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PubMed:24632946 JSONTXT

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sonoma2

Id Subject Object Predicate Lexical cue
T0 0-10 VAR denotes Disruption
T1 57-69 GENE denotes β-catenin si
T2 77-83 REG denotes causes
T3 84-107 DISEASE denotes anorectal malformations
T4 87-110 DISEASE denotes rectal malformations. T
T5 257-281 DISEASE denotes genital malformations, s
T6 288-311 DISEASE denotes anorectal malformations
T7 291-314 DISEASE denotes rectal malformations (A
T8 313-317 DISEASE denotes ARMs
T9 421-433 GENE denotes atenin is a
T10 603-615 GENE denotes nin is obser
T11 631-651 DISEASE denotes l epithelia, includi
T12 663-676 DISEASE denotes elia. We modu
T13 672-681 VAR denotes modulated
T14 686-695 GENE denotes β-catenin
T15 695-707 GENE denotes gene condit
T16 730-750 DISEASE denotes pithelia by utilizin
T17 789-800 GENE denotes Shh(CreERT2
T18 809-818 GENE denotes β-catenin
T19 819-824 NEGREG denotes loss-
T20 821-833 GENE denotes ss- and gain
T21 829-845 POSREG denotes gain-of-function
T22 855-858 POSREG denotes GOF
T23 860-867 VAR denotes mutants
T24 868-877 REG denotes displayed
T25 887-893 CPA denotes clefts
T26 921-932 NEGREG denotes hypoplastic
T27 933-943 CPA denotes elongation
T28 936-947 DISEASE denotes ngation of
T29 960-967 VAR denotes mutants
T30 983-990 NEGREG denotes reduced
T31 991-1009 CPA denotes cell proliferation
T32 1050-1059 GENE denotes β-catenin
T33 1060-1071 VAR denotes GOF mutants
T34 1065-1077 GENE denotes utants displ
T35 1082-1089 NEGREG denotes reduced
T36 1090-1099 CPA denotes apoptosis
T37 1117-1126 POSREG denotes increased
T38 1127-1136 CPA denotes apoptosis
T39 1198-1205 NEGREG denotes reduced
T40 1206-1216 MPA denotes expression
T41 1316-1326 MPA denotes expression
T42 1348-1374 GENE denotes protein (Bmp) genes, such
T43 1358-1361 GENE denotes Bmp
T44 1376-1379 GENE denotes s B
T45 1378-1382 GENE denotes Bmp4
T46 1387-1391 GENE denotes Bmp7
T47 1396-1400 GENE denotes als
T48 1405-1409 GENE denotes opic
T49 1414-1421 POSREG denotes induced
T50 1457-1466 GENE denotes β-catenin
T51 1467-1478 VAR denotes GOF mutants
T52 1475-1487 GENE denotes nts. The exp
T53 1484-1494 MPA denotes expression
T54 1502-1506 GENE denotes Msx2
T55 1516-1540 GENE denotes phosphorylated-Smad1/5/8
T56 1523-1527 GENE denotes ryla
T57 1584-1587 GENE denotes so
T58 1587-1596 POSREG denotes increased
T59 1604-1611 VAR denotes mutants
T60 1651-1659 VAR denotes mutation
T61 1685-1691 GENE denotes BmprIA
T62 1687-1690 GENE denotes prI
T63 1734-1758 GENE denotes ); BmprIA(flox/-) mutant
T64 1752-1759 VAR denotes mutants
T65 1778-1789 NEGREG denotes restoration
T66 1793-1807 MPA denotes URS elongation
T67 1826-1835 GENE denotes β-catenin
T68 1836-1847 VAR denotes GOF mutants
T69 1850-1862 GENE denotes hese results
T70 1882-1885 DISEASE denotes ARM
T71 1886-1896 CPA denotes phenotypes
T72 1904-1913 GENE denotes β-catenin
T73 1914-1925 VAR denotes GOF mutants
T74 1931-1937 REG denotes caused
T75 1931-1943 GENE denotes caused by ab
T76 1980-1983 GENE denotes lys
T77 2058-2070 GENE denotes phenotypes.
T78 2152-2156 DISEASE denotes ARMs
R0 T0 T2 CauseOf Disruption,causes
R1 T3 T2 ThemeOf anorectal malformations,causes
R2 T6 T8 ThemeOf anorectal malformations,ARMs
R3 T14 T13 ThemeOf β-catenin,modulated
R4 T18 T23 ThemeOf β-catenin,mutants
R5 T19 T21 CauseOf loss-,gain-of-function
R6 T22 T19 CauseOf GOF,loss-
R7 T19 T24 CauseOf loss-,displayed
R8 T19 T26 CauseOf loss-,hypoplastic
R9 T22 T21 CauseOf GOF,gain-of-function
R10 T21 T24 CauseOf gain-of-function,displayed
R11 T21 T26 CauseOf gain-of-function,hypoplastic
R12 T22 T24 CauseOf GOF,displayed
R13 T22 T26 CauseOf GOF,hypoplastic
R14 T23 T19 CauseOf mutants,loss-
R15 T23 T21 CauseOf mutants,gain-of-function
R16 T23 T22 CauseOf mutants,GOF
R17 T23 T24 CauseOf mutants,displayed
R18 T23 T26 CauseOf mutants,hypoplastic
R19 T25 T24 ThemeOf clefts,displayed
R20 T27 T24 ThemeOf elongation,displayed
R21 T27 T26 ThemeOf elongation,hypoplastic
R22 T29 T30 CauseOf mutants,reduced
R23 T31 T30 ThemeOf cell proliferation,reduced
R24 T32 T33 ThemeOf β-catenin,GOF mutants
R25 T33 T35 CauseOf GOF mutants,reduced
R26 T33 T37 CauseOf GOF mutants,increased
R27 T36 T35 ThemeOf apoptosis,reduced
R28 T38 T37 ThemeOf apoptosis,increased
R29 T40 T39 ThemeOf expression,reduced
R30 T41 T49 ThemeOf expression,induced
R31 T43 T41 ThemeOf Bmp,expression
R32 T45 T41 ThemeOf Bmp4,expression
R33 T46 T41 ThemeOf Bmp7,expression
R34 T50 T51 ThemeOf β-catenin,GOF mutants
R35 T51 T49 CauseOf GOF mutants,induced
R36 T53 T58 ThemeOf expression,increased
R37 T54 T53 ThemeOf Msx2,expression
R38 T55 T53 ThemeOf phosphorylated-Smad1/5/8,expression
R39 T59 T58 CauseOf mutants,increased
R40 T60 T65 CauseOf mutation,restoration
R41 T61 T60 ThemeOf BmprIA,mutation
R42 T61 T64 ThemeOf BmprIA,mutants
R43 T64 T65 CauseOf mutants,restoration
R44 T66 T65 ThemeOf URS elongation,restoration
R45 T67 T68 ThemeOf β-catenin,GOF mutants
R46 T68 T65 CauseOf GOF mutants,restoration
R47 T70 T71 ThemeOf ARM,phenotypes
R48 T73 T70 CauseOf GOF mutants,ARM
R49 T70 T74 ThemeOf ARM,caused
R50 T73 T71 CauseOf GOF mutants,phenotypes
R51 T71 T74 ThemeOf phenotypes,caused
R52 T72 T71 ThemeOf β-catenin,phenotypes
R53 T72 T73 ThemeOf β-catenin,GOF mutants
R54 T73 T74 CauseOf GOF mutants,caused

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9784 57-66 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9785 84-107 DiseaseOrPhenotypicFeature denotes anorectal malformations MESH:D000071056
9786 254-278 DiseaseOrPhenotypicFeature denotes congenital malformations MESH:D000013
9787 288-311 DiseaseOrPhenotypicFeature denotes anorectal malformations MESH:D000071056
9788 313-317 DiseaseOrPhenotypicFeature denotes ARMs MESH:D000071056
9789 418-427 GeneOrGeneProduct denotes β-Catenin NCBIGene:12387
9790 465-468 GeneOrGeneProduct denotes Wnt NCBIGene:22408
9791 597-606 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9792 686-695 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9793 752-761 ChemicalEntity denotes tamoxifen MESH:D013629
9794 789-792 GeneOrGeneProduct denotes Shh NCBIGene:20423
9795 809-818 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9796 921-932 DiseaseOrPhenotypicFeature denotes hypoplastic MESH:D029502
9797 1050-1059 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9798 1260-1269 GeneOrGeneProduct denotes keratin 1 NCBIGene:16678
9799 1274-1283 GeneOrGeneProduct denotes filaggrin NCBIGene:14246
9800 1330-1356 GeneOrGeneProduct denotes bone morphogenetic protein NCBIGene:12159|NCBIGene:12162
9801 1358-1361 GeneOrGeneProduct denotes Bmp NCBIGene:12159|NCBIGene:12162
9802 1378-1382 GeneOrGeneProduct denotes Bmp4 NCBIGene:12159
9803 1387-1391 GeneOrGeneProduct denotes Bmp7 NCBIGene:12162
9804 1457-1466 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9805 1502-1506 GeneOrGeneProduct denotes Msx2 NCBIGene:17702
9806 1531-1540 GeneOrGeneProduct denotes Smad1/5/8 NCBIGene:17125|NCBIGene:17129|NCBIGene:55994
9807 1563-1566 GeneOrGeneProduct denotes Bmp NCBIGene:12159|NCBIGene:12162
9808 1666-1678 GeneOrGeneProduct denotes Bmp receptor NCBIGene:12166
9809 1685-1691 GeneOrGeneProduct denotes BmprIA NCBIGene:12166
9810 1697-1700 GeneOrGeneProduct denotes Shh NCBIGene:20423
9811 1713-1722 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9812 1737-1743 GeneOrGeneProduct denotes BmprIA NCBIGene:12166
9813 1826-1835 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9814 1882-1885 DiseaseOrPhenotypicFeature denotes ARM MESH:D000071056
9815 1904-1913 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9816 1950-1953 GeneOrGeneProduct denotes Bmp NCBIGene:12159|NCBIGene:12162
9817 2028-2037 GeneOrGeneProduct denotes β-catenin NCBIGene:12387
9818 2055-2058 DiseaseOrPhenotypicFeature denotes ARM MESH:D000071056
9819 2146-2151 OrganismTaxon denotes human NCBITaxon:9606
9820 2152-2156 DiseaseOrPhenotypicFeature denotes ARMs MESH:D000071056

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 39-45 OrganismTaxon denotes cloaca NCBItxid:547
T2 113-119 OrganismTaxon denotes cloaca NCBItxid:547
T3 2146-2151 OrganismTaxon denotes human NCBItxid:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations.
T2 109-244 Sentence denotes The cloaca is temporally formed and eventually divided by the urorectal septum (URS) during urogenital and anorectal organ development.
T3 245-578 Sentence denotes Although congenital malformations, such as anorectal malformations (ARMs), are frequently observed during this process, the underlying pathogenic mechanisms remain unclear. β-Catenin is a critical component of canonical Wnt signaling and is essential for the regulation of cell differentiation and morphogenesis during embryogenesis.
T4 579-668 Sentence denotes The expression of β-catenin is observed in endodermal epithelia, including URS epithelia.
T5 669-803 Sentence denotes We modulated the β-catenin gene conditionally in endodermal epithelia by utilizing tamoxifen-inducible Cre driver line (Shh(CreERT2)).
T6 804-955 Sentence denotes Both β-catenin loss- and gain-of-function (LOF and GOF) mutants displayed abnormal clefts in the perineal region and hypoplastic elongation of the URS.
T7 956-1032 Sentence denotes The mutants also displayed reduced cell proliferation in the URS mesenchyme.
T8 1033-1159 Sentence denotes In addition, the β-catenin GOF mutants displayed reduced apoptosis and subsequently increased apoptosis in the URS epithelium.
T9 1160-1311 Sentence denotes This instability possibly resulted in reduced expression levels of differentiation markers, such as keratin 1 and filaggrin, in the perineal epithelia.
T10 1312-1479 Sentence denotes The expression of bone morphogenetic protein (Bmp) genes, such as Bmp4 and Bmp7, was also ectopically induced in the epithelia of the URS in the β-catenin GOF mutants.
T11 1480-1612 Sentence denotes The expression of the Msx2 gene and phosphorylated-Smad1/5/8, possible readouts of Bmp signaling, was also increased in the mutants.
T12 1613-1684 Sentence denotes Moreover, we introduced an additional mutation for a Bmp receptor gene:
T13 1685-1692 Sentence denotes BmprIA.
T14 1693-1848 Sentence denotes The Shh(CreERT2/+); β-catenin(flox(ex3)/+); BmprIA(flox/-) mutants displayed partial restoration of URS elongation compared with the β-catenin GOF mutants.
T15 1849-1964 Sentence denotes These results indicate that some ARM phenotypes in the β-catenin GOF mutants were caused by abnormal Bmp signaling.
T16 1965-2070 Sentence denotes The current analysis revealed the close relation of endodermal β-catenin signaling to the ARM phenotypes.
T17 2071-2157 Sentence denotes These results are considered to shed light on the pathogenic mechanisms of human ARMs.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 84-107 DiseaseOrPhenotypicFeature denotes anorectal malformations 0019938
T2 254-264 DiseaseOrPhenotypicFeature denotes congenital 0021140
T3 288-311 DiseaseOrPhenotypicFeature denotes anorectal malformations 0019938

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-10 GeneOrGeneProduct denotes Disruption
T2 29-38 GeneOrGeneProduct denotes regulated
T3 59-66 GeneOrGeneProduct denotes catenin
T4 94-107 GeneOrGeneProduct denotes malformations
T5 201-211 GeneOrGeneProduct denotes urogenital
T6 265-278 GeneOrGeneProduct denotes malformations
T7 298-311 GeneOrGeneProduct denotes malformations
T8 313-317 GeneOrGeneProduct denotes ARMs
T9 356-363 GeneOrGeneProduct denotes process
T10 409-416 GeneOrGeneProduct denotes unclear
T11 420-427 GeneOrGeneProduct denotes Catenin
T12 504-514 GeneOrGeneProduct denotes regulation
T13 518-538 GeneOrGeneProduct denotes cell differentiation
T14 599-606 GeneOrGeneProduct denotes catenin
T15 688-695 GeneOrGeneProduct denotes catenin
T16 762-771 GeneOrGeneProduct denotes inducible
T17 783-787 GeneOrGeneProduct denotes line
T18 811-818 GeneOrGeneProduct denotes catenin
T19 860-867 GeneOrGeneProduct denotes mutants
T20 887-893 GeneOrGeneProduct denotes clefts
T21 933-943 GeneOrGeneProduct denotes elongation
T22 960-967 GeneOrGeneProduct denotes mutants
T23 983-990 GeneOrGeneProduct denotes reduced
T24 991-995 GeneOrGeneProduct denotes cell
T25 1052-1059 GeneOrGeneProduct denotes catenin
T45 1666-1669 GeneOrGeneProduct denotes Bmp
T26 1064-1071 GeneOrGeneProduct denotes mutants
T27 1082-1089 GeneOrGeneProduct denotes reduced
T28 1090-1099 GeneOrGeneProduct denotes apoptosis
T29 1127-1136 GeneOrGeneProduct denotes apoptosis
T30 1198-1205 GeneOrGeneProduct denotes reduced
T31 1260-1269 GeneOrGeneProduct denotes keratin 1
T32 1274-1283 GeneOrGeneProduct denotes filaggrin
T33 1330-1356 GeneOrGeneProduct denotes bone morphogenetic protein
T34 1358-1361 GeneOrGeneProduct denotes Bmp
T35 1378-1382 GeneOrGeneProduct denotes Bmp4
T36 1387-1391 GeneOrGeneProduct denotes Bmp7
T37 1414-1421 GeneOrGeneProduct denotes induced
T38 1459-1466 GeneOrGeneProduct denotes catenin
T39 1471-1478 GeneOrGeneProduct denotes mutants
T40 1502-1506 GeneOrGeneProduct denotes Msx2
T41 1531-1538 GeneOrGeneProduct denotes Smad1/5
T42 1563-1566 GeneOrGeneProduct denotes Bmp
T43 1604-1611 GeneOrGeneProduct denotes mutants
T44 1651-1659 GeneOrGeneProduct denotes mutation
T46 1670-1678 GeneOrGeneProduct denotes receptor
T47 1685-1691 GeneOrGeneProduct denotes BmprIA
T48 1715-1722 GeneOrGeneProduct denotes catenin
T49 1737-1743 GeneOrGeneProduct denotes BmprIA
T50 1752-1759 GeneOrGeneProduct denotes mutants
T51 1797-1807 GeneOrGeneProduct denotes elongation
T52 1828-1835 GeneOrGeneProduct denotes catenin
T53 1840-1847 GeneOrGeneProduct denotes mutants
T54 1882-1885 GeneOrGeneProduct denotes ARM
T55 1906-1913 GeneOrGeneProduct denotes catenin
T56 1918-1925 GeneOrGeneProduct denotes mutants
T57 1950-1953 GeneOrGeneProduct denotes Bmp
T58 2030-2037 GeneOrGeneProduct denotes catenin
T59 2055-2058 GeneOrGeneProduct denotes ARM
T60 2108-2113 GeneOrGeneProduct denotes light
T61 2152-2156 GeneOrGeneProduct denotes ARMs

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 59-66 GeneOrGeneProduct denotes catenin
T2 201-211 GeneOrGeneProduct denotes urogenital
T3 409-416 GeneOrGeneProduct denotes unclear
T4 420-427 GeneOrGeneProduct denotes Catenin
T5 518-538 GeneOrGeneProduct denotes cell differentiation
T6 599-606 GeneOrGeneProduct denotes catenin
T7 688-695 GeneOrGeneProduct denotes catenin
T8 762-771 GeneOrGeneProduct denotes inducible
T9 811-818 GeneOrGeneProduct denotes catenin
T10 983-990 GeneOrGeneProduct denotes reduced
T11 991-995 GeneOrGeneProduct denotes cell
T12 1052-1059 GeneOrGeneProduct denotes catenin
T13 1082-1089 GeneOrGeneProduct denotes reduced
T14 1090-1099 GeneOrGeneProduct denotes apoptosis
T15 1127-1136 GeneOrGeneProduct denotes apoptosis
T16 1198-1205 GeneOrGeneProduct denotes reduced
T17 1260-1269 GeneOrGeneProduct denotes keratin 1
T18 1274-1283 GeneOrGeneProduct denotes filaggrin
T19 1330-1356 GeneOrGeneProduct denotes bone morphogenetic protein
T20 1358-1361 GeneOrGeneProduct denotes Bmp
T21 1378-1382 GeneOrGeneProduct denotes Bmp4
T22 1387-1391 GeneOrGeneProduct denotes Bmp7
T23 1459-1466 GeneOrGeneProduct denotes catenin
T24 1502-1506 GeneOrGeneProduct denotes Msx2
T25 1531-1538 GeneOrGeneProduct denotes Smad1/5
T26 1563-1566 GeneOrGeneProduct denotes Bmp
T27 1666-1669 GeneOrGeneProduct denotes Bmp
T28 1670-1678 GeneOrGeneProduct denotes receptor
T29 1715-1722 GeneOrGeneProduct denotes catenin
T30 1828-1835 GeneOrGeneProduct denotes catenin
T31 1906-1913 GeneOrGeneProduct denotes catenin
T32 1950-1953 GeneOrGeneProduct denotes Bmp
T33 2030-2037 GeneOrGeneProduct denotes catenin
T34 2108-2113 GeneOrGeneProduct denotes light

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 84-107 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T2 288-311 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T3 313-317 DiseaseOrPhenotypicFeature denotes ARMs D000071056
T4 2152-2156 DiseaseOrPhenotypicFeature denotes ARMs D000071056

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 59-66 GeneOrGeneProduct denotes catenin
T2 201-211 GeneOrGeneProduct denotes urogenital
T3 420-427 GeneOrGeneProduct denotes Catenin
T4 599-606 GeneOrGeneProduct denotes catenin
T5 688-695 GeneOrGeneProduct denotes catenin
T6 811-818 GeneOrGeneProduct denotes catenin
T7 1052-1059 GeneOrGeneProduct denotes catenin
T8 1260-1269 GeneOrGeneProduct denotes keratin 1
T9 1274-1283 GeneOrGeneProduct denotes filaggrin
T10 1330-1356 GeneOrGeneProduct denotes bone morphogenetic protein
T11 1358-1361 GeneOrGeneProduct denotes Bmp
T12 1378-1382 GeneOrGeneProduct denotes Bmp4
T13 1387-1391 GeneOrGeneProduct denotes Bmp7
T14 1459-1466 GeneOrGeneProduct denotes catenin
T15 1502-1506 GeneOrGeneProduct denotes Msx2
T16 1531-1538 GeneOrGeneProduct denotes Smad1/5
T17 1563-1566 GeneOrGeneProduct denotes Bmp
T18 1666-1678 GeneOrGeneProduct denotes Bmp receptor
T20 1715-1722 GeneOrGeneProduct denotes catenin
T21 1828-1835 GeneOrGeneProduct denotes catenin
T22 1906-1913 GeneOrGeneProduct denotes catenin
T23 1950-1953 GeneOrGeneProduct denotes Bmp
T24 2030-2037 GeneOrGeneProduct denotes catenin

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 84-107 DiseaseOrPhenotypicFeature denotes anorectal malformations 0001046
T2 288-311 DiseaseOrPhenotypicFeature denotes anorectal malformations 0001046
T3 313-317 DiseaseOrPhenotypicFeature denotes ARMs 0001046
T4 2152-2156 DiseaseOrPhenotypicFeature denotes ARMs 0001046

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 84-107 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T2 254-278 DiseaseOrPhenotypicFeature denotes congenital malformations DISEASE
T3 288-311 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T4 313-317 DiseaseOrPhenotypicFeature denotes ARMs D000071056
T5 921-932 DiseaseOrPhenotypicFeature denotes hypoplastic DISEASE
T6 1882-1885 DiseaseOrPhenotypicFeature denotes ARM DISEASE
T7 2055-2058 DiseaseOrPhenotypicFeature denotes ARM DISEASE
T8 2152-2156 DiseaseOrPhenotypicFeature denotes ARMs D000071056

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 84-107 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T2 254-278 DiseaseOrPhenotypicFeature denotes congenital malformations DISEASE
T3 288-311 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T4 313-317 DiseaseOrPhenotypicFeature denotes ARMs D000071056
T5 921-932 DiseaseOrPhenotypicFeature denotes hypoplastic DISEASE
T6 1882-1885 DiseaseOrPhenotypicFeature denotes ARM DISEASE
T7 2055-2058 DiseaseOrPhenotypicFeature denotes ARM DISEASE
T8 2152-2156 DiseaseOrPhenotypicFeature denotes ARMs D000071056

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 752-761 ChemicalEntity denotes tamoxifen D013629|http://purl.obolibrary.org/obo/CHEBI_41774
T3 1227-1250 ChemicalEntity denotes differentiation markers D000943

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 39-45 OrganismTaxon denotes cloaca
T2 113-119 OrganismTaxon denotes cloaca
T3 2146-2151 OrganismTaxon denotes human

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T3 1227-1250 ChemicalEntity denotes differentiation markers D000943
T1 752-761 ChemicalEntity denotes tamoxifen http://purl.obolibrary.org/obo/CHEBI_41774|D013629
T24 2030-2037 GeneOrGeneProduct denotes catenin
T23 1950-1953 GeneOrGeneProduct denotes Bmp
T22 1906-1913 GeneOrGeneProduct denotes catenin
T21 1828-1835 GeneOrGeneProduct denotes catenin
T20 1715-1722 GeneOrGeneProduct denotes catenin
T18 1666-1678 GeneOrGeneProduct denotes Bmp receptor
T17 1563-1566 GeneOrGeneProduct denotes Bmp
T16 1531-1538 GeneOrGeneProduct denotes Smad1/5
T15 1502-1506 GeneOrGeneProduct denotes Msx2
T14 1459-1466 GeneOrGeneProduct denotes catenin
T13 1387-1391 GeneOrGeneProduct denotes Bmp7
T12 1378-1382 GeneOrGeneProduct denotes Bmp4
T11 1358-1361 GeneOrGeneProduct denotes Bmp
T10 1330-1356 GeneOrGeneProduct denotes bone morphogenetic protein
T9 1274-1283 GeneOrGeneProduct denotes filaggrin
T8 1260-1269 GeneOrGeneProduct denotes keratin 1
T7 1052-1059 GeneOrGeneProduct denotes catenin
T6 811-818 GeneOrGeneProduct denotes catenin
T5 688-695 GeneOrGeneProduct denotes catenin
T4 599-606 GeneOrGeneProduct denotes catenin
T79000 420-427 GeneOrGeneProduct denotes Catenin
T2 201-211 GeneOrGeneProduct denotes urogenital
T1674 59-66 GeneOrGeneProduct denotes catenin
T99015 2152-2156 DiseaseOrPhenotypicFeature denotes ARMs D000071056
T53676 2055-2058 DiseaseOrPhenotypicFeature denotes ARM DISEASE
T35060 1882-1885 DiseaseOrPhenotypicFeature denotes ARM DISEASE
T90754 921-932 DiseaseOrPhenotypicFeature denotes hypoplastic DISEASE
T78214 313-317 DiseaseOrPhenotypicFeature denotes ARMs D000071056
T7978 288-311 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T44392 254-278 DiseaseOrPhenotypicFeature denotes congenital malformations DISEASE
T66265 84-107 DiseaseOrPhenotypicFeature denotes anorectal malformations D000071056
T64018 2146-2151 OrganismTaxon denotes human
T40876 113-119 OrganismTaxon denotes cloaca
T75708 39-45 OrganismTaxon denotes cloaca

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 288-311 HP_0012732 denotes anorectal malformations

Allie

Id Subject Object Predicate Lexical cue
SS1_24632946_1_0 171-187 expanded denotes urorectal septum
SS2_24632946_1_0 189-192 abbr denotes URS
SS1_24632946_2_0 288-311 expanded denotes anorectal malformations
SS2_24632946_2_0 313-317 abbr denotes ARMs
SS1_24632946_5_0 819-845 expanded denotes loss- and gain-of-function
SS2_24632946_5_0 847-858 abbr denotes LOF and GOF
SS1_24632946_9_0 1330-1356 expanded denotes bone morphogenetic protein
SS2_24632946_9_0 1358-1361 abbr denotes Bmp
AE1_24632946_1_0 SS1_24632946_1_0 SS2_24632946_1_0 abbreviatedTo urorectal septum,URS
AE1_24632946_2_0 SS1_24632946_2_0 SS2_24632946_2_0 abbreviatedTo anorectal malformations,ARMs
AE1_24632946_5_0 SS1_24632946_5_0 SS2_24632946_5_0 abbreviatedTo loss- and gain-of-function,LOF and GOF
AE1_24632946_9_0 SS1_24632946_9_0 SS2_24632946_9_0 abbreviatedTo bone morphogenetic protein,Bmp

kaiyin_test

Id Subject Object Predicate Lexical cue
T4 809-818 Protein denotes β-catenin
T34 819-823 NegReg denotes loss
T33 829-845 PosReg denotes gain-of-function
T3 860-867 Var denotes mutants
T1 887-916 CPA denotes clefts in the perineal region
T2 921-954 CPA denotes hypoplastic elongation of the URS
T7 960-967 Var denotes mutants
T5 983-990 NegReg denotes reduced
T6 991-1031 CPA denotes cell proliferation in the URS mesenchyme
T10 1050-1059 Protein denotes β-catenin
T11 1064-1071 Var denotes mutants
T14 1198-1205 NegReg denotes reduced
T15 1206-1223 MPA denotes expression levels
T35 1260-1269 Protein denotes keratin 1
T36 1274-1283 Protein denotes filaggrin
T16 1316-1326 MPA denotes expression
T18 1330-1368 Gene denotes bone morphogenetic protein (Bmp) genes
T37 1378-1382 Gene denotes Bmp4
T38 1387-1391 Gene denotes Bmp7
T19 1414-1421 PosReg denotes induced
T20 1457-1466 Protein denotes β-catenin
T21 1471-1478 Var denotes mutants
T22 1484-1494 MPA denotes expression
T23 1502-1511 Gene denotes Msx2 gene
T26 1551-1576 MPA denotes readouts of Bmp signaling
T25 1587-1596 PosReg denotes increased
T31 1604-1611 Var denotes mutants
T39 1882-1885 Disease denotes ARM
T40 1904-1913 Protein denotes β-catenin
T41 1914-1917 PosReg denotes GOF
T42 1918-1925 Var denotes mutants
T43 1931-1940 Reg denotes caused by
T29 1950-1963 MPA denotes Bmp signaling
R1 T4 T3 ThemeOf β-catenin,mutants
R12 T15 T14 ThemeOf expression levels,reduced
R15 T16 T19 CauseOf expression,induced
R16 T20 T21 ThemeOf β-catenin,mutants
R17 T21 T19 ThemeOf mutants,induced
R18 T23 T22 ThemeOf Msx2 gene,expression
R20 T22 T25 ThemeOf expression,increased
R21 T26 T25 ThemeOf readouts of Bmp signaling,increased
R22 T31 T25 CauseOf mutants,increased
R25 T3 T33 CauseOf mutants,gain-of-function
R26 T3 T34 CauseOf mutants,loss
R27 T1 T34 ThemeOf clefts in the perineal region,loss
R28 T2 T33 ThemeOf hypoplastic elongation of the URS,gain-of-function
R29 T2 T34 CauseOf hypoplastic elongation of the URS,loss
R30 T1 T33 CauseOf clefts in the perineal region,gain-of-function
R31 T35 T15 ThemeOf keratin 1,expression levels
R32 T36 T15 ThemeOf filaggrin,expression levels
R33 T11 T14 CauseOf mutants,reduced
R34 T18 T16 ThemeOf bone morphogenetic protein (Bmp) genes,expression
R35 T37 T18 ThemeOf Bmp4,bone morphogenetic protein (Bmp) genes
R36 T38 T18 ThemeOf Bmp7,bone morphogenetic protein (Bmp) genes
R37 T39 T41 ThemeOf ARM,GOF
R38 T42 T43 CauseOf mutants,caused by
R39 T29 T43 ThemeOf Bmp signaling,caused by
R4 T7 T5 CauseOf mutants,reduced
R40 T40 T42 ThemeOf β-catenin,mutants
R41 T43 T41 CauseOf caused by,GOF
R5 T6 T5 ThemeOf cell proliferation in the URS mesenchyme,reduced
R6 T10 T11 ThemeOf β-catenin,mutants

name_no

Id Subject Object Predicate Lexical cue
T4 809-818 Protein denotes β-catenin
T34 819-823 NegReg denotes loss
T33 829-845 PosReg denotes gain-of-function
T3 860-867 Var denotes mutants
T1 887-916 CPA denotes clefts in the perineal region
T2 921-954 CPA denotes hypoplastic elongation of the URS
T7 960-967 Var denotes mutants
T5 983-990 NegReg denotes reduced
T6 991-1031 CPA denotes cell proliferation in the URS mesenchyme
T10 1050-1059 Protein denotes β-catenin
T11 1064-1071 Var denotes mutants
T14 1198-1205 NegReg denotes reduced
T15 1206-1223 MPA denotes expression levels
T35 1260-1269 Protein denotes keratin 1
T36 1274-1283 Protein denotes filaggrin
T16 1316-1326 MPA denotes expression
T18 1330-1368 Gene denotes bone morphogenetic protein (Bmp) genes
T37 1378-1382 Gene denotes Bmp4
T38 1387-1391 Gene denotes Bmp7
T19 1414-1421 PosReg denotes induced
T20 1457-1466 Protein denotes β-catenin
T21 1471-1478 Var denotes mutants
T22 1484-1494 MPA denotes expression
T23 1502-1511 Gene denotes Msx2 gene
T26 1551-1576 MPA denotes readouts of Bmp signaling
T25 1587-1596 PosReg denotes increased
T31 1604-1611 Var denotes mutants
T39 1882-1885 Disease denotes ARM
T40 1904-1913 Protein denotes β-catenin
T41 1914-1917 PosReg denotes GOF
T42 1918-1925 Var denotes mutants
T43 1931-1940 Reg denotes caused by
T29 1950-1963 MPA denotes Bmp signaling
R1 T4 T3 ThemeOf β-catenin,mutants
R12 T15 T14 ThemeOf expression levels,reduced
R15 T16 T19 CauseOf expression,induced
R16 T20 T21 ThemeOf β-catenin,mutants
R17 T21 T19 ThemeOf mutants,induced
R18 T23 T22 ThemeOf Msx2 gene,expression
R20 T22 T25 ThemeOf expression,increased
R21 T26 T25 ThemeOf readouts of Bmp signaling,increased
R22 T31 T25 CauseOf mutants,increased
R25 T3 T33 CauseOf mutants,gain-of-function
R26 T3 T34 CauseOf mutants,loss
R27 T1 T34 ThemeOf clefts in the perineal region,loss
R28 T2 T33 ThemeOf hypoplastic elongation of the URS,gain-of-function
R29 T2 T34 CauseOf hypoplastic elongation of the URS,loss
R30 T1 T33 CauseOf clefts in the perineal region,gain-of-function
R31 T35 T15 ThemeOf keratin 1,expression levels
R32 T36 T15 ThemeOf filaggrin,expression levels
R33 T11 T14 CauseOf mutants,reduced
R34 T18 T16 ThemeOf bone morphogenetic protein (Bmp) genes,expression
R35 T37 T18 ThemeOf Bmp4,bone morphogenetic protein (Bmp) genes
R36 T38 T18 ThemeOf Bmp7,bone morphogenetic protein (Bmp) genes
R37 T39 T41 ThemeOf ARM,GOF
R38 T42 T43 CauseOf mutants,caused by
R39 T29 T43 ThemeOf Bmp signaling,caused by
R4 T7 T5 CauseOf mutants,reduced
R40 T40 T42 ThemeOf β-catenin,mutants
R41 T43 T41 CauseOf caused by,GOF
R5 T6 T5 ThemeOf cell proliferation in the URS mesenchyme,reduced
R6 T10 T11 ThemeOf β-catenin,mutants