PubMed:24603336 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24603336","sourcedb":"PubMed","sourceid":"24603336","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/24603336","text":"Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity.\nMutation of p53 is the most common genetic change in human cancer, causing complex effects including not only loss of wild-type function but also gain of novel oncogenic functions (GOF). It is increasingly likely that p53-hotspot mutations may confer different types and magnitudes of GOF, but the evidences are mainly supported by cellular and transgenic animal models. Here we combine large-scale cancer genomic data to characterize the prognostic significance of different p53 mutations in human cancers. Unexpectedly, only mutations on the Arg248 and Arg282 positions displayed significant association with shorter patient survival, but such association was not evident for other hotspot GOF mutations. Gene set enrichment analysis on these mutations revealed higher activity of drug-metabolizing enzymes, including the CYP3A4 cytochrome P450. Ectopic expression of p53 mutant R282W in H1299 and SaOS2 cells significantly upregulated CYP3A4 mRNA and protein levels, and cancer cell lines bearing mortality-associated p53 mutations display higher CYP3A4 expression and resistance to several CYP3A4-metabolized chemotherapeutic drugs. Our results suggest that p53 mutations have unequal GOF activities in human cancers, and future evaluation of p53 as a cancer biomarker should consider which mutation is present in the tumor, rather than having comparison between wild-type and mutant genotypes.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_24603336_1_0","span":{"begin":270,"end":303},"obj":"expanded"},{"id":"SS2_24603336_1_0","span":{"begin":305,"end":308},"obj":"abbr"}],"relations":[{"id":"AE1_24603336_1_0","pred":"abbreviatedTo","subj":"SS1_24603336_1_0","obj":"SS2_24603336_1_0"}],"attributes":[{"subj":"SS1_24603336_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_24603336_1_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":183,"end":189},"obj":"HP_0002664"},{"id":"T2","span":{"begin":523,"end":529},"obj":"HP_0002664"},{"id":"T3","span":{"begin":623,"end":630},"obj":"HP_0002664"},{"id":"T4","span":{"begin":1098,"end":1104},"obj":"HP_0002664"},{"id":"T5","span":{"begin":1337,"end":1344},"obj":"HP_0002664"},{"id":"T6","span":{"begin":1380,"end":1386},"obj":"HP_0002664"},{"id":"T7","span":{"begin":1446,"end":1451},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":33,"end":36},"obj":"gene:7157"},{"id":"T1","span":{"begin":73,"end":80},"obj":"disease:C0006826"},{"id":"T2","span":{"begin":136,"end":139},"obj":"gene:7157"},{"id":"T3","span":{"begin":183,"end":189},"obj":"disease:C0006826"},{"id":"T4","span":{"begin":136,"end":139},"obj":"gene:7157"},{"id":"T5","span":{"begin":183,"end":189},"obj":"disease:C1306459"},{"id":"T6","span":{"begin":600,"end":603},"obj":"gene:7157"},{"id":"T7","span":{"begin":523,"end":529},"obj":"disease:C0006826"},{"id":"T8","span":{"begin":600,"end":603},"obj":"gene:7157"},{"id":"T9","span":{"begin":523,"end":529},"obj":"disease:C1306459"},{"id":"T10","span":{"begin":600,"end":603},"obj":"gene:7157"},{"id":"T11","span":{"begin":623,"end":630},"obj":"disease:C0006826"},{"id":"T12","span":{"begin":994,"end":997},"obj":"gene:7157"},{"id":"T13","span":{"begin":1098,"end":1104},"obj":"disease:C1306459"},{"id":"T14","span":{"begin":994,"end":997},"obj":"gene:7157"},{"id":"T15","span":{"begin":1098,"end":1104},"obj":"disease:C0006826"},{"id":"T16","span":{"begin":1062,"end":1068},"obj":"gene:1576"},{"id":"T17","span":{"begin":1098,"end":1104},"obj":"disease:C0006826"},{"id":"T18","span":{"begin":1218,"end":1224},"obj":"gene:1576"},{"id":"T19","span":{"begin":1098,"end":1104},"obj":"disease:C1306459"},{"id":"T20","span":{"begin":1145,"end":1148},"obj":"gene:7157"},{"id":"T21","span":{"begin":1098,"end":1104},"obj":"disease:C0006826"},{"id":"T22","span":{"begin":1145,"end":1148},"obj":"gene:7157"},{"id":"T23","span":{"begin":1098,"end":1104},"obj":"disease:C1306459"},{"id":"T24","span":{"begin":1174,"end":1180},"obj":"gene:1576"},{"id":"T25","span":{"begin":1098,"end":1104},"obj":"disease:C0006826"},{"id":"T26","span":{"begin":1174,"end":1180},"obj":"gene:1576"},{"id":"T27","span":{"begin":1098,"end":1104},"obj":"disease:C1306459"},{"id":"T28","span":{"begin":1218,"end":1224},"obj":"gene:1576"},{"id":"T29","span":{"begin":1098,"end":1104},"obj":"disease:C0006826"},{"id":"T30","span":{"begin":1062,"end":1068},"obj":"gene:1576"},{"id":"T31","span":{"begin":1098,"end":1104},"obj":"disease:C1306459"},{"id":"T32","span":{"begin":1286,"end":1289},"obj":"gene:7157"},{"id":"T33","span":{"begin":1337,"end":1344},"obj":"disease:C0006826"},{"id":"T34","span":{"begin":1371,"end":1374},"obj":"gene:7157"},{"id":"T35","span":{"begin":1380,"end":1386},"obj":"disease:C0006826"},{"id":"T36","span":{"begin":1371,"end":1374},"obj":"gene:7157"},{"id":"T37","span":{"begin":1380,"end":1386},"obj":"disease:C1306459"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"},{"id":"R9","pred":"associated_with","subj":"T16","obj":"T17"},{"id":"R10","pred":"associated_with","subj":"T18","obj":"T19"},{"id":"R11","pred":"associated_with","subj":"T20","obj":"T21"},{"id":"R12","pred":"associated_with","subj":"T22","obj":"T23"},{"id":"R13","pred":"associated_with","subj":"T24","obj":"T25"},{"id":"R14","pred":"associated_with","subj":"T26","obj":"T27"},{"id":"R15","pred":"associated_with","subj":"T28","obj":"T29"},{"id":"R16","pred":"associated_with","subj":"T30","obj":"T31"},{"id":"R17","pred":"associated_with","subj":"T32","obj":"T33"},{"id":"R18","pred":"associated_with","subj":"T34","obj":"T35"},{"id":"R19","pred":"associated_with","subj":"T36","obj":"T37"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"},{"subj":"T14","pred":"source","obj":"DisGeNET"},{"subj":"T15","pred":"source","obj":"DisGeNET"},{"subj":"T16","pred":"source","obj":"DisGeNET"},{"subj":"T17","pred":"source","obj":"DisGeNET"},{"subj":"T18","pred":"source","obj":"DisGeNET"},{"subj":"T19","pred":"source","obj":"DisGeNET"},{"subj":"T20","pred":"source","obj":"DisGeNET"},{"subj":"T21","pred":"source","obj":"DisGeNET"},{"subj":"T22","pred":"source","obj":"DisGeNET"},{"subj":"T23","pred":"source","obj":"DisGeNET"},{"subj":"T24","pred":"source","obj":"DisGeNET"},{"subj":"T25","pred":"source","obj":"DisGeNET"},{"subj":"T26","pred":"source","obj":"DisGeNET"},{"subj":"T27","pred":"source","obj":"DisGeNET"},{"subj":"T28","pred":"source","obj":"DisGeNET"},{"subj":"T29","pred":"source","obj":"DisGeNET"},{"subj":"T30","pred":"source","obj":"DisGeNET"},{"subj":"T31","pred":"source","obj":"DisGeNET"},{"subj":"T32","pred":"source","obj":"DisGeNET"},{"subj":"T33","pred":"source","obj":"DisGeNET"},{"subj":"T34","pred":"source","obj":"DisGeNET"},{"subj":"T35","pred":"source","obj":"DisGeNET"},{"subj":"T36","pred":"source","obj":"DisGeNET"},{"subj":"T37","pred":"source","obj":"DisGeNET"}]},{"project":"kaiyin_test","denotations":[{"id":"T30","span":{"begin":600,"end":603},"obj":"Gene"},{"id":"T10","span":{"begin":651,"end":685},"obj":"Var"},{"id":"T29","span":{"begin":735,"end":742},"obj":"NegReg"},{"id":"T12","span":{"begin":743,"end":759},"obj":"CPA"},{"id":"T21","span":{"begin":869,"end":878},"obj":"Var"},{"id":"T13","span":{"begin":888,"end":894},"obj":"PosReg"},{"id":"T14","span":{"begin":895,"end":903},"obj":"MPA"},{"id":"T32","span":{"begin":907,"end":932},"obj":"Enzyme"},{"id":"T33","span":{"begin":948,"end":970},"obj":"Enzyme"},{"id":"T22","span":{"begin":972,"end":990},"obj":"MPA"},{"id":"T23","span":{"begin":994,"end":997},"obj":"Gene"},{"id":"T24","span":{"begin":998,"end":1010},"obj":"Var"},{"id":"T16","span":{"begin":1050,"end":1061},"obj":"PosReg"},{"id":"T17","span":{"begin":1062,"end":1092},"obj":"MPA"},{"id":"T25","span":{"begin":1145,"end":1148},"obj":"Gene"},{"id":"T26","span":{"begin":1149,"end":1158},"obj":"Var"},{"id":"T18","span":{"begin":1167,"end":1173},"obj":"PosReg"},{"id":"T31","span":{"begin":1174,"end":1180},"obj":"Enzyme"},{"id":"T19","span":{"begin":1181,"end":1191},"obj":"MPA"},{"id":"T20","span":{"begin":1196,"end":1259},"obj":"CPA"}],"relations":[{"id":"R10","pred":"CauseOf","subj":"T21","obj":"T13"},{"id":"R11","pred":"ThemeOf","subj":"T14","obj":"T13"},{"id":"R12","pred":"ThemeOf","subj":"T23","obj":"T24"},{"id":"R13","pred":"ThemeOf","subj":"T24","obj":"T22"},{"id":"R14","pred":"CauseOf","subj":"T22","obj":"T16"},{"id":"R15","pred":"ThemeOf","subj":"T17","obj":"T16"},{"id":"R16","pred":"ThemeOf","subj":"T19","obj":"T18"},{"id":"R17","pred":"ThemeOf","subj":"T20","obj":"T18"},{"id":"R18","pred":"ThemeOf","subj":"T25","obj":"T26"},{"id":"R19","pred":"CauseOf","subj":"T26","obj":"T18"},{"id":"R22","pred":"CauseOf","subj":"T10","obj":"T29"},{"id":"R23","pred":"ThemeOf","subj":"T12","obj":"T29"},{"id":"R24","pred":"ThemeOf","subj":"T30","obj":"T10"},{"id":"R25","pred":"ThemeOf","subj":"T32","obj":"T14"},{"id":"R26","pred":"ThemeOf","subj":"T33","obj":"T32"},{"id":"R27","pred":"ThemeOf","subj":"T31","obj":"T19"}],"attributes":[{"subj":"T30","pred":"source","obj":"kaiyin_test"},{"subj":"T10","pred":"source","obj":"kaiyin_test"},{"subj":"T29","pred":"source","obj":"kaiyin_test"},{"subj":"T12","pred":"source","obj":"kaiyin_test"},{"subj":"T21","pred":"source","obj":"kaiyin_test"},{"subj":"T13","pred":"source","obj":"kaiyin_test"},{"subj":"T14","pred":"source","obj":"kaiyin_test"},{"subj":"T32","pred":"source","obj":"kaiyin_test"},{"subj":"T33","pred":"source","obj":"kaiyin_test"},{"subj":"T22","pred":"source","obj":"kaiyin_test"},{"subj":"T23","pred":"source","obj":"kaiyin_test"},{"subj":"T24","pred":"source","obj":"kaiyin_test"},{"subj":"T16","pred":"source","obj":"kaiyin_test"},{"subj":"T17","pred":"source","obj":"kaiyin_test"},{"subj":"T25","pred":"source","obj":"kaiyin_test"},{"subj":"T26","pred":"source","obj":"kaiyin_test"},{"subj":"T18","pred":"source","obj":"kaiyin_test"},{"subj":"T31","pred":"source","obj":"kaiyin_test"},{"subj":"T19","pred":"source","obj":"kaiyin_test"},{"subj":"T20","pred":"source","obj":"kaiyin_test"}]},{"project":"name_no","denotations":[{"id":"T30","span":{"begin":600,"end":603},"obj":"Gene"},{"id":"T10","span":{"begin":651,"end":685},"obj":"Var"},{"id":"T29","span":{"begin":735,"end":742},"obj":"NegReg"},{"id":"T12","span":{"begin":743,"end":759},"obj":"CPA"},{"id":"T21","span":{"begin":869,"end":878},"obj":"Var"},{"id":"T13","span":{"begin":888,"end":894},"obj":"PosReg"},{"id":"T14","span":{"begin":895,"end":903},"obj":"MPA"},{"id":"T32","span":{"begin":907,"end":932},"obj":"Enzyme"},{"id":"T33","span":{"begin":948,"end":970},"obj":"Enzyme"},{"id":"T22","span":{"begin":972,"end":990},"obj":"MPA"},{"id":"T23","span":{"begin":994,"end":997},"obj":"Gene"},{"id":"T24","span":{"begin":998,"end":1010},"obj":"Var"},{"id":"T16","span":{"begin":1050,"end":1061},"obj":"PosReg"},{"id":"T17","span":{"begin":1062,"end":1092},"obj":"MPA"},{"id":"T25","span":{"begin":1145,"end":1148},"obj":"Gene"},{"id":"T26","span":{"begin":1149,"end":1158},"obj":"Var"},{"id":"T18","span":{"begin":1167,"end":1173},"obj":"PosReg"},{"id":"T31","span":{"begin":1174,"end":1180},"obj":"Enzyme"},{"id":"T19","span":{"begin":1181,"end":1191},"obj":"MPA"},{"id":"T20","span":{"begin":1196,"end":1259},"obj":"CPA"}],"relations":[{"id":"R10","pred":"CauseOf","subj":"T21","obj":"T13"},{"id":"R11","pred":"ThemeOf","subj":"T14","obj":"T13"},{"id":"R12","pred":"ThemeOf","subj":"T23","obj":"T24"},{"id":"R13","pred":"ThemeOf","subj":"T24","obj":"T22"},{"id":"R14","pred":"CauseOf","subj":"T22","obj":"T16"},{"id":"R15","pred":"ThemeOf","subj":"T17","obj":"T16"},{"id":"R16","pred":"ThemeOf","subj":"T19","obj":"T18"},{"id":"R17","pred":"ThemeOf","subj":"T20","obj":"T18"},{"id":"R18","pred":"ThemeOf","subj":"T25","obj":"T26"},{"id":"R19","pred":"CauseOf","subj":"T26","obj":"T18"},{"id":"R22","pred":"CauseOf","subj":"T10","obj":"T29"},{"id":"R23","pred":"ThemeOf","subj":"T12","obj":"T29"},{"id":"R24","pred":"ThemeOf","subj":"T30","obj":"T10"},{"id":"R25","pred":"ThemeOf","subj":"T32","obj":"T14"},{"id":"R26","pred":"ThemeOf","subj":"T33","obj":"T32"},{"id":"R27","pred":"ThemeOf","subj":"T31","obj":"T19"}],"attributes":[{"subj":"T30","pred":"source","obj":"name_no"},{"subj":"T10","pred":"source","obj":"name_no"},{"subj":"T29","pred":"source","obj":"name_no"},{"subj":"T12","pred":"source","obj":"name_no"},{"subj":"T21","pred":"source","obj":"name_no"},{"subj":"T13","pred":"source","obj":"name_no"},{"subj":"T14","pred":"source","obj":"name_no"},{"subj":"T32","pred":"source","obj":"name_no"},{"subj":"T33","pred":"source","obj":"name_no"},{"subj":"T22","pred":"source","obj":"name_no"},{"subj":"T23","pred":"source","obj":"name_no"},{"subj":"T24","pred":"source","obj":"name_no"},{"subj":"T16","pred":"source","obj":"name_no"},{"subj":"T17","pred":"source","obj":"name_no"},{"subj":"T25","pred":"source","obj":"name_no"},{"subj":"T26","pred":"source","obj":"name_no"},{"subj":"T18","pred":"source","obj":"name_no"},{"subj":"T31","pred":"source","obj":"name_no"},{"subj":"T19","pred":"source","obj":"name_no"},{"subj":"T20","pred":"source","obj":"name_no"}]},{"project":"sonoma2","denotations":[{"id":"T0","span":{"begin":33,"end":36},"obj":"GENE"},{"id":"T1","span":{"begin":37,"end":53},"obj":"POSREG"},{"id":"T2","span":{"begin":54,"end":63},"obj":"VAR"},{"id":"T3","span":{"begin":73,"end":80},"obj":"DISEASE"},{"id":"T4","span":{"begin":96,"end":122},"obj":"MPA"},{"id":"T5","span":{"begin":124,"end":132},"obj":"VAR"},{"id":"T6","span":{"begin":136,"end":139},"obj":"GENE"},{"id":"T7","span":{"begin":152,"end":158},"obj":"REG"},{"id":"T8","span":{"begin":183,"end":189},"obj":"DISEASE"},{"id":"T9","span":{"begin":234,"end":238},"obj":"NEGREG"},{"id":"T10","span":{"begin":252,"end":260},"obj":"MPA"},{"id":"T11","span":{"begin":270,"end":274},"obj":"POSREG"},{"id":"T12","span":{"begin":342,"end":353},"obj":"GENE"},{"id":"T13","span":{"begin":354,"end":363},"obj":"VAR"},{"id":"T14","span":{"begin":368,"end":374},"obj":"REG"},{"id":"T15","span":{"begin":523,"end":529},"obj":"DISEASE"},{"id":"T16","span":{"begin":600,"end":603},"obj":"GENE"},{"id":"T17","span":{"begin":604,"end":613},"obj":"VAR"},{"id":"T18","span":{"begin":623,"end":630},"obj":"DISEASE"},{"id":"T19","span":{"begin":651,"end":660},"obj":"VAR"},{"id":"T20","span":{"begin":668,"end":674},"obj":"VAR"},{"id":"T21","span":{"begin":679,"end":685},"obj":"VAR"},{"id":"T22","span":{"begin":718,"end":729},"obj":"REG"},{"id":"T23","span":{"begin":735,"end":742},"obj":"NEGREG"},{"id":"T24","span":{"begin":751,"end":759},"obj":"CPA"},{"id":"T25","span":{"begin":869,"end":878},"obj":"VAR"},{"id":"T26","span":{"begin":888,"end":894},"obj":"POSREG"},{"id":"T27","span":{"begin":895,"end":903},"obj":"MPA"},{"id":"T28","span":{"begin":948,"end":954},"obj":"GENE"},{"id":"T29","span":{"begin":994,"end":997},"obj":"GENE"},{"id":"T30","span":{"begin":1005,"end":1010},"obj":"VAR"},{"id":"T31","span":{"begin":1050,"end":1061},"obj":"POSREG"},{"id":"T32","span":{"begin":1062,"end":1068},"obj":"GENE"},{"id":"T33","span":{"begin":1078,"end":1092},"obj":"MPA"},{"id":"T34","span":{"begin":1098,"end":1104},"obj":"DISEASE"},{"id":"T35","span":{"begin":1124,"end":1144},"obj":"REG"},{"id":"T36","span":{"begin":1145,"end":1148},"obj":"GENE"},{"id":"T37","span":{"begin":1149,"end":1158},"obj":"VAR"},{"id":"T38","span":{"begin":1167,"end":1173},"obj":"POSREG"},{"id":"T39","span":{"begin":1174,"end":1180},"obj":"GENE"},{"id":"T40","span":{"begin":1181,"end":1191},"obj":"MPA"},{"id":"T41","span":{"begin":1218,"end":1253},"obj":"MPA"},{"id":"T42","span":{"begin":1218,"end":1236},"obj":"GENE"},{"id":"T43","span":{"begin":1286,"end":1289},"obj":"GENE"},{"id":"T44","span":{"begin":1290,"end":1299},"obj":"VAR"},{"id":"T45","span":{"begin":1337,"end":1344},"obj":"DISEASE"},{"id":"T46","span":{"begin":1371,"end":1374},"obj":"GENE"},{"id":"T47","span":{"begin":1380,"end":1386},"obj":"DISEASE"},{"id":"T48","span":{"begin":1419,"end":1427},"obj":"VAR"},{"id":"T49","span":{"begin":1446,"end":1451},"obj":"DISEASE"}],"relations":[{"id":"R0","pred":"ThemeOf","subj":"T0","obj":"T2"},{"id":"R1","pred":"CauseOf","subj":"T2","obj":"T1"},{"id":"R2","pred":"CauseOf","subj":"T5","obj":"T7"},{"id":"R3","pred":"CauseOf","subj":"T5","obj":"T9"},{"id":"R4","pred":"CauseOf","subj":"T5","obj":"T11"},{"id":"R5","pred":"ThemeOf","subj":"T6","obj":"T5"},{"id":"R6","pred":"ThemeOf","subj":"T10","obj":"T9"},{"id":"R7","pred":"CauseOf","subj":"T13","obj":"T14"},{"id":"R8","pred":"ThemeOf","subj":"T16","obj":"T17"},{"id":"R9","pred":"CauseOf","subj":"T19","obj":"T22"},{"id":"R10","pred":"CauseOf","subj":"T19","obj":"T23"},{"id":"R11","pred":"ThemeOf","subj":"T20","obj":"T19"},{"id":"R12","pred":"CauseOf","subj":"T20","obj":"T22"},{"id":"R13","pred":"CauseOf","subj":"T20","obj":"T23"},{"id":"R14","pred":"ThemeOf","subj":"T21","obj":"T19"},{"id":"R15","pred":"CauseOf","subj":"T21","obj":"T22"},{"id":"R16","pred":"CauseOf","subj":"T21","obj":"T23"},{"id":"R17","pred":"ThemeOf","subj":"T24","obj":"T22"},{"id":"R18","pred":"ThemeOf","subj":"T24","obj":"T23"},{"id":"R19","pred":"CauseOf","subj":"T25","obj":"T26"},{"id":"R20","pred":"ThemeOf","subj":"T27","obj":"T26"},{"id":"R21","pred":"ThemeOf","subj":"T29","obj":"T30"},{"id":"R22","pred":"CauseOf","subj":"T30","obj":"T31"},{"id":"R23","pred":"CauseOf","subj":"T30","obj":"T38"},{"id":"R24","pred":"ThemeOf","subj":"T33","obj":"T31"},{"id":"R25","pred":"CauseOf","subj":"T37","obj":"T35"},{"id":"R26","pred":"ThemeOf","subj":"T36","obj":"T37"},{"id":"R27","pred":"CauseOf","subj":"T37","obj":"T38"},{"id":"R28","pred":"ThemeOf","subj":"T40","obj":"T38"},{"id":"R29","pred":"ThemeOf","subj":"T43","obj":"T44"},{"id":"R30","pred":"ThemeOf","subj":"T46","obj":"T48"}],"attributes":[{"subj":"T0","pred":"source","obj":"sonoma2"},{"subj":"T1","pred":"source","obj":"sonoma2"},{"subj":"T2","pred":"source","obj":"sonoma2"},{"subj":"T3","pred":"source","obj":"sonoma2"},{"subj":"T4","pred":"source","obj":"sonoma2"},{"subj":"T5","pred":"source","obj":"sonoma2"},{"subj":"T6","pred":"source","obj":"sonoma2"},{"subj":"T7","pred":"source","obj":"sonoma2"},{"subj":"T8","pred":"source","obj":"sonoma2"},{"subj":"T9","pred":"source","obj":"sonoma2"},{"subj":"T10","pred":"source","obj":"sonoma2"},{"subj":"T11","pred":"source","obj":"sonoma2"},{"subj":"T12","pred":"source","obj":"sonoma2"},{"subj":"T13","pred":"source","obj":"sonoma2"},{"subj":"T14","pred":"source","obj":"sonoma2"},{"subj":"T15","pred":"source","obj":"sonoma2"},{"subj":"T16","pred":"source","obj":"sonoma2"},{"subj":"T17","pred":"source","obj":"sonoma2"},{"subj":"T18","pred":"source","obj":"sonoma2"},{"subj":"T19","pred":"source","obj":"sonoma2"},{"subj":"T20","pred":"source","obj":"sonoma2"},{"subj":"T21","pred":"source","obj":"sonoma2"},{"subj":"T22","pred":"source","obj":"sonoma2"},{"subj":"T23","pred":"source","obj":"sonoma2"},{"subj":"T24","pred":"source","obj":"sonoma2"},{"subj":"T25","pred":"source","obj":"sonoma2"},{"subj":"T26","pred":"source","obj":"sonoma2"},{"subj":"T27","pred":"source","obj":"sonoma2"},{"subj":"T28","pred":"source","obj":"sonoma2"},{"subj":"T29","pred":"source","obj":"sonoma2"},{"subj":"T30","pred":"source","obj":"sonoma2"},{"subj":"T31","pred":"source","obj":"sonoma2"},{"subj":"T32","pred":"source","obj":"sonoma2"},{"subj":"T33","pred":"source","obj":"sonoma2"},{"subj":"T34","pred":"source","obj":"sonoma2"},{"subj":"T35","pred":"source","obj":"sonoma2"},{"subj":"T36","pred":"source","obj":"sonoma2"},{"subj":"T37","pred":"source","obj":"sonoma2"},{"subj":"T38","pred":"source","obj":"sonoma2"},{"subj":"T39","pred":"source","obj":"sonoma2"},{"subj":"T40","pred":"source","obj":"sonoma2"},{"subj":"T41","pred":"source","obj":"sonoma2"},{"subj":"T42","pred":"source","obj":"sonoma2"},{"subj":"T43","pred":"source","obj":"sonoma2"},{"subj":"T44","pred":"source","obj":"sonoma2"},{"subj":"T45","pred":"source","obj":"sonoma2"},{"subj":"T46","pred":"source","obj":"sonoma2"},{"subj":"T47","pred":"source","obj":"sonoma2"},{"subj":"T48","pred":"source","obj":"sonoma2"},{"subj":"T49","pred":"source","obj":"sonoma2"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#bf93ec","default":true},{"id":"PubmedHPO","color":"#93eca5"},{"id":"DisGeNET","color":"#ec939b"},{"id":"kaiyin_test","color":"#93b5ec"},{"id":"name_no","color":"#cfec93"},{"id":"sonoma2","color":"#ec93e9"}]}]}}