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PubMed:25074924 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 113-133 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T2 146-168 Cell denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL:0002248
T3 512-524 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T4 604-608 Cell denotes band http://purl.obolibrary.org/obo/CL:0000560
T5 680-705 Cell denotes amniotic epithelial cells http://purl.obolibrary.org/obo/CL:0002536
T6 781-794 Cell denotes keratinocytes http://purl.obolibrary.org/obo/CL:0000312
T7 796-807 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T8 812-829 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T9 906-918 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T10 989-1000 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T11 1183-1195 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T12 1300-1312 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T13 1729-1741 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T14 1792-1809 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 1258-1266 GlycoEpitope denotes TRA-1-60 http://www.glycoepitope.jp/epitopes/AN0727
T2 1340-1348 GlycoEpitope denotes TRA-1-60 http://www.glycoepitope.jp/epitopes/AN0727

sentences

Id Subject Object Predicate Lexical cue
T1 0-106 Sentence denotes Expression of the clustered NeuAcα2-3Galβ O-glycan determines the cell differentiation state of the cells.
T2 107-350 Sentence denotes Human embryonic stem cells (hESCs) are pluripotent stem cells from early embryos, and their self-renewal capacity depends on the sustained expression of hESC-specific molecules and the suppressed expression of differentiation-associated genes.
T3 351-543 Sentence denotes To discover novel molecules expressed on hESCs, we generated a panel of monoclonal antibodies against undifferentiated hESCs and evaluated their ability to mark cancer cells, as well as hESCs.
T4 544-665 Sentence denotes MAb7 recognized undifferentiated hESCs and showed a diffuse band with molecular mass of >239 kDa in the lysates of hESCs.
T5 666-830 Sentence denotes Although some amniotic epithelial cells expressed MAb7 antigen, its expression was barely detected in normal human keratinocytes, fibroblasts, or endothelial cells.
T6 831-1007 Sentence denotes The expression of MAb7 antigen was observed only in pancreatic and gastric cancer cells, and its levels were elevated in metastatic and poorly differentiated cancer cell lines.
T7 1008-1196 Sentence denotes Analyses of MAb7 antigen suggested that the clustered NeuAcα2-3Galβ O-linked oligosaccharides on DMBT1 (deleted in malignant brain tumors 1) were critical for MAb7 binding in cancer cells.
T8 1197-1357 Sentence denotes Although features of MAb7 epitope were similar with those of TRA-1-60, distribution of MAb7 antigen in cancer cells was different from that of TRA-1-60 antigen.
T9 1358-1530 Sentence denotes Exposure of a histone deacetylase inhibitor to differentiated gastric cancer MKN74 cells evoked the expression of MAb7 antigen, whereas DMBT1 expression remained unchanged.
T10 1531-1680 Sentence denotes Cell sorting followed by DNA microarray analyses identified the down-regulated genes responsible for the biosynthesis of MAb7 antigen in MKN74 cells.
T11 1681-1810 Sentence denotes In addition, treatment of metastatic pancreatic cancer cells with MAb7 significantly abrogated the adhesion to endothelial cells.
T12 1811-2008 Sentence denotes These results raised the possibility that MAb7 epitope is a novel marker for undifferentiated cells such as hESCs and cancer stem-like cells and plays a possible role in the undifferentiated cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 123-133 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T2 123-127 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T3 158-168 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T4 158-162 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T5 180-187 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos
T6 1133-1138 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T7 1936-1940 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1112-1147 gene:1755 denotes deleted in malignant brain tumors 1
T1 1183-1189 disease:C1306459 denotes cancer
T2 1112-1147 gene:1755 denotes deleted in malignant brain tumors 1
T3 1183-1189 disease:C0006826 denotes cancer
T4 1105-1110 gene:1755 denotes DMBT1
T5 1183-1189 disease:C0006826 denotes cancer
T6 1105-1110 gene:1755 denotes DMBT1
T7 1183-1189 disease:C1306459 denotes cancer
T8 1494-1499 gene:1755 denotes DMBT1
T9 1420-1434 disease:C0699791 denotes gastric cancer
T10 1494-1499 gene:1755 denotes DMBT1
T11 1420-1434 disease:C0024623 denotes gastric cancer
R1 T0 T1 associated_with deleted in malignant brain tumors 1,cancer
R2 T2 T3 associated_with deleted in malignant brain tumors 1,cancer
R3 T4 T5 associated_with DMBT1,cancer
R4 T6 T7 associated_with DMBT1,cancer
R5 T8 T9 associated_with DMBT1,gastric cancer
R6 T10 T11 associated_with DMBT1,gastric cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 512-518 HP_0002664 denotes cancer
T2 883-912 HP_0002894 denotes pancreatic and gastric cancer
T3 898-912 HP_0012126 denotes gastric cancer
T4 906-912 HP_0002664 denotes cancer
T5 989-995 HP_0002664 denotes cancer
T6 1139-1145 HP_0002664 denotes tumors
T7 1183-1189 HP_0002664 denotes cancer
T8 1300-1306 HP_0002664 denotes cancer
T9 1420-1434 HP_0012126 denotes gastric cancer
T10 1428-1434 HP_0002664 denotes cancer
T11 1718-1735 HP_0002894 denotes pancreatic cancer
T12 1729-1735 HP_0002664 denotes cancer
T13 1929-1935 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25074924-8#136#141#gene1755 1494-1499 gene1755 denotes DMBT1
25074924-8#62#76#diseaseC0024623 1420-1434 diseaseC0024623 denotes gastric cancer
25074924-8#62#76#diseaseC0699791 1420-1434 diseaseC0699791 denotes gastric cancer
136#141#gene175562#76#diseaseC0024623 25074924-8#136#141#gene1755 25074924-8#62#76#diseaseC0024623 associated_with DMBT1,gastric cancer
136#141#gene175562#76#diseaseC0699791 25074924-8#136#141#gene1755 25074924-8#62#76#diseaseC0699791 associated_with DMBT1,gastric cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 512-518 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 898-912 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056
T3 989-995 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 1123-1145 Disease denotes malignant brain tumors http://purl.obolibrary.org/obo/MONDO_0001657
T5 1183-1189 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T6 1300-1306 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T7 1420-1434 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056
T8 1718-1735 Disease denotes pancreatic cancer http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831
T10 1929-1935 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 512-518 Phenotype denotes cancer HP:0002664
T2 898-912 Phenotype denotes gastric cancer HP:0012126
T3 989-995 Phenotype denotes cancer HP:0002664
T4 1133-1145 Phenotype denotes brain tumors HP:0030692
T5 1183-1189 Phenotype denotes cancer HP:0002664
T6 1300-1306 Phenotype denotes cancer HP:0002664
T7 1420-1434 Phenotype denotes gastric cancer HP:0012126
T8 1718-1735 Phenotype denotes pancreatic cancer HP:0002894
T9 1929-1935 Phenotype denotes cancer HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 28-33 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1062-1067 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1258-1266 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes TRA-1-60 http://www.glycoepitope.jp/epitopes/AN0727
T2 1340-1348 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes TRA-1-60 http://www.glycoepitope.jp/epitopes/AN0727

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 512-518 Phenotype denotes cancer HP:0002664
T2 898-912 Phenotype denotes gastric cancer HP:0012126
T3 989-995 Phenotype denotes cancer HP:0002664
T4 1133-1145 Phenotype denotes brain tumors HP:0030692
T5 1183-1189 Phenotype denotes cancer HP:0002664
T6 1300-1306 Phenotype denotes cancer HP:0002664
T7 1420-1434 Phenotype denotes gastric cancer HP:0012126
T8 1718-1735 Phenotype denotes pancreatic cancer HP:0002894
T9 1929-1935 Phenotype denotes cancer HP:0002664

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 512-518 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 898-912 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056
T3 989-995 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 1123-1145 Disease denotes malignant brain tumors http://purl.obolibrary.org/obo/MONDO_0001657
T5 1183-1189 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T6 1300-1306 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T7 1420-1434 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056
T8 1718-1735 Disease denotes pancreatic cancer http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831
T10 1929-1935 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 107-112 OrganismTaxon denotes Human 9606
T2 775-780 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 113-133 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T2 146-168 Cell denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL:0002248
T3 512-524 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T4 604-608 Cell denotes band http://purl.obolibrary.org/obo/CL:0000560
T5 680-705 Cell denotes amniotic epithelial cells http://purl.obolibrary.org/obo/CL:0002536
T6 781-794 Cell denotes keratinocytes http://purl.obolibrary.org/obo/CL:0000312
T7 796-807 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T8 812-829 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T9 906-918 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T10 989-1000 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T11 1183-1195 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T12 1300-1312 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T13 1729-1741 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T14 1792-1809 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 123-133 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034
T2 146-168 Body_part denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL_0002248
T3 174-187 Body_part denotes early embryos http://purl.obolibrary.org/obo/UBERON_0019248
T4 680-705 Body_part denotes amniotic epithelial cells http://purl.obolibrary.org/obo/CL_0002536
T5 781-794 Body_part denotes keratinocytes http://purl.obolibrary.org/obo/CL_0000312
T6 796-807 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T7 812-829 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T8 1133-1138 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T10 1792-1809 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 123-133 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T2 158-168 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T3 180-187 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T4 1133-1138 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T5 1936-1940 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239

sentences

Id Subject Object Predicate Lexical cue
T1 0-106 Sentence denotes Expression of the clustered NeuAcα2-3Galβ O-glycan determines the cell differentiation state of the cells.
T2 107-350 Sentence denotes Human embryonic stem cells (hESCs) are pluripotent stem cells from early embryos, and their self-renewal capacity depends on the sustained expression of hESC-specific molecules and the suppressed expression of differentiation-associated genes.
T3 351-543 Sentence denotes To discover novel molecules expressed on hESCs, we generated a panel of monoclonal antibodies against undifferentiated hESCs and evaluated their ability to mark cancer cells, as well as hESCs.
T4 544-665 Sentence denotes MAb7 recognized undifferentiated hESCs and showed a diffuse band with molecular mass of >239 kDa in the lysates of hESCs.
T5 666-830 Sentence denotes Although some amniotic epithelial cells expressed MAb7 antigen, its expression was barely detected in normal human keratinocytes, fibroblasts, or endothelial cells.
T6 831-1007 Sentence denotes The expression of MAb7 antigen was observed only in pancreatic and gastric cancer cells, and its levels were elevated in metastatic and poorly differentiated cancer cell lines.
T7 1008-1196 Sentence denotes Analyses of MAb7 antigen suggested that the clustered NeuAcα2-3Galβ O-linked oligosaccharides on DMBT1 (deleted in malignant brain tumors 1) were critical for MAb7 binding in cancer cells.
T8 1197-1357 Sentence denotes Although features of MAb7 epitope were similar with those of TRA-1-60, distribution of MAb7 antigen in cancer cells was different from that of TRA-1-60 antigen.
T9 1358-1530 Sentence denotes Exposure of a histone deacetylase inhibitor to differentiated gastric cancer MKN74 cells evoked the expression of MAb7 antigen, whereas DMBT1 expression remained unchanged.
T10 1531-1680 Sentence denotes Cell sorting followed by DNA microarray analyses identified the down-regulated genes responsible for the biosynthesis of MAb7 antigen in MKN74 cells.
T11 1681-1810 Sentence denotes In addition, treatment of metastatic pancreatic cancer cells with MAb7 significantly abrogated the adhesion to endothelial cells.
T12 1811-2008 Sentence denotes These results raised the possibility that MAb7 epitope is a novel marker for undifferentiated cells such as hESCs and cancer stem-like cells and plays a possible role in the undifferentiated cells.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-106 Sentence denotes Expression of the clustered NeuAcα2-3Galβ O-glycan determines the cell differentiation state of the cells.
T2 107-350 Sentence denotes Human embryonic stem cells (hESCs) are pluripotent stem cells from early embryos, and their self-renewal capacity depends on the sustained expression of hESC-specific molecules and the suppressed expression of differentiation-associated genes.
T3 351-543 Sentence denotes To discover novel molecules expressed on hESCs, we generated a panel of monoclonal antibodies against undifferentiated hESCs and evaluated their ability to mark cancer cells, as well as hESCs.
T4 544-665 Sentence denotes MAb7 recognized undifferentiated hESCs and showed a diffuse band with molecular mass of >239 kDa in the lysates of hESCs.
T5 666-830 Sentence denotes Although some amniotic epithelial cells expressed MAb7 antigen, its expression was barely detected in normal human keratinocytes, fibroblasts, or endothelial cells.
T6 831-1007 Sentence denotes The expression of MAb7 antigen was observed only in pancreatic and gastric cancer cells, and its levels were elevated in metastatic and poorly differentiated cancer cell lines.
T7 1008-1196 Sentence denotes Analyses of MAb7 antigen suggested that the clustered NeuAcα2-3Galβ O-linked oligosaccharides on DMBT1 (deleted in malignant brain tumors 1) were critical for MAb7 binding in cancer cells.
T8 1197-1357 Sentence denotes Although features of MAb7 epitope were similar with those of TRA-1-60, distribution of MAb7 antigen in cancer cells was different from that of TRA-1-60 antigen.
T9 1358-1530 Sentence denotes Exposure of a histone deacetylase inhibitor to differentiated gastric cancer MKN74 cells evoked the expression of MAb7 antigen, whereas DMBT1 expression remained unchanged.
T10 1531-1680 Sentence denotes Cell sorting followed by DNA microarray analyses identified the down-regulated genes responsible for the biosynthesis of MAb7 antigen in MKN74 cells.
T11 1681-1810 Sentence denotes In addition, treatment of metastatic pancreatic cancer cells with MAb7 significantly abrogated the adhesion to endothelial cells.
T12 1811-2008 Sentence denotes These results raised the possibility that MAb7 epitope is a novel marker for undifferentiated cells such as hESCs and cancer stem-like cells and plays a possible role in the undifferentiated cells.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 28-33 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1062-1067 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1258-1266 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes TRA-1-60 http://www.glycoepitope.jp/epitopes/AN0727
T2 1340-1348 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes TRA-1-60 http://www.glycoepitope.jp/epitopes/AN0727

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 107-112 OrganismTaxon denotes Human 9606
T2 775-780 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 123-133 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T2 158-168 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T3 180-187 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T4 1133-1138 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T5 1936-1940 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 123-133 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034
T2 146-168 Body_part denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL_0002248
T3 174-187 Body_part denotes early embryos http://purl.obolibrary.org/obo/UBERON_0019248
T4 680-705 Body_part denotes amniotic epithelial cells http://purl.obolibrary.org/obo/CL_0002536
T5 781-794 Body_part denotes keratinocytes http://purl.obolibrary.org/obo/CL_0000312
T6 796-807 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T7 812-829 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T8 1133-1138 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T10 1792-1809 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115