PubMed:24743235 JSON TXT

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LitCoin-sentences

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T2","span":{"begin":85,"end":194},"obj":"Sentence"},{"id":"T3","span":{"begin":195,"end":334},"obj":"Sentence"},{"id":"T4","span":{"begin":335,"end":414},"obj":"Sentence"},{"id":"T5","span":{"begin":415,"end":550},"obj":"Sentence"},{"id":"T6","span":{"begin":551,"end":716},"obj":"Sentence"},{"id":"T7","span":{"begin":717,"end":814},"obj":"Sentence"},{"id":"T8","span":{"begin":815,"end":929},"obj":"Sentence"},{"id":"T9","span":{"begin":930,"end":1079},"obj":"Sentence"},{"id":"T10","span":{"begin":1080,"end":1246},"obj":"Sentence"}],"text":"IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.\nUnraveling the mechanisms of hematopoiesis regulated by multiple cytokines remains a challenge in hematology. IL-3 is an allergic cytokine with the multilineage potential, while CSF-1 is produced in the steady state with restricted lineage coverage. Here, we uncovered an instructive role of CSF-1 in IL-3-mediated hematopoiesis. CSF-1 significantly promoted IL-3-driven CD11c+ cell expansion and dampened basophil and mast cell generation from C57BL/6 bone marrow. Further studies indicated that the CSF-1/CSF-1R axis contributed significantly to IL-3-induced CD11c+ cell generation through enhancing c-Fos-associated monopoiesis. CD11c+ cells induced by IL-3 or IL-3/CSF-1 were competent in cellular maturation and endocytosis. Both IL-3 and IL-3/CSF-1 cells lacked classical dendritic cell appearance and resembled macrophages in morphology. Both populations produced a high level of IL-10, in addition to IL-1, IL-6 and TNFα, in response to LPS, and were relatively poor T cell stimulators. Collectively, these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages."}

LitCoin-entities

LitCoin-GeneOrGeneProduct-v2

LitCoin-GeneOrGeneProduct-v0

LitCoin-GeneOrGeneProduct-v3

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":9,"end":14},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":49,"end":54},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":56,"end":61},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":195,"end":199},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":263,"end":268},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":344,"end":353},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":377,"end":382},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":386,"end":390},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":415,"end":420},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":444,"end":448},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":456,"end":461},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":468,"end":477},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":482,"end":490},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":504,"end":508},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":586,"end":591},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":592,"end":598},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":633,"end":637},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":646,"end":651},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":687,"end":692},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":717,"end":722},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":741,"end":745},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":749,"end":753},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":754,"end":759},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":820,"end":824},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":829,"end":833},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":834,"end":839},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":972,"end":977},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":994,"end":998},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1000,"end":1004},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1127,"end":1132},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1150,"end":1154},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":1214,"end":1223},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":1227,"end":1232},"obj":"GeneOrGeneProduct"}],"text":"IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.\nUnraveling the mechanisms of hematopoiesis regulated by multiple cytokines remains a challenge in hematology. IL-3 is an allergic cytokine with the multilineage potential, while CSF-1 is produced in the steady state with restricted lineage coverage. Here, we uncovered an instructive role of CSF-1 in IL-3-mediated hematopoiesis. CSF-1 significantly promoted IL-3-driven CD11c+ cell expansion and dampened basophil and mast cell generation from C57BL/6 bone marrow. Further studies indicated that the CSF-1/CSF-1R axis contributed significantly to IL-3-induced CD11c+ cell generation through enhancing c-Fos-associated monopoiesis. CD11c+ cells induced by IL-3 or IL-3/CSF-1 were competent in cellular maturation and endocytosis. Both IL-3 and IL-3/CSF-1 cells lacked classical dendritic cell appearance and resembled macrophages in morphology. Both populations produced a high level of IL-10, in addition to IL-1, IL-6 and TNFα, in response to LPS, and were relatively poor T cell stimulators. Collectively, these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages."}

LitCoin_Mondo_095

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":206,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":1030,"end":1033},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0004980"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0019508"}],"text":"IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.\nUnraveling the mechanisms of hematopoiesis regulated by multiple cytokines remains a challenge in hematology. IL-3 is an allergic cytokine with the multilineage potential, while CSF-1 is produced in the steady state with restricted lineage coverage. Here, we uncovered an instructive role of CSF-1 in IL-3-mediated hematopoiesis. CSF-1 significantly promoted IL-3-driven CD11c+ cell expansion and dampened basophil and mast cell generation from C57BL/6 bone marrow. Further studies indicated that the CSF-1/CSF-1R axis contributed significantly to IL-3-induced CD11c+ cell generation through enhancing c-Fos-associated monopoiesis. CD11c+ cells induced by IL-3 or IL-3/CSF-1 were competent in cellular maturation and endocytosis. Both IL-3 and IL-3/CSF-1 cells lacked classical dendritic cell appearance and resembled macrophages in morphology. Both populations produced a high level of IL-10, in addition to IL-1, IL-6 and TNFα, in response to LPS, and were relatively poor T cell stimulators. Collectively, these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages."}

LitCoin_CellLine

{"project":"LitCoin_CellLine","denotations":[{"id":"T1","span":{"begin":530,"end":537},"obj":"CellLine"}],"attributes":[{"id":"A1","pred":"cellosaurus_accession_id","subj":"T1","obj":"AddedByYayamamo"}],"text":"IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.\nUnraveling the mechanisms of hematopoiesis regulated by multiple cytokines remains a challenge in hematology. IL-3 is an allergic cytokine with the multilineage potential, while CSF-1 is produced in the steady state with restricted lineage coverage. Here, we uncovered an instructive role of CSF-1 in IL-3-mediated hematopoiesis. CSF-1 significantly promoted IL-3-driven CD11c+ cell expansion and dampened basophil and mast cell generation from C57BL/6 bone marrow. Further studies indicated that the CSF-1/CSF-1R axis contributed significantly to IL-3-induced CD11c+ cell generation through enhancing c-Fos-associated monopoiesis. CD11c+ cells induced by IL-3 or IL-3/CSF-1 were competent in cellular maturation and endocytosis. Both IL-3 and IL-3/CSF-1 cells lacked classical dendritic cell appearance and resembled macrophages in morphology. Both populations produced a high level of IL-10, in addition to IL-1, IL-6 and TNFα, in response to LPS, and were relatively poor T cell stimulators. Collectively, these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages."}

LitCoin-Chemical-MeSH-CHEBI

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":1030,"end":1033},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_89981"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_52603"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_16412"}],"text":"IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.\nUnraveling the mechanisms of hematopoiesis regulated by multiple cytokines remains a challenge in hematology. IL-3 is an allergic cytokine with the multilineage potential, while CSF-1 is produced in the steady state with restricted lineage coverage. Here, we uncovered an instructive role of CSF-1 in IL-3-mediated hematopoiesis. CSF-1 significantly promoted IL-3-driven CD11c+ cell expansion and dampened basophil and mast cell generation from C57BL/6 bone marrow. Further studies indicated that the CSF-1/CSF-1R axis contributed significantly to IL-3-induced CD11c+ cell generation through enhancing c-Fos-associated monopoiesis. CD11c+ cells induced by IL-3 or IL-3/CSF-1 were competent in cellular maturation and endocytosis. Both IL-3 and IL-3/CSF-1 cells lacked classical dendritic cell appearance and resembled macrophages in morphology. Both populations produced a high level of IL-10, in addition to IL-1, IL-6 and TNFα, in response to LPS, and were relatively poor T cell stimulators. Collectively, these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages."}

LitCoin-training-merged