the South African clawed frog, Xenopus laevis, were exposed to ritodrine or nifedipine. |
| T4 | 322-385 | DRI_Background | denotes | Exposure media were changed and monitored at 24-hour intervals. |
| T5 | 653-839 | DRI_Outcome | denotes | Nifedipine was determined to be the more toxic and teratogenic than ritodrine, with a LC50 of 0.606 µg/L, an EC50 of 0.006 µg/L, and a teratogenicity Index (TI) value (LC50/EC50) of 101. |
| T6 | 840-897 | DRI_Outcome | denotes | On the other hand, the LC50 of ritodrine was 28.571 mg/L. |
| T7 | 898-1073 | DRI_Background | denotes | In addition; the LC50, EC50 and TI values for nifedipine in the 5 mg/L ritodrine + nifedipine combination group were determined as 1.050 µg/L, 0.868 µg/L and 1.5 respectively. |
| T8 | 1074-1167 | DRI_Approach | denotes | For ritodrine, the NOAEC and LOAEC values were determined as 2 mg/L and 4 mg/L, respectively. |
| T9 | 1168-1309 | DRI_Background | denotes | For the nifedipine and the ritodrine + nifedipine groups; while the LOAEC values of these groups were 0.0001 µg/L and 0.1 µg/L, respectively. |
| T10 | 1310-1345 | DRI_Approach | denotes | NOAEC value couldn't be determined. |
| T11 | 1346-1469 | DRI_Outcome | denotes | Our results demonstrated that nifedipine administration was associated with higher levels of teratogenic and toxic effects. |
| T12 | 1470-1598 | DRI_Background | denotes | However, the ritodrine + nifedipine combination form reduced the toxic and teratogenic effects of nifedipine on Xenopus embryos. |
| T13 | 1599-1753 | DRI_Approach | denotes | Further studies should be conducted in order to investigate the optimal combination concentrations of these substances for the treatment of preterm labor. |
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 33-42 | D012312 | denotes | Ritodrine |
| T2 | 33-42 | D012312 | denotes | Ritodrine |
| T3 | 33-42 | CHEBI:8872 | denotes | Ritodrine |
| T4 | 47-57 | 7417 | denotes | Nifedipine |
| T5 | 47-57 | D009543 | denotes | Nifedipine |
| T6 | 47-57 | CHEBI:7565 | denotes | Nifedipine |
| T7 | 47-57 | D009543 | denotes | Nifedipine |
| T8 | 66-70 | CVCL_0C97 | denotes | Frog |
| T9 | 71-77 | UBERON:0000922 | denotes | Embryo |
| T10 | 78-91 | D064793 | denotes | Teratogenesis |
| T11 | 78-91 | D064793 | denotes | Teratogenesis |
| T12 | 111-115 | CVCL_0C97 | denotes | Frog |
| T13 | 116-122 | UBERON:0000922 | denotes | Embryo |
| T14 | 123-136 | D064793 | denotes | Teratogenesis |
| T15 | 123-136 | D064793 | denotes | Teratogenesis |
| T16 | 143-150 | 451443 | denotes | Xenopus |
| T17 | 143-150 | 451444 | denotes | Xenopus |
| T18 | 143-150 | 288623 | denotes | Xenopus |
| T19 | 143-150 | 1589957 | denotes | Xenopus |
| T20 | 143-150 | 8364 | denotes | Xenopus |
| T21 | 143-150 | D014981 | denotes | Xenopus |
| T22 | 143-150 | 698687 | denotes | Xenopus |
| T23 | 143-150 | 224340 | denotes | Xenopus |
| T118 | 1483-1492 | D012312 | denotes | ritodrine |
| T119 | 1483-1492 | D012312 | denotes | ritodrine |
| T24 | 211-221 | D015149 | denotes | tocolytics |
| T25 | 211-221 | D015149 | denotes | tocolytics |
| T26 | 211-221 | CHEBI:66993 | denotes | tocolytics |
| T27 | 244-263 | 8355 | denotes | African clawed frog |
| T30 | 252-279 | 8355 | denotes | clawed frog, Xenopus laevis |
| T31 | 259-263 | CVCL_0C97 | denotes | frog |
| T42 | 297-306 | D012312 | denotes | ritodrine |
| T43 | 297-306 | D012312 | denotes | ritodrine |
| T44 | 297-306 | CHEBI:8872 | denotes | ritodrine |
| T45 | 310-320 | 7417 | denotes | nifedipine |
| T46 | 310-320 | D009543 | denotes | nifedipine |
| T47 | 310-320 | CHEBI:7565 | denotes | nifedipine |
| T48 | 310-320 | D009543 | denotes | nifedipine |
| T50 | 439-443 | CVCL_IR37 | denotes | EC50 |
| T51 | 647-651 | CHEBI:23888 | denotes | drug |
| T52 | 653-663 | 7417 | denotes | Nifedipine |
| T53 | 653-663 | D009543 | denotes | Nifedipine |
| T54 | 653-663 | CHEBI:7565 | denotes | Nifedipine |
| T55 | 653-663 | D009543 | denotes | Nifedipine |
| T56 | 721-730 | D012312 | denotes | ritodrine |
| T57 | 721-730 | D012312 | denotes | ritodrine |
| T58 | 721-730 | CHEBI:8872 | denotes | ritodrine |
| T59 | 762-766 | CVCL_IR37 | denotes | EC50 |
| T60 | 826-830 | CVCL_IR37 | denotes | EC50 |
| T61 | 871-880 | D012312 | denotes | ritodrine |
| T62 | 871-880 | D012312 | denotes | ritodrine |
| T63 | 871-880 | CHEBI:8872 | denotes | ritodrine |
| T64 | 921-925 | CVCL_IR37 | denotes | EC50 |
| T65 | 944-954 | 7417 | denotes | nifedipine |
| T66 | 944-954 | D009543 | denotes | nifedipine |
| T67 | 944-954 | CHEBI:7565 | denotes | nifedipine |
| T68 | 944-954 | D009543 | denotes | nifedipine |
| T69 | 969-978 | D012312 | denotes | ritodrine |
| T70 | 969-978 | D012312 | denotes | ritodrine |
| T71 | 969-978 | CHEBI:8872 | denotes | ritodrine |
| T72 | 981-991 | 7417 | denotes | nifedipine |
| T73 | 981-991 | D009543 | denotes | nifedipine |
| T74 | 981-991 | CHEBI:7565 | denotes | nifedipine |
| T75 | 981-991 | D009543 | denotes | nifedipine |
| T90 | 1078-1087 | D012312 | denotes | ritodrine |
| T91 | 1078-1087 | D012312 | denotes | ritodrine |
| T92 | 1078-1087 | CHEBI:8872 | denotes | ritodrine |
| T103 | 1176-1186 | 7417 | denotes | nifedipine |
| T104 | 1176-1186 | D009543 | denotes | nifedipine |
| T105 | 1176-1186 | CHEBI:7565 | denotes | nifedipine |
| T106 | 1176-1186 | D009543 | denotes | nifedipine |
| T107 | 1195-1204 | D012312 | denotes | ritodrine |
| T108 | 1195-1204 | D012312 | denotes | ritodrine |
| T109 | 1195-1204 | CHEBI:8872 | denotes | ritodrine |
| T110 | 1207-1217 | 7417 | denotes | nifedipine |
| T111 | 1207-1217 | D009543 | denotes | nifedipine |
| T112 | 1207-1217 | CHEBI:7565 | denotes | nifedipine |
| T113 | 1207-1217 | D009543 | denotes | nifedipine |
| T114 | 1376-1386 | 7417 | denotes | nifedipine |
| T115 | 1376-1386 | D009543 | denotes | nifedipine |
| T116 | 1376-1386 | CHEBI:7565 | denotes | nifedipine |
| T117 | 1376-1386 | D009543 | denotes | nifedipine |
| T120 | 1483-1492 | CHEBI:8872 | denotes | ritodrine |
| T121 | 1495-1505 | 7417 | denotes | nifedipine |
| T122 | 1495-1505 | D009543 | denotes | nifedipine |
| T123 | 1495-1505 | CHEBI:7565 | denotes | nifedipine |
| T124 | 1495-1505 | D009543 | denotes | nifedipine |
| T125 | 1568-1578 | 7417 | denotes | nifedipine |
| T126 | 1568-1578 | D009543 | denotes | nifedipine |
| T127 | 1568-1578 | CHEBI:7565 | denotes | nifedipine |
| T128 | 1568-1578 | D009543 | denotes | nifedipine |
| T129 | 1582-1589 | 451443 | denotes | Xenopus |
| T130 | 1582-1589 | 451444 | denotes | Xenopus |
| T131 | 1582-1589 | 288623 | denotes | Xenopus |
| T132 | 1582-1589 | 1589957 | denotes | Xenopus |
| T133 | 1582-1589 | 8364 | denotes | Xenopus |
| T134 | 1582-1589 | D014981 | denotes | Xenopus |
| T135 | 1582-1589 | 698687 | denotes | Xenopus |
| T136 | 1582-1589 | 224340 | denotes | Xenopus |
| T137 | 1739-1752 | D007752 | denotes | preterm labor |
| T138 | 1739-1752 | D007752 | denotes | preterm labor |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 64-65 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T2 | 66-70 | CVCL_0C97|Cancer_cell_line|Canis lupus familiaris | denotes | Frog |
| T3 | 111-115 | CVCL_0C97|Cancer_cell_line|Canis lupus familiaris | denotes | Frog |
| T4 | 259-263 | CVCL_0C97|Cancer_cell_line|Canis lupus familiaris | denotes | frog |
| T5 | 342-349 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | changed |
| T6 | 439-443 | CVCL_IR37|Cancer_cell_line|Homo sapiens | denotes | EC50 |
| T7 | 737-738 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T8 | 759-761 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
| T9 | 759-761 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
| T10 | 762-766 | CVCL_IR37|Cancer_cell_line|Homo sapiens | denotes | EC50 |
| T11 | 786-787 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T12 | 826-830 | CVCL_IR37|Cancer_cell_line|Homo sapiens | denotes | EC50 |
| T13 | 921-925 | CVCL_IR37|Cancer_cell_line|Homo sapiens | denotes | EC50 |
| T14 | 1132-1136 | CVCL_XH98|Hybridoma|Mus musculus | denotes | as 2 |
| T15 | 1142-1147 | CVCL_K225|Induced_pluripotent_stem_cell|Homo sapiens | denotes | and 4 |