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PubMed:25107371 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 217-224 HP_0002664 denotes cancers
T2 243-248 HP_0002664 denotes tumor
T3 353-359 HP_0002664 denotes cancer
T4 417-431 HP_0009725 denotes bladder cancer
T5 425-431 HP_0002664 denotes cancer
T6 485-499 HP_0009725 denotes bladder cancer
T7 493-499 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25107371-0#0#7#gene406979 0-7 gene406979 denotes miR-19a
25107371-0#61#75#diseaseC0005684 61-75 diseaseC0005684 denotes bladder cancer
25107371-0#61#75#diseaseC0005695 61-75 diseaseC0005695 denotes bladder cancer
25107371-0#61#75#diseaseC0699885 61-75 diseaseC0699885 denotes bladder cancer
25107371-10#74#78#gene5728 2083-2087 gene5728 denotes PTEN
25107371-10#32#46#diseaseC0005684 2041-2055 diseaseC0005684 denotes bladder cancer
25107371-10#32#46#diseaseC0005695 2041-2055 diseaseC0005695 denotes bladder cancer
25107371-10#32#46#diseaseC0699885 2041-2055 diseaseC0699885 denotes bladder cancer
25107371-9#24#31#gene406979 1879-1886 gene406979 denotes miR-19a
25107371-9#138#152#diseaseC0596263 1993-2007 diseaseC0596263 denotes carcinogenesis
0#7#gene40697961#75#diseaseC0005684 25107371-0#0#7#gene406979 25107371-0#61#75#diseaseC0005684 associated_with miR-19a,bladder cancer
0#7#gene40697961#75#diseaseC0005695 25107371-0#0#7#gene406979 25107371-0#61#75#diseaseC0005695 associated_with miR-19a,bladder cancer
0#7#gene40697961#75#diseaseC0699885 25107371-0#0#7#gene406979 25107371-0#61#75#diseaseC0699885 associated_with miR-19a,bladder cancer
74#78#gene572832#46#diseaseC0005684 25107371-10#74#78#gene5728 25107371-10#32#46#diseaseC0005684 associated_with PTEN,bladder cancer
74#78#gene572832#46#diseaseC0005695 25107371-10#74#78#gene5728 25107371-10#32#46#diseaseC0005695 associated_with PTEN,bladder cancer
74#78#gene572832#46#diseaseC0699885 25107371-10#74#78#gene5728 25107371-10#32#46#diseaseC0699885 associated_with PTEN,bladder cancer
24#31#gene406979138#152#diseaseC0596263 25107371-9#24#31#gene406979 25107371-9#138#152#diseaseC0596263 associated_with miR-19a,carcinogenesis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T67 2083-2087 gene:5728 denotes PTEN
T68 2041-2055 disease:C0005684 denotes bladder cancer
R1 T67 T68 associated_with PTEN,bladder cancer
R2 T67 T68 associated_with PTEN,bladder cancer
R3 T67 T68 associated_with PTEN,bladder cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-76 Sentence denotes miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer.
TextSentencer_T2 77-88 Sentence denotes BACKGROUND:
TextSentencer_T3 89-225 Sentence denotes The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers.
TextSentencer_T4 226-370 Sentence denotes The discovery of tumor associated miRNAs in serum of patients supported the use of plasma/serum miRNAs as noninvasive means of cancer detection.
TextSentencer_T5 371-522 Sentence denotes However, the aberrant expression of miRNAs in bladder cancer patients and their intensive roles and mechanisms in bladder cancer are poorly understood.
TextSentencer_T6 523-531 Sentence denotes METHODS:
TextSentencer_T7 532-993 Sentence denotes Taqman probe stem-loop real-time PCR was used to accurately measure the levels of miR-19a in bladder cancer cell lines, 100 pairs of bladder cancer tissues and the adjacent non-neoplastic tissues and also the plasma collected from bladder cancer patients and normal controls. miR-19a mimics and inhibitors were transfected into bladder cancer cells to investigate its role on regulating cell proliferation which was measured by CCK-8 and colony formation assay.
TextSentencer_T8 994-1184 Sentence denotes The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid.
TextSentencer_T9 1185-1351 Sentence denotes RESULTS: miR-19a was significantly up-regulated in bladder cancer tissues and high-level of miR-19a was correlative with more aggressive phenotypes of bladder cancer.
TextSentencer_T10 1352-1573 Sentence denotes Meanwhile, gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN.
TextSentencer_T11 1574-1841 Sentence denotes Furthermore, investigation of miR-19a expression in the plasma of bladder cancer patients showed that miR-19a was also increased in plasma of bladder cancer patients which strongly supported miR-19a could be developed as potential diagnostic marker of bladder cancer.
TextSentencer_T12 1842-1854 Sentence denotes CONCLUSIONS:
TextSentencer_T13 1855-2008 Sentence denotes Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis.
TextSentencer_T14 2009-2088 Sentence denotes The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN.
T1 0-76 Sentence denotes miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer.
T2 77-88 Sentence denotes BACKGROUND:
T3 89-225 Sentence denotes The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers.
T4 226-370 Sentence denotes The discovery of tumor associated miRNAs in serum of patients supported the use of plasma/serum miRNAs as noninvasive means of cancer detection.
T5 371-522 Sentence denotes However, the aberrant expression of miRNAs in bladder cancer patients and their intensive roles and mechanisms in bladder cancer are poorly understood.
T6 523-531 Sentence denotes METHODS:
T7 532-993 Sentence denotes Taqman probe stem-loop real-time PCR was used to accurately measure the levels of miR-19a in bladder cancer cell lines, 100 pairs of bladder cancer tissues and the adjacent non-neoplastic tissues and also the plasma collected from bladder cancer patients and normal controls. miR-19a mimics and inhibitors were transfected into bladder cancer cells to investigate its role on regulating cell proliferation which was measured by CCK-8 and colony formation assay.
T8 994-1184 Sentence denotes The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid.
T9 1185-1351 Sentence denotes RESULTS: miR-19a was significantly up-regulated in bladder cancer tissues and high-level of miR-19a was correlative with more aggressive phenotypes of bladder cancer.
T10 1352-1573 Sentence denotes Meanwhile, gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN.
T11 1574-1841 Sentence denotes Furthermore, investigation of miR-19a expression in the plasma of bladder cancer patients showed that miR-19a was also increased in plasma of bladder cancer patients which strongly supported miR-19a could be developed as potential diagnostic marker of bladder cancer.
T12 1842-1854 Sentence denotes CONCLUSIONS:
T13 1855-2008 Sentence denotes Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis.
T14 2009-2088 Sentence denotes The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 270-275 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 316-321 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 680-687 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T4 720-727 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T5 1251-1258 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 270-275 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 316-321 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 680-687 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T4 720-727 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T5 1251-1258 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues